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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24634

FusionGeneSummary for NOTCH2NL_UBE2H

check button Fusion gene summary
Fusion gene informationFusion gene name: NOTCH2NL_UBE2H
Fusion gene ID: 24634
HgeneTgene
Gene symbol

NOTCH2NL

UBE2H

Gene ID

388677

7328

Gene namenotch 2 N-terminal likeubiquitin conjugating enzyme E2 H
SynonymsN2NE2-20K|GID3|UBC8|UBCH|UBCH2
Cytomap

1q21.1

7q32.2

Type of geneprotein-codingprotein-coding
Descriptionnotch homolog 2 N-terminal-like proteinNotch homolog 2 N-terminal like proteinubiquitin-conjugating enzyme E2 H(E3-independent) E2 ubiquitin-conjugating enzyme HE2 ubiquitin-conjugating enzyme HGID complex subunit 3, UBC8 homologubiquitin carrier protein Hubiquitin conjugating enzyme E2Hubiquitin-conjugating enzyme E2-20Kubi
Modification date2018051920180523
UniProtAcc

Q7Z3S9

P62256

Ensembl transtripts involved in fusion geneENST00000362074, ENST00000344859, 
ENST00000369340, ENST00000479995, 
ENST00000355621, ENST00000473814, 
Fusion gene scores* DoF score5 X 2 X 5=507 X 8 X 4=224
# samples 510
** MAII scorelog2(5/50*10)=0log2(10/224*10)=-1.16349873228288
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NOTCH2NL [Title/Abstract] AND UBE2H [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUBE2H

GO:0070936

protein K48-linked ubiquitination

20061386

TgeneUBE2H

GO:0070979

protein K11-linked ubiquitination

20061386


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVOVTCGA-25-1323-01ANOTCH2NLchr1

145209436

+UBE2Hchr7

129498781

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000362074ENST00000355621NOTCH2NLchr1

145209436

+UBE2Hchr7

129498781

-
5UTR-intronENST00000362074ENST00000473814NOTCH2NLchr1

145209436

+UBE2Hchr7

129498781

-
5UTR-3CDSENST00000344859ENST00000355621NOTCH2NLchr1

145209436

+UBE2Hchr7

129498781

-
5UTR-intronENST00000344859ENST00000473814NOTCH2NLchr1

145209436

+UBE2Hchr7

129498781

-
intron-3CDSENST00000369340ENST00000355621NOTCH2NLchr1

145209436

+UBE2Hchr7

129498781

-
intron-intronENST00000369340ENST00000473814NOTCH2NLchr1

145209436

+UBE2Hchr7

129498781

-
intron-3CDSENST00000479995ENST00000355621NOTCH2NLchr1

145209436

+UBE2Hchr7

129498781

-
intron-intronENST00000479995ENST00000473814NOTCH2NLchr1

145209436

+UBE2Hchr7

129498781

-

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FusionProtFeatures for NOTCH2NL_UBE2H


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NOTCH2NL

Q7Z3S9

UBE2H

P62256

May function in the Notch signaling pathway and regulateneutrophil differentiation. {ECO:0000269|PubMed:14673143}. Accepts ubiquitin from the E1 complex and catalyzes itscovalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, toubiquitinate histone H2A. {ECO:0000269|PubMed:20061386,ECO:0000269|PubMed:8132613}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NOTCH2NL_UBE2H


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NOTCH2NL_UBE2H


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NOTCH2NLELANE, UBQLN4, POLR2G, CA6, DGCR6, ESR2, KIF1A, MVP, QPRT, AES, ALDH3B1, ALPI, SLC25A6, FASLG, AQP1, AQP5, BMP7, CHRNG, COL8A1, CSF1, SLC25A10, CST2, CTSG, CTSZ, DOCK2, ARID3A, EFNA3, EPHB6, FAAH, GABRD, GATA2, GEM, GIP, GLP1R, GNAI2, NPBWR2, GSTP1, HBZ, HCK, HOXA1, HPCAL1, HSBP1, HSPD1, ICAM4, IL2RG, INPP5D, ITGB2, ITGB5, KRTAP5-9, KRT83, LMO2, LRCH4, MATN3, SMCP, MFI2, MXI1, NAB2, NEU2, NPPB, P2RX4, PCSK5, PDE9A, PRKAA2, PRPS2, PSMA1, PTGER3, PVR, PVRL2, RGL2, RAB3IL1, RET, TRIM27, RPS28, CXCL5, SDCBP, SMARCD2, SMARCE1, SNAI1, SPG7, SPINK2, XCL2, TSPAN4, TNP2, ZNF32, ZNF124, HIST1H2AK, UXT, RECK, STK16, PPAP2C, CHRD, CD164, LIN7A, CDK5R1, CLDN2, MTA1, GTF3C5, EIF4E2, THEMIS2, CREB5, JOSD1, SLC23A1, NR1D2, GNE, NUBP2, DNAL4, TNK2, GLYAT, SPRY1, RAMP3, IFI30, GLRX3, FARS2, FRS3, NMU, BLCAP, KLK8, R3HDM2, MAPKBP1, CARHSP1, HSPBP1, PGLS, YIPF3, RCHY1, PTPN23, PVRL3, PRPF31, CHIC2, FOXB1, GNMT, POM121L8P, WT1-AS, ZNF581, GFOD1, FBXW5, KRT20, CCDC93, CRCT1, SLC6A20, SEMA4C, CHCHD3, PID1, MRGBP, C19orf66, CHDH, TRPV6, ZNF446, LIMS2, CARKD, NPDC1, NMUR2, PSMG2, PLSCR4, ADAMTSL3, MARK4, CXCL16, DMRT3, SLC22A23, SMOC1, TINAGL1, PCED1A, CERK, MRPL40, LRFN4, SCNM1, ZFYVE21, KCTD15, ASPSCR1, ATG9A, WDR25, TMEM231, LONRF3, FAM124B, TNIP3, FBXL18, C16orf59, HSD3B7, THAP7, TXNDC5, MXD3, KRTAP4-12, KRTAP3-1, KRTAP9-2, UTP23, LNX1, CRACR2A, POMGNT2, ZNF587, KRTAP9-4, KRTAP4-7, KRTAP4-2, TMEM41A, ZNF439, PCED1B, ACY3, PIGS, PTPMT1, DHRS1, HSPA12B, CATSPER1, TBC1D16, ZNF440, CST9L, TMEM150A, CCDC26, SELM, SPATA8, RTN4RL1, LINC00526, ZNF417, FAM71C, CCER1, LINC00656, ADCK5, BCL6B, FAM71E2, C5orf60, TRIM42, KRTAP13-3, ADAMTSL5, KLHL38, CLEC18A, LCE1B, LCE2D, LCE3C, LCE3E, KRTAP12-2, TBC1D10C, KRTAP10-7, KRTAP10-9, KRTAP10-1, KRTAP10-11, KRTAP10-5, KRTAP10-8, KRTAP10-3, KRTAP12-4, KRTAP26-1, C11orf87, FAM74A4, KRTAP5-6, KRTAP4-11, SHMT2, MOV10, NXF1, TRIM25UBE2HRNF216, STAM2, EPS15, POLM, POLL, HDAC6, UBASH3B, RNF103, NEURL1, RNF186, TRIM56, UBOX5, DZIP3, RNF34, TRIM27, RNF4, TRAIP, TRIM36, DTX3, RNF114, BRAP, LRSAM1, CBLC, DTX3L, MKRN3, TRIM23, RNF10, RNF113B, RNF133, RNF139, RNF144A, RNF146, RNF166, RNF185, MARCH10, RNF2, RNF38, RNF6, TRIM17, TRIM2, TRIM37, TRIM5, ELAVL1, HDAC2, RELA, CD99, TRIM28, UBR2, TRIM21, RNF128, RAG1, SEC23IP, LACTB2, TXNDC17, TXNL1, UBA3, UBAP2L, SSU72, THOP1, PRDX1, PRDX2, USP5, UFC1, TRIM72, ANXA6, IDH1, MTAP, GOT1, MARCH1, MARCH2, MARCH4, MARCH8, PTK2, UBA1, UBE2H, NHLRC1, JADE1, BYSL, UBR3, TRIM69, CDK2, WDR26, ARMC8, RMND5B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NOTCH2NL_UBE2H


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NOTCH2NL_UBE2H


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneUBE2HC0004352Autistic Disorder1CTD_human
TgeneUBE2HC0032460Polycystic Ovary Syndrome1CTD_human