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Fusion gene ID: 24685 |
FusionGeneSummary for NPEPPS_CREB3L1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: NPEPPS_CREB3L1 | Fusion gene ID: 24685 | Hgene | Tgene | Gene symbol | NPEPPS | CREB3L1 | Gene ID | 9520 | 90993 |
Gene name | aminopeptidase puromycin sensitive | cAMP responsive element binding protein 3 like 1 | |
Synonyms | AAP-S|MP100|PSA | OASIS | |
Cytomap | 17q21.32 | 11p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | puromycin-sensitive aminopeptidasecytosol alanyl aminopeptidasemetalloproteinase MP100 | cyclic AMP-responsive element-binding protein 3-like protein 1BBF-2 homologcAMP-responsive element-binding protein 3-like protein 1old astrocyte specifically-induced substance | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P55786 | Q96BA8 | |
Ensembl transtripts involved in fusion gene | ENST00000525037, ENST00000530173, ENST00000322157, ENST00000544660, | ENST00000529193, ENST00000288400, ENST00000534616, | |
Fusion gene scores | * DoF score | 9 X 6 X 7=378 | 2 X 2 X 2=8 |
# samples | 10 | 2 | |
** MAII score | log2(10/378*10)=-1.91838623444635 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: NPEPPS [Title/Abstract] AND CREB3L1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NPEPPS | GO:0071456 | cellular response to hypoxia | 21056661 |
Tgene | CREB3L1 | GO:0010629 | negative regulation of gene expression | 27121396 |
Tgene | CREB3L1 | GO:0032967 | positive regulation of collagen biosynthetic process | 25310401 |
Tgene | CREB3L1 | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway | 27121396 |
Tgene | CREB3L1 | GO:0045892 | negative regulation of transcription, DNA-templated | 27121396 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | UCS | TCGA-NA-A5I1-01A | NPEPPS | chr17 | 45623359 | + | CREB3L1 | chr11 | 46341815 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000525037 | ENST00000529193 | NPEPPS | chr17 | 45623359 | + | CREB3L1 | chr11 | 46341815 | + |
3UTR-3CDS | ENST00000525037 | ENST00000288400 | NPEPPS | chr17 | 45623359 | + | CREB3L1 | chr11 | 46341815 | + |
3UTR-3UTR | ENST00000525037 | ENST00000534616 | NPEPPS | chr17 | 45623359 | + | CREB3L1 | chr11 | 46341815 | + |
In-frame | ENST00000530173 | ENST00000529193 | NPEPPS | chr17 | 45623359 | + | CREB3L1 | chr11 | 46341815 | + |
In-frame | ENST00000530173 | ENST00000288400 | NPEPPS | chr17 | 45623359 | + | CREB3L1 | chr11 | 46341815 | + |
5CDS-3UTR | ENST00000530173 | ENST00000534616 | NPEPPS | chr17 | 45623359 | + | CREB3L1 | chr11 | 46341815 | + |
In-frame | ENST00000322157 | ENST00000529193 | NPEPPS | chr17 | 45623359 | + | CREB3L1 | chr11 | 46341815 | + |
In-frame | ENST00000322157 | ENST00000288400 | NPEPPS | chr17 | 45623359 | + | CREB3L1 | chr11 | 46341815 | + |
5CDS-3UTR | ENST00000322157 | ENST00000534616 | NPEPPS | chr17 | 45623359 | + | CREB3L1 | chr11 | 46341815 | + |
In-frame | ENST00000544660 | ENST00000529193 | NPEPPS | chr17 | 45623359 | + | CREB3L1 | chr11 | 46341815 | + |
In-frame | ENST00000544660 | ENST00000288400 | NPEPPS | chr17 | 45623359 | + | CREB3L1 | chr11 | 46341815 | + |
5CDS-3UTR | ENST00000544660 | ENST00000534616 | NPEPPS | chr17 | 45623359 | + | CREB3L1 | chr11 | 46341815 | + |
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FusionProtFeatures for NPEPPS_CREB3L1 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
NPEPPS | CREB3L1 |
Aminopeptidase with broad substrate specificity forseveral peptides. Involved in proteolytic events essential forcell growth and viability. May act as regulator of neuropeptideactivity. Plays a role in the antigen-processing pathway for MHCclass I molecules. Involved in the N-terminal trimming ofcytotoxic T-cell epitope precursors. Digests the poly-Q peptidesfound in many cellular proteins. Digests tau from normal brainmore efficiently than tau from Alzheimer disease brain.{ECO:0000269|PubMed:10978616, ECO:0000269|PubMed:11062501,ECO:0000269|PubMed:17154549, ECO:0000269|PubMed:17318184,ECO:0000269|PubMed:19917696}. | Transcription factor involved in unfolded proteinresponse (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3'(PubMed:21767813). In the absence of endoplasmic reticulum (ER)stress, inserted into ER membranes, with N-terminal DNA-bindingand transcription activation domains oriented toward the cytosolicface of the membrane. In response to ER stress, transported to theGolgi, where it is cleaved in a site-specific manner by residentproteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminalcytosolic domain is translocated to the nucleus to effecttranscription of specific target genes. Plays a critical role inbone formation through the transcription of COL1A1, and possiblyCOL1A2, and the secretion of bone matrix proteins. Directly bindsto the UPR element (UPRE)-like sequence in an osteoblast-specificCOL1A1 promoter region and induces its transcription. Does notregulate COL1A1 in other tissues, such as skin (By similarity).Required to protect astrocytes from ER stress-induced cell death.In astrocytes, binds to the cAMP response element (CRE) of theBiP/HSPA5 promoter and participate in its transcriptionalactivation (By similarity). Required for TGFB1 to activate genesinvolved in the assembly of collagen extracellular matrix(PubMed:25310401). {ECO:0000250|UniProtKB:Q9Z125,ECO:0000269|PubMed:12054625, ECO:0000269|PubMed:21767813,ECO:0000269|PubMed:25310401}. (Microbial infection) May play a role in limiting virusspread by inhibiting proliferation of virus-infected cells. Uponinfection with diverse DNA and RNA viruses, inhibits cell-cycleprogression by binding to promoters and activating transcriptionof genes encoding cell-cycle inhibitors, such as p21/CDKN1A(PubMed:21767813). {ECO:0000269|PubMed:21767813}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NPEPPS_CREB3L1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_NPEPPS_ENST00000530173_chr17_45623359_+_CREB3L1_ENST00000529193_chr11_46341815_+_210aa MASFSMDCSPSFCVPGLWNPFIIFRSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIV MNCADIDIITASYAPEGDEVPSRSLLFYDDGAGLWEDGRSTLLPMEPPDGWEINPGGPAEQRPRDHLQHDHLDSTHETTKYLSEAWPKDG >In-frame_NPEPPS_ENST00000530173_chr17_45623359_+_CREB3L1_ENST00000288400_chr11_46341815_+_210aa MASFSMDCSPSFCVPGLWNPFIIFRSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIV MNCADIDIITASYAPEGDEVPSRSLLFYDDGAGLWEDGRSTLLPMEPPDGWEINPGGPAEQRPRDHLQHDHLDSTHETTKYLSEAWPKDG >In-frame_NPEPPS_ENST00000322157_chr17_45623359_+_CREB3L1_ENST00000529193_chr11_46341815_+_214aa MWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQAT NQIVMNCADIDIITASYAPEGDEVPSRSLLFYDDGAGLWEDGRSTLLPMEPPDGWEINPGGPAEQRPRDHLQHDHLDSTHETTKYLSEAW >In-frame_NPEPPS_ENST00000322157_chr17_45623359_+_CREB3L1_ENST00000288400_chr11_46341815_+_214aa MWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQAT NQIVMNCADIDIITASYAPEGDEVPSRSLLFYDDGAGLWEDGRSTLLPMEPPDGWEINPGGPAEQRPRDHLQHDHLDSTHETTKYLSEAW >In-frame_NPEPPS_ENST00000544660_chr17_45623359_+_CREB3L1_ENST00000529193_chr11_46341815_+_170aa MPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEVPSRSLLFYDDGAGLWEDGRS >In-frame_NPEPPS_ENST00000544660_chr17_45623359_+_CREB3L1_ENST00000288400_chr11_46341815_+_170aa MPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEVPSRSLLFYDDGAGLWEDGRS |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_NPEPPS_ENST00000530173_chr17_45623359_+_CREB3L1_ENST00000529193_chr11_46341815_+_630nt ATGGCATCATTTTCCATGGATTGCTCTCCAAGTTTTTGTGTTCCTGGCCTTTGGAACCCCTTCATCATATTCCGCAGCCGCTCCTCTCGC CGCCGCCTCCACAGCCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGC CTTTGCCTCAAGCCCGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTG ATGAATTGTGCTGATATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGTGCCCTCCCGAAGCCTCCTATTCTACGATGAC GGGGCAGGCTTATGGGAAGATGGCCGCAGCACCCTGCTGCCCATGGAGCCCCCAGATGGCTGGGAAATCAACCCCGGGGGGCCGGCAGAG CAGCGGCCCCGGGACCACCTGCAGCATGATCACCTGGACAGCACCCACGAGACCACCAAGTACCTGAGTGAGGCCTGGCCTAAAGACGGT GGAAACGGCACCAGCCCCGACTTCTCCCACTCCAAGGAGTGGTTCCACGACAGGGATCTGGGCCCCAACACCACCATCAAACTCTCCTAG >In-frame_NPEPPS_ENST00000530173_chr17_45623359_+_CREB3L1_ENST00000288400_chr11_46341815_+_630nt ATGGCATCATTTTCCATGGATTGCTCTCCAAGTTTTTGTGTTCCTGGCCTTTGGAACCCCTTCATCATATTCCGCAGCCGCTCCTCTCGC CGCCGCCTCCACAGCCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGC CTTTGCCTCAAGCCCGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTG ATGAATTGTGCTGATATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGTGCCCTCCCGAAGCCTCCTATTCTACGATGAC GGGGCAGGCTTATGGGAAGATGGCCGCAGCACCCTGCTGCCCATGGAGCCCCCAGATGGCTGGGAAATCAACCCCGGGGGGCCGGCAGAG CAGCGGCCCCGGGACCACCTGCAGCATGATCACCTGGACAGCACCCACGAGACCACCAAGTACCTGAGTGAGGCCTGGCCTAAAGACGGT GGAAACGGCACCAGCCCCGACTTCTCCCACTCCAAGGAGTGGTTCCACGACAGGGATCTGGGCCCCAACACCACCATCAAACTCTCCTAG >In-frame_NPEPPS_ENST00000322157_chr17_45623359_+_CREB3L1_ENST00000529193_chr11_46341815_+_642nt ATGTGGCTGGCAGCTGCCGCCCCCTCCCTCGCTCGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGC CGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCC ATCAACTACAGCCTTTGCCTCAAGCCCGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACT AATCAGATTGTGATGAATTGTGCTGATATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGTGCCCTCCCGAAGCCTCCTA TTCTACGATGACGGGGCAGGCTTATGGGAAGATGGCCGCAGCACCCTGCTGCCCATGGAGCCCCCAGATGGCTGGGAAATCAACCCCGGG GGGCCGGCAGAGCAGCGGCCCCGGGACCACCTGCAGCATGATCACCTGGACAGCACCCACGAGACCACCAAGTACCTGAGTGAGGCCTGG CCTAAAGACGGTGGAAACGGCACCAGCCCCGACTTCTCCCACTCCAAGGAGTGGTTCCACGACAGGGATCTGGGCCCCAACACCACCATC >In-frame_NPEPPS_ENST00000322157_chr17_45623359_+_CREB3L1_ENST00000288400_chr11_46341815_+_642nt ATGTGGCTGGCAGCTGCCGCCCCCTCCCTCGCTCGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGC CGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCC ATCAACTACAGCCTTTGCCTCAAGCCCGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACT AATCAGATTGTGATGAATTGTGCTGATATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGTGCCCTCCCGAAGCCTCCTA TTCTACGATGACGGGGCAGGCTTATGGGAAGATGGCCGCAGCACCCTGCTGCCCATGGAGCCCCCAGATGGCTGGGAAATCAACCCCGGG GGGCCGGCAGAGCAGCGGCCCCGGGACCACCTGCAGCATGATCACCTGGACAGCACCCACGAGACCACCAAGTACCTGAGTGAGGCCTGG CCTAAAGACGGTGGAAACGGCACCAGCCCCGACTTCTCCCACTCCAAGGAGTGGTTCCACGACAGGGATCTGGGCCCCAACACCACCATC >In-frame_NPEPPS_ENST00000544660_chr17_45623359_+_CREB3L1_ENST00000529193_chr11_46341815_+_510nt ATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTGCTGGACTTC ACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGATATTGATATTATTACA GCTTCATATGCACCAGAAGGAGATGAAGTGCCCTCCCGAAGCCTCCTATTCTACGATGACGGGGCAGGCTTATGGGAAGATGGCCGCAGC ACCCTGCTGCCCATGGAGCCCCCAGATGGCTGGGAAATCAACCCCGGGGGGCCGGCAGAGCAGCGGCCCCGGGACCACCTGCAGCATGAT CACCTGGACAGCACCCACGAGACCACCAAGTACCTGAGTGAGGCCTGGCCTAAAGACGGTGGAAACGGCACCAGCCCCGACTTCTCCCAC >In-frame_NPEPPS_ENST00000544660_chr17_45623359_+_CREB3L1_ENST00000288400_chr11_46341815_+_510nt ATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTGCTGGACTTC ACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGATATTGATATTATTACA GCTTCATATGCACCAGAAGGAGATGAAGTGCCCTCCCGAAGCCTCCTATTCTACGATGACGGGGCAGGCTTATGGGAAGATGGCCGCAGC ACCCTGCTGCCCATGGAGCCCCCAGATGGCTGGGAAATCAACCCCGGGGGGCCGGCAGAGCAGCGGCCCCGGGACCACCTGCAGCATGAT CACCTGGACAGCACCCACGAGACCACCAAGTACCTGAGTGAGGCCTGGCCTAAAGACGGTGGAAACGGCACCAGCCCCGACTTCTCCCAC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_NPEPPS_ENST00000530173_chr17_45623359_+_CREB3L1_ENST00000529193_chr11_46341815_+_1336nt AAGTTACGGAAGAGTCAAGGCTGGGACCTCATGGCATCATTTTCCATGGATTGCTCTCCAAGTTTTTGTGTTCCTGGCCTTTGGAACCCC TTCATCATATTCCGCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTG CCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCC CAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGATATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGTG CCCTCCCGAAGCCTCCTATTCTACGATGACGGGGCAGGCTTATGGGAAGATGGCCGCAGCACCCTGCTGCCCATGGAGCCCCCAGATGGC TGGGAAATCAACCCCGGGGGGCCGGCAGAGCAGCGGCCCCGGGACCACCTGCAGCATGATCACCTGGACAGCACCCACGAGACCACCAAG TACCTGAGTGAGGCCTGGCCTAAAGACGGTGGAAACGGCACCAGCCCCGACTTCTCCCACTCCAAGGAGTGGTTCCACGACAGGGATCTG GGCCCCAACACCACCATCAAACTCTCCTAGGCCATGCCAAGACCCAGGACATAGGACGGACCCCTGGTACCCAGAAGAGGAGTTCTTGCT CACTAACCCGGATCCGCCTCGTGCCCCTGCCTCCTGGAGCTTCCCATTCCAGGAGAAAAGGCTCCACTTCCCAGCCCTTCCTTGCCCCTG ACATTTGGACTCTTCCCTTGGGCCGACCACTCTGTTCTCATTCTCCTTCCCACCAACATCCATCCGTCCTTCTCAGACAAACCACTCACT GGGTACCCCACCTCCTCTCTCATATGCCCAACACGACCACTGCCTCCCTGCCCCCACACCTGCACCCAAACAGACACATCAACGCACCCC ACTCACAGACACCCCTTACCCCACCCCCACTGTACAGAGACCAAGAACAGAAATTGTTTGTAAATAATGAACCTTATTTTTTATTATTGC CAATCCCCTAAGATATTGTATTTTACAAATCTCCCTCTTCCCTTCGCCCCTCCCTTGTTTTATATTTTATGAAGTTAGTGCGGGCTTTGC TGCTCCCTGGCCCAGGAAAGAGGGACTACCTGACCCTCACCTGGCACCCCCCTGCTGCTGCCCAAGCCGCTGGGCCTTTTTAATTGCCAA >In-frame_NPEPPS_ENST00000530173_chr17_45623359_+_CREB3L1_ENST00000288400_chr11_46341815_+_1334nt AAGTTACGGAAGAGTCAAGGCTGGGACCTCATGGCATCATTTTCCATGGATTGCTCTCCAAGTTTTTGTGTTCCTGGCCTTTGGAACCCC TTCATCATATTCCGCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTG CCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCC CAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGATATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGTG CCCTCCCGAAGCCTCCTATTCTACGATGACGGGGCAGGCTTATGGGAAGATGGCCGCAGCACCCTGCTGCCCATGGAGCCCCCAGATGGC TGGGAAATCAACCCCGGGGGGCCGGCAGAGCAGCGGCCCCGGGACCACCTGCAGCATGATCACCTGGACAGCACCCACGAGACCACCAAG TACCTGAGTGAGGCCTGGCCTAAAGACGGTGGAAACGGCACCAGCCCCGACTTCTCCCACTCCAAGGAGTGGTTCCACGACAGGGATCTG GGCCCCAACACCACCATCAAACTCTCCTAGGCCATGCCAAGACCCAGGACATAGGACGGACCCCTGGTACCCAGAAGAGGAGTTCTTGCT CACTAACCCGGATCCGCCTCGTGCCCCTGCCTCCTGGAGCTTCCCATTCCAGGAGAAAAGGCTCCACTTCCCAGCCCTTCCTTGCCCCTG ACATTTGGACTCTTCCCTTGGGCCGACCACTCTGTTCTCATTCTCCTTCCCACCAACATCCATCCGTCCTTCTCAGACAAACCACTCACT GGGTACCCCACCTCCTCTCTCATATGCCCAACACGACCACTGCCTCCCTGCCCCCACACCTGCACCCAAACAGACACATCAACGCACCCC ACTCACAGACACCCCTTACCCCACCCCCACTGTACAGAGACCAAGAACAGAAATTGTTTGTAAATAATGAACCTTATTTTTTATTATTGC CAATCCCCTAAGATATTGTATTTTACAAATCTCCCTCTTCCCTTCGCCCCTCCCTTGTTTTATATTTTATGAAGTTAGTGCGGGCTTTGC TGCTCCCTGGCCCAGGAAAGAGGGACTACCTGACCCTCACCTGGCACCCCCCTGCTGCTGCCCAAGCCGCTGGGCCTTTTTAATTGCCAA >In-frame_NPEPPS_ENST00000322157_chr17_45623359_+_CREB3L1_ENST00000529193_chr11_46341815_+_1555nt GGGCGCGCCCGGCCGGCGGGGCCGCGCACGCAGCCGCCGCCACCACTTCCCCCTCTCCCTCCCTCCTTGCGGGCCCTCCTCCCCTTCCCT CCCCTCCGCCCCCTTCCCCGTAGGCAGCCCGCCCGCCAGTCCGCCCGCACCGCCTCCTTCCCAGCCCCTAGCGCTCCGGCTGGGTCTCTC CCCCGCCCCCCAGGCTCCCCCGGTCGCTCTCCTCCGGCGGTCGCCCGCGCTCGGTGGATGTGGCTGGCAGCTGCCGCCCCCTCCCTCGCT CGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGC CTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTG CTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGATATTGAT ATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGTGCCCTCCCGAAGCCTCCTATTCTACGATGACGGGGCAGGCTTATGGGAAGAT GGCCGCAGCACCCTGCTGCCCATGGAGCCCCCAGATGGCTGGGAAATCAACCCCGGGGGGCCGGCAGAGCAGCGGCCCCGGGACCACCTG CAGCATGATCACCTGGACAGCACCCACGAGACCACCAAGTACCTGAGTGAGGCCTGGCCTAAAGACGGTGGAAACGGCACCAGCCCCGAC TTCTCCCACTCCAAGGAGTGGTTCCACGACAGGGATCTGGGCCCCAACACCACCATCAAACTCTCCTAGGCCATGCCAAGACCCAGGACA TAGGACGGACCCCTGGTACCCAGAAGAGGAGTTCTTGCTCACTAACCCGGATCCGCCTCGTGCCCCTGCCTCCTGGAGCTTCCCATTCCA GGAGAAAAGGCTCCACTTCCCAGCCCTTCCTTGCCCCTGACATTTGGACTCTTCCCTTGGGCCGACCACTCTGTTCTCATTCTCCTTCCC ACCAACATCCATCCGTCCTTCTCAGACAAACCACTCACTGGGTACCCCACCTCCTCTCTCATATGCCCAACACGACCACTGCCTCCCTGC CCCCACACCTGCACCCAAACAGACACATCAACGCACCCCACTCACAGACACCCCTTACCCCACCCCCACTGTACAGAGACCAAGAACAGA AATTGTTTGTAAATAATGAACCTTATTTTTTATTATTGCCAATCCCCTAAGATATTGTATTTTACAAATCTCCCTCTTCCCTTCGCCCCT CCCTTGTTTTATATTTTATGAAGTTAGTGCGGGCTTTGCTGCTCCCTGGCCCAGGAAAGAGGGACTACCTGACCCTCACCTGGCACCCCC CTGCTGCTGCCCAAGCCGCTGGGCCTTTTTAATTGCCAAACTGCTCTCTTCATCAGCTCAGCACATGCTTTAAGAAAGCAAAACCAAAAA >In-frame_NPEPPS_ENST00000322157_chr17_45623359_+_CREB3L1_ENST00000288400_chr11_46341815_+_1553nt GGGCGCGCCCGGCCGGCGGGGCCGCGCACGCAGCCGCCGCCACCACTTCCCCCTCTCCCTCCCTCCTTGCGGGCCCTCCTCCCCTTCCCT CCCCTCCGCCCCCTTCCCCGTAGGCAGCCCGCCCGCCAGTCCGCCCGCACCGCCTCCTTCCCAGCCCCTAGCGCTCCGGCTGGGTCTCTC CCCCGCCCCCCAGGCTCCCCCGGTCGCTCTCCTCCGGCGGTCGCCCGCGCTCGGTGGATGTGGCTGGCAGCTGCCGCCCCCTCCCTCGCT CGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGC CTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTG CTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGATATTGAT ATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGTGCCCTCCCGAAGCCTCCTATTCTACGATGACGGGGCAGGCTTATGGGAAGAT GGCCGCAGCACCCTGCTGCCCATGGAGCCCCCAGATGGCTGGGAAATCAACCCCGGGGGGCCGGCAGAGCAGCGGCCCCGGGACCACCTG CAGCATGATCACCTGGACAGCACCCACGAGACCACCAAGTACCTGAGTGAGGCCTGGCCTAAAGACGGTGGAAACGGCACCAGCCCCGAC TTCTCCCACTCCAAGGAGTGGTTCCACGACAGGGATCTGGGCCCCAACACCACCATCAAACTCTCCTAGGCCATGCCAAGACCCAGGACA TAGGACGGACCCCTGGTACCCAGAAGAGGAGTTCTTGCTCACTAACCCGGATCCGCCTCGTGCCCCTGCCTCCTGGAGCTTCCCATTCCA GGAGAAAAGGCTCCACTTCCCAGCCCTTCCTTGCCCCTGACATTTGGACTCTTCCCTTGGGCCGACCACTCTGTTCTCATTCTCCTTCCC ACCAACATCCATCCGTCCTTCTCAGACAAACCACTCACTGGGTACCCCACCTCCTCTCTCATATGCCCAACACGACCACTGCCTCCCTGC CCCCACACCTGCACCCAAACAGACACATCAACGCACCCCACTCACAGACACCCCTTACCCCACCCCCACTGTACAGAGACCAAGAACAGA AATTGTTTGTAAATAATGAACCTTATTTTTTATTATTGCCAATCCCCTAAGATATTGTATTTTACAAATCTCCCTCTTCCCTTCGCCCCT CCCTTGTTTTATATTTTATGAAGTTAGTGCGGGCTTTGCTGCTCCCTGGCCCAGGAAAGAGGGACTACCTGACCCTCACCTGGCACCCCC CTGCTGCTGCCCAAGCCGCTGGGCCTTTTTAATTGCCAAACTGCTCTCTTCATCAGCTCAGCACATGCTTTAAGAAAGCAAAACCAAAAA >In-frame_NPEPPS_ENST00000544660_chr17_45623359_+_CREB3L1_ENST00000529193_chr11_46341815_+_1292nt CCTCGCTCGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAG CCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCC CGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGA TATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGTGCCCTCCCGAAGCCTCCTATTCTACGATGACGGGGCAGGCTTATG GGAAGATGGCCGCAGCACCCTGCTGCCCATGGAGCCCCCAGATGGCTGGGAAATCAACCCCGGGGGGCCGGCAGAGCAGCGGCCCCGGGA CCACCTGCAGCATGATCACCTGGACAGCACCCACGAGACCACCAAGTACCTGAGTGAGGCCTGGCCTAAAGACGGTGGAAACGGCACCAG CCCCGACTTCTCCCACTCCAAGGAGTGGTTCCACGACAGGGATCTGGGCCCCAACACCACCATCAAACTCTCCTAGGCCATGCCAAGACC CAGGACATAGGACGGACCCCTGGTACCCAGAAGAGGAGTTCTTGCTCACTAACCCGGATCCGCCTCGTGCCCCTGCCTCCTGGAGCTTCC CATTCCAGGAGAAAAGGCTCCACTTCCCAGCCCTTCCTTGCCCCTGACATTTGGACTCTTCCCTTGGGCCGACCACTCTGTTCTCATTCT CCTTCCCACCAACATCCATCCGTCCTTCTCAGACAAACCACTCACTGGGTACCCCACCTCCTCTCTCATATGCCCAACACGACCACTGCC TCCCTGCCCCCACACCTGCACCCAAACAGACACATCAACGCACCCCACTCACAGACACCCCTTACCCCACCCCCACTGTACAGAGACCAA GAACAGAAATTGTTTGTAAATAATGAACCTTATTTTTTATTATTGCCAATCCCCTAAGATATTGTATTTTACAAATCTCCCTCTTCCCTT CGCCCCTCCCTTGTTTTATATTTTATGAAGTTAGTGCGGGCTTTGCTGCTCCCTGGCCCAGGAAAGAGGGACTACCTGACCCTCACCTGG CACCCCCCTGCTGCTGCCCAAGCCGCTGGGCCTTTTTAATTGCCAAACTGCTCTCTTCATCAGCTCAGCACATGCTTTAAGAAAGCAAAA >In-frame_NPEPPS_ENST00000544660_chr17_45623359_+_CREB3L1_ENST00000288400_chr11_46341815_+_1290nt CCTCGCTCGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAG CCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCC CGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGA TATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGTGCCCTCCCGAAGCCTCCTATTCTACGATGACGGGGCAGGCTTATG GGAAGATGGCCGCAGCACCCTGCTGCCCATGGAGCCCCCAGATGGCTGGGAAATCAACCCCGGGGGGCCGGCAGAGCAGCGGCCCCGGGA CCACCTGCAGCATGATCACCTGGACAGCACCCACGAGACCACCAAGTACCTGAGTGAGGCCTGGCCTAAAGACGGTGGAAACGGCACCAG CCCCGACTTCTCCCACTCCAAGGAGTGGTTCCACGACAGGGATCTGGGCCCCAACACCACCATCAAACTCTCCTAGGCCATGCCAAGACC CAGGACATAGGACGGACCCCTGGTACCCAGAAGAGGAGTTCTTGCTCACTAACCCGGATCCGCCTCGTGCCCCTGCCTCCTGGAGCTTCC CATTCCAGGAGAAAAGGCTCCACTTCCCAGCCCTTCCTTGCCCCTGACATTTGGACTCTTCCCTTGGGCCGACCACTCTGTTCTCATTCT CCTTCCCACCAACATCCATCCGTCCTTCTCAGACAAACCACTCACTGGGTACCCCACCTCCTCTCTCATATGCCCAACACGACCACTGCC TCCCTGCCCCCACACCTGCACCCAAACAGACACATCAACGCACCCCACTCACAGACACCCCTTACCCCACCCCCACTGTACAGAGACCAA GAACAGAAATTGTTTGTAAATAATGAACCTTATTTTTTATTATTGCCAATCCCCTAAGATATTGTATTTTACAAATCTCCCTCTTCCCTT CGCCCCTCCCTTGTTTTATATTTTATGAAGTTAGTGCGGGCTTTGCTGCTCCCTGGCCCAGGAAAGAGGGACTACCTGACCCTCACCTGG CACCCCCCTGCTGCTGCCCAAGCCGCTGGGCCTTTTTAATTGCCAAACTGCTCTCTTCATCAGCTCAGCACATGCTTTAAGAAAGCAAAA |
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FusionGenePPI for NPEPPS_CREB3L1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NPEPPS | EIF6, OTUD4, DMWD, CLN3, GBAS, RYK, HDAC5, SIRT7, FBXO25, CUL3, CDK2, UBA6, STRAP, ECT2, CAMKMT, CFTR, FBXO6, CNDP2, NANS, CKB, CSE1L, DAK, FTO, GBP1, LDHB, METAP2, PAK2, PDIA3, RPLP2, PFAS, RPS6KA1, RPS6KA3, SCLY, SLC9A3R1, TGM2, UBFD1, ZNF622, PHKG2, STAU1, CUL7, CCDC8, FAF2, DYNLT1, STXBP1, NTRK1, MED20, FAM204A, ZNF746, LRRC8E, TRIM25, CCND2, BRCA1, CDK20 | CREB3L1 | CREB3L1, CREB3L3, CREB3, DDIT3, PRKAB2, TSPO, C5, RUNX1T1, GPR25, TMEM147, FAM3C, PGRMC1, NRM, FXYD6, TMEM234, JAGN1, SLC35B4, MFSD5, SLC30A8, TMEM218, FXYD3, C17orf62, TMEM128, TMEM11, FBXW7, CREB3L2, UHRF1BP1, TRRAP, AP3B1, USP22 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NPEPPS_CREB3L1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | NPEPPS | P55786 | DB11638 | Artenimol | Puromycin-sensitive aminopeptidase | small molecule | approved|investigational |
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RelatedDiseases for NPEPPS_CREB3L1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |