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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24714

FusionGeneSummary for NPIPB7_GNAI2

check button Fusion gene summary
Fusion gene informationFusion gene name: NPIPB7_GNAI2
Fusion gene ID: 24714
HgeneTgene
Gene symbol

NPIPB7

GNAI2

Gene ID

440350

2771

Gene namenuclear pore complex interacting protein family member B7G protein subunit alpha i2
SynonymsA-575C2.4|A-761H5.5|NPIPL1GIP|GNAI2B|H_LUCA15.1|H_LUCA16.1
Cytomap

16p12.1

3p21.31

Type of genepseudoprotein-coding
Descriptionnuclear pore complex-interacting protein-like 1guanine nucleotide-binding protein G(i) subunit alpha-2GTP-binding regulatory protein Gi alpha-2 chainadenylate cyclase-inhibiting G alpha proteinguanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2guanine nucleotide
Modification date2018032920180523
UniProtAcc

O75200

P04899

Ensembl transtripts involved in fusion geneENST00000452313, ENST00000422163, 
ENST00000491100, ENST00000313601, 
ENST00000536647, ENST00000440628, 
ENST00000451956, ENST00000266027, 
Fusion gene scores* DoF score15 X 17 X 1=2555 X 5 X 2=50
# samples 175
** MAII scorelog2(17/255*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/50*10)=0
Context

PubMed: NPIPB7 [Title/Abstract] AND GNAI2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI031334NPIPB7chr16

28512693

+GNAI2chr3

50281808

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000452313ENST00000422163NPIPB7chr16

28512693

+GNAI2chr3

50281808

+
intron-intronENST00000452313ENST00000491100NPIPB7chr16

28512693

+GNAI2chr3

50281808

+
intron-intronENST00000452313ENST00000313601NPIPB7chr16

28512693

+GNAI2chr3

50281808

+
intron-intronENST00000452313ENST00000536647NPIPB7chr16

28512693

+GNAI2chr3

50281808

+
intron-intronENST00000452313ENST00000440628NPIPB7chr16

28512693

+GNAI2chr3

50281808

+
intron-intronENST00000452313ENST00000451956NPIPB7chr16

28512693

+GNAI2chr3

50281808

+
intron-intronENST00000452313ENST00000266027NPIPB7chr16

28512693

+GNAI2chr3

50281808

+

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FusionProtFeatures for NPIPB7_GNAI2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NPIPB7

O75200

GNAI2

P04899

Guanine nucleotide-binding proteins (G proteins) areinvolved as modulators or transducers in various transmembranesignaling systems. The G(i) proteins are involved in hormonalregulation of adenylate cyclase: they inhibit the cyclase inresponse to beta-adrenergic stimuli. May play a role in celldivision. {ECO:0000269|PubMed:17635935}. Isoform sGi2: Regulates the cell surface density ofdopamine receptors DRD2 by sequestrating them as an intracellularpool. {ECO:0000269|PubMed:17550964}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NPIPB7_GNAI2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NPIPB7_GNAI2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NPIPB7_GNAI2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NPIPB7_GNAI2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGNAI2C0004245Atrioventricular Block1CTD_human
TgeneGNAI2C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneGNAI2C0024667Animal Mammary Neoplasms1CTD_human
TgeneGNAI2C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneGNAI2C0027643Neoplasm Recurrence, Local1CTD_human
TgeneGNAI2C0428977Bradycardia1CTD_human
TgeneGNAI2C1458155Mammary Neoplasms1CTD_human