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Fusion gene ID: 24732 |
FusionGeneSummary for NPLOC4_P4HB |
Fusion gene summary |
Fusion gene information | Fusion gene name: NPLOC4_P4HB | Fusion gene ID: 24732 | Hgene | Tgene | Gene symbol | NPLOC4 | P4HB | Gene ID | 55666 | 5034 |
Gene name | NPL4 homolog, ubiquitin recognition factor | prolyl 4-hydroxylase subunit beta | |
Synonyms | NPL4 | CLCRP1|DSI|ERBA2L|GIT|P4Hbeta|PDI|PDIA1|PHDB|PO4DB|PO4HB|PROHB | |
Cytomap | 17q25.3 | 17q25.3 | |
Type of gene | protein-coding | protein-coding | |
Description | nuclear protein localization protein 4 homologNPLOC4 ubiquitin recognition factornuclear protein localization 4 homolog | protein disulfide-isomerasecellular thyroid hormone-binding proteincollagen prolyl 4-hydroxylase betaglutathione-insulin transhydrogenasep55procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptideprolyl 4-hydroxyla | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8TAT6 | P07237 | |
Ensembl transtripts involved in fusion gene | ENST00000331134, ENST00000374747, ENST00000539314, ENST00000572760, ENST00000573876, ENST00000574344, | ENST00000331483, ENST00000576390, ENST00000439918, ENST00000472244, | |
Fusion gene scores | * DoF score | 11 X 9 X 7=693 | 8 X 5 X 5=200 |
# samples | 13 | 7 | |
** MAII score | log2(13/693*10)=-2.41434372910876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/200*10)=-1.51457317282976 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NPLOC4 [Title/Abstract] AND P4HB [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | P4HB | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline | 7753822 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUSC | TCGA-21-1076-01A | NPLOC4 | chr17 | 79596751 | - | P4HB | chr17 | 79805223 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000331134 | ENST00000331483 | NPLOC4 | chr17 | 79596751 | - | P4HB | chr17 | 79805223 | - |
5CDS-intron | ENST00000331134 | ENST00000576390 | NPLOC4 | chr17 | 79596751 | - | P4HB | chr17 | 79805223 | - |
5CDS-intron | ENST00000331134 | ENST00000439918 | NPLOC4 | chr17 | 79596751 | - | P4HB | chr17 | 79805223 | - |
5CDS-5UTR | ENST00000331134 | ENST00000472244 | NPLOC4 | chr17 | 79596751 | - | P4HB | chr17 | 79805223 | - |
In-frame | ENST00000374747 | ENST00000331483 | NPLOC4 | chr17 | 79596751 | - | P4HB | chr17 | 79805223 | - |
5CDS-intron | ENST00000374747 | ENST00000576390 | NPLOC4 | chr17 | 79596751 | - | P4HB | chr17 | 79805223 | - |
5CDS-intron | ENST00000374747 | ENST00000439918 | NPLOC4 | chr17 | 79596751 | - | P4HB | chr17 | 79805223 | - |
5CDS-5UTR | ENST00000374747 | ENST00000472244 | NPLOC4 | chr17 | 79596751 | - | P4HB | chr17 | 79805223 | - |
5UTR-3CDS | ENST00000539314 | ENST00000331483 | NPLOC4 | chr17 | 79596751 | - | P4HB | chr17 | 79805223 | - |
5UTR-intron | ENST00000539314 | ENST00000576390 | NPLOC4 | chr17 | 79596751 | - | P4HB | chr17 | 79805223 | - |
5UTR-intron | ENST00000539314 | ENST00000439918 | NPLOC4 | chr17 | 79596751 | - | P4HB | chr17 | 79805223 | - |
5UTR-5UTR | ENST00000539314 | ENST00000472244 | NPLOC4 | chr17 | 79596751 | - | P4HB | chr17 | 79805223 | - |
intron-3CDS | ENST00000572760 | ENST00000331483 | NPLOC4 | chr17 | 79596751 | - | P4HB | chr17 | 79805223 | - |
intron-intron | ENST00000572760 | ENST00000576390 | NPLOC4 | chr17 | 79596751 | - | P4HB | chr17 | 79805223 | - |
intron-intron | ENST00000572760 | ENST00000439918 | NPLOC4 | chr17 | 79596751 | - | P4HB | chr17 | 79805223 | - |
intron-5UTR | ENST00000572760 | ENST00000472244 | NPLOC4 | chr17 | 79596751 | - | P4HB | chr17 | 79805223 | - |
intron-3CDS | ENST00000573876 | ENST00000331483 | NPLOC4 | chr17 | 79596751 | - | P4HB | chr17 | 79805223 | - |
intron-intron | ENST00000573876 | ENST00000576390 | NPLOC4 | chr17 | 79596751 | - | P4HB | chr17 | 79805223 | - |
intron-intron | ENST00000573876 | ENST00000439918 | NPLOC4 | chr17 | 79596751 | - | P4HB | chr17 | 79805223 | - |
intron-5UTR | ENST00000573876 | ENST00000472244 | NPLOC4 | chr17 | 79596751 | - | P4HB | chr17 | 79805223 | - |
intron-3CDS | ENST00000574344 | ENST00000331483 | NPLOC4 | chr17 | 79596751 | - | P4HB | chr17 | 79805223 | - |
intron-intron | ENST00000574344 | ENST00000576390 | NPLOC4 | chr17 | 79596751 | - | P4HB | chr17 | 79805223 | - |
intron-intron | ENST00000574344 | ENST00000439918 | NPLOC4 | chr17 | 79596751 | - | P4HB | chr17 | 79805223 | - |
intron-5UTR | ENST00000574344 | ENST00000472244 | NPLOC4 | chr17 | 79596751 | - | P4HB | chr17 | 79805223 | - |
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FusionProtFeatures for NPLOC4_P4HB |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
NPLOC4 | P4HB |
The ternary complex containing UFD1, VCP and NPLOC4binds ubiquitinated proteins and is necessary for the export ofmisfolded proteins from the ER to the cytoplasm, where they aredegraded by the proteasome. The NPLOC4-UFD1-VCP complex regulatesspindle disassembly at the end of mitosis and is necessary for theformation of a closed nuclear envelope (By similarity). Acts as anegative regulator of type I interferon production via the complexformed with VCP and UFD1, which binds to DDX58/RIG-I and recruitsRNF125 to promote ubiquitination and degradation of DDX58/RIG-I(PubMed:26471729). {ECO:0000250|UniProtKB:Q9ES54,ECO:0000269|PubMed:26471729}. | This multifunctional protein catalyzes the formation,breakage and rearrangement of disulfide bonds. At the cellsurface, seems to act as a reductase that cleaves disulfide bondsof proteins attached to the cell. May therefore cause structuralmodifications of exofacial proteins. Inside the cell, seems toform/rearrange disulfide bonds of nascent proteins. At highconcentrations, functions as a chaperone that inhibits aggregationof misfolded proteins. At low concentrations, facilitatesaggregation (anti-chaperone activity). May be involved with otherchaperones in the structural modification of the TG precursor inhormone biogenesis. Also acts a structural subunit of variousenzymes such as prolyl 4-hydroxylase and microsomaltriacylglycerol transfer protein MTTP. Receptor for LGALS9; theinteraction retains P4HB at the cell surface of Th2 T helpercells, increasing disulfide reductase activity at the plasmamembrane, altering the plasma membrane redox state and enhancingcell migration (PubMed:21670307). {ECO:0000269|PubMed:10636893,ECO:0000269|PubMed:12485997, ECO:0000269|PubMed:21670307}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >P4HB | chr17:79596751 | chr17:79805223 | ENST00000331483 | - | 3 | 11 | 349_475 | 208 | 509 | Domain | Thioredoxin 2 |
Tgene | >P4HB | chr17:79596751 | chr17:79805223 | ENST00000331483 | - | 3 | 11 | 505_508 | 208 | 509 | Motif | Note=Prevents secretion from ER |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >NPLOC4 | chr17:79596751 | chr17:79805223 | ENST00000331134 | - | 2 | 17 | 226_363 | 32 | 609 | Domain | MPN |
Hgene | >NPLOC4 | chr17:79596751 | chr17:79805223 | ENST00000374747 | - | 2 | 16 | 226_363 | 32 | 618 | Domain | MPN |
Hgene | >NPLOC4 | chr17:79596751 | chr17:79805223 | ENST00000331134 | - | 2 | 17 | 580_608 | 32 | 609 | Zinc finger | RanBP2-type |
Hgene | >NPLOC4 | chr17:79596751 | chr17:79805223 | ENST00000374747 | - | 2 | 16 | 580_608 | 32 | 618 | Zinc finger | RanBP2-type |
Tgene | P4HB | chr17:79596751 | chr17:79805223 | ENST00000331483 | - | 3 | 11 | 18_134 | 208 | 509 | Domain | Thioredoxin 1 |
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FusionGeneSequence for NPLOC4_P4HB |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_NPLOC4_ENST00000331134_chr17_79596751_-_P4HB_ENST00000331483_chr17_79805223_-_333aa MAESIIIRVQSPDGVKRITATKRETAATFLKKFDEGRNNFEGEVTKENLLDFIKHNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVS DYDGKLSNFKTAAESFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRLITLEEEMTKYKPESEELTAERITEFCHRFLEGKIKPHLM SQELPEDWDKQPVKVLVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEAVKVHSFPTLKFF >In-frame_NPLOC4_ENST00000374747_chr17_79596751_-_P4HB_ENST00000331483_chr17_79805223_-_333aa MAESIIIRVQSPDGVKRITATKRETAATFLKKFDEGRNNFEGEVTKENLLDFIKHNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVS DYDGKLSNFKTAAESFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRLITLEEEMTKYKPESEELTAERITEFCHRFLEGKIKPHLM SQELPEDWDKQPVKVLVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEAVKVHSFPTLKFF |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_NPLOC4_ENST00000331134_chr17_79596751_-_P4HB_ENST00000331483_chr17_79805223_-_999nt ATGGCCGAGAGCATCATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCGGATCACAGCAACAAAGAGAGAAACAGCAGCAACATTTTTG AAAAAGTTTGATGAAGGCCGGAACAACTTTGAAGGGGAGGTCACCAAGGAGAACCTGCTGGACTTTATCAAACACAACCAGCTGCCCCTT GTCATCGAGTTCACCGAGCAGACAGCCCCGAAGATTTTTGGAGGTGAAATCAAGACTCACATCCTGCTGTTCTTGCCCAAGAGTGTGTCT GACTATGACGGCAAACTGAGCAACTTCAAAACAGCAGCCGAGAGCTTCAAGGGCAAGATCCTGTTCATCTTCATCGACAGCGACCACACC GACAACCAGCGCATCCTCGAGTTCTTTGGCCTGAAGAAGGAAGAGTGCCCGGCCGTGCGCCTCATCACCCTGGAGGAGGAGATGACCAAG TACAAGCCCGAATCGGAGGAGCTGACGGCAGAGAGGATCACAGAGTTCTGCCACCGCTTCCTGGAGGGCAAAATCAAGCCCCACCTGATG AGCCAGGAGCTGCCGGAGGACTGGGACAAGCAGCCTGTCAAGGTGCTTGTTGGGAAGAACTTTGAAGACGTGGCTTTTGATGAGAAAAAA AACGTCTTTGTGGAGTTCTATGCCCCATGGTGTGGTCACTGCAAACAGTTGGCTCCCATTTGGGATAAACTGGGAGAGACGTACAAGGAC CATGAGAACATCGTCATCGCCAAGATGGACTCGACTGCCAACGAGGTGGAGGCCGTCAAAGTGCACAGCTTCCCCACACTCAAGTTCTTT CCTGCCAGTGCCGACAGGACGGTCATTGATTACAACGGGGAACGCACGCTGGATGGTTTTAAGAAATTCCTGGAGAGCGGTGGCCAGGAT GGGGCAGGGGATGATGACGATCTCGAGGACCTGGAAGAAGCAGAGGAGCCAGACATGGAGGAAGACGATGATCAGAAAGCTGTGAAAGAT >In-frame_NPLOC4_ENST00000374747_chr17_79596751_-_P4HB_ENST00000331483_chr17_79805223_-_999nt ATGGCCGAGAGCATCATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCGGATCACAGCAACAAAGAGAGAAACAGCAGCAACATTTTTG AAAAAGTTTGATGAAGGCCGGAACAACTTTGAAGGGGAGGTCACCAAGGAGAACCTGCTGGACTTTATCAAACACAACCAGCTGCCCCTT GTCATCGAGTTCACCGAGCAGACAGCCCCGAAGATTTTTGGAGGTGAAATCAAGACTCACATCCTGCTGTTCTTGCCCAAGAGTGTGTCT GACTATGACGGCAAACTGAGCAACTTCAAAACAGCAGCCGAGAGCTTCAAGGGCAAGATCCTGTTCATCTTCATCGACAGCGACCACACC GACAACCAGCGCATCCTCGAGTTCTTTGGCCTGAAGAAGGAAGAGTGCCCGGCCGTGCGCCTCATCACCCTGGAGGAGGAGATGACCAAG TACAAGCCCGAATCGGAGGAGCTGACGGCAGAGAGGATCACAGAGTTCTGCCACCGCTTCCTGGAGGGCAAAATCAAGCCCCACCTGATG AGCCAGGAGCTGCCGGAGGACTGGGACAAGCAGCCTGTCAAGGTGCTTGTTGGGAAGAACTTTGAAGACGTGGCTTTTGATGAGAAAAAA AACGTCTTTGTGGAGTTCTATGCCCCATGGTGTGGTCACTGCAAACAGTTGGCTCCCATTTGGGATAAACTGGGAGAGACGTACAAGGAC CATGAGAACATCGTCATCGCCAAGATGGACTCGACTGCCAACGAGGTGGAGGCCGTCAAAGTGCACAGCTTCCCCACACTCAAGTTCTTT CCTGCCAGTGCCGACAGGACGGTCATTGATTACAACGGGGAACGCACGCTGGATGGTTTTAAGAAATTCCTGGAGAGCGGTGGCCAGGAT GGGGCAGGGGATGATGACGATCTCGAGGACCTGGAAGAAGCAGAGGAGCCAGACATGGAGGAAGACGATGATCAGAAAGCTGTGAAAGAT |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_NPLOC4_ENST00000331134_chr17_79596751_-_P4HB_ENST00000331483_chr17_79805223_-_2068nt AACCTGGTTTCCCGGCCTCGCGCCCGAGGGGAGCGTATTGAGCGAGGCACCGGGACGTCGGCGGCTGGCGGAGCCGGGCGGGCGAAGCTG GAGCGGCGGTGGCGGCGGCGTAGGGAGGCCGGGGCCGGGGCTGAGGCCGCGGCCGGGTCTGCGAGGCCCTTGGGGCGGCAGGCGGCGGCG GCCCGGGGCTCGAGCCCGGAGGCAGGAGCAGCCGCCATGGCCGAGAGCATCATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCGGATC ACAGCAACAAAGAGAGAAACAGCAGCAACATTTTTGAAAAAGTTTGATGAAGGCCGGAACAACTTTGAAGGGGAGGTCACCAAGGAGAAC CTGCTGGACTTTATCAAACACAACCAGCTGCCCCTTGTCATCGAGTTCACCGAGCAGACAGCCCCGAAGATTTTTGGAGGTGAAATCAAG ACTCACATCCTGCTGTTCTTGCCCAAGAGTGTGTCTGACTATGACGGCAAACTGAGCAACTTCAAAACAGCAGCCGAGAGCTTCAAGGGC AAGATCCTGTTCATCTTCATCGACAGCGACCACACCGACAACCAGCGCATCCTCGAGTTCTTTGGCCTGAAGAAGGAAGAGTGCCCGGCC GTGCGCCTCATCACCCTGGAGGAGGAGATGACCAAGTACAAGCCCGAATCGGAGGAGCTGACGGCAGAGAGGATCACAGAGTTCTGCCAC CGCTTCCTGGAGGGCAAAATCAAGCCCCACCTGATGAGCCAGGAGCTGCCGGAGGACTGGGACAAGCAGCCTGTCAAGGTGCTTGTTGGG AAGAACTTTGAAGACGTGGCTTTTGATGAGAAAAAAAACGTCTTTGTGGAGTTCTATGCCCCATGGTGTGGTCACTGCAAACAGTTGGCT CCCATTTGGGATAAACTGGGAGAGACGTACAAGGACCATGAGAACATCGTCATCGCCAAGATGGACTCGACTGCCAACGAGGTGGAGGCC GTCAAAGTGCACAGCTTCCCCACACTCAAGTTCTTTCCTGCCAGTGCCGACAGGACGGTCATTGATTACAACGGGGAACGCACGCTGGAT GGTTTTAAGAAATTCCTGGAGAGCGGTGGCCAGGATGGGGCAGGGGATGATGACGATCTCGAGGACCTGGAAGAAGCAGAGGAGCCAGAC ATGGAGGAAGACGATGATCAGAAAGCTGTGAAAGATGAACTGTAATACGCAAAGCCAGACCCGGGCGCTGCCGAGACCCCTCGGGGGCTG CACACCCAGCAGCAGCGCACGCCTCCGAAGCCTGCGGCCTCGCTTGAAGGAGGGCGTCGCCGGAAACCCAGGGAACCTCTCTGAAGTGAC ACCTCACCCCTACACACCGTCCGTTCACCCCCGTCTCTTCCTTCTGCTTTTCGGTTTTTGGAAAGGGATCCATCTCCAGGCAGCCCACCC TGGTGGGGCTTGTTTCCTGAAACCATGATGTACTTTTTCATACATGAGTCTGTCCAGAGTGCTTGCTACCGTGTTCGGAGTCTCGCTGCC TCCCTCCCGCGGGAGGTTTCTCCTCTTTTTGAAAATTCCGTCTGTGGGATTTTTAGACATTTTTCGACATCAGGGTATTTGTTCCACCTT GGCCAGGCCTCCTCGGAGAAGCTTGTCCCCCGTGTGGGAGGGACGGAGCCGGACTGGACATGGTCACTCAGTACCGCCTGCAGTGTCGCC ATGACTGATCATGGCTCTTGCATTTTTGGGTAAATGGAGACTTCCGGATCCTGTCAGGGTGTCCCCCATGCCTGGAAGAGGAGCTGGTGG CTGCCAGCCCTGGGGCCCGGCACAGGCCTGGGCCTTCCCCTTCCCTCAAGCCAGGGCTCCTCCTCCTGTCGTGGGCTCATTGTGACCACT GGCCTCTCTACAGCACGGCCTGTGGCCTGTTCAAGGCAGAACCACGACCCTTGACTCCCGGGTGGGGAGGTGGCCAAGGATGCTGGAGCT >In-frame_NPLOC4_ENST00000374747_chr17_79596751_-_P4HB_ENST00000331483_chr17_79805223_-_1982nt GCTGGAGCGGCGGTGGCGGCGGCGTAGGGAGGCCGGGGCCGGGGCTGAGGCCGCGGCCGGGTCTGCGAGGCCCTTGGGGCGGCAGGCGGC GGCGGCCCGGGGCTCGAGCCCGGAGGCAGGAGCAGCCGCCATGGCCGAGAGCATCATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCG GATCACAGCAACAAAGAGAGAAACAGCAGCAACATTTTTGAAAAAGTTTGATGAAGGCCGGAACAACTTTGAAGGGGAGGTCACCAAGGA GAACCTGCTGGACTTTATCAAACACAACCAGCTGCCCCTTGTCATCGAGTTCACCGAGCAGACAGCCCCGAAGATTTTTGGAGGTGAAAT CAAGACTCACATCCTGCTGTTCTTGCCCAAGAGTGTGTCTGACTATGACGGCAAACTGAGCAACTTCAAAACAGCAGCCGAGAGCTTCAA GGGCAAGATCCTGTTCATCTTCATCGACAGCGACCACACCGACAACCAGCGCATCCTCGAGTTCTTTGGCCTGAAGAAGGAAGAGTGCCC GGCCGTGCGCCTCATCACCCTGGAGGAGGAGATGACCAAGTACAAGCCCGAATCGGAGGAGCTGACGGCAGAGAGGATCACAGAGTTCTG CCACCGCTTCCTGGAGGGCAAAATCAAGCCCCACCTGATGAGCCAGGAGCTGCCGGAGGACTGGGACAAGCAGCCTGTCAAGGTGCTTGT TGGGAAGAACTTTGAAGACGTGGCTTTTGATGAGAAAAAAAACGTCTTTGTGGAGTTCTATGCCCCATGGTGTGGTCACTGCAAACAGTT GGCTCCCATTTGGGATAAACTGGGAGAGACGTACAAGGACCATGAGAACATCGTCATCGCCAAGATGGACTCGACTGCCAACGAGGTGGA GGCCGTCAAAGTGCACAGCTTCCCCACACTCAAGTTCTTTCCTGCCAGTGCCGACAGGACGGTCATTGATTACAACGGGGAACGCACGCT GGATGGTTTTAAGAAATTCCTGGAGAGCGGTGGCCAGGATGGGGCAGGGGATGATGACGATCTCGAGGACCTGGAAGAAGCAGAGGAGCC AGACATGGAGGAAGACGATGATCAGAAAGCTGTGAAAGATGAACTGTAATACGCAAAGCCAGACCCGGGCGCTGCCGAGACCCCTCGGGG GCTGCACACCCAGCAGCAGCGCACGCCTCCGAAGCCTGCGGCCTCGCTTGAAGGAGGGCGTCGCCGGAAACCCAGGGAACCTCTCTGAAG TGACACCTCACCCCTACACACCGTCCGTTCACCCCCGTCTCTTCCTTCTGCTTTTCGGTTTTTGGAAAGGGATCCATCTCCAGGCAGCCC ACCCTGGTGGGGCTTGTTTCCTGAAACCATGATGTACTTTTTCATACATGAGTCTGTCCAGAGTGCTTGCTACCGTGTTCGGAGTCTCGC TGCCTCCCTCCCGCGGGAGGTTTCTCCTCTTTTTGAAAATTCCGTCTGTGGGATTTTTAGACATTTTTCGACATCAGGGTATTTGTTCCA CCTTGGCCAGGCCTCCTCGGAGAAGCTTGTCCCCCGTGTGGGAGGGACGGAGCCGGACTGGACATGGTCACTCAGTACCGCCTGCAGTGT CGCCATGACTGATCATGGCTCTTGCATTTTTGGGTAAATGGAGACTTCCGGATCCTGTCAGGGTGTCCCCCATGCCTGGAAGAGGAGCTG GTGGCTGCCAGCCCTGGGGCCCGGCACAGGCCTGGGCCTTCCCCTTCCCTCAAGCCAGGGCTCCTCCTCCTGTCGTGGGCTCATTGTGAC CACTGGCCTCTCTACAGCACGGCCTGTGGCCTGTTCAAGGCAGAACCACGACCCTTGACTCCCGGGTGGGGAGGTGGCCAAGGATGCTGG AGCTGAATCAGACGCTGACAGTTCTTCAGGCATTTCTATTTCACAATCGAATTGAACACATTGGCCAAATAAAGTTGAAATTTTACCACC |
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FusionGenePPI for NPLOC4_P4HB |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NPLOC4 | UFD1L, VCP, SVIP, VIMP, USP13, VCPIP1, UBL4A, UBC, NSFL1C, FAF2, FAF1, UBXN7, UBXN1, UBXN8, UBXN11, UBXN10, ASPSCR1, ELAVL1, AMFR, GZMK, SPRTN, UBXN6, HNRNPL, HNRNPR, FLOT1, MRPL19, MRPS9, MTPN, LMNA, ADRB2, NFKBIA, HECW2, ADSL, CBS, DR1, EIF4A3, DNAAF5, METTL1, ARMC9, DPP9, FKBP10, FNTB, LPP, PDLIM5, PKM, RPRD1A, RPRD1B, SURF2, UFM1, PDE12, PLIN3, RAD23B, SAE1, SRP14, SSB, UBA2, UBE3A, UBQLN2, WDR4, CDC25A, BTRC, ZFAND2B, YOD1, RAF1, ENO1, MOV10, NXF1, EZH2, MAP3K1, KCNK16, ETNK2, TMEM62, SLC38A6, CD2AP, NDUFS3, ASNS, CAP1, FUS, GARS, HNRNPK, MTMR12, PTPRF, RRM2, SH3KBP1, UBA1, PICALM, NTRK1, CEP128, DCTN1, MCM2, IFT74, TTC26, ADK, UBAC2, PYCR2, TRIP10, SLC17A2, ATG9A, FAM189B, KDELR1, CYP19A1, KCNC4, TRIM13, ALG10B, FADS3, PSEN2, TRIM25 | P4HB | UBQLN1, TRIP6, EIF4A2, CUL2, ELF3, PUF60, CD2BP2, TNFRSF14, FEZ1, PTN, TG, ERO1L, ERO1LB, H2AFX, HDAC5, PSMA3, ARRB1, ARRB2, SIRT7, CUL3, CDK2, FBXO6, LMAN1, HSPA5, PDIA6, PPIB, PDIA4, HSP90B1, ATP5B, ATP5A1, SURF4, CCT4, SERPINH1, GANAB, TXNL1, CALR, TMED9, PRKCSH, CCT7, ATF2, UBL4A, CXCR4, BAG3, EGFR, CSNK2A2, HNRNPD, PARK2, CALU, ACAA2, CLNS1A, P3H1, PABPC1, TPD52L2, UBA2, UBQLN2, USP5, PFDN2, PLIN3, PSMD9, TCEAL4, AGO2, P4HB, CUL7, CCDC8, EZH2, SUZ12, RNF2, BMI1, ARAF, ESR1, TRIM4, SUCO, ZNF292, P4HA2, ZBTB2, HNRNPA1, LGALS9, ITGB3, DNAJC3, GSTO1, HSD17B10, HSPD1, NACA2, P4HA1, BCAP29, CLIC4, ENO1, ENO3, EZR, GLRX3, HSP90AA1, HSP90AB1, MSN, PCNA, PDIA3, PGD, RDX, SAFB, TKT, UQCRC2, PRPF40B, PSMA7, RCN1, UCHL3, VCP, NTRK1, EWSR1, TCTN3, CEP104, TCTN1, PPME1, CCDC6, SYMPK, EDEM1, RBM8A, CPSF3, FIP1L1, MTTP, MCM2, UBXN10, U2AF2, IAPP, VWF, GPX7, PTPRN, ACP5, DUSP13, GXYLT1, P4HA3, PTPRO, NEK7, PDHA1, SOD1, BRCA1 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NPLOC4_P4HB |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | P4HB | P07237 | DB01593 | Zinc | Protein disulfide-isomerase | small molecule | approved|investigational |
Tgene | P4HB | P07237 | DB03615 | Ribostamycin | Protein disulfide-isomerase | small molecule | approved|investigational |
Tgene | P4HB | P07237 | DB11638 | Artenimol | Protein disulfide-isomerase | small molecule | approved|investigational |
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RelatedDiseases for NPLOC4_P4HB |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | P4HB | C0029456 | Osteoporosis | 1 | CTD_human |
Tgene | P4HB | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | P4HB | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Tgene | P4HB | C1846707 | SPINOCEREBELLAR ATAXIA 17 | 1 | CTD_human |
Tgene | P4HB | C1862178 | Cole Carpenter syndrome | 1 | ORPHANET;UNIPROT |