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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24687

FusionGeneSummary for NPEPPS_GNGT2

check button Fusion gene summary
Fusion gene informationFusion gene name: NPEPPS_GNGT2
Fusion gene ID: 24687
HgeneTgene
Gene symbol

NPEPPS

GNGT2

Gene ID

9520

2793

Gene nameaminopeptidase puromycin sensitiveG protein subunit gamma transducin 2
SynonymsAAP-S|MP100|PSAG-GAMMA-8|G-GAMMA-C|GNG8|GNG9|GNGT8
Cytomap

17q21.32

17q21.32

Type of geneprotein-codingprotein-coding
Descriptionpuromycin-sensitive aminopeptidasecytosol alanyl aminopeptidasemetalloproteinase MP100guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2G protein cone gamma 8 subunitG-gamma-9g gamma-Cgamma-T2 subunitguanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2guanine nucleotide binding prot
Modification date2018052320180523
UniProtAcc

P55786

O14610

Ensembl transtripts involved in fusion geneENST00000525037, ENST00000530173, 
ENST00000322157, ENST00000544660, 
ENST00000503070, ENST00000511277, 
ENST00000300406, ENST00000515635, 
ENST00000507680, ENST00000511673, 
Fusion gene scores* DoF score9 X 6 X 7=3781 X 1 X 1=1
# samples 101
** MAII scorelog2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: NPEPPS [Title/Abstract] AND GNGT2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNPEPPS

GO:0071456

cellular response to hypoxia

21056661


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-C8-A12T-01ANPEPPSchr17

45646860

+GNGT2chr17

47280394

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000525037ENST00000503070NPEPPSchr17

45646860

+GNGT2chr17

47280394

-
3UTR-intronENST00000525037ENST00000511277NPEPPSchr17

45646860

+GNGT2chr17

47280394

-
3UTR-intronENST00000525037ENST00000300406NPEPPSchr17

45646860

+GNGT2chr17

47280394

-
3UTR-intronENST00000525037ENST00000515635NPEPPSchr17

45646860

+GNGT2chr17

47280394

-
3UTR-intronENST00000525037ENST00000507680NPEPPSchr17

45646860

+GNGT2chr17

47280394

-
3UTR-intronENST00000525037ENST00000511673NPEPPSchr17

45646860

+GNGT2chr17

47280394

-
In-frameENST00000530173ENST00000503070NPEPPSchr17

45646860

+GNGT2chr17

47280394

-
5CDS-intronENST00000530173ENST00000511277NPEPPSchr17

45646860

+GNGT2chr17

47280394

-
5CDS-intronENST00000530173ENST00000300406NPEPPSchr17

45646860

+GNGT2chr17

47280394

-
5CDS-intronENST00000530173ENST00000515635NPEPPSchr17

45646860

+GNGT2chr17

47280394

-
5CDS-intronENST00000530173ENST00000507680NPEPPSchr17

45646860

+GNGT2chr17

47280394

-
5CDS-intronENST00000530173ENST00000511673NPEPPSchr17

45646860

+GNGT2chr17

47280394

-
In-frameENST00000322157ENST00000503070NPEPPSchr17

45646860

+GNGT2chr17

47280394

-
5CDS-intronENST00000322157ENST00000511277NPEPPSchr17

45646860

+GNGT2chr17

47280394

-
5CDS-intronENST00000322157ENST00000300406NPEPPSchr17

45646860

+GNGT2chr17

47280394

-
5CDS-intronENST00000322157ENST00000515635NPEPPSchr17

45646860

+GNGT2chr17

47280394

-
5CDS-intronENST00000322157ENST00000507680NPEPPSchr17

45646860

+GNGT2chr17

47280394

-
5CDS-intronENST00000322157ENST00000511673NPEPPSchr17

45646860

+GNGT2chr17

47280394

-
In-frameENST00000544660ENST00000503070NPEPPSchr17

45646860

+GNGT2chr17

47280394

-
5CDS-intronENST00000544660ENST00000511277NPEPPSchr17

45646860

+GNGT2chr17

47280394

-
5CDS-intronENST00000544660ENST00000300406NPEPPSchr17

45646860

+GNGT2chr17

47280394

-
5CDS-intronENST00000544660ENST00000515635NPEPPSchr17

45646860

+GNGT2chr17

47280394

-
5CDS-intronENST00000544660ENST00000507680NPEPPSchr17

45646860

+GNGT2chr17

47280394

-
5CDS-intronENST00000544660ENST00000511673NPEPPSchr17

45646860

+GNGT2chr17

47280394

-

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FusionProtFeatures for NPEPPS_GNGT2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NPEPPS

P55786

GNGT2

O14610

Aminopeptidase with broad substrate specificity forseveral peptides. Involved in proteolytic events essential forcell growth and viability. May act as regulator of neuropeptideactivity. Plays a role in the antigen-processing pathway for MHCclass I molecules. Involved in the N-terminal trimming ofcytotoxic T-cell epitope precursors. Digests the poly-Q peptidesfound in many cellular proteins. Digests tau from normal brainmore efficiently than tau from Alzheimer disease brain.{ECO:0000269|PubMed:10978616, ECO:0000269|PubMed:11062501,ECO:0000269|PubMed:17154549, ECO:0000269|PubMed:17318184,ECO:0000269|PubMed:19917696}. Guanine nucleotide-binding proteins (G proteins) areinvolved as a modulator or transducer in various transmembranesignaling systems. The beta and gamma chains are required for theGTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NPEPPS_GNGT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NPEPPS_ENST00000530173_chr17_45646860_+_GNGT2_ENST00000503070_chr17_47280394_-_161aa
MASFSMDCSPSFCVPGLWNPFIIFRSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIV

>In-frame_NPEPPS_ENST00000322157_chr17_45646860_+_GNGT2_ENST00000503070_chr17_47280394_-_165aa
MWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQAT

>In-frame_NPEPPS_ENST00000544660_chr17_45646860_+_GNGT2_ENST00000503070_chr17_47280394_-_121aa
MPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEEIHATGFNYQNEDEKVTLSFP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NPEPPS_ENST00000530173_chr17_45646860_+_GNGT2_ENST00000503070_chr17_47280394_-_483nt
ATGGCATCATTTTCCATGGATTGCTCTCCAAGTTTTTGTGTTCCTGGCCTTTGGAACCCCTTCATCATATTCCGCAGCCGCTCCTCTCGC
CGCCGCCTCCACAGCCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGC
CTTTGCCTCAAGCCCGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTG
ATGAATTGTGCTGATATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGAAATACATGCTACAGGATTTAACTATCAGAAT
GAAGATGAAAAAGTCACCTTGTCTTTCCCTAGTACTCTGCAAACAGGACCCACATTTAACGCCTTACTTCTTTTGCTGGGAAGAGCTTCT

>In-frame_NPEPPS_ENST00000322157_chr17_45646860_+_GNGT2_ENST00000503070_chr17_47280394_-_495nt
ATGTGGCTGGCAGCTGCCGCCCCCTCCCTCGCTCGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGC
CGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCC
ATCAACTACAGCCTTTGCCTCAAGCCCGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACT
AATCAGATTGTGATGAATTGTGCTGATATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGAAATACATGCTACAGGATTT
AACTATCAGAATGAAGATGAAAAAGTCACCTTGTCTTTCCCTAGTACTCTGCAAACAGGACCCACATTTAACGCCTTACTTCTTTTGCTG

>In-frame_NPEPPS_ENST00000544660_chr17_45646860_+_GNGT2_ENST00000503070_chr17_47280394_-_363nt
ATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTGCTGGACTTC
ACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGATATTGATATTATTACA
GCTTCATATGCACCAGAAGGAGATGAAGAAATACATGCTACAGGATTTAACTATCAGAATGAAGATGAAAAAGTCACCTTGTCTTTCCCT
AGTACTCTGCAAACAGGACCCACATTTAACGCCTTACTTCTTTTGCTGGGAAGAGCTTCTTGGTTGGAGCTAACCTGGTCTAGGACACCG


* Fusion transcript sequences (Full-length transcript).
>In-frame_NPEPPS_ENST00000530173_chr17_45646860_+_GNGT2_ENST00000503070_chr17_47280394_-_678nt
AAGTTACGGAAGAGTCAAGGCTGGGACCTCATGGCATCATTTTCCATGGATTGCTCTCCAAGTTTTTGTGTTCCTGGCCTTTGGAACCCC
TTCATCATATTCCGCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTG
CCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCC
CAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGATATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGAA
ATACATGCTACAGGATTTAACTATCAGAATGAAGATGAAAAAGTCACCTTGTCTTTCCCTAGTACTCTGCAAACAGGACCCACATTTAAC
GCCTTACTTCTTTTGCTGGGAAGAGCTTCTTGGTTGGAGCTAACCTGGTCTAGGACACCGTAGCTGCCTAGAAGACATCACATGAATCCA
TAGATGGTGGTGTTGGCAGGGAATACAAACTCAATTCCTGAATAAGTGCCTATTCCAGTGAGGACAATTCTGTGTCCCTTCCATTGACCT

>In-frame_NPEPPS_ENST00000322157_chr17_45646860_+_GNGT2_ENST00000503070_chr17_47280394_-_897nt
GGGCGCGCCCGGCCGGCGGGGCCGCGCACGCAGCCGCCGCCACCACTTCCCCCTCTCCCTCCCTCCTTGCGGGCCCTCCTCCCCTTCCCT
CCCCTCCGCCCCCTTCCCCGTAGGCAGCCCGCCCGCCAGTCCGCCCGCACCGCCTCCTTCCCAGCCCCTAGCGCTCCGGCTGGGTCTCTC
CCCCGCCCCCCAGGCTCCCCCGGTCGCTCTCCTCCGGCGGTCGCCCGCGCTCGGTGGATGTGGCTGGCAGCTGCCGCCCCCTCCCTCGCT
CGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGC
CTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTG
CTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGATATTGAT
ATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGAAATACATGCTACAGGATTTAACTATCAGAATGAAGATGAAAAAGTCACCTTG
TCTTTCCCTAGTACTCTGCAAACAGGACCCACATTTAACGCCTTACTTCTTTTGCTGGGAAGAGCTTCTTGGTTGGAGCTAACCTGGTCT
AGGACACCGTAGCTGCCTAGAAGACATCACATGAATCCATAGATGGTGGTGTTGGCAGGGAATACAAACTCAATTCCTGAATAAGTGCCT

>In-frame_NPEPPS_ENST00000544660_chr17_45646860_+_GNGT2_ENST00000503070_chr17_47280394_-_634nt
CCTCGCTCGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAG
CCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCC
CGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGA
TATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGAAATACATGCTACAGGATTTAACTATCAGAATGAAGATGAAAAAGT
CACCTTGTCTTTCCCTAGTACTCTGCAAACAGGACCCACATTTAACGCCTTACTTCTTTTGCTGGGAAGAGCTTCTTGGTTGGAGCTAAC
CTGGTCTAGGACACCGTAGCTGCCTAGAAGACATCACATGAATCCATAGATGGTGGTGTTGGCAGGGAATACAAACTCAATTCCTGAATA
AGTGCCTATTCCAGTGAGGACAATTCTGTGTCCCTTCCATTGACCTGCCACCAGAGAACTGGATGGTTGCCTTGAGGTCTGGTACTGTAT


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FusionGenePPI for NPEPPS_GNGT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NPEPPSEIF6, OTUD4, DMWD, CLN3, GBAS, RYK, HDAC5, SIRT7, FBXO25, CUL3, CDK2, UBA6, STRAP, ECT2, CAMKMT, CFTR, FBXO6, CNDP2, NANS, CKB, CSE1L, DAK, FTO, GBP1, LDHB, METAP2, PAK2, PDIA3, RPLP2, PFAS, RPS6KA1, RPS6KA3, SCLY, SLC9A3R1, TGM2, UBFD1, ZNF622, PHKG2, STAU1, CUL7, CCDC8, FAF2, DYNLT1, STXBP1, NTRK1, MED20, FAM204A, ZNF746, LRRC8E, TRIM25, CCND2, BRCA1, CDK20GNGT2KCNJ4, GNB2, GNB4, GNB1, GNB3, SRPK2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NPEPPS_GNGT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneNPEPPSP55786DB11638ArtenimolPuromycin-sensitive aminopeptidasesmall moleculeapproved|investigational

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RelatedDiseases for NPEPPS_GNGT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGNGT2C0023893Liver Cirrhosis, Experimental1CTD_human