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Fusion gene ID: 2459 |
FusionGeneSummary for ARHGAP42_KMO |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARHGAP42_KMO | Fusion gene ID: 2459 | Hgene | Tgene | Gene symbol | ARHGAP42 | KMO | Gene ID | 143872 | 8564 |
| Gene name | Rho GTPase activating protein 42 | kynurenine 3-monooxygenase | |
| Synonyms | AD031|GRAF3|TMEM133 | dJ317G22.1 | |
| Cytomap | 11q22.1 | 1q43 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho GTPase-activating protein 42rho-type GTPase-activating protein 42transmembrane protein 133 | kynurenine 3-monooxygenasekynurenine 3-hydroxylase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | A6NI28 | O15229 | |
| Ensembl transtripts involved in fusion gene | ENST00000524892, ENST00000298815, ENST00000534060, | ENST00000366558, ENST00000366559, ENST00000484628, ENST00000366557, | |
| Fusion gene scores | * DoF score | 7 X 4 X 6=168 | 3 X 2 X 3=18 |
| # samples | 7 | 4 | |
| ** MAII score | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ARHGAP42 [Title/Abstract] AND KMO [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ARHGAP42 | GO:0090630 | activation of GTPase activity | 24335996 |
| Tgene | KMO | GO:0009651 | response to salt stress | 10672018 |
| Tgene | KMO | GO:0019674 | NAD metabolic process | 23575632|29429898 |
| Tgene | KMO | GO:0070189 | kynurenine metabolic process | 10672018|26752518|29208702|29429898 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-BC-A8YO-01A | ARHGAP42 | chr11 | 100730356 | + | KMO | chr1 | 241749981 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000524892 | ENST00000366558 | ARHGAP42 | chr11 | 100730356 | + | KMO | chr1 | 241749981 | + |
| In-frame | ENST00000524892 | ENST00000366559 | ARHGAP42 | chr11 | 100730356 | + | KMO | chr1 | 241749981 | + |
| 5CDS-intron | ENST00000524892 | ENST00000484628 | ARHGAP42 | chr11 | 100730356 | + | KMO | chr1 | 241749981 | + |
| 5CDS-intron | ENST00000524892 | ENST00000366557 | ARHGAP42 | chr11 | 100730356 | + | KMO | chr1 | 241749981 | + |
| In-frame | ENST00000298815 | ENST00000366558 | ARHGAP42 | chr11 | 100730356 | + | KMO | chr1 | 241749981 | + |
| In-frame | ENST00000298815 | ENST00000366559 | ARHGAP42 | chr11 | 100730356 | + | KMO | chr1 | 241749981 | + |
| 5CDS-intron | ENST00000298815 | ENST00000484628 | ARHGAP42 | chr11 | 100730356 | + | KMO | chr1 | 241749981 | + |
| 5CDS-intron | ENST00000298815 | ENST00000366557 | ARHGAP42 | chr11 | 100730356 | + | KMO | chr1 | 241749981 | + |
| 3UTR-3CDS | ENST00000534060 | ENST00000366558 | ARHGAP42 | chr11 | 100730356 | + | KMO | chr1 | 241749981 | + |
| 3UTR-3CDS | ENST00000534060 | ENST00000366559 | ARHGAP42 | chr11 | 100730356 | + | KMO | chr1 | 241749981 | + |
| 3UTR-intron | ENST00000534060 | ENST00000484628 | ARHGAP42 | chr11 | 100730356 | + | KMO | chr1 | 241749981 | + |
| 3UTR-intron | ENST00000534060 | ENST00000366557 | ARHGAP42 | chr11 | 100730356 | + | KMO | chr1 | 241749981 | + |
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FusionProtFeatures for ARHGAP42_KMO |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARHGAP42 | KMO |
| May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle.{ECO:0000269|PubMed:24335996}. | Catalyzes the hydroxylation of L-kynurenine (L-Kyn) toform 3-hydroxy-L-kynurenine (L-3OHKyn) (PubMed:29429898,PubMed:23575632, PubMed:26752518, PubMed:28604669,PubMed:29208702). Required for synthesis of quinolinic acid, aneurotoxic NMDA receptor antagonist and potential endogenousinhibitor of NMDA receptor signaling in axonal targeting,synaptogenesis and apoptosis during brain development. Quinolinicacid may also affect NMDA receptor signaling in pancreatic betacells, osteoblasts, myocardial cells, and the gastrointestinaltract (Probable). {ECO:0000269|PubMed:23575632,ECO:0000269|PubMed:26752518, ECO:0000269|PubMed:28604669,ECO:0000269|PubMed:29208702, ECO:0000269|PubMed:29429898,ECO:0000305|PubMed:12402501}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >KMO | chr11:100730356 | chr1:241749981 | ENST00000366557 | + | 9 | 14 | 317_318 | 319 | 453 | Nucleotide binding | FAD |
| Tgene | >KMO | chr11:100730356 | chr1:241749981 | ENST00000366558 | + | 9 | 15 | 317_318 | 319 | 474 | Nucleotide binding | FAD |
| Tgene | >KMO | chr11:100730356 | chr1:241749981 | ENST00000366559 | + | 9 | 15 | 317_318 | 319 | 487 | Nucleotide binding | FAD |
| Tgene | >KMO | chr11:100730356 | chr1:241749981 | ENST00000366557 | + | 9 | 14 | 385_404 | 319 | 453 | Transmembrane | Helical |
| Tgene | >KMO | chr11:100730356 | chr1:241749981 | ENST00000366557 | + | 9 | 14 | 425_445 | 319 | 453 | Transmembrane | Helical |
| Tgene | >KMO | chr11:100730356 | chr1:241749981 | ENST00000366558 | + | 9 | 15 | 385_404 | 319 | 474 | Transmembrane | Helical |
| Tgene | >KMO | chr11:100730356 | chr1:241749981 | ENST00000366558 | + | 9 | 15 | 425_445 | 319 | 474 | Transmembrane | Helical |
| Tgene | >KMO | chr11:100730356 | chr1:241749981 | ENST00000366559 | + | 9 | 15 | 385_404 | 319 | 487 | Transmembrane | Helical |
| Tgene | >KMO | chr11:100730356 | chr1:241749981 | ENST00000366559 | + | 9 | 15 | 425_445 | 319 | 487 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ARHGAP42 | chr11:100730356 | chr1:241749981 | ENST00000298815 | + | 4 | 24 | 225_261 | 128 | 875 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >ARHGAP42 | chr11:100730356 | chr1:241749981 | ENST00000298815 | + | 4 | 24 | 619_762 | 128 | 875 | Compositional bias | Note=Ser-rich |
| Hgene | >ARHGAP42 | chr11:100730356 | chr1:241749981 | ENST00000298815 | + | 4 | 24 | 265_374 | 128 | 875 | Domain | PH |
| Hgene | >ARHGAP42 | chr11:100730356 | chr1:241749981 | ENST00000298815 | + | 4 | 24 | 376_572 | 128 | 875 | Domain | Rho-GAP |
| Hgene | >ARHGAP42 | chr11:100730356 | chr1:241749981 | ENST00000298815 | + | 4 | 24 | 7_262 | 128 | 875 | Domain | Note=BAR |
| Hgene | >ARHGAP42 | chr11:100730356 | chr1:241749981 | ENST00000298815 | + | 4 | 24 | 816_874 | 128 | 875 | Domain | SH3 |
| Tgene | KMO | chr11:100730356 | chr1:241749981 | ENST00000366557 | + | 9 | 14 | 37_40 | 319 | 453 | Nucleotide binding | FAD |
| Tgene | KMO | chr11:100730356 | chr1:241749981 | ENST00000366558 | + | 9 | 15 | 37_40 | 319 | 474 | Nucleotide binding | FAD |
| Tgene | KMO | chr11:100730356 | chr1:241749981 | ENST00000366559 | + | 9 | 15 | 37_40 | 319 | 487 | Nucleotide binding | FAD |
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FusionGeneSequence for ARHGAP42_KMO |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ARHGAP42_ENST00000524892_chr11_100730356_+_KMO_ENST00000366558_chr1_241749981_+_283aa MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF ARLLIAVEEERRRLIQNANDVLIAPLEKFRKEQIGAAKGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEKNMER FLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAV >In-frame_ARHGAP42_ENST00000524892_chr11_100730356_+_KMO_ENST00000366559_chr1_241749981_+_296aa MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF ARLLIAVEEERRRLIQNANDVLIAPLEKFRKEQIGAAKGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEMRAHV NSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIA >In-frame_ARHGAP42_ENST00000298815_chr11_100730356_+_KMO_ENST00000366558_chr1_241749981_+_283aa MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF ARLLIAVEEERRRLIQNANDVLIAPLEKFRKEQIGAAKGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEKNMER FLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAV >In-frame_ARHGAP42_ENST00000298815_chr11_100730356_+_KMO_ENST00000366559_chr1_241749981_+_296aa MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF ARLLIAVEEERRRLIQNANDVLIAPLEKFRKEQIGAAKGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEMRAHV NSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ARHGAP42_ENST00000524892_chr11_100730356_+_KMO_ENST00000366558_chr1_241749981_+_849nt ATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTGGAG CGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAATCTGTCTATGGCAGTGCAGAAATTT TCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTAGTATTGCTCAGTCACTAAAAGAATTT GCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGATCCAAAACGCTAACGATGTATTAATTGCACCACTTGAGAAATTTCGA AAAGAACAGATAGGTGCAGCAAAAGGCTTTGAAGACTGCTTGGTATTTGATGAGTTAATGGATAAATTCAGTAACGACCTTAGTTTGTGT CTTCCTGTGTTCTCAAGATTGAGAATCCCAGATGATCACGCGATTTCAGACCTATCCATGTACAATTACATAGAGAAGAACATGGAGAGA TTTCTTCATGCGATTATGCCATCGACCTTTATCCCTCTCTATACAATGGTCACTTTTTCCAGAATAAGATACCATGAGGCTGTGCAGCGT TGGCATTGGCAAAAAAAGGTGATAAACAAAGGACTCTTTTTCTTGGGATCACTGATAGCCATCAGCAGTACCTACCTACTTATACACTAC ATGTCACCACGATCTTTCCTCCGCTTGAGAAGACCATGGAACTGGATAGCTCACTTCCGGAATACAACATGTTTCCCCGCAAAGGCCGTG >In-frame_ARHGAP42_ENST00000524892_chr11_100730356_+_KMO_ENST00000366559_chr1_241749981_+_888nt ATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTGGAG CGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAATCTGTCTATGGCAGTGCAGAAATTT TCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTAGTATTGCTCAGTCACTAAAAGAATTT GCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGATCCAAAACGCTAACGATGTATTAATTGCACCACTTGAGAAATTTCGA AAAGAACAGATAGGTGCAGCAAAAGGCTTTGAAGACTGCTTGGTATTTGATGAGTTAATGGATAAATTCAGTAACGACCTTAGTTTGTGT CTTCCTGTGTTCTCAAGATTGAGAATCCCAGATGATCACGCGATTTCAGACCTATCCATGTACAATTACATAGAGATGCGAGCACATGTC AACTCAAGCTGGTTCATTTTTCAGAAGAACATGGAGAGATTTCTTCATGCGATTATGCCATCGACCTTTATCCCTCTCTATACAATGGTC ACTTTTTCCAGAATAAGATACCATGAGGCTGTGCAGCGTTGGCATTGGCAAAAAAAGGTGATAAACAAAGGACTCTTTTTCTTGGGATCA CTGATAGCCATCAGCAGTACCTACCTACTTATACACTACATGTCACCACGATCTTTCCTCCGCTTGAGAAGACCATGGAACTGGATAGCT >In-frame_ARHGAP42_ENST00000298815_chr11_100730356_+_KMO_ENST00000366558_chr1_241749981_+_849nt ATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTGGAG CGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAATCTGTCTATGGCAGTGCAGAAATTT TCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTAGTATTGCTCAGTCACTAAAAGAATTT GCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGATCCAAAACGCTAACGATGTATTAATTGCACCACTTGAGAAATTTCGA AAAGAACAGATAGGTGCAGCAAAAGGCTTTGAAGACTGCTTGGTATTTGATGAGTTAATGGATAAATTCAGTAACGACCTTAGTTTGTGT CTTCCTGTGTTCTCAAGATTGAGAATCCCAGATGATCACGCGATTTCAGACCTATCCATGTACAATTACATAGAGAAGAACATGGAGAGA TTTCTTCATGCGATTATGCCATCGACCTTTATCCCTCTCTATACAATGGTCACTTTTTCCAGAATAAGATACCATGAGGCTGTGCAGCGT TGGCATTGGCAAAAAAAGGTGATAAACAAAGGACTCTTTTTCTTGGGATCACTGATAGCCATCAGCAGTACCTACCTACTTATACACTAC ATGTCACCACGATCTTTCCTCCGCTTGAGAAGACCATGGAACTGGATAGCTCACTTCCGGAATACAACATGTTTCCCCGCAAAGGCCGTG >In-frame_ARHGAP42_ENST00000298815_chr11_100730356_+_KMO_ENST00000366559_chr1_241749981_+_888nt ATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTGGAG CGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAATCTGTCTATGGCAGTGCAGAAATTT TCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTAGTATTGCTCAGTCACTAAAAGAATTT GCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGATCCAAAACGCTAACGATGTATTAATTGCACCACTTGAGAAATTTCGA AAAGAACAGATAGGTGCAGCAAAAGGCTTTGAAGACTGCTTGGTATTTGATGAGTTAATGGATAAATTCAGTAACGACCTTAGTTTGTGT CTTCCTGTGTTCTCAAGATTGAGAATCCCAGATGATCACGCGATTTCAGACCTATCCATGTACAATTACATAGAGATGCGAGCACATGTC AACTCAAGCTGGTTCATTTTTCAGAAGAACATGGAGAGATTTCTTCATGCGATTATGCCATCGACCTTTATCCCTCTCTATACAATGGTC ACTTTTTCCAGAATAAGATACCATGAGGCTGTGCAGCGTTGGCATTGGCAAAAAAAGGTGATAAACAAAGGACTCTTTTTCTTGGGATCA CTGATAGCCATCAGCAGTACCTACCTACTTATACACTACATGTCACCACGATCTTTCCTCCGCTTGAGAAGACCATGGAACTGGATAGCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ARHGAP42_ENST00000524892_chr11_100730356_+_KMO_ENST00000366558_chr1_241749981_+_1010nt CGGCCGCCGCTGGCAGCGCCTGTGCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCT TGCAGTGTCACGAGATTGAGCTGGAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGA ATCTGTCTATGGCAGTGCAGAAATTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTA GTATTGCTCAGTCACTAAAAGAATTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGATCCAAAACGCTAACGATGTAT TAATTGCACCACTTGAGAAATTTCGAAAAGAACAGATAGGTGCAGCAAAAGGCTTTGAAGACTGCTTGGTATTTGATGAGTTAATGGATA AATTCAGTAACGACCTTAGTTTGTGTCTTCCTGTGTTCTCAAGATTGAGAATCCCAGATGATCACGCGATTTCAGACCTATCCATGTACA ATTACATAGAGAAGAACATGGAGAGATTTCTTCATGCGATTATGCCATCGACCTTTATCCCTCTCTATACAATGGTCACTTTTTCCAGAA TAAGATACCATGAGGCTGTGCAGCGTTGGCATTGGCAAAAAAAGGTGATAAACAAAGGACTCTTTTTCTTGGGATCACTGATAGCCATCA GCAGTACCTACCTACTTATACACTACATGTCACCACGATCTTTCCTCCGCTTGAGAAGACCATGGAACTGGATAGCTCACTTCCGGAATA CAACATGTTTCCCCGCAAAGGCCGTGGACTCCCTAGAACAAATTTCCAATCTCATTAGCAGGTGATAGAAAGGTTTTGTGGTAGCAAATG CATGATTTCTCTGTGACCAAAATTAAGCATGAAAAAAATGTTTCCATTGCCATATTTGATTCACTAGTGGAAGATAGTGTTCTGCTTATA >In-frame_ARHGAP42_ENST00000524892_chr11_100730356_+_KMO_ENST00000366559_chr1_241749981_+_4403nt CGGCCGCCGCTGGCAGCGCCTGTGCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCT TGCAGTGTCACGAGATTGAGCTGGAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGA ATCTGTCTATGGCAGTGCAGAAATTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTA GTATTGCTCAGTCACTAAAAGAATTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGATCCAAAACGCTAACGATGTAT TAATTGCACCACTTGAGAAATTTCGAAAAGAACAGATAGGTGCAGCAAAAGGCTTTGAAGACTGCTTGGTATTTGATGAGTTAATGGATA AATTCAGTAACGACCTTAGTTTGTGTCTTCCTGTGTTCTCAAGATTGAGAATCCCAGATGATCACGCGATTTCAGACCTATCCATGTACA ATTACATAGAGATGCGAGCACATGTCAACTCAAGCTGGTTCATTTTTCAGAAGAACATGGAGAGATTTCTTCATGCGATTATGCCATCGA CCTTTATCCCTCTCTATACAATGGTCACTTTTTCCAGAATAAGATACCATGAGGCTGTGCAGCGTTGGCATTGGCAAAAAAAGGTGATAA ACAAAGGACTCTTTTTCTTGGGATCACTGATAGCCATCAGCAGTACCTACCTACTTATACACTACATGTCACCACGATCTTTCCTCCGCT TGAGAAGACCATGGAACTGGATAGCTCACTTCCGGAATACAACATGTTTCCCCGCAAAGGCCGTGGACTCCCTAGAACAAATTTCCAATC TCATTAGCAGGTGATAGAAAGGTTTTGTGGTAGCAAATGCATGATTTCTCTGTGACCAAAATTAAGCATGAAAAAAATGTTTCCATTGCC ATATTTGATTCACTAGTGGAAGATAGTGTTCTGCTTATAATTAAACTGAATGTAGAGTATCTCTGTATGTTAATTGCAATTACTGGTTGG GGGGTGCATTTTAAAAGATGAAACATGCAGCTTCCCTACATTACACACACTCAGGTTGAGTCATTCTAACTATAAAAGTGCAATGACTAA GATCCTTCACTTCTCTGAAAGTAAGGCCCTAGATGCCTCAGGGAAGACAGTAATCATGCCTTTTCTTTAAAAGACACAATAGGACTCGCA ACAGCATTGACTCAACACCTAGGACTAAAAATCACAACTTAACTAGCATGTTAACTGCACTTTTCATTACGTGAATGGAACTTACCTAAC CACAGGGCTCAGACTTACTAGATAAAACCAGAAATGGAAATAAGGAATTCAGGGGAGTTCCAGAGACTTACAAAATGAACTCATTTTATT TTCCCACCTTCAAATATAAGTATTATCATCTATCTGTTTATCGTCTATCTATCTATCATCTATCTATCTATCTATCATCTATCTATCTAT CTATCTATCTATCTATCTATCTATCTATCTCTATTTATTTATGTATTTAGAGATCAGGTCTCACTCTGTTGACCAGGCTGGAGTGCAGTG GTGAGATCTGGGTTCACTGCAACCTCTGCCTCCTGGGCTCAAGCAATCCTCCCACTTCAGCCTCCCAAATAGCTGGGGCTACCATGGTAT TTTTCAGTAGAGACCGGGTCTTGCCATGCTGCCCAGGCCAGTCTCAAACTCCTGGCCTCATGTGATCTGCCCACCTCAGCCTCCCAAAGT ACAGGGATTAGAGTTGTGAGCCACCGCTGCCAGCCCAGAGTTACCCTCTAAAGATAAGAAAAAGGCTATTAATATCATACTAAGTGAAGG ACAGGAAAGGGTTTTATTCATAAATTAAATGTCTACATGTGCCAGAATGGAAAGGAAACAAGGGGAGACAACTTTTATAGAAATACAAAG CCATTACTTTATTCAATTTCAGACCCTCAGAAGCAATTTACTAATTTATTCTTCGACTACATACTGCAGCAGAACCAGCAATACACTTGA TTTTTAAAAGCACATTTAGTGAAATGTTTTCTTTGGTTCATCCTTCTTTAACAGGCTGCTGAGTCACTCAGAAATCCTTCAAACATGATT AATTATGAAGATGAAACACTAGAGTCATATAAGAAATAAAAATTGGGCAATAAAATAAAATGATTCAGTGTTTCTTTTCTATATTGTCAA TGAAAACCTTGAGTTCTAATAATCCATGTTCAGTTTGTAGGGAAAGAAAAAATAATTTTTCCTTCTACCCACTTTAGGTTCCTTGGCTGG GGCCCCTATAACAAAAGACAGATTGACAAGAGAAAAACAAACATAAATTTATTAGCGGGTATATGTAATATATATGTGGGAAATACAGGG GAATGAGCAAATCTCAAAGAGCTGGCGTCTTAGAACTCCCTGGCTTATATAGCATCGACAAAGAACAGTAAATTTTTAGAGAAACAACAA AACAAAGAAAAAGAGCTTTGAGTCTGTAGGGGCAGCAATTTGGGGGAAGCAAATATATGGGAGTTTGCCTTGTAGATTCCTCTGGTGCTG GTCTCCAGGCTGACAAGGATTCAAAGTTGTCTCTGAAACTCCTCTTTGTCATACTGCACATATAAAACGTCTTTTGTTTCCAACAAGAGG ATTTTCTTTTTCATTCTAGAATTATCTCCTTGATAACTTGATCAGATATAGGACATGACACTGAATAGAGTCCAACAGTACAAAAAAAAT TCAGTATGTTCTAGCTACTTCACACATGTGTACGCGACAGTTATTTTTACAGTAAGGTATTTTCGAGAAAAATGCATTACGTGTTTTGGA AAATAGAGTAATTTAAAAAATATATTTGAAATGAAAATCTCCAACACATTAGAAGATGATGATGTTAGATGCCCATCGTGTGCCACAAGT GGTTTTTTCATTATGTAAAGCACCCGTTGAATTAAAAGAATTTGTTTTTGTTCAACCTCTTCCTGAGGCCCAAGAGCATATGGGCAATTC GGATTTCCTGCTGGACCACAAGGTTCTGTTGATATTACATAGAACGGGTATTCCAGACACTTCTTATGATGAAAGTCCAAAAGTGGCATC CAATTTAAGGCCCCATCTTTCGTTGCCATTCTTCATTCCTACAAAGGACGAACTTGGATTACATCAACTTTGGACCCATTGGTTTTGTCG CTGTCGTCAACTGACAGTGATTCATCACTGGTGATGATAAAAATGATGGAAGAAGAGTTGAAAGTCACTTTTTTCTTTGGCCTGTCCCCA TCTTTCTGTGACATCACAATGGGTCTGATCTGCATTTCACTTCCAGCTGCTGGTAGGTCTTTAGCAGGCCTCTGGCACCTCAGCAGTCGG AGGCACAGAAGCTGCAAAAGGGATCTTCGAAACTGGGCAGAGAAAAAATAAAGTGGAATATTAAGTAAAAGTTGGGCACTAATCTGGATT AACATTCGAGGAAATCAGTTGAGCTGAATTTAAGTTGTTTTTTGTTTGTTAGCAGGTGTGGATGTGGGGTTATGTGGTCATGCTCAGATC TACCTAAATCACCCCAGAGCTTTATGTCTTTTATTCATTCTAATTCTTATTAACCGGAATATGTAGGACCATTTCAATACCTTGTAATCC TCCAAGCTTCAATCTGCACACACTTTCTATGAGGGCAGGTACAACTATTAAGAGATTTTGAACATTAAGTTAGTCCACAAATATTCAGTG GGCATCTACTAGGTGACAGCCACTGTGCTATAATTAGAGACTTTTTACTATAAGCATCAAAAACAGATAAGGCTCTTCCTGGCAGAGTTT ACAGCCTGGTGTACTTGCTAATGTCTCTTTAATTAGGTGAAGAATTTTTTTTTTCTATCGAAATTACTAATCAGTTGGGGAAAAAAATAC TATAGCAGACAGCACTAATGTCATCAACAAACATTGTTCTTCTCCGTGTCCTGGGTACAACATCGAATAATATTTCTTGGCCTCCTTTCC GCTTCTCCTCTCTGCTGTTCCTCTCTACAAGAACCTGGGAGGCCAACGCCTAAAGATCATAATATCACACAATGGAAGGAACCTAGATTC CTAAATGACTGCATAGGACAGATCCCATCTCCTCCACCCAATACATTATTAGACTGAACTGTGACCTGAAATGAGCAATAAACTCTGTAT TAATTCACTGAAATGTTGGGGTTGCTTGTTATAGTAGTCGGTCCATCATGACCAGTAAAACATAAATCAAAAGTTAATGTAATTGTTATC >In-frame_ARHGAP42_ENST00000298815_chr11_100730356_+_KMO_ENST00000366558_chr1_241749981_+_987nt GCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTG GAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAATCTGTCTATGGCAGTGCAGAAA TTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTAGTATTGCTCAGTCACTAAAAGAA TTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGATCCAAAACGCTAACGATGTATTAATTGCACCACTTGAGAAATTT CGAAAAGAACAGATAGGTGCAGCAAAAGGCTTTGAAGACTGCTTGGTATTTGATGAGTTAATGGATAAATTCAGTAACGACCTTAGTTTG TGTCTTCCTGTGTTCTCAAGATTGAGAATCCCAGATGATCACGCGATTTCAGACCTATCCATGTACAATTACATAGAGAAGAACATGGAG AGATTTCTTCATGCGATTATGCCATCGACCTTTATCCCTCTCTATACAATGGTCACTTTTTCCAGAATAAGATACCATGAGGCTGTGCAG CGTTGGCATTGGCAAAAAAAGGTGATAAACAAAGGACTCTTTTTCTTGGGATCACTGATAGCCATCAGCAGTACCTACCTACTTATACAC TACATGTCACCACGATCTTTCCTCCGCTTGAGAAGACCATGGAACTGGATAGCTCACTTCCGGAATACAACATGTTTCCCCGCAAAGGCC GTGGACTCCCTAGAACAAATTTCCAATCTCATTAGCAGGTGATAGAAAGGTTTTGTGGTAGCAAATGCATGATTTCTCTGTGACCAAAAT >In-frame_ARHGAP42_ENST00000298815_chr11_100730356_+_KMO_ENST00000366559_chr1_241749981_+_4380nt GCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTG GAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAATCTGTCTATGGCAGTGCAGAAA TTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTAGTATTGCTCAGTCACTAAAAGAA TTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGATCCAAAACGCTAACGATGTATTAATTGCACCACTTGAGAAATTT CGAAAAGAACAGATAGGTGCAGCAAAAGGCTTTGAAGACTGCTTGGTATTTGATGAGTTAATGGATAAATTCAGTAACGACCTTAGTTTG TGTCTTCCTGTGTTCTCAAGATTGAGAATCCCAGATGATCACGCGATTTCAGACCTATCCATGTACAATTACATAGAGATGCGAGCACAT GTCAACTCAAGCTGGTTCATTTTTCAGAAGAACATGGAGAGATTTCTTCATGCGATTATGCCATCGACCTTTATCCCTCTCTATACAATG GTCACTTTTTCCAGAATAAGATACCATGAGGCTGTGCAGCGTTGGCATTGGCAAAAAAAGGTGATAAACAAAGGACTCTTTTTCTTGGGA TCACTGATAGCCATCAGCAGTACCTACCTACTTATACACTACATGTCACCACGATCTTTCCTCCGCTTGAGAAGACCATGGAACTGGATA GCTCACTTCCGGAATACAACATGTTTCCCCGCAAAGGCCGTGGACTCCCTAGAACAAATTTCCAATCTCATTAGCAGGTGATAGAAAGGT TTTGTGGTAGCAAATGCATGATTTCTCTGTGACCAAAATTAAGCATGAAAAAAATGTTTCCATTGCCATATTTGATTCACTAGTGGAAGA TAGTGTTCTGCTTATAATTAAACTGAATGTAGAGTATCTCTGTATGTTAATTGCAATTACTGGTTGGGGGGTGCATTTTAAAAGATGAAA CATGCAGCTTCCCTACATTACACACACTCAGGTTGAGTCATTCTAACTATAAAAGTGCAATGACTAAGATCCTTCACTTCTCTGAAAGTA AGGCCCTAGATGCCTCAGGGAAGACAGTAATCATGCCTTTTCTTTAAAAGACACAATAGGACTCGCAACAGCATTGACTCAACACCTAGG ACTAAAAATCACAACTTAACTAGCATGTTAACTGCACTTTTCATTACGTGAATGGAACTTACCTAACCACAGGGCTCAGACTTACTAGAT AAAACCAGAAATGGAAATAAGGAATTCAGGGGAGTTCCAGAGACTTACAAAATGAACTCATTTTATTTTCCCACCTTCAAATATAAGTAT TATCATCTATCTGTTTATCGTCTATCTATCTATCATCTATCTATCTATCTATCATCTATCTATCTATCTATCTATCTATCTATCTATCTA TCTATCTCTATTTATTTATGTATTTAGAGATCAGGTCTCACTCTGTTGACCAGGCTGGAGTGCAGTGGTGAGATCTGGGTTCACTGCAAC CTCTGCCTCCTGGGCTCAAGCAATCCTCCCACTTCAGCCTCCCAAATAGCTGGGGCTACCATGGTATTTTTCAGTAGAGACCGGGTCTTG CCATGCTGCCCAGGCCAGTCTCAAACTCCTGGCCTCATGTGATCTGCCCACCTCAGCCTCCCAAAGTACAGGGATTAGAGTTGTGAGCCA CCGCTGCCAGCCCAGAGTTACCCTCTAAAGATAAGAAAAAGGCTATTAATATCATACTAAGTGAAGGACAGGAAAGGGTTTTATTCATAA ATTAAATGTCTACATGTGCCAGAATGGAAAGGAAACAAGGGGAGACAACTTTTATAGAAATACAAAGCCATTACTTTATTCAATTTCAGA CCCTCAGAAGCAATTTACTAATTTATTCTTCGACTACATACTGCAGCAGAACCAGCAATACACTTGATTTTTAAAAGCACATTTAGTGAA ATGTTTTCTTTGGTTCATCCTTCTTTAACAGGCTGCTGAGTCACTCAGAAATCCTTCAAACATGATTAATTATGAAGATGAAACACTAGA GTCATATAAGAAATAAAAATTGGGCAATAAAATAAAATGATTCAGTGTTTCTTTTCTATATTGTCAATGAAAACCTTGAGTTCTAATAAT CCATGTTCAGTTTGTAGGGAAAGAAAAAATAATTTTTCCTTCTACCCACTTTAGGTTCCTTGGCTGGGGCCCCTATAACAAAAGACAGAT TGACAAGAGAAAAACAAACATAAATTTATTAGCGGGTATATGTAATATATATGTGGGAAATACAGGGGAATGAGCAAATCTCAAAGAGCT GGCGTCTTAGAACTCCCTGGCTTATATAGCATCGACAAAGAACAGTAAATTTTTAGAGAAACAACAAAACAAAGAAAAAGAGCTTTGAGT CTGTAGGGGCAGCAATTTGGGGGAAGCAAATATATGGGAGTTTGCCTTGTAGATTCCTCTGGTGCTGGTCTCCAGGCTGACAAGGATTCA AAGTTGTCTCTGAAACTCCTCTTTGTCATACTGCACATATAAAACGTCTTTTGTTTCCAACAAGAGGATTTTCTTTTTCATTCTAGAATT ATCTCCTTGATAACTTGATCAGATATAGGACATGACACTGAATAGAGTCCAACAGTACAAAAAAAATTCAGTATGTTCTAGCTACTTCAC ACATGTGTACGCGACAGTTATTTTTACAGTAAGGTATTTTCGAGAAAAATGCATTACGTGTTTTGGAAAATAGAGTAATTTAAAAAATAT ATTTGAAATGAAAATCTCCAACACATTAGAAGATGATGATGTTAGATGCCCATCGTGTGCCACAAGTGGTTTTTTCATTATGTAAAGCAC CCGTTGAATTAAAAGAATTTGTTTTTGTTCAACCTCTTCCTGAGGCCCAAGAGCATATGGGCAATTCGGATTTCCTGCTGGACCACAAGG TTCTGTTGATATTACATAGAACGGGTATTCCAGACACTTCTTATGATGAAAGTCCAAAAGTGGCATCCAATTTAAGGCCCCATCTTTCGT TGCCATTCTTCATTCCTACAAAGGACGAACTTGGATTACATCAACTTTGGACCCATTGGTTTTGTCGCTGTCGTCAACTGACAGTGATTC ATCACTGGTGATGATAAAAATGATGGAAGAAGAGTTGAAAGTCACTTTTTTCTTTGGCCTGTCCCCATCTTTCTGTGACATCACAATGGG TCTGATCTGCATTTCACTTCCAGCTGCTGGTAGGTCTTTAGCAGGCCTCTGGCACCTCAGCAGTCGGAGGCACAGAAGCTGCAAAAGGGA TCTTCGAAACTGGGCAGAGAAAAAATAAAGTGGAATATTAAGTAAAAGTTGGGCACTAATCTGGATTAACATTCGAGGAAATCAGTTGAG CTGAATTTAAGTTGTTTTTTGTTTGTTAGCAGGTGTGGATGTGGGGTTATGTGGTCATGCTCAGATCTACCTAAATCACCCCAGAGCTTT ATGTCTTTTATTCATTCTAATTCTTATTAACCGGAATATGTAGGACCATTTCAATACCTTGTAATCCTCCAAGCTTCAATCTGCACACAC TTTCTATGAGGGCAGGTACAACTATTAAGAGATTTTGAACATTAAGTTAGTCCACAAATATTCAGTGGGCATCTACTAGGTGACAGCCAC TGTGCTATAATTAGAGACTTTTTACTATAAGCATCAAAAACAGATAAGGCTCTTCCTGGCAGAGTTTACAGCCTGGTGTACTTGCTAATG TCTCTTTAATTAGGTGAAGAATTTTTTTTTTCTATCGAAATTACTAATCAGTTGGGGAAAAAAATACTATAGCAGACAGCACTAATGTCA TCAACAAACATTGTTCTTCTCCGTGTCCTGGGTACAACATCGAATAATATTTCTTGGCCTCCTTTCCGCTTCTCCTCTCTGCTGTTCCTC TCTACAAGAACCTGGGAGGCCAACGCCTAAAGATCATAATATCACACAATGGAAGGAACCTAGATTCCTAAATGACTGCATAGGACAGAT CCCATCTCCTCCACCCAATACATTATTAGACTGAACTGTGACCTGAAATGAGCAATAAACTCTGTATTAATTCACTGAAATGTTGGGGTT GCTTGTTATAGTAGTCGGTCCATCATGACCAGTAAAACATAAATCAAAAGTTAATGTAATTGTTATCCCATTATTTAGAGCGAAATAAAT |
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FusionGenePPI for ARHGAP42_KMO |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ARHGAP42 | DEF6, CAPZA2, MYO19, ARHGAP26, DENND2C | KMO | HSPA7, GPHN |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ARHGAP42_KMO |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ARHGAP42_KMO |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | KMO | C0036341 | Schizophrenia | 5 | PSYGENET |
| Tgene | KMO | C0041696 | Unipolar Depression | 2 | PSYGENET |
| Tgene | KMO | C1269683 | Major Depressive Disorder | 2 | PSYGENET |
| Tgene | KMO | C0005587 | Depression, Bipolar | 1 | PSYGENET |
| Tgene | KMO | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | KMO | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |
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