|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 24660 |
FusionGeneSummary for NOXO1_ECI1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NOXO1_ECI1 | Fusion gene ID: 24660 | Hgene | Tgene | Gene symbol | NOXO1 | ECI1 | Gene ID | 124056 | 1632 |
| Gene name | NADPH oxidase organizer 1 | enoyl-CoA delta isomerase 1 | |
| Synonyms | P41NOX|P41NOXA|P41NOXB|P41NOXC|SH3PXD5|SNX28 | DCI | |
| Cytomap | 16p13.3 | 16p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | NADPH oxidase organizer 1NADPH oxidase regulatory proteinNox organizer 1SH3 and PX domain-containing protein 5nox-organizing protein 1regulatory protein P41NOX | enoyl-CoA delta isomerase 1, mitochondrial3,2 trans-enoyl-Coenzyme A isomerase3,2-trans-enoyl-CoA isomerase, mitochondrialD3,D2-enoyl-CoA isomeraseacetylene-allene isomerasedelta(3),Delta(2)-enoyl-CoA isomerasedodecenoyl-CoA delta isomerase (3,2 tra | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8NFA2 | P42126 | |
| Ensembl transtripts involved in fusion gene | ENST00000356120, ENST00000354249, ENST00000566005, ENST00000397280, | ENST00000301729, ENST00000562238, ENST00000570258, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 4=64 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NOXO1 [Title/Abstract] AND ECI1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-61-1918-01A | NOXO1 | chr16 | 2029247 | - | ECI1 | chr16 | 2296987 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000356120 | ENST00000301729 | NOXO1 | chr16 | 2029247 | - | ECI1 | chr16 | 2296987 | - |
| intron-3CDS | ENST00000356120 | ENST00000562238 | NOXO1 | chr16 | 2029247 | - | ECI1 | chr16 | 2296987 | - |
| intron-5UTR | ENST00000356120 | ENST00000570258 | NOXO1 | chr16 | 2029247 | - | ECI1 | chr16 | 2296987 | - |
| intron-3CDS | ENST00000354249 | ENST00000301729 | NOXO1 | chr16 | 2029247 | - | ECI1 | chr16 | 2296987 | - |
| intron-3CDS | ENST00000354249 | ENST00000562238 | NOXO1 | chr16 | 2029247 | - | ECI1 | chr16 | 2296987 | - |
| intron-5UTR | ENST00000354249 | ENST00000570258 | NOXO1 | chr16 | 2029247 | - | ECI1 | chr16 | 2296987 | - |
| intron-3CDS | ENST00000566005 | ENST00000301729 | NOXO1 | chr16 | 2029247 | - | ECI1 | chr16 | 2296987 | - |
| intron-3CDS | ENST00000566005 | ENST00000562238 | NOXO1 | chr16 | 2029247 | - | ECI1 | chr16 | 2296987 | - |
| intron-5UTR | ENST00000566005 | ENST00000570258 | NOXO1 | chr16 | 2029247 | - | ECI1 | chr16 | 2296987 | - |
| intron-3CDS | ENST00000397280 | ENST00000301729 | NOXO1 | chr16 | 2029247 | - | ECI1 | chr16 | 2296987 | - |
| intron-3CDS | ENST00000397280 | ENST00000562238 | NOXO1 | chr16 | 2029247 | - | ECI1 | chr16 | 2296987 | - |
| intron-5UTR | ENST00000397280 | ENST00000570258 | NOXO1 | chr16 | 2029247 | - | ECI1 | chr16 | 2296987 | - |
Top |
FusionProtFeatures for NOXO1_ECI1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NOXO1 | ECI1 |
| Constitutively potentiates the superoxide-generatingactivity of NOX1 and NOX3 and is required for the biogenesis ofotoconia/otolith, which are crystalline structures of the innerear involved in the perception of gravity. Isoform 3 is morepotent than isoform 1 in activating NOX3. Together with NOXA1, mayalso substitute to NCF1/p47phox and NCF2/p67phox in supporting thephagocyte NOX2/gp91phox superoxide-generating activity.{ECO:0000269|PubMed:12657628, ECO:0000269|PubMed:14617635,ECO:0000269|PubMed:15326186, ECO:0000269|PubMed:15824103,ECO:0000269|PubMed:15949904, ECO:0000269|PubMed:16329988,ECO:0000269|PubMed:17126813, ECO:0000269|PubMed:19755710}. | Able to isomerize both 3-cis and 3-trans double bondsinto the 2-trans form in a range of enoyl-CoA species. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for NOXO1_ECI1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for NOXO1_ECI1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NOXO1 | ECI1 | ICT1, APP, ACOX1, MAPKAP1, POT1, FABP5, PRDX6, TAGLN2, HIBCH, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for NOXO1_ECI1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for NOXO1_ECI1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|