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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24700

FusionGeneSummary for NPHP4_CDKN2A

check button Fusion gene summary
Fusion gene informationFusion gene name: NPHP4_CDKN2A
Fusion gene ID: 24700
HgeneTgene
Gene symbol

NPHP4

CDKN2A

Gene ID

261734

1029

Gene namenephrocystin 4cyclin dependent kinase inhibitor 2A
SynonymsPOC10|SLSN4ARF|CDK4I|CDKN2|CMM2|INK4|INK4A|MLM|MTS-1|MTS1|P14|P14ARF|P16|P16-INK4A|P16INK4|P16INK4A|P19|P19ARF|TP16
Cytomap

1p36.31

9p21.3

Type of geneprotein-codingprotein-coding
Descriptionnephrocystin-4POC10 centriolar protein homolognephroretinincyclin-dependent kinase inhibitor 2ACDK4 inhibitor p16-INK4alternative reading framecell cycle negative regulator betacyclin-dependent kinase 4 inhibitor Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)multiple tumor suppressor 1
Modification date2018051920180527
UniProtAcc

O75161

Q8N726

Ensembl transtripts involved in fusion geneENST00000478423, ENST00000378156, 
ENST00000361570, ENST00000304494, 
ENST00000579755, ENST00000579122, 
ENST00000578845, ENST00000530628, 
ENST00000498124, ENST00000498628, 
ENST00000494262, ENST00000446177, 
ENST00000479692, ENST00000497750, 
ENST00000470819, 
Fusion gene scores* DoF score4 X 5 X 4=806 X 3 X 6=108
# samples 57
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/108*10)=-0.625604485218502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NPHP4 [Title/Abstract] AND CDKN2A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNPHP4

GO:0090090

negative regulation of canonical Wnt signaling pathway

22654112

TgeneCDKN2A

GO:0000082

G1/S transition of mitotic cell cycle

10208428

TgeneCDKN2A

GO:0007050

cell cycle arrest

15149599

TgeneCDKN2A

GO:0008285

negative regulation of cell proliferation

15149599

TgeneCDKN2A

GO:0030308

negative regulation of cell growth

10208428

TgeneCDKN2A

GO:0032088

negative regulation of NF-kappaB transcription factor activity

10353611

TgeneCDKN2A

GO:0042326

negative regulation of phosphorylation

8259215|10208428

TgeneCDKN2A

GO:0045736

negative regulation of cyclin-dependent protein serine/threonine kinase activity

7739547|8259215


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-EE-A20H-06ANPHP4chr1

6046215

-CDKN2Achr9

21971207

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000478423ENST00000361570NPHP4chr1

6046215

-CDKN2Achr9

21971207

-
intron-3CDSENST00000478423ENST00000304494NPHP4chr1

6046215

-CDKN2Achr9

21971207

-
intron-3CDSENST00000478423ENST00000579755NPHP4chr1

6046215

-CDKN2Achr9

21971207

-
intron-3CDSENST00000478423ENST00000579122NPHP4chr1

6046215

-CDKN2Achr9

21971207

-
intron-5UTRENST00000478423ENST00000578845NPHP4chr1

6046215

-CDKN2Achr9

21971207

-
intron-5UTRENST00000478423ENST00000530628NPHP4chr1

6046215

-CDKN2Achr9

21971207

-
intron-5UTRENST00000478423ENST00000498124NPHP4chr1

6046215

-CDKN2Achr9

21971207

-
intron-5UTRENST00000478423ENST00000498628NPHP4chr1

6046215

-CDKN2Achr9

21971207

-
intron-5UTRENST00000478423ENST00000494262NPHP4chr1

6046215

-CDKN2Achr9

21971207

-
intron-5UTRENST00000478423ENST00000446177NPHP4chr1

6046215

-CDKN2Achr9

21971207

-
intron-5UTRENST00000478423ENST00000479692NPHP4chr1

6046215

-CDKN2Achr9

21971207

-
intron-5UTRENST00000478423ENST00000497750NPHP4chr1

6046215

-CDKN2Achr9

21971207

-
intron-intronENST00000478423ENST00000470819NPHP4chr1

6046215

-CDKN2Achr9

21971207

-
Frame-shitENST00000378156ENST00000361570NPHP4chr1

6046215

-CDKN2Achr9

21971207

-
In-frameENST00000378156ENST00000304494NPHP4chr1

6046215

-CDKN2Achr9

21971207

-
Frame-shitENST00000378156ENST00000579755NPHP4chr1

6046215

-CDKN2Achr9

21971207

-
In-frameENST00000378156ENST00000579122NPHP4chr1

6046215

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000378156ENST00000578845NPHP4chr1

6046215

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000378156ENST00000530628NPHP4chr1

6046215

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000378156ENST00000498124NPHP4chr1

6046215

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000378156ENST00000498628NPHP4chr1

6046215

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000378156ENST00000494262NPHP4chr1

6046215

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000378156ENST00000446177NPHP4chr1

6046215

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000378156ENST00000479692NPHP4chr1

6046215

-CDKN2Achr9

21971207

-
5CDS-5UTRENST00000378156ENST00000497750NPHP4chr1

6046215

-CDKN2Achr9

21971207

-
5CDS-intronENST00000378156ENST00000470819NPHP4chr1

6046215

-CDKN2Achr9

21971207

-

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FusionProtFeatures for NPHP4_CDKN2A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NPHP4

O75161

CDKN2A

Q8N726

Involved in the organization of apical junctions; thefunction is proposed to implicate a NPHP1-4-8 module(PubMed:19755384, PubMed:21565611). Does not seem to be strictlyrequired for ciliogenesis (PubMed:21565611). Required for buildingfunctional cilia. Involved in the organization of the subapicalactin network in multiciliated epithelial cells. Seems to recruitINT to basal bodies of motile cilia which subsequently interactswith actin-modifying proteins such as DAAM1 (By similarity). Incooperation with INVS may downregulate the canonical Wnt pathwayand promote the Wnt-PCP pathway by regulating expression andsubcellular location of disheveled proteins. Stabilizes proteinlevels of JADE1 and promotes its translocation to the nucleusleading to cooperative inhibition of canonical Wnt signaling(PubMed:21498478, PubMed:22654112). Acts as negative regulator ofthe hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ(PubMed:21555462). {ECO:0000250|UniProtKB:B0DOB4,ECO:0000250|UniProtKB:P59240, ECO:0000269|PubMed:21498478,ECO:0000269|PubMed:21555462, ECO:0000269|PubMed:21565611,ECO:0000269|PubMed:22654112, ECO:0000305|PubMed:19755384}. Capable of inducing cell cycle arrest in G1 and G2phases. Acts as a tumor suppressor. Binds to MDM2 and blocks itsnucleocytoplasmic shuttling by sequestering it in the nucleolus.This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependenttransactivation and apoptosis. Also induces G2 arrest andapoptosis in a p53-independent manner by preventing the activationof cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulatesBCL6-induced transcriptional repression. Binds to E2F1 and MYC andblocks their transcriptional activator activity but has no effecton MYC transcriptional repression. Binds to TOP1/TOPOI andstimulates its activity. This complex binds to rRNA gene promotersand may play a role in rRNA transcription and/or maturation.Interacts with NPM1/B23 and promotes its polyubiquitination anddegradation, thus inhibiting rRNA processing. Interacts withCOMMD1 and promotes its 'Lys63'-linked polyubiquitination.Interacts with UBE2I/UBC9 and enhances sumoylation of a number ofits binding partners including MDM2 and E2F1. Binds to HUWE1 andrepresses its ubiquitin ligase activity. May play a role incontrolling cell proliferation and apoptosis during mammary glanddevelopment. Isoform smARF may be involved in regulation ofautophagy and caspase-independent cell death; the short-livedmitochondrial isoform is stabilized by C1QBP.{ECO:0000269|PubMed:11314011, ECO:0000269|PubMed:11314038,ECO:0000269|PubMed:12660818, ECO:0000269|PubMed:14636574,ECO:0000269|PubMed:15361825, ECO:0000269|PubMed:15567177,ECO:0000269|PubMed:15876874, ECO:0000269|PubMed:15989956,ECO:0000269|PubMed:16713577, ECO:0000269|PubMed:18305112,ECO:0000269|PubMed:22094112, ECO:0000269|PubMed:9724636}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NPHP4_CDKN2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NPHP4_ENST00000378156_chr1_6046215_-_CDKN2A_ENST00000304494_chr9_21971207_-_152aa
MNDWHRIFTQNVLVPPHPQRARQPWKESTAFQCVLKWLDGPVIRQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLV

>In-frame_NPHP4_ENST00000378156_chr1_6046215_-_CDKN2A_ENST00000579122_chr9_21971207_-_134aa
MNDWHRIFTQNVLVPPHPQRARQPWKESTAFQCVLKWLDGPVIRQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NPHP4_ENST00000378156_chr1_6046215_-_CDKN2A_ENST00000304494_chr9_21971207_-_456nt
ATGAACGACTGGCACAGGATCTTCACCCAAAACGTGCTTGTCCCTCCCCACCCACAGAGAGCGCGCCAGCCTTGGAAGGAATCCACGGCA
TTCCAGTGTGTCCTCAAGTGGCTGGACGGACCGGTAATTAGGCAGGTCATGATGATGGGCAGCGCCCGAGTGGCGGAGCTGCTGCTGCTC
CACGGCGCGGAGCCCAACTGCGCCGACCCCGCCACTCTCACCCGACCCGTGCACGACGCTGCCCGGGAGGGCTTCCTGGACACGCTGGTG
GTGCTGCACCGGGCCGGGGCGCGGCTGGACGTGCGCGATGCCTGGGGCCGTCTGCCCGTGGACCTGGCTGAGGAGCTGGGCCATCGCGAT
GTCGCACGGTACCTGCGCGCGGCTGCGGGGGGCACCAGAGGCAGTAACCATGCCCGCATAGATGCCGCGGAAGGTCCCTCAGACATCCCC

>In-frame_NPHP4_ENST00000378156_chr1_6046215_-_CDKN2A_ENST00000579122_chr9_21971207_-_402nt
ATGAACGACTGGCACAGGATCTTCACCCAAAACGTGCTTGTCCCTCCCCACCCACAGAGAGCGCGCCAGCCTTGGAAGGAATCCACGGCA
TTCCAGTGTGTCCTCAAGTGGCTGGACGGACCGGTAATTAGGCAGGTCATGATGATGGGCAGCGCCCGAGTGGCGGAGCTGCTGCTGCTC
CACGGCGCGGAGCCCAACTGCGCCGACCCCGCCACTCTCACCCGACCCGTGCACGACGCTGCCCGGGAGGGCTTCCTGGACACGCTGGTG
GTGCTGCACCGGGCCGGGGCGCGGCTGGACGTGCGCGATGCCTGGGGCCGTCTGCCCGTGGACCTGGCTGAGGAGCTGGGCCATCGCGAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_NPHP4_ENST00000378156_chr1_6046215_-_CDKN2A_ENST00000304494_chr9_21971207_-_1198nt
GACGCGAGGCGGGTTCTTGGACTGAGTGTGCGGCGCGGTGCGCCGCCTTCCGAGGCTCCTCCCGCGGGTGGCAGCGGACGGGGCGCGCCC
CTCGGCCAGTCCTCGGTCCTCAGGCTTGTGGCTCCGTTGAGCACCGGCCGCCGGGCCTCTGGGTCCGTCGAGTGGAGACTCTCTGAAAAG
CGTGGGCTCCGTGGCCTCCGGCGCGGCCGCGGCGGGTCGGTCTCCTAGATCATCCGGGAAGCCCACGGGACCCTCAGGCGGGCAGGATGA
ACGACTGGCACAGGATCTTCACCCAAAACGTGCTTGTCCCTCCCCACCCACAGAGAGCGCGCCAGCCTTGGAAGGAATCCACGGCATTCC
AGTGTGTCCTCAAGTGGCTGGACGGACCGGTAATTAGGCAGGTCATGATGATGGGCAGCGCCCGAGTGGCGGAGCTGCTGCTGCTCCACG
GCGCGGAGCCCAACTGCGCCGACCCCGCCACTCTCACCCGACCCGTGCACGACGCTGCCCGGGAGGGCTTCCTGGACACGCTGGTGGTGC
TGCACCGGGCCGGGGCGCGGCTGGACGTGCGCGATGCCTGGGGCCGTCTGCCCGTGGACCTGGCTGAGGAGCTGGGCCATCGCGATGTCG
CACGGTACCTGCGCGCGGCTGCGGGGGGCACCAGAGGCAGTAACCATGCCCGCATAGATGCCGCGGAAGGTCCCTCAGACATCCCCGATT
GAAAGAACCAGAGAGGCTCTGAGAAACCTCGGGAAACTTAGATCATCAGTCACCGAAGGTCCTACAGGGCCACAACTGCCCCCGCCACAA
CCCACCCCGCTTTCGTAGTTTTCATTTAGAAAATAGAGCTTTTAAAAATGTCCTGCCTTTTAACGTAGATATATGCCTTCCCCCACTACC
GTAAATGTCCATTTATATCATTTTTTATATATTCTTATAAAAATGTAAAAAAGAAAAACACCGCTTCTGCCTTTTCACTGTGTTGGAGTT
TTCTGGAGTGAGCACTCACGCCCTAAGCGCACATTCATGTGGGCATTTCTTGCGAGCCTCGCAGCCTCCGGAAGCTGTCGACTTCATGAC
AAGCATTTTGTGAACTAGGGAAGCTCAGGGGGGTTACTGGCTTCTCTTGAGTCACACTGCTAGCAAATGGCAGAACCAAAGCTCAAATAA

>In-frame_NPHP4_ENST00000378156_chr1_6046215_-_CDKN2A_ENST00000579122_chr9_21971207_-_886nt
GACGCGAGGCGGGTTCTTGGACTGAGTGTGCGGCGCGGTGCGCCGCCTTCCGAGGCTCCTCCCGCGGGTGGCAGCGGACGGGGCGCGCCC
CTCGGCCAGTCCTCGGTCCTCAGGCTTGTGGCTCCGTTGAGCACCGGCCGCCGGGCCTCTGGGTCCGTCGAGTGGAGACTCTCTGAAAAG
CGTGGGCTCCGTGGCCTCCGGCGCGGCCGCGGCGGGTCGGTCTCCTAGATCATCCGGGAAGCCCACGGGACCCTCAGGCGGGCAGGATGA
ACGACTGGCACAGGATCTTCACCCAAAACGTGCTTGTCCCTCCCCACCCACAGAGAGCGCGCCAGCCTTGGAAGGAATCCACGGCATTCC
AGTGTGTCCTCAAGTGGCTGGACGGACCGGTAATTAGGCAGGTCATGATGATGGGCAGCGCCCGAGTGGCGGAGCTGCTGCTGCTCCACG
GCGCGGAGCCCAACTGCGCCGACCCCGCCACTCTCACCCGACCCGTGCACGACGCTGCCCGGGAGGGCTTCCTGGACACGCTGGTGGTGC
TGCACCGGGCCGGGGCGCGGCTGGACGTGCGCGATGCCTGGGGCCGTCTGCCCGTGGACCTGGCTGAGGAGCTGGGCCATCGCGATGTCG
CACGACATCCCCGATTGAAAGAACCAGAGAGGCTCTGAGAAACCTCGGGAAACTTAGATCATCAGTCACCGAAGGTCCTACAGGGCCACA
ACTGCCCCCGCCACAACCCACCCCGCTTTCGTAGTTTTCATTTAGAAAATAGAGCTTTTAAAAATGTCCTGCCTTTTAACGTAGATATAT


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FusionGenePPI for NPHP4_CDKN2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NPHP4NPHP1, LATS1, CEP164, DDB1, RPGRIP1, JADE1, SKAP1, RPGRIP1L, CEP128, CEP89, AIP, CACYBP, HSP90AA1, HSP90AB1, HSPA1B, HSPA1L, HSPA2, INVS, IRS4, NUDC, NUDCD2, NUDCD3, RPAP3, TUBB, TUBB2B, TUBB4B, BAG2, DNAJC7, FKBP4, HSPA6, HSPA8, PIH1D1, STIP1, SUGT1, TTC4, TUBAL3, RPGR, PPP4R2, EGFR, SSSCA1, TUBB1, GKAP1, RPP25L, TEFM, CLUH, ECT2, NEK4, RAF1CDKN2APPP1R9B, CDK4, AURKA, CDK6, CCND2, SERTAD1, MDM2, RPL11, TP53, UBE2A, FKBP2, CCND1, E4F1, CCNG1, MDM4, ING4, DAXX, TOP1, PSME3, PSMC3, LAMTOR3, SMARCA4, ING1, KAT5, YY1, NPM1, SAP25, TRIP12, HUWE1, PCNA, MCM6, UCHL1, VHL, SP1, TTF1, HIST3H2BB, HDAC1, ARFIP2, GGA1, WRN, TP63, NCL, PPP1CB, PPP1CC, COMMD1, TRADD, UBE2I, CUL2, COPS5, SENP3, CDK5RAP3, CTBP2, RNF2, PIAS2, MYC, BRCA1, IKBKB, GGA3, CDKN2AIP, NMI, ATR, MYCN, HIF1A, E2F1, EGR1, SLC4A1, ZNF420, SIVA1, GMNN, ORC4, CDC6, CDC5L, CDC45, CDC7, MCM2, MCM10, MCM5, MAPK8, MAPK10, DEAF1, TDRD7, CRELD2, HNRNPU, FN1, PRKCA, DYRK1B, HIPK4, CDK11A, CLK2, UBE4B, USP26, SNRPA, TUBA1C, TUBB4B, TUBA1A, TUBB, HSPA9, SNRPB, RUVBL2, RIN2, PDCD6, MMRN1, MYL12A, MTR, HNRNPC, HSPA4, HSPA8, HSP90AB1, HSP90AA1, GAPDH, EPHA3, EEF2, ACLY, ACTN4, ACTG1, ACTB, HNRNPA2B1, BRK1, ACTA1, ACTBL2, CSTF2, LSM8, NCKAP1, RPP38, GNL3, DGCR8, BCL2L1, C1QBP, BECN1, RELA, MOV10, NXF1, PA2G4, ZBTB17, ANGPTL4, CASC3, NAT2, WHSC1L1, MYO1C, IQGAP1, MIS12, BAG6, CFAP97, TRIM28, PML, KAT2B, GLTSCR2, RRM2, IGF1R, PTEN, UBC, ANKRA2, ASPRV1, AZIN1, ANAPC15, ZGRF1, CCNDBP1, CENPA, EFHC2, EXOC2, HLA-DOB, MAF1, MGC34796, PTP4A3, RBM26, SIX2, UBL7, VAMP1, ZNF687, ZUFSP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NPHP4_CDKN2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NPHP4_CDKN2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNPHP4C1847013NEPHRONOPHTHISIS 46CTD_human;UNIPROT
HgeneNPHP4C1846979SENIOR-LOKEN SYNDROME 43CTD_human;UNIPROT
TgeneCDKN2AC1835044MELANOMA, CUTANEOUS MALIGNANT, 211CTD_human;UNIPROT
TgeneCDKN2AC0024121Lung Neoplasms4CTD_human
TgeneCDKN2AC0011570Mental Depression3PSYGENET
TgeneCDKN2AC0011581Depressive disorder3PSYGENET
TgeneCDKN2AC0023903Liver neoplasms3CTD_human
TgeneCDKN2AC0005695Bladder Neoplasm2CTD_human
TgeneCDKN2AC0006118Brain Neoplasms2CTD_human
TgeneCDKN2AC0007131Non-Small Cell Lung Carcinoma2CTD_human
TgeneCDKN2AC0017638Glioma2CTD_human
TgeneCDKN2AC0030297Pancreatic Neoplasm2CTD_human
TgeneCDKN2AC0040715Chromosomal translocation2CTD_human
TgeneCDKN2AC0041696Unipolar Depression2PSYGENET
TgeneCDKN2AC0345967Malignant mesothelioma2CTD_human
TgeneCDKN2AC1168401Squamous cell carcinoma of the head and neck2CTD_human
TgeneCDKN2AC1269683Major Depressive Disorder2PSYGENET
TgeneCDKN2AC0001418Adenocarcinoma1CTD_human
TgeneCDKN2AC0001624Adrenal Gland Neoplasms1CTD_human
TgeneCDKN2AC0007137Squamous cell carcinoma1CTD_human;HPO
TgeneCDKN2AC0008628Chromosome Deletion1CTD_human
TgeneCDKN2AC0014859Esophageal Neoplasms1CTD_human
TgeneCDKN2AC0017601Glaucoma1CTD_human
TgeneCDKN2AC0022783Vulvar Lichen Sclerosus1CTD_human
TgeneCDKN2AC0024299Lymphoma1CTD_human
TgeneCDKN2AC0025202melanoma1CTD_human;HPO
TgeneCDKN2AC0025500Mesothelioma1CTD_human
TgeneCDKN2AC0026640Mouth Neoplasms1CTD_human
TgeneCDKN2AC0026764Multiple Myeloma1CTD_human
TgeneCDKN2AC0027626Neoplasm Invasiveness1CTD_human
TgeneCDKN2AC0027819Neuroblastoma1CTD_human
TgeneCDKN2AC0031117Peripheral Neuropathy1CTD_human
TgeneCDKN2AC0032927Precancerous Conditions1CTD_human
TgeneCDKN2AC0036920Sezary Syndrome1CTD_human
TgeneCDKN2AC0038356Stomach Neoplasms1CTD_human
TgeneCDKN2AC0040100Thymoma1CTD_human
TgeneCDKN2AC0041107Trisomy1CTD_human
TgeneCDKN2AC0042065Genitourinary Neoplasms1CTD_human
TgeneCDKN2AC0079744Diffuse Large B-Cell Lymphoma1CTD_human
TgeneCDKN2AC0079773Lymphoma, T-Cell, Cutaneous1CTD_human
TgeneCDKN2AC0151779Cutaneous Melanoma1CTD_human
TgeneCDKN2AC0206686Adrenocortical carcinoma1CTD_human
TgeneCDKN2AC0206727Nerve Sheath Tumors1CTD_human
TgeneCDKN2AC0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneCDKN2AC0279628Adenocarcinoma Of Esophagus1CTD_human
TgeneCDKN2AC0596263Carcinogenesis1CTD_human
TgeneCDKN2AC0677866Brain Stem Neoplasms1CTD_human
TgeneCDKN2AC0887833Carcinoma, Pancreatic Ductal1CTD_human
TgeneCDKN2AC1449861Micronuclei, Chromosome-Defective1CTD_human
TgeneCDKN2AC1458155Mammary Neoplasms1CTD_human
TgeneCDKN2AC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneCDKN2AC2239176Liver carcinoma1CTD_human
TgeneCDKN2AC2931822Nasopharyngeal carcinoma1CTD_human