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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24713

FusionGeneSummary for NPIPB7_GABARAPL1

check button Fusion gene summary
Fusion gene informationFusion gene name: NPIPB7_GABARAPL1
Fusion gene ID: 24713
HgeneTgene
Gene symbol

NPIPB7

GABARAPL1

Gene ID

440350

23710

Gene namenuclear pore complex interacting protein family member B7GABA type A receptor associated protein like 1
SynonymsA-575C2.4|A-761H5.5|NPIPL1APG8-LIKE|APG8L|ATG8|ATG8B|ATG8L|GEC1
Cytomap

16p12.1

12p13.2

Type of genepseudoprotein-coding
Descriptionnuclear pore complex-interacting protein-like 1gamma-aminobutyric acid receptor-associated protein-like 1GABA(A) receptor-associated protein-like 1early estrogen-regulated proteinglandular epithelial cell protein 1
Modification date2018032920180524
UniProtAcc

O75200

Q9H0R8

Ensembl transtripts involved in fusion geneENST00000452313, ENST00000266458, 
ENST00000421801, ENST00000544284, 
ENST00000545047, ENST00000543602, 
ENST00000545887, ENST00000539289, 
ENST00000546017, ENST00000535576, 
ENST00000539170, 
Fusion gene scores* DoF score15 X 17 X 1=2555 X 5 X 2=50
# samples 175
** MAII scorelog2(17/255*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/50*10)=0
Context

PubMed: NPIPB7 [Title/Abstract] AND GABARAPL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA296513NPIPB7chr16

28875269

+GABARAPL1chr12

10370659

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000452313ENST00000266458NPIPB7chr16

28875269

+GABARAPL1chr12

10370659

+
intron-3CDSENST00000452313ENST00000421801NPIPB7chr16

28875269

+GABARAPL1chr12

10370659

+
intron-5UTRENST00000452313ENST00000544284NPIPB7chr16

28875269

+GABARAPL1chr12

10370659

+
intron-intronENST00000452313ENST00000545047NPIPB7chr16

28875269

+GABARAPL1chr12

10370659

+
intron-intronENST00000452313ENST00000543602NPIPB7chr16

28875269

+GABARAPL1chr12

10370659

+
intron-intronENST00000452313ENST00000545887NPIPB7chr16

28875269

+GABARAPL1chr12

10370659

+
intron-3UTRENST00000452313ENST00000539289NPIPB7chr16

28875269

+GABARAPL1chr12

10370659

+
intron-5UTRENST00000452313ENST00000546017NPIPB7chr16

28875269

+GABARAPL1chr12

10370659

+
intron-5UTRENST00000452313ENST00000535576NPIPB7chr16

28875269

+GABARAPL1chr12

10370659

+
intron-5UTRENST00000452313ENST00000539170NPIPB7chr16

28875269

+GABARAPL1chr12

10370659

+

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FusionProtFeatures for NPIPB7_GABARAPL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NPIPB7

O75200

GABARAPL1

Q9H0R8

Ubiquitin-like modifier that increases cell-surfaceexpression of kappa-type opioid receptor through facilitatinganterograde intracellular trafficking of the receptor. Involved information of autophagosomal vacuoles. Whereas LC3s are involved inelongation of the phagophore membrane, the GABARAP/GATE-16subfamily is essential for a later stage in autophagosomematuration. {ECO:0000269|PubMed:16431922,ECO:0000269|PubMed:20404487}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NPIPB7_GABARAPL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NPIPB7_GABARAPL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NPIPB7_GABARAPL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NPIPB7_GABARAPL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource