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Fusion gene ID: 24625 |
FusionGeneSummary for NOTCH1_MAPK1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NOTCH1_MAPK1 | Fusion gene ID: 24625 | Hgene | Tgene | Gene symbol | NOTCH1 | MAPK1 | Gene ID | 4851 | 5594 |
| Gene name | notch 1 | mitogen-activated protein kinase 1 | |
| Synonyms | AOS5|AOVD1|TAN1|hN1 | ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK | |
| Cytomap | 9q34.3 | 22q11.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | neurogenic locus notch homolog protein 1Notch homolog 1, translocation-associatedtranslocation-associated notch protein TAN-1 | mitogen-activated protein kinase 1MAP kinase 1MAP kinase 2MAP kinase isoform p42MAPK 2extracellular signal-regulated kinase 2mitogen-activated protein kinase 2protein tyrosine kinase ERK2 | |
| Modification date | 20180527 | 20180529 | |
| UniProtAcc | P46531 | P28482 | |
| Ensembl transtripts involved in fusion gene | ENST00000277541, ENST00000491649, | ENST00000215832, ENST00000398822, ENST00000544786, ENST00000491588, | |
| Fusion gene scores | * DoF score | 11 X 9 X 10=990 | 9 X 6 X 5=270 |
| # samples | 12 | 9 | |
| ** MAII score | log2(12/990*10)=-3.04439411935845 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/270*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NOTCH1 [Title/Abstract] AND MAPK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NOTCH1 | GO:0007050 | cell cycle arrest | 11306509 |
| Hgene | NOTCH1 | GO:0007219 | Notch signaling pathway | 11306509 |
| Hgene | NOTCH1 | GO:0008284 | positive regulation of cell proliferation | 17849174 |
| Hgene | NOTCH1 | GO:0008285 | negative regulation of cell proliferation | 11306509|20616313 |
| Hgene | NOTCH1 | GO:0010629 | negative regulation of gene expression | 11306509 |
| Hgene | NOTCH1 | GO:0010812 | negative regulation of cell-substrate adhesion | 16501043 |
| Hgene | NOTCH1 | GO:0035924 | cellular response to vascular endothelial growth factor stimulus | 20616313 |
| Hgene | NOTCH1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 20616313 |
| Hgene | NOTCH1 | GO:0045967 | negative regulation of growth rate | 11306509 |
| Hgene | NOTCH1 | GO:0046579 | positive regulation of Ras protein signal transduction | 11306509 |
| Hgene | NOTCH1 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 11306509 |
| Hgene | NOTCH1 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus | 20613903 |
| Hgene | NOTCH1 | GO:0090051 | negative regulation of cell migration involved in sprouting angiogenesis | 20616313 |
| Hgene | NOTCH1 | GO:2001027 | negative regulation of endothelial cell chemotaxis | 20616313 |
| Tgene | MAPK1 | GO:0006468 | protein phosphorylation | 23184662 |
| Tgene | MAPK1 | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 16314496 |
| Tgene | MAPK1 | GO:0018105 | peptidyl-serine phosphorylation | 15850461 |
| Tgene | MAPK1 | GO:0034198 | cellular response to amino acid starvation | 11096076 |
| Tgene | MAPK1 | GO:0038127 | ERBB signaling pathway | 15133037 |
| Tgene | MAPK1 | GO:0051403 | stress-activated MAPK cascade | 11096076 |
| Tgene | MAPK1 | GO:0070371 | ERK1 and ERK2 cascade | 16314496 |
| Tgene | MAPK1 | GO:0070849 | response to epidermal growth factor | 18794356 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-CN-A498-01A | NOTCH1 | chr9 | 139405604 | - | MAPK1 | chr22 | 22143097 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000277541 | ENST00000215832 | NOTCH1 | chr9 | 139405604 | - | MAPK1 | chr22 | 22143097 | - |
| Frame-shift | ENST00000277541 | ENST00000398822 | NOTCH1 | chr9 | 139405604 | - | MAPK1 | chr22 | 22143097 | - |
| Frame-shift | ENST00000277541 | ENST00000544786 | NOTCH1 | chr9 | 139405604 | - | MAPK1 | chr22 | 22143097 | - |
| 5CDS-intron | ENST00000277541 | ENST00000491588 | NOTCH1 | chr9 | 139405604 | - | MAPK1 | chr22 | 22143097 | - |
| intron-3CDS | ENST00000491649 | ENST00000215832 | NOTCH1 | chr9 | 139405604 | - | MAPK1 | chr22 | 22143097 | - |
| intron-3CDS | ENST00000491649 | ENST00000398822 | NOTCH1 | chr9 | 139405604 | - | MAPK1 | chr22 | 22143097 | - |
| intron-3CDS | ENST00000491649 | ENST00000544786 | NOTCH1 | chr9 | 139405604 | - | MAPK1 | chr22 | 22143097 | - |
| intron-intron | ENST00000491649 | ENST00000491588 | NOTCH1 | chr9 | 139405604 | - | MAPK1 | chr22 | 22143097 | - |
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FusionProtFeatures for NOTCH1_MAPK1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NOTCH1 | MAPK1 |
| Functions as a receptor for membrane-bound ligandsJagged1, Jagged2 and Delta1 to regulate cell-fate determination.Upon ligand activation through the released notch intracellulardomain (NICD) it forms a transcriptional activator complex withRBPJ/RBPSUH and activates genes of the enhancer of split locus.Affects the implementation of differentiation, proliferation andapoptotic programs. Involved in angiogenesis; negatively regulatesendothelial cell proliferation and migration and angiogenicsprouting. Involved in the maturation of both CD4+ and CD8+ cellsin the thymus. Important for follicular differentiation andpossibly cell fate selection within the follicle. Duringcerebellar development, functions as a receptor for neuronal DNERand is involved in the differentiation of Bergmann glia. Repressesneuronal and myogenic differentiation. May play an essential rolein postimplantation development, probably in some aspect of cellspecification and/or differentiation. May be involved in mesodermdevelopment, somite formation and neurogenesis. May enhance HIF1Afunction by sequestering HIF1AN away from HIF1A. Required for theTHBS4 function in regulating protective astrogenesis from thesubventricular zone (SVZ) niche after injury. Involved indetermination of left/right symmetry by modulating the balancebetween motile and immotile (sensory) cilia at the left-rightorganiser (LRO). {ECO:0000269|PubMed:20616313}. | Serine/threonine kinase which acts as an essentialcomponent of the MAP kinase signal transduction pathway.MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an importantrole in the MAPK/ERK cascade. They participate also in a signalingcascade initiated by activated KIT and KITLG/SCF. Depending on thecellular context, the MAPK/ERK cascade mediates diverse biologicalfunctions such as cell growth, adhesion, survival anddifferentiation through the regulation of transcription,translation, cytoskeletal rearrangements. The MAPK/ERK cascadeplays also a role in initiation and regulation of meiosis,mitosis, and postmitotic functions in differentiated cells byphosphorylating a number of transcription factors. About 160substrates have already been discovered for ERKs. Many of thesesubstrates are localized in the nucleus, and seem to participatein the regulation of transcription upon stimulation. However,other substrates are found in the cytosol as well as in othercellular organelles, and those are responsible for processes suchas translation, mitosis and apoptosis. Moreover, the MAPK/ERKcascade is also involved in the regulation of the endosomaldynamics, including lysosome processing and endosome cyclingthrough the perinuclear recycling compartment (PNRC); as well asin the fragmentation of the Golgi apparatus during mitosis. Thesubstrates include transcription factors (such as ATF2, BCL6,ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such asCANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators ofapoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG),regulators of translation (such as EIF4EBP1) and a variety ofother signaling-related molecules (like ARHGEF2, DCC, FRS2 orGRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2,RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2,RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases(such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates whichenable the propagation the MAPK/ERK signal to additional cytosolicand nuclear targets, thereby extending the specificity of thecascade. Mediates phosphorylation of TPR in respons to EGFstimulation. May play a role in the spindle assembly checkpoint.Phosphorylates PML and promotes its interaction with PIN1, leadingto PML degradation. Phosphorylates CDK2AP2 (By similarity).{ECO:0000250|UniProtKB:P63086, ECO:0000269|PubMed:10617468,ECO:0000269|PubMed:10637505, ECO:0000269|PubMed:11154262,ECO:0000269|PubMed:12110590, ECO:0000269|PubMed:12356731,ECO:0000269|PubMed:12792650, ECO:0000269|PubMed:12794087,ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:15184391,ECO:0000269|PubMed:15241487, ECO:0000269|PubMed:15616583,ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:15788397,ECO:0000269|PubMed:15952796, ECO:0000269|PubMed:16581800,ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:19265199,ECO:0000269|PubMed:19879846, ECO:0000269|PubMed:22033920,ECO:0000269|PubMed:7588608, ECO:0000269|PubMed:8622688,ECO:0000269|PubMed:9480836, ECO:0000269|PubMed:9596579,ECO:0000269|PubMed:9649500, ECO:0000269|PubMed:9687510,ECO:0000303|PubMed:15526160, ECO:0000303|PubMed:16393692,ECO:0000303|PubMed:19565474, ECO:0000303|PubMed:21779493}. Acts as a transcriptional repressor. Binds to a[GC]AAA[GC] consensus sequence. Repress the expression ofinterferon gamma-induced genes. Seems to bind to the promoter ofCCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 andSTAT1. Transcriptional activity is independent of kinase activity.{ECO:0000269|PubMed:19879846}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NOTCH1_MAPK1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NOTCH1_MAPK1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NOTCH1 | SMAD3, LCK, PIK3CA, CNTN1, YY1, RBPJ, DTX1, SNW1, NOTCH3, XRCC6, RELA, NFKB1, DLL1, JAG1, JAG2, LEF1, NUMB, GSK3B, NOTCH1, MAML1, NOV, PSEN1, FBXW7, MAML2, MAML3, EP300, AKT1, CBL, CTNNB1, CACNA1A, SNAI1, MDM2, RUNX3, HEY1, HEY2, KAT5, APP, APBB1, EIF3F, EPN1, ILK, GFI1B, NOTCH2, PRKAA1, MAPK1, LIMK2, ROCK1, TAB1, MOB1A, HCLS1, RANBP9, RANBP10, VAV1, ARHGEF2, USP7, USP11, USP15, PPP2CA, PPP2R1A, PPP2R2A, PPP6R1, PPP6R3, ARIH1, ARIH2, TRIM32, ANAPC7, ANAPC1, CDC23, CDC27, ANAPC5, STK38, GPS1, CAND1, SLFN5, SLFN11, RLTPR, LRCH1, WDR11, NCKAP1L, ARMC8, ERH, WDR6, C18orf8, PTBP3, CCZ1B, SMARCA4, PBRM1, SMARCC2, SMARCC1, HLTF, SMARCA5, SMC1A, SMC3, PDS5A, MAU2, SMCHD1, TRIM28, WIZ, RB1, PHF8, RNF40, CHD4, RBBP4, GATAD2B, HDAC1, KDM1A, RING1, RNF2, FRYL, HCFC1, C14orf166, ASCC3, SRRT, TBL1XR1, WWTR1, DDX17, HTATSF1, MED23, MED25, BCL11B, IKZF1, IKZF2, IKZF3, TCF12, RUNX1, SMAD9, ZBTB2, ZBED4, RFX1, IFI16, PRKDC, PARP1, TOP2B, MCM3, MCM5, RFC1, RFC4, MMS19, RIF1, PRPF6, PRPF8, PRPF19, RBM10, DHX15, DHX8, SART1, PTBP1, CNOT1, XPO5, NBEA, LRBA, MDN1, TNPO1, KPNB1, IPO5, TRAPPC9, TRAPPC10, CCT3, CCT6A, CCT8, VPS39, VPS11, KIF3A, KIF2A, PPP2CB, CAMK4, XIAP, ITCH, NEDD4L, ARRB1, EGFL7, LATS2, WWP1, TGFBR1, USP12, ANKRD44, PTEN, TMEM17, RND3, PRKCD, RAB5A, RAB7A, LAMP1, HGS, ZMIZ1, MAP1LC3A, SQSTM1, MAP3K1, CDH1, CTDSPL, DLK2, FANCA, FANCC, FANCF, FANCG, MAGEA1, TRIM25, ARL6IP5, B3GALT4, LINC00260, CEP57L1, C9orf62, COL4A6, EXT1, FAM185A, KIAA1191, LNX2, RHOA, GOLGA2, HMGN5, MAGED1, GOPC, POU2AF1, TLE3, DAZAP2, KCTD10, CUL3, DTX4, ADAM10 | MAPK1 | NEK2, MYC, AR, SORBS3, MAPKAPK2, ATP1A1, FHL2, MKNK2, RPS6KA1, RPS6KA2, CASP9, MAP2K1, MAPK14, ELK1, UBR5, TPR, RPS6KA5, RPS6KA3, ADAM17, PTPN7, MAP2K2, RAF1, INSR, PRKCE, ESR1, PEBP1, PTPRR, PTPN5, SNCG, SNCA, LAMTOR3, MKNK1, VAV1, TSC2, GATA4, IER3, PECAM1, TNIP1, TNKS2, HMMR, STAT5A, DYRK1B, DUSP3, PEA15, CEBPB, ATF2, MAP3K1, DUSP16, SHC1, C1QBP, DUSP1, TOB1, DUSP6, HDAC4, SREBF1, SREBF2, TP53, TH, KRT8, CIITA, JUN, FOS, ALK, CDC25C, MTPN, PGR, ARRB2, JUND, TFCP2, ESR2, ARHGEF2, TOP2A, CENPE, EP300, VDR, HNF4A, RXRA, SFPQ, CCND1, SMAD1, RYK, DCC, AGTR1, PPP1CC, MINOS1, YBX3, YBX1, NUP153, CTSD, GAPDH, ID2, IFI35, GTF2I, ARRB1, TNFRSF1A, TNFRSF25, UBTF, SP1, RARA, CAV1, PTPRE, NCOA3, RPS6KA4, SMAD3, HIST1H2AB, HIST1H4A, VDAC1, RABGEF1, KARS, PARK2, FOXO3, SYNE2, PML, MAPK1, CACYBP, RPTOR, ICK, WDR83, GSTP1, CASP8, EIF4EBP1, BRCA1, MBP, GAB2, GSK3B, MAP2K7, STAB2, HSF4, NTMT1, NEB, HSF1, GORASP2, STAT3, ARHGAP9, IQGAP1, BARD1, ITGB6, ECT2, TP53BP1, NOTCH1, DAPK1, KLF11, VCP, PPP2R5B, PPP2R5C, CAPN2, ADAM15, NOXA1, MAP3K10, LCK, TIAL1, GADD45A, MAP2K4, BRAF, CUEDC2, SQSTM1, CRP, SUPT20H, TNIP2, MTIF3, PRPSAP1, ENAH, GNPTAB, SHANK3, EGLN3, KRAS, PDE4D, MAPK3, MAPK12, PDCD6IP, CEP350, NAV1, HMGB1, DGCR8, HDAC6, MAP2K6, PTGDR, ZC3HC1, HIF1A, CREBBP, TTN, PPARG, CUL7, ABCE1, ATP6V1D, CHEK1, CHEK2, DNAAF5, HNRNPR, ILKAP, ITPK1, DCUN1D1, FERMT2, LMNB2, PFKM, PTPRF, RRM2, XPO6, NTRK1, PAX5, ELK4, BCL2, BANP, ETS1, FGF5, MAPKAPK5, PXN, RET, CITED2, COPS6, MCM2, OTUB1, REST, PLA2G4A, ITGAV, SRC, PRDX6, CSNK2A1, BCL2L11, DUSP2, DUSP4, DUSP9, PTPDC1, DUSP12, DUSP19, DUSP8, PKM, SLC9A3R1, KDR, RMDN3, FH, MTOR, RPS11, STYX, PTTG1, TRIM25, BCL3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NOTCH1_MAPK1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | MAPK1 | P28482 | DB01064 | Isoprenaline | Mitogen-activated protein kinase 1 | small molecule | approved|investigational |
| Tgene | MAPK1 | P28482 | DB01169 | Arsenic trioxide | Mitogen-activated protein kinase 1 | small molecule | approved|investigational |
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RelatedDiseases for NOTCH1_MAPK1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NOTCH1 | C1961099 | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 4 | CTD_human |
| Hgene | NOTCH1 | C1458155 | Mammary Neoplasms | 2 | CTD_human |
| Hgene | NOTCH1 | C0000768 | Congenital Abnormality | 1 | CTD_human |
| Hgene | NOTCH1 | C0004114 | Astrocytoma | 1 | CTD_human |
| Hgene | NOTCH1 | C0006663 | Calcinosis | 1 | CTD_human |
| Hgene | NOTCH1 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| Hgene | NOTCH1 | C0007873 | Uterine Cervical Neoplasm | 1 | CTD_human |
| Hgene | NOTCH1 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| Hgene | NOTCH1 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Hgene | NOTCH1 | C0017636 | Glioblastoma | 1 | CTD_human |
| Hgene | NOTCH1 | C0018824 | Heart valve disease | 1 | CTD_human |
| Hgene | NOTCH1 | C0023492 | Leukemia, T-Cell | 1 | CTD_human |
| Hgene | NOTCH1 | C0024299 | Lymphoma | 1 | CTD_human |
| Hgene | NOTCH1 | C0027765 | nervous system disorder | 1 | CTD_human |
| Hgene | NOTCH1 | C0036439 | Scoliosis, unspecified | 1 | CTD_human |
| Hgene | NOTCH1 | C0038002 | Splenomegaly | 1 | CTD_human |
| Hgene | NOTCH1 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| Hgene | NOTCH1 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
| Hgene | NOTCH1 | C0428791 | Aortic valve calcification | 1 | CTD_human |
| Hgene | NOTCH1 | C0887833 | Carcinoma, Pancreatic Ductal | 1 | CTD_human |
| Hgene | NOTCH1 | C4014970 | ADAMS-OLIVER SYNDROME 5 | 1 | UNIPROT |
| Tgene | MAPK1 | C0020429 | Hyperalgesia | 2 | CTD_human |
| Tgene | MAPK1 | C0024121 | Lung Neoplasms | 2 | CTD_human |
| Tgene | MAPK1 | C0236736 | Cocaine-Related Disorders | 2 | CTD_human |
| Tgene | MAPK1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | MAPK1 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Tgene | MAPK1 | C0007786 | Brain Ischemia | 1 | CTD_human |
| Tgene | MAPK1 | C0017639 | Gliosis | 1 | CTD_human |
| Tgene | MAPK1 | C0018671 | Head and Neck Neoplasms | 1 | CTD_human |
| Tgene | MAPK1 | C0020564 | Hypertrophy | 1 | CTD_human |
| Tgene | MAPK1 | C0021361 | Female infertility | 1 | CTD_human |
| Tgene | MAPK1 | C0022665 | Kidney Neoplasm | 1 | CTD_human |
| Tgene | MAPK1 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Tgene | MAPK1 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Tgene | MAPK1 | C0027746 | Nerve Degeneration | 1 | CTD_human |
| Tgene | MAPK1 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | MAPK1 | C0036920 | Sezary Syndrome | 1 | CTD_human |
| Tgene | MAPK1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Tgene | MAPK1 | C0038587 | Substance Withdrawal Syndrome | 1 | CTD_human |
| Tgene | MAPK1 | C0040997 | Trigeminal Neuralgia | 1 | CTD_human |
| Tgene | MAPK1 | C0155862 | Streptococcal pneumonia | 1 | CTD_human |
| Tgene | MAPK1 | C0178417 | Anhedonia | 1 | PSYGENET |
| Tgene | MAPK1 | C0243026 | Sepsis | 1 | CTD_human |
| Tgene | MAPK1 | C0878544 | Cardiomyopathies | 1 | CTD_human |
| Tgene | MAPK1 | C0919267 | ovarian neoplasm | 1 | CTD_human |
| Tgene | MAPK1 | C1866282 | CEROID LIPOFUSCINOSIS, NEURONAL, 6 | 1 | CTD_human |
| Tgene | MAPK1 | C3495559 | Juvenile arthritis | 1 | CTD_human |
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