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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 24732

FusionGeneSummary for NPLOC4_P4HB

check button Fusion gene summary
Fusion gene informationFusion gene name: NPLOC4_P4HB
Fusion gene ID: 24732
HgeneTgene
Gene symbol

NPLOC4

P4HB

Gene ID

55666

5034

Gene nameNPL4 homolog, ubiquitin recognition factorprolyl 4-hydroxylase subunit beta
SynonymsNPL4CLCRP1|DSI|ERBA2L|GIT|P4Hbeta|PDI|PDIA1|PHDB|PO4DB|PO4HB|PROHB
Cytomap

17q25.3

17q25.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear protein localization protein 4 homologNPLOC4 ubiquitin recognition factornuclear protein localization 4 homologprotein disulfide-isomerasecellular thyroid hormone-binding proteincollagen prolyl 4-hydroxylase betaglutathione-insulin transhydrogenasep55procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptideprolyl 4-hydroxyla
Modification date2018052320180523
UniProtAcc

Q8TAT6

P07237

Ensembl transtripts involved in fusion geneENST00000331134, ENST00000374747, 
ENST00000539314, ENST00000572760, 
ENST00000573876, ENST00000574344, 
ENST00000331483, ENST00000576390, 
ENST00000439918, ENST00000472244, 
Fusion gene scores* DoF score11 X 9 X 7=6938 X 5 X 5=200
# samples 137
** MAII scorelog2(13/693*10)=-2.41434372910876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/200*10)=-1.51457317282976
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NPLOC4 [Title/Abstract] AND P4HB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneP4HB

GO:0018401

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

7753822


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-21-1076-01ANPLOC4chr17

79596751

-P4HBchr17

79805223

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000331134ENST00000331483NPLOC4chr17

79596751

-P4HBchr17

79805223

-
5CDS-intronENST00000331134ENST00000576390NPLOC4chr17

79596751

-P4HBchr17

79805223

-
5CDS-intronENST00000331134ENST00000439918NPLOC4chr17

79596751

-P4HBchr17

79805223

-
5CDS-5UTRENST00000331134ENST00000472244NPLOC4chr17

79596751

-P4HBchr17

79805223

-
In-frameENST00000374747ENST00000331483NPLOC4chr17

79596751

-P4HBchr17

79805223

-
5CDS-intronENST00000374747ENST00000576390NPLOC4chr17

79596751

-P4HBchr17

79805223

-
5CDS-intronENST00000374747ENST00000439918NPLOC4chr17

79596751

-P4HBchr17

79805223

-
5CDS-5UTRENST00000374747ENST00000472244NPLOC4chr17

79596751

-P4HBchr17

79805223

-
5UTR-3CDSENST00000539314ENST00000331483NPLOC4chr17

79596751

-P4HBchr17

79805223

-
5UTR-intronENST00000539314ENST00000576390NPLOC4chr17

79596751

-P4HBchr17

79805223

-
5UTR-intronENST00000539314ENST00000439918NPLOC4chr17

79596751

-P4HBchr17

79805223

-
5UTR-5UTRENST00000539314ENST00000472244NPLOC4chr17

79596751

-P4HBchr17

79805223

-
intron-3CDSENST00000572760ENST00000331483NPLOC4chr17

79596751

-P4HBchr17

79805223

-
intron-intronENST00000572760ENST00000576390NPLOC4chr17

79596751

-P4HBchr17

79805223

-
intron-intronENST00000572760ENST00000439918NPLOC4chr17

79596751

-P4HBchr17

79805223

-
intron-5UTRENST00000572760ENST00000472244NPLOC4chr17

79596751

-P4HBchr17

79805223

-
intron-3CDSENST00000573876ENST00000331483NPLOC4chr17

79596751

-P4HBchr17

79805223

-
intron-intronENST00000573876ENST00000576390NPLOC4chr17

79596751

-P4HBchr17

79805223

-
intron-intronENST00000573876ENST00000439918NPLOC4chr17

79596751

-P4HBchr17

79805223

-
intron-5UTRENST00000573876ENST00000472244NPLOC4chr17

79596751

-P4HBchr17

79805223

-
intron-3CDSENST00000574344ENST00000331483NPLOC4chr17

79596751

-P4HBchr17

79805223

-
intron-intronENST00000574344ENST00000576390NPLOC4chr17

79596751

-P4HBchr17

79805223

-
intron-intronENST00000574344ENST00000439918NPLOC4chr17

79596751

-P4HBchr17

79805223

-
intron-5UTRENST00000574344ENST00000472244NPLOC4chr17

79596751

-P4HBchr17

79805223

-

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FusionProtFeatures for NPLOC4_P4HB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NPLOC4

Q8TAT6

P4HB

P07237

The ternary complex containing UFD1, VCP and NPLOC4binds ubiquitinated proteins and is necessary for the export ofmisfolded proteins from the ER to the cytoplasm, where they aredegraded by the proteasome. The NPLOC4-UFD1-VCP complex regulatesspindle disassembly at the end of mitosis and is necessary for theformation of a closed nuclear envelope (By similarity). Acts as anegative regulator of type I interferon production via the complexformed with VCP and UFD1, which binds to DDX58/RIG-I and recruitsRNF125 to promote ubiquitination and degradation of DDX58/RIG-I(PubMed:26471729). {ECO:0000250|UniProtKB:Q9ES54,ECO:0000269|PubMed:26471729}. This multifunctional protein catalyzes the formation,breakage and rearrangement of disulfide bonds. At the cellsurface, seems to act as a reductase that cleaves disulfide bondsof proteins attached to the cell. May therefore cause structuralmodifications of exofacial proteins. Inside the cell, seems toform/rearrange disulfide bonds of nascent proteins. At highconcentrations, functions as a chaperone that inhibits aggregationof misfolded proteins. At low concentrations, facilitatesaggregation (anti-chaperone activity). May be involved with otherchaperones in the structural modification of the TG precursor inhormone biogenesis. Also acts a structural subunit of variousenzymes such as prolyl 4-hydroxylase and microsomaltriacylglycerol transfer protein MTTP. Receptor for LGALS9; theinteraction retains P4HB at the cell surface of Th2 T helpercells, increasing disulfide reductase activity at the plasmamembrane, altering the plasma membrane redox state and enhancingcell migration (PubMed:21670307). {ECO:0000269|PubMed:10636893,ECO:0000269|PubMed:12485997, ECO:0000269|PubMed:21670307}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneP4HBchr17:79596751chr17:79805223ENST00000331483-311349_475208509DomainThioredoxin 2
TgeneP4HBchr17:79596751chr17:79805223ENST00000331483-311505_508208509MotifNote=Prevents secretion from ER

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNPLOC4chr17:79596751chr17:79805223ENST00000331134-217226_36332609DomainMPN
HgeneNPLOC4chr17:79596751chr17:79805223ENST00000374747-216226_36332618DomainMPN
HgeneNPLOC4chr17:79596751chr17:79805223ENST00000331134-217580_60832609Zinc fingerRanBP2-type
HgeneNPLOC4chr17:79596751chr17:79805223ENST00000374747-216580_60832618Zinc fingerRanBP2-type
TgeneP4HBchr17:79596751chr17:79805223ENST00000331483-31118_134208509DomainThioredoxin 1


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FusionGeneSequence for NPLOC4_P4HB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NPLOC4_ENST00000331134_chr17_79596751_-_P4HB_ENST00000331483_chr17_79805223_-_333aa
MAESIIIRVQSPDGVKRITATKRETAATFLKKFDEGRNNFEGEVTKENLLDFIKHNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVS
DYDGKLSNFKTAAESFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRLITLEEEMTKYKPESEELTAERITEFCHRFLEGKIKPHLM
SQELPEDWDKQPVKVLVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEAVKVHSFPTLKFF

>In-frame_NPLOC4_ENST00000374747_chr17_79596751_-_P4HB_ENST00000331483_chr17_79805223_-_333aa
MAESIIIRVQSPDGVKRITATKRETAATFLKKFDEGRNNFEGEVTKENLLDFIKHNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVS
DYDGKLSNFKTAAESFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRLITLEEEMTKYKPESEELTAERITEFCHRFLEGKIKPHLM
SQELPEDWDKQPVKVLVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEAVKVHSFPTLKFF


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NPLOC4_ENST00000331134_chr17_79596751_-_P4HB_ENST00000331483_chr17_79805223_-_999nt
ATGGCCGAGAGCATCATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCGGATCACAGCAACAAAGAGAGAAACAGCAGCAACATTTTTG
AAAAAGTTTGATGAAGGCCGGAACAACTTTGAAGGGGAGGTCACCAAGGAGAACCTGCTGGACTTTATCAAACACAACCAGCTGCCCCTT
GTCATCGAGTTCACCGAGCAGACAGCCCCGAAGATTTTTGGAGGTGAAATCAAGACTCACATCCTGCTGTTCTTGCCCAAGAGTGTGTCT
GACTATGACGGCAAACTGAGCAACTTCAAAACAGCAGCCGAGAGCTTCAAGGGCAAGATCCTGTTCATCTTCATCGACAGCGACCACACC
GACAACCAGCGCATCCTCGAGTTCTTTGGCCTGAAGAAGGAAGAGTGCCCGGCCGTGCGCCTCATCACCCTGGAGGAGGAGATGACCAAG
TACAAGCCCGAATCGGAGGAGCTGACGGCAGAGAGGATCACAGAGTTCTGCCACCGCTTCCTGGAGGGCAAAATCAAGCCCCACCTGATG
AGCCAGGAGCTGCCGGAGGACTGGGACAAGCAGCCTGTCAAGGTGCTTGTTGGGAAGAACTTTGAAGACGTGGCTTTTGATGAGAAAAAA
AACGTCTTTGTGGAGTTCTATGCCCCATGGTGTGGTCACTGCAAACAGTTGGCTCCCATTTGGGATAAACTGGGAGAGACGTACAAGGAC
CATGAGAACATCGTCATCGCCAAGATGGACTCGACTGCCAACGAGGTGGAGGCCGTCAAAGTGCACAGCTTCCCCACACTCAAGTTCTTT
CCTGCCAGTGCCGACAGGACGGTCATTGATTACAACGGGGAACGCACGCTGGATGGTTTTAAGAAATTCCTGGAGAGCGGTGGCCAGGAT
GGGGCAGGGGATGATGACGATCTCGAGGACCTGGAAGAAGCAGAGGAGCCAGACATGGAGGAAGACGATGATCAGAAAGCTGTGAAAGAT

>In-frame_NPLOC4_ENST00000374747_chr17_79596751_-_P4HB_ENST00000331483_chr17_79805223_-_999nt
ATGGCCGAGAGCATCATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCGGATCACAGCAACAAAGAGAGAAACAGCAGCAACATTTTTG
AAAAAGTTTGATGAAGGCCGGAACAACTTTGAAGGGGAGGTCACCAAGGAGAACCTGCTGGACTTTATCAAACACAACCAGCTGCCCCTT
GTCATCGAGTTCACCGAGCAGACAGCCCCGAAGATTTTTGGAGGTGAAATCAAGACTCACATCCTGCTGTTCTTGCCCAAGAGTGTGTCT
GACTATGACGGCAAACTGAGCAACTTCAAAACAGCAGCCGAGAGCTTCAAGGGCAAGATCCTGTTCATCTTCATCGACAGCGACCACACC
GACAACCAGCGCATCCTCGAGTTCTTTGGCCTGAAGAAGGAAGAGTGCCCGGCCGTGCGCCTCATCACCCTGGAGGAGGAGATGACCAAG
TACAAGCCCGAATCGGAGGAGCTGACGGCAGAGAGGATCACAGAGTTCTGCCACCGCTTCCTGGAGGGCAAAATCAAGCCCCACCTGATG
AGCCAGGAGCTGCCGGAGGACTGGGACAAGCAGCCTGTCAAGGTGCTTGTTGGGAAGAACTTTGAAGACGTGGCTTTTGATGAGAAAAAA
AACGTCTTTGTGGAGTTCTATGCCCCATGGTGTGGTCACTGCAAACAGTTGGCTCCCATTTGGGATAAACTGGGAGAGACGTACAAGGAC
CATGAGAACATCGTCATCGCCAAGATGGACTCGACTGCCAACGAGGTGGAGGCCGTCAAAGTGCACAGCTTCCCCACACTCAAGTTCTTT
CCTGCCAGTGCCGACAGGACGGTCATTGATTACAACGGGGAACGCACGCTGGATGGTTTTAAGAAATTCCTGGAGAGCGGTGGCCAGGAT
GGGGCAGGGGATGATGACGATCTCGAGGACCTGGAAGAAGCAGAGGAGCCAGACATGGAGGAAGACGATGATCAGAAAGCTGTGAAAGAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_NPLOC4_ENST00000331134_chr17_79596751_-_P4HB_ENST00000331483_chr17_79805223_-_2068nt
AACCTGGTTTCCCGGCCTCGCGCCCGAGGGGAGCGTATTGAGCGAGGCACCGGGACGTCGGCGGCTGGCGGAGCCGGGCGGGCGAAGCTG
GAGCGGCGGTGGCGGCGGCGTAGGGAGGCCGGGGCCGGGGCTGAGGCCGCGGCCGGGTCTGCGAGGCCCTTGGGGCGGCAGGCGGCGGCG
GCCCGGGGCTCGAGCCCGGAGGCAGGAGCAGCCGCCATGGCCGAGAGCATCATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCGGATC
ACAGCAACAAAGAGAGAAACAGCAGCAACATTTTTGAAAAAGTTTGATGAAGGCCGGAACAACTTTGAAGGGGAGGTCACCAAGGAGAAC
CTGCTGGACTTTATCAAACACAACCAGCTGCCCCTTGTCATCGAGTTCACCGAGCAGACAGCCCCGAAGATTTTTGGAGGTGAAATCAAG
ACTCACATCCTGCTGTTCTTGCCCAAGAGTGTGTCTGACTATGACGGCAAACTGAGCAACTTCAAAACAGCAGCCGAGAGCTTCAAGGGC
AAGATCCTGTTCATCTTCATCGACAGCGACCACACCGACAACCAGCGCATCCTCGAGTTCTTTGGCCTGAAGAAGGAAGAGTGCCCGGCC
GTGCGCCTCATCACCCTGGAGGAGGAGATGACCAAGTACAAGCCCGAATCGGAGGAGCTGACGGCAGAGAGGATCACAGAGTTCTGCCAC
CGCTTCCTGGAGGGCAAAATCAAGCCCCACCTGATGAGCCAGGAGCTGCCGGAGGACTGGGACAAGCAGCCTGTCAAGGTGCTTGTTGGG
AAGAACTTTGAAGACGTGGCTTTTGATGAGAAAAAAAACGTCTTTGTGGAGTTCTATGCCCCATGGTGTGGTCACTGCAAACAGTTGGCT
CCCATTTGGGATAAACTGGGAGAGACGTACAAGGACCATGAGAACATCGTCATCGCCAAGATGGACTCGACTGCCAACGAGGTGGAGGCC
GTCAAAGTGCACAGCTTCCCCACACTCAAGTTCTTTCCTGCCAGTGCCGACAGGACGGTCATTGATTACAACGGGGAACGCACGCTGGAT
GGTTTTAAGAAATTCCTGGAGAGCGGTGGCCAGGATGGGGCAGGGGATGATGACGATCTCGAGGACCTGGAAGAAGCAGAGGAGCCAGAC
ATGGAGGAAGACGATGATCAGAAAGCTGTGAAAGATGAACTGTAATACGCAAAGCCAGACCCGGGCGCTGCCGAGACCCCTCGGGGGCTG
CACACCCAGCAGCAGCGCACGCCTCCGAAGCCTGCGGCCTCGCTTGAAGGAGGGCGTCGCCGGAAACCCAGGGAACCTCTCTGAAGTGAC
ACCTCACCCCTACACACCGTCCGTTCACCCCCGTCTCTTCCTTCTGCTTTTCGGTTTTTGGAAAGGGATCCATCTCCAGGCAGCCCACCC
TGGTGGGGCTTGTTTCCTGAAACCATGATGTACTTTTTCATACATGAGTCTGTCCAGAGTGCTTGCTACCGTGTTCGGAGTCTCGCTGCC
TCCCTCCCGCGGGAGGTTTCTCCTCTTTTTGAAAATTCCGTCTGTGGGATTTTTAGACATTTTTCGACATCAGGGTATTTGTTCCACCTT
GGCCAGGCCTCCTCGGAGAAGCTTGTCCCCCGTGTGGGAGGGACGGAGCCGGACTGGACATGGTCACTCAGTACCGCCTGCAGTGTCGCC
ATGACTGATCATGGCTCTTGCATTTTTGGGTAAATGGAGACTTCCGGATCCTGTCAGGGTGTCCCCCATGCCTGGAAGAGGAGCTGGTGG
CTGCCAGCCCTGGGGCCCGGCACAGGCCTGGGCCTTCCCCTTCCCTCAAGCCAGGGCTCCTCCTCCTGTCGTGGGCTCATTGTGACCACT
GGCCTCTCTACAGCACGGCCTGTGGCCTGTTCAAGGCAGAACCACGACCCTTGACTCCCGGGTGGGGAGGTGGCCAAGGATGCTGGAGCT

>In-frame_NPLOC4_ENST00000374747_chr17_79596751_-_P4HB_ENST00000331483_chr17_79805223_-_1982nt
GCTGGAGCGGCGGTGGCGGCGGCGTAGGGAGGCCGGGGCCGGGGCTGAGGCCGCGGCCGGGTCTGCGAGGCCCTTGGGGCGGCAGGCGGC
GGCGGCCCGGGGCTCGAGCCCGGAGGCAGGAGCAGCCGCCATGGCCGAGAGCATCATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCG
GATCACAGCAACAAAGAGAGAAACAGCAGCAACATTTTTGAAAAAGTTTGATGAAGGCCGGAACAACTTTGAAGGGGAGGTCACCAAGGA
GAACCTGCTGGACTTTATCAAACACAACCAGCTGCCCCTTGTCATCGAGTTCACCGAGCAGACAGCCCCGAAGATTTTTGGAGGTGAAAT
CAAGACTCACATCCTGCTGTTCTTGCCCAAGAGTGTGTCTGACTATGACGGCAAACTGAGCAACTTCAAAACAGCAGCCGAGAGCTTCAA
GGGCAAGATCCTGTTCATCTTCATCGACAGCGACCACACCGACAACCAGCGCATCCTCGAGTTCTTTGGCCTGAAGAAGGAAGAGTGCCC
GGCCGTGCGCCTCATCACCCTGGAGGAGGAGATGACCAAGTACAAGCCCGAATCGGAGGAGCTGACGGCAGAGAGGATCACAGAGTTCTG
CCACCGCTTCCTGGAGGGCAAAATCAAGCCCCACCTGATGAGCCAGGAGCTGCCGGAGGACTGGGACAAGCAGCCTGTCAAGGTGCTTGT
TGGGAAGAACTTTGAAGACGTGGCTTTTGATGAGAAAAAAAACGTCTTTGTGGAGTTCTATGCCCCATGGTGTGGTCACTGCAAACAGTT
GGCTCCCATTTGGGATAAACTGGGAGAGACGTACAAGGACCATGAGAACATCGTCATCGCCAAGATGGACTCGACTGCCAACGAGGTGGA
GGCCGTCAAAGTGCACAGCTTCCCCACACTCAAGTTCTTTCCTGCCAGTGCCGACAGGACGGTCATTGATTACAACGGGGAACGCACGCT
GGATGGTTTTAAGAAATTCCTGGAGAGCGGTGGCCAGGATGGGGCAGGGGATGATGACGATCTCGAGGACCTGGAAGAAGCAGAGGAGCC
AGACATGGAGGAAGACGATGATCAGAAAGCTGTGAAAGATGAACTGTAATACGCAAAGCCAGACCCGGGCGCTGCCGAGACCCCTCGGGG
GCTGCACACCCAGCAGCAGCGCACGCCTCCGAAGCCTGCGGCCTCGCTTGAAGGAGGGCGTCGCCGGAAACCCAGGGAACCTCTCTGAAG
TGACACCTCACCCCTACACACCGTCCGTTCACCCCCGTCTCTTCCTTCTGCTTTTCGGTTTTTGGAAAGGGATCCATCTCCAGGCAGCCC
ACCCTGGTGGGGCTTGTTTCCTGAAACCATGATGTACTTTTTCATACATGAGTCTGTCCAGAGTGCTTGCTACCGTGTTCGGAGTCTCGC
TGCCTCCCTCCCGCGGGAGGTTTCTCCTCTTTTTGAAAATTCCGTCTGTGGGATTTTTAGACATTTTTCGACATCAGGGTATTTGTTCCA
CCTTGGCCAGGCCTCCTCGGAGAAGCTTGTCCCCCGTGTGGGAGGGACGGAGCCGGACTGGACATGGTCACTCAGTACCGCCTGCAGTGT
CGCCATGACTGATCATGGCTCTTGCATTTTTGGGTAAATGGAGACTTCCGGATCCTGTCAGGGTGTCCCCCATGCCTGGAAGAGGAGCTG
GTGGCTGCCAGCCCTGGGGCCCGGCACAGGCCTGGGCCTTCCCCTTCCCTCAAGCCAGGGCTCCTCCTCCTGTCGTGGGCTCATTGTGAC
CACTGGCCTCTCTACAGCACGGCCTGTGGCCTGTTCAAGGCAGAACCACGACCCTTGACTCCCGGGTGGGGAGGTGGCCAAGGATGCTGG
AGCTGAATCAGACGCTGACAGTTCTTCAGGCATTTCTATTTCACAATCGAATTGAACACATTGGCCAAATAAAGTTGAAATTTTACCACC


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FusionGenePPI for NPLOC4_P4HB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NPLOC4UFD1L, VCP, SVIP, VIMP, USP13, VCPIP1, UBL4A, UBC, NSFL1C, FAF2, FAF1, UBXN7, UBXN1, UBXN8, UBXN11, UBXN10, ASPSCR1, ELAVL1, AMFR, GZMK, SPRTN, UBXN6, HNRNPL, HNRNPR, FLOT1, MRPL19, MRPS9, MTPN, LMNA, ADRB2, NFKBIA, HECW2, ADSL, CBS, DR1, EIF4A3, DNAAF5, METTL1, ARMC9, DPP9, FKBP10, FNTB, LPP, PDLIM5, PKM, RPRD1A, RPRD1B, SURF2, UFM1, PDE12, PLIN3, RAD23B, SAE1, SRP14, SSB, UBA2, UBE3A, UBQLN2, WDR4, CDC25A, BTRC, ZFAND2B, YOD1, RAF1, ENO1, MOV10, NXF1, EZH2, MAP3K1, KCNK16, ETNK2, TMEM62, SLC38A6, CD2AP, NDUFS3, ASNS, CAP1, FUS, GARS, HNRNPK, MTMR12, PTPRF, RRM2, SH3KBP1, UBA1, PICALM, NTRK1, CEP128, DCTN1, MCM2, IFT74, TTC26, ADK, UBAC2, PYCR2, TRIP10, SLC17A2, ATG9A, FAM189B, KDELR1, CYP19A1, KCNC4, TRIM13, ALG10B, FADS3, PSEN2, TRIM25P4HBUBQLN1, TRIP6, EIF4A2, CUL2, ELF3, PUF60, CD2BP2, TNFRSF14, FEZ1, PTN, TG, ERO1L, ERO1LB, H2AFX, HDAC5, PSMA3, ARRB1, ARRB2, SIRT7, CUL3, CDK2, FBXO6, LMAN1, HSPA5, PDIA6, PPIB, PDIA4, HSP90B1, ATP5B, ATP5A1, SURF4, CCT4, SERPINH1, GANAB, TXNL1, CALR, TMED9, PRKCSH, CCT7, ATF2, UBL4A, CXCR4, BAG3, EGFR, CSNK2A2, HNRNPD, PARK2, CALU, ACAA2, CLNS1A, P3H1, PABPC1, TPD52L2, UBA2, UBQLN2, USP5, PFDN2, PLIN3, PSMD9, TCEAL4, AGO2, P4HB, CUL7, CCDC8, EZH2, SUZ12, RNF2, BMI1, ARAF, ESR1, TRIM4, SUCO, ZNF292, P4HA2, ZBTB2, HNRNPA1, LGALS9, ITGB3, DNAJC3, GSTO1, HSD17B10, HSPD1, NACA2, P4HA1, BCAP29, CLIC4, ENO1, ENO3, EZR, GLRX3, HSP90AA1, HSP90AB1, MSN, PCNA, PDIA3, PGD, RDX, SAFB, TKT, UQCRC2, PRPF40B, PSMA7, RCN1, UCHL3, VCP, NTRK1, EWSR1, TCTN3, CEP104, TCTN1, PPME1, CCDC6, SYMPK, EDEM1, RBM8A, CPSF3, FIP1L1, MTTP, MCM2, UBXN10, U2AF2, IAPP, VWF, GPX7, PTPRN, ACP5, DUSP13, GXYLT1, P4HA3, PTPRO, NEK7, PDHA1, SOD1, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NPLOC4_P4HB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneP4HBP07237DB01593ZincProtein disulfide-isomerasesmall moleculeapproved|investigational
TgeneP4HBP07237DB03615RibostamycinProtein disulfide-isomerasesmall moleculeapproved|investigational
TgeneP4HBP07237DB11638ArtenimolProtein disulfide-isomerasesmall moleculeapproved|investigational

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RelatedDiseases for NPLOC4_P4HB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneP4HBC0029456Osteoporosis1CTD_human
TgeneP4HBC0033578Prostatic Neoplasms1CTD_human
TgeneP4HBC0151744Myocardial Ischemia1CTD_human
TgeneP4HBC1846707SPINOCEREBELLAR ATAXIA 171CTD_human
TgeneP4HBC1862178Cole Carpenter syndrome1ORPHANET;UNIPROT