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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24599

FusionGeneSummary for NOP58_NAMPT

check button Fusion gene summary
Fusion gene informationFusion gene name: NOP58_NAMPT
Fusion gene ID: 24599
HgeneTgene
Gene symbol

NOP58

NAMPT

Gene ID

51602

10135

Gene nameNOP58 ribonucleoproteinnicotinamide phosphoribosyltransferase
SynonymsHSPC120|NOP5|NOP5/NOP581110035O14Rik|PBEF|PBEF1|VF|VISFATIN
Cytomap

2q33.1

7q22.3

Type of geneprotein-codingprotein-coding
Descriptionnucleolar protein 58NOP58 ribonucleoprotein homolognucleolar protein 5nucleolar protein NOP5/NOP58nicotinamide phosphoribosyltransferaseNAmPRTasepre-B cell-enhancing factorpre-B-cell colony-enhancing factor 1
Modification date2018052320180519
UniProtAcc

Q9Y2X3

P43490

Ensembl transtripts involved in fusion geneENST00000264279, ENST00000467734, 
ENST00000222553, ENST00000354289, 
ENST00000484527, 
Fusion gene scores* DoF score3 X 3 X 2=185 X 5 X 2=50
# samples 35
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/50*10)=0
Context

PubMed: NOP58 [Title/Abstract] AND NAMPT [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNAMPT

GO:0008286

insulin receptor signaling pathway

17983582

TgeneNAMPT

GO:0045944

positive regulation of transcription by RNA polymerase II

23001182

TgeneNAMPT

GO:0051770

positive regulation of nitric-oxide synthase biosynthetic process

19727662

TgeneNAMPT

GO:0060612

adipose tissue development

17983582


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA677790NOP58chr2

203142907

+NAMPTchr7

105925426

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000264279ENST00000222553NOP58chr2

203142907

+NAMPTchr7

105925426

-
intron-intronENST00000264279ENST00000354289NOP58chr2

203142907

+NAMPTchr7

105925426

-
intron-intronENST00000264279ENST00000484527NOP58chr2

203142907

+NAMPTchr7

105925426

-
intron-5UTRENST00000467734ENST00000222553NOP58chr2

203142907

+NAMPTchr7

105925426

-
intron-intronENST00000467734ENST00000354289NOP58chr2

203142907

+NAMPTchr7

105925426

-
intron-intronENST00000467734ENST00000484527NOP58chr2

203142907

+NAMPTchr7

105925426

-

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FusionProtFeatures for NOP58_NAMPT


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NOP58

Q9Y2X3

NAMPT

P43490

Required for 60S ribosomal subunit biogenesis (Bysimilarity). Core component of box C/D small nucleolarribonucleoprotein (snoRNP) particles. Required for the biogenesisof box C/D snoRNAs such as U3, U8 and U14 snoRNAs. {ECO:0000250,ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:17636026,ECO:0000269|PubMed:19620283}. Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamidemononucleotide, an intermediate in the biosynthesis of NAD. It isthe rate limiting component in the mammalian NAD biosynthesispathway. The secreted form behaves both as a cytokine withimmunomodulating properties and an adipokine with anti-diabeticproperties, it has no enzymatic activity, partly because of lackof activation by ATP, which has a low level in extracellular spaceand plasma. Plays a role in the modulation of circadian clockfunction. NAMPT-dependent oscillatory production of NAD regulatesoscillation of clock target gene expression by releasing the coreclock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependentSIRT1-mediated suppression (By similarity).{ECO:0000250|UniProtKB:Q99KQ4, ECO:0000269|PubMed:24130902}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NOP58_NAMPT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NOP58_NAMPT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NOP58_NAMPT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NOP58_NAMPT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNAMPTC0009319Colitis1CTD_human
TgeneNAMPTC0009404Colorectal Neoplasms1CTD_human
TgeneNAMPTC0028754Obesity1CTD_human
TgeneNAMPTC0162820Dermatitis, Allergic Contact1CTD_human