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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24594

FusionGeneSummary for NOP2_SNRPN

check button Fusion gene summary
Fusion gene informationFusion gene name: NOP2_SNRPN
Fusion gene ID: 24594
HgeneTgene
Gene symbol

NOP2

SNRPN

Gene ID

4839

6638

Gene nameNOP2 nucleolar proteinsmall nuclear ribonucleoprotein polypeptide N
SynonymsNOL1|NOP120|NSUN1|p120HCERN3|PWCR|RT-LI|SM-D|SMN|SNRNP-N|SNURF-SNRPN|sm-N
Cytomap

12p13.31

15q11.2

Type of geneprotein-codingprotein-coding
Descriptionprobable 28S rRNA (cytosine(4447)-C(5))-methyltransferaseNOL1/NOP2/Sun domain family, member 1NOP2 nucleolar protein homolognucleolar protein 1, 120kDanucleolar protein 2 homologproliferating-cell nucleolar antigen p120proliferation-associated nuclesmall nuclear ribonucleoprotein-associated protein NSM protein Nsm protein Dtissue-specific splicing protein
Modification date2018052320180523
UniProtAcc

P46087

P63162

Ensembl transtripts involved in fusion geneENST00000537442, ENST00000382421, 
ENST00000545200, ENST00000399466, 
ENST00000322166, ENST00000541778, 
ENST00000542015, ENST00000545915, 
ENST00000540228, 
ENST00000400098, 
ENST00000400100, ENST00000400097, 
ENST00000553597, ENST00000390687, 
ENST00000346403, ENST00000554227, 
ENST00000577565, ENST00000444203, 
Fusion gene scores* DoF score3 X 4 X 2=247 X 10 X 2=140
# samples 411
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(11/140*10)=-0.347923303420307
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NOP2 [Title/Abstract] AND SNRPN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNOP2

GO:0008284

positive regulation of cell proliferation

1394192


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF769740NOP2chr12

6666239

-SNRPNchr15

25213171

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000537442ENST00000400098NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000537442ENST00000400100NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000537442ENST00000400097NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-3UTRENST00000537442ENST00000553597NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000537442ENST00000390687NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000537442ENST00000346403NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000537442ENST00000554227NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000537442ENST00000577565NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-intronENST00000537442ENST00000444203NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000382421ENST00000400098NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000382421ENST00000400100NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000382421ENST00000400097NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-3UTRENST00000382421ENST00000553597NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000382421ENST00000390687NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000382421ENST00000346403NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000382421ENST00000554227NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000382421ENST00000577565NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-intronENST00000382421ENST00000444203NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000545200ENST00000400098NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000545200ENST00000400100NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000545200ENST00000400097NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-3UTRENST00000545200ENST00000553597NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000545200ENST00000390687NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000545200ENST00000346403NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000545200ENST00000554227NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000545200ENST00000577565NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-intronENST00000545200ENST00000444203NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000399466ENST00000400098NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000399466ENST00000400100NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000399466ENST00000400097NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-3UTRENST00000399466ENST00000553597NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000399466ENST00000390687NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000399466ENST00000346403NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000399466ENST00000554227NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000399466ENST00000577565NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-intronENST00000399466ENST00000444203NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000322166ENST00000400098NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000322166ENST00000400100NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000322166ENST00000400097NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-3UTRENST00000322166ENST00000553597NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000322166ENST00000390687NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000322166ENST00000346403NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000322166ENST00000554227NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000322166ENST00000577565NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-intronENST00000322166ENST00000444203NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000541778ENST00000400098NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000541778ENST00000400100NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000541778ENST00000400097NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-3UTRENST00000541778ENST00000553597NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000541778ENST00000390687NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000541778ENST00000346403NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000541778ENST00000554227NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000541778ENST00000577565NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-intronENST00000541778ENST00000444203NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000542015ENST00000400098NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000542015ENST00000400100NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000542015ENST00000400097NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-3UTRENST00000542015ENST00000553597NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000542015ENST00000390687NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000542015ENST00000346403NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000542015ENST00000554227NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000542015ENST00000577565NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-intronENST00000542015ENST00000444203NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000545915ENST00000400098NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000545915ENST00000400100NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000545915ENST00000400097NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-3UTRENST00000545915ENST00000553597NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000545915ENST00000390687NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000545915ENST00000346403NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000545915ENST00000554227NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000545915ENST00000577565NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-intronENST00000545915ENST00000444203NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000540228ENST00000400098NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000540228ENST00000400100NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000540228ENST00000400097NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-3UTRENST00000540228ENST00000553597NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000540228ENST00000390687NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000540228ENST00000346403NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000540228ENST00000554227NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-5UTRENST00000540228ENST00000577565NOP2chr12

6666239

-SNRPNchr15

25213171

-
intron-intronENST00000540228ENST00000444203NOP2chr12

6666239

-SNRPNchr15

25213171

-

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FusionProtFeatures for NOP2_SNRPN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NOP2

P46087

SNRPN

P63162

Involved in ribosomal large subunit assembly(PubMed:24120868). S-adenosyl-L-methionine-dependentmethyltransferase that specifically methylates the C(5) positionof cytosine 4447 in 28S rRNA (Probable). May play a role in theregulation of the cell cycle and the increased nucleolar activitythat is associated with the cell proliferation (Probable).{ECO:0000269|PubMed:24120868, ECO:0000305,ECO:0000305|PubMed:23913415}. May be involved in tissue-specific alternative RNAprocessing events.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NOP2_SNRPN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NOP2_SNRPN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NOP2_SNRPN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NOP2_SNRPN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource