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Fusion gene ID: 24687 |
FusionGeneSummary for NPEPPS_GNGT2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: NPEPPS_GNGT2 | Fusion gene ID: 24687 | Hgene | Tgene | Gene symbol | NPEPPS | GNGT2 | Gene ID | 9520 | 2793 |
Gene name | aminopeptidase puromycin sensitive | G protein subunit gamma transducin 2 | |
Synonyms | AAP-S|MP100|PSA | G-GAMMA-8|G-GAMMA-C|GNG8|GNG9|GNGT8 | |
Cytomap | 17q21.32 | 17q21.32 | |
Type of gene | protein-coding | protein-coding | |
Description | puromycin-sensitive aminopeptidasecytosol alanyl aminopeptidasemetalloproteinase MP100 | guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2G protein cone gamma 8 subunitG-gamma-9g gamma-Cgamma-T2 subunitguanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2guanine nucleotide binding prot | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P55786 | O14610 | |
Ensembl transtripts involved in fusion gene | ENST00000525037, ENST00000530173, ENST00000322157, ENST00000544660, | ENST00000503070, ENST00000511277, ENST00000300406, ENST00000515635, ENST00000507680, ENST00000511673, | |
Fusion gene scores | * DoF score | 9 X 6 X 7=378 | 1 X 1 X 1=1 |
# samples | 10 | 1 | |
** MAII score | log2(10/378*10)=-1.91838623444635 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: NPEPPS [Title/Abstract] AND GNGT2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NPEPPS | GO:0071456 | cellular response to hypoxia | 21056661 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-C8-A12T-01A | NPEPPS | chr17 | 45646860 | + | GNGT2 | chr17 | 47280394 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000525037 | ENST00000503070 | NPEPPS | chr17 | 45646860 | + | GNGT2 | chr17 | 47280394 | - |
3UTR-intron | ENST00000525037 | ENST00000511277 | NPEPPS | chr17 | 45646860 | + | GNGT2 | chr17 | 47280394 | - |
3UTR-intron | ENST00000525037 | ENST00000300406 | NPEPPS | chr17 | 45646860 | + | GNGT2 | chr17 | 47280394 | - |
3UTR-intron | ENST00000525037 | ENST00000515635 | NPEPPS | chr17 | 45646860 | + | GNGT2 | chr17 | 47280394 | - |
3UTR-intron | ENST00000525037 | ENST00000507680 | NPEPPS | chr17 | 45646860 | + | GNGT2 | chr17 | 47280394 | - |
3UTR-intron | ENST00000525037 | ENST00000511673 | NPEPPS | chr17 | 45646860 | + | GNGT2 | chr17 | 47280394 | - |
In-frame | ENST00000530173 | ENST00000503070 | NPEPPS | chr17 | 45646860 | + | GNGT2 | chr17 | 47280394 | - |
5CDS-intron | ENST00000530173 | ENST00000511277 | NPEPPS | chr17 | 45646860 | + | GNGT2 | chr17 | 47280394 | - |
5CDS-intron | ENST00000530173 | ENST00000300406 | NPEPPS | chr17 | 45646860 | + | GNGT2 | chr17 | 47280394 | - |
5CDS-intron | ENST00000530173 | ENST00000515635 | NPEPPS | chr17 | 45646860 | + | GNGT2 | chr17 | 47280394 | - |
5CDS-intron | ENST00000530173 | ENST00000507680 | NPEPPS | chr17 | 45646860 | + | GNGT2 | chr17 | 47280394 | - |
5CDS-intron | ENST00000530173 | ENST00000511673 | NPEPPS | chr17 | 45646860 | + | GNGT2 | chr17 | 47280394 | - |
In-frame | ENST00000322157 | ENST00000503070 | NPEPPS | chr17 | 45646860 | + | GNGT2 | chr17 | 47280394 | - |
5CDS-intron | ENST00000322157 | ENST00000511277 | NPEPPS | chr17 | 45646860 | + | GNGT2 | chr17 | 47280394 | - |
5CDS-intron | ENST00000322157 | ENST00000300406 | NPEPPS | chr17 | 45646860 | + | GNGT2 | chr17 | 47280394 | - |
5CDS-intron | ENST00000322157 | ENST00000515635 | NPEPPS | chr17 | 45646860 | + | GNGT2 | chr17 | 47280394 | - |
5CDS-intron | ENST00000322157 | ENST00000507680 | NPEPPS | chr17 | 45646860 | + | GNGT2 | chr17 | 47280394 | - |
5CDS-intron | ENST00000322157 | ENST00000511673 | NPEPPS | chr17 | 45646860 | + | GNGT2 | chr17 | 47280394 | - |
In-frame | ENST00000544660 | ENST00000503070 | NPEPPS | chr17 | 45646860 | + | GNGT2 | chr17 | 47280394 | - |
5CDS-intron | ENST00000544660 | ENST00000511277 | NPEPPS | chr17 | 45646860 | + | GNGT2 | chr17 | 47280394 | - |
5CDS-intron | ENST00000544660 | ENST00000300406 | NPEPPS | chr17 | 45646860 | + | GNGT2 | chr17 | 47280394 | - |
5CDS-intron | ENST00000544660 | ENST00000515635 | NPEPPS | chr17 | 45646860 | + | GNGT2 | chr17 | 47280394 | - |
5CDS-intron | ENST00000544660 | ENST00000507680 | NPEPPS | chr17 | 45646860 | + | GNGT2 | chr17 | 47280394 | - |
5CDS-intron | ENST00000544660 | ENST00000511673 | NPEPPS | chr17 | 45646860 | + | GNGT2 | chr17 | 47280394 | - |
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FusionProtFeatures for NPEPPS_GNGT2 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
NPEPPS | GNGT2 |
Aminopeptidase with broad substrate specificity forseveral peptides. Involved in proteolytic events essential forcell growth and viability. May act as regulator of neuropeptideactivity. Plays a role in the antigen-processing pathway for MHCclass I molecules. Involved in the N-terminal trimming ofcytotoxic T-cell epitope precursors. Digests the poly-Q peptidesfound in many cellular proteins. Digests tau from normal brainmore efficiently than tau from Alzheimer disease brain.{ECO:0000269|PubMed:10978616, ECO:0000269|PubMed:11062501,ECO:0000269|PubMed:17154549, ECO:0000269|PubMed:17318184,ECO:0000269|PubMed:19917696}. | Guanine nucleotide-binding proteins (G proteins) areinvolved as a modulator or transducer in various transmembranesignaling systems. The beta and gamma chains are required for theGTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NPEPPS_GNGT2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_NPEPPS_ENST00000530173_chr17_45646860_+_GNGT2_ENST00000503070_chr17_47280394_-_161aa MASFSMDCSPSFCVPGLWNPFIIFRSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIV >In-frame_NPEPPS_ENST00000322157_chr17_45646860_+_GNGT2_ENST00000503070_chr17_47280394_-_165aa MWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQAT >In-frame_NPEPPS_ENST00000544660_chr17_45646860_+_GNGT2_ENST00000503070_chr17_47280394_-_121aa MPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEEIHATGFNYQNEDEKVTLSFP |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_NPEPPS_ENST00000530173_chr17_45646860_+_GNGT2_ENST00000503070_chr17_47280394_-_483nt ATGGCATCATTTTCCATGGATTGCTCTCCAAGTTTTTGTGTTCCTGGCCTTTGGAACCCCTTCATCATATTCCGCAGCCGCTCCTCTCGC CGCCGCCTCCACAGCCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGC CTTTGCCTCAAGCCCGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTG ATGAATTGTGCTGATATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGAAATACATGCTACAGGATTTAACTATCAGAAT GAAGATGAAAAAGTCACCTTGTCTTTCCCTAGTACTCTGCAAACAGGACCCACATTTAACGCCTTACTTCTTTTGCTGGGAAGAGCTTCT >In-frame_NPEPPS_ENST00000322157_chr17_45646860_+_GNGT2_ENST00000503070_chr17_47280394_-_495nt ATGTGGCTGGCAGCTGCCGCCCCCTCCCTCGCTCGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGC CGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCC ATCAACTACAGCCTTTGCCTCAAGCCCGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACT AATCAGATTGTGATGAATTGTGCTGATATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGAAATACATGCTACAGGATTT AACTATCAGAATGAAGATGAAAAAGTCACCTTGTCTTTCCCTAGTACTCTGCAAACAGGACCCACATTTAACGCCTTACTTCTTTTGCTG >In-frame_NPEPPS_ENST00000544660_chr17_45646860_+_GNGT2_ENST00000503070_chr17_47280394_-_363nt ATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTGCTGGACTTC ACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGATATTGATATTATTACA GCTTCATATGCACCAGAAGGAGATGAAGAAATACATGCTACAGGATTTAACTATCAGAATGAAGATGAAAAAGTCACCTTGTCTTTCCCT AGTACTCTGCAAACAGGACCCACATTTAACGCCTTACTTCTTTTGCTGGGAAGAGCTTCTTGGTTGGAGCTAACCTGGTCTAGGACACCG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_NPEPPS_ENST00000530173_chr17_45646860_+_GNGT2_ENST00000503070_chr17_47280394_-_678nt AAGTTACGGAAGAGTCAAGGCTGGGACCTCATGGCATCATTTTCCATGGATTGCTCTCCAAGTTTTTGTGTTCCTGGCCTTTGGAACCCC TTCATCATATTCCGCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTG CCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCC CAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGATATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGAA ATACATGCTACAGGATTTAACTATCAGAATGAAGATGAAAAAGTCACCTTGTCTTTCCCTAGTACTCTGCAAACAGGACCCACATTTAAC GCCTTACTTCTTTTGCTGGGAAGAGCTTCTTGGTTGGAGCTAACCTGGTCTAGGACACCGTAGCTGCCTAGAAGACATCACATGAATCCA TAGATGGTGGTGTTGGCAGGGAATACAAACTCAATTCCTGAATAAGTGCCTATTCCAGTGAGGACAATTCTGTGTCCCTTCCATTGACCT >In-frame_NPEPPS_ENST00000322157_chr17_45646860_+_GNGT2_ENST00000503070_chr17_47280394_-_897nt GGGCGCGCCCGGCCGGCGGGGCCGCGCACGCAGCCGCCGCCACCACTTCCCCCTCTCCCTCCCTCCTTGCGGGCCCTCCTCCCCTTCCCT CCCCTCCGCCCCCTTCCCCGTAGGCAGCCCGCCCGCCAGTCCGCCCGCACCGCCTCCTTCCCAGCCCCTAGCGCTCCGGCTGGGTCTCTC CCCCGCCCCCCAGGCTCCCCCGGTCGCTCTCCTCCGGCGGTCGCCCGCGCTCGGTGGATGTGGCTGGCAGCTGCCGCCCCCTCCCTCGCT CGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGC CTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTG CTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGATATTGAT ATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGAAATACATGCTACAGGATTTAACTATCAGAATGAAGATGAAAAAGTCACCTTG TCTTTCCCTAGTACTCTGCAAACAGGACCCACATTTAACGCCTTACTTCTTTTGCTGGGAAGAGCTTCTTGGTTGGAGCTAACCTGGTCT AGGACACCGTAGCTGCCTAGAAGACATCACATGAATCCATAGATGGTGGTGTTGGCAGGGAATACAAACTCAATTCCTGAATAAGTGCCT >In-frame_NPEPPS_ENST00000544660_chr17_45646860_+_GNGT2_ENST00000503070_chr17_47280394_-_634nt CCTCGCTCGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAG CCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCC CGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGA TATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGAAATACATGCTACAGGATTTAACTATCAGAATGAAGATGAAAAAGT CACCTTGTCTTTCCCTAGTACTCTGCAAACAGGACCCACATTTAACGCCTTACTTCTTTTGCTGGGAAGAGCTTCTTGGTTGGAGCTAAC CTGGTCTAGGACACCGTAGCTGCCTAGAAGACATCACATGAATCCATAGATGGTGGTGTTGGCAGGGAATACAAACTCAATTCCTGAATA AGTGCCTATTCCAGTGAGGACAATTCTGTGTCCCTTCCATTGACCTGCCACCAGAGAACTGGATGGTTGCCTTGAGGTCTGGTACTGTAT |
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FusionGenePPI for NPEPPS_GNGT2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NPEPPS | EIF6, OTUD4, DMWD, CLN3, GBAS, RYK, HDAC5, SIRT7, FBXO25, CUL3, CDK2, UBA6, STRAP, ECT2, CAMKMT, CFTR, FBXO6, CNDP2, NANS, CKB, CSE1L, DAK, FTO, GBP1, LDHB, METAP2, PAK2, PDIA3, RPLP2, PFAS, RPS6KA1, RPS6KA3, SCLY, SLC9A3R1, TGM2, UBFD1, ZNF622, PHKG2, STAU1, CUL7, CCDC8, FAF2, DYNLT1, STXBP1, NTRK1, MED20, FAM204A, ZNF746, LRRC8E, TRIM25, CCND2, BRCA1, CDK20 | GNGT2 | KCNJ4, GNB2, GNB4, GNB1, GNB3, SRPK2 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NPEPPS_GNGT2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | NPEPPS | P55786 | DB11638 | Artenimol | Puromycin-sensitive aminopeptidase | small molecule | approved|investigational |
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RelatedDiseases for NPEPPS_GNGT2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | GNGT2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |