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Fusion gene ID: 2458 |
FusionGeneSummary for ARHGAP42_HIBCH |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARHGAP42_HIBCH | Fusion gene ID: 2458 | Hgene | Tgene | Gene symbol | ARHGAP42 | HIBCH | Gene ID | 143872 | 26275 |
| Gene name | Rho GTPase activating protein 42 | 3-hydroxyisobutyryl-CoA hydrolase | |
| Synonyms | AD031|GRAF3|TMEM133 | HIBYLCOAH | |
| Cytomap | 11q22.1 | 2q32.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho GTPase-activating protein 42rho-type GTPase-activating protein 42transmembrane protein 133 | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial3-hydroxyisobutyryl-Coenzyme A hydrolaseHIB-CoA hydrolaseHIBYL-CoA-Htesticular tissue protein Li 86 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | A6NI28 | Q6NVY1 | |
| Ensembl transtripts involved in fusion gene | ENST00000524892, ENST00000298815, ENST00000534060, | ENST00000392332, ENST00000359678, ENST00000410045, ENST00000486981, | |
| Fusion gene scores | * DoF score | 7 X 4 X 6=168 | 3 X 2 X 3=18 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ARHGAP42 [Title/Abstract] AND HIBCH [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ARHGAP42 | GO:0090630 | activation of GTPase activity | 24335996 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-24-2281-01A | ARHGAP42 | chr11 | 100665897 | + | HIBCH | chr2 | 191077801 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000524892 | ENST00000392332 | ARHGAP42 | chr11 | 100665897 | + | HIBCH | chr2 | 191077801 | - |
| In-frame | ENST00000524892 | ENST00000359678 | ARHGAP42 | chr11 | 100665897 | + | HIBCH | chr2 | 191077801 | - |
| In-frame | ENST00000524892 | ENST00000410045 | ARHGAP42 | chr11 | 100665897 | + | HIBCH | chr2 | 191077801 | - |
| 5CDS-5UTR | ENST00000524892 | ENST00000486981 | ARHGAP42 | chr11 | 100665897 | + | HIBCH | chr2 | 191077801 | - |
| In-frame | ENST00000298815 | ENST00000392332 | ARHGAP42 | chr11 | 100665897 | + | HIBCH | chr2 | 191077801 | - |
| In-frame | ENST00000298815 | ENST00000359678 | ARHGAP42 | chr11 | 100665897 | + | HIBCH | chr2 | 191077801 | - |
| In-frame | ENST00000298815 | ENST00000410045 | ARHGAP42 | chr11 | 100665897 | + | HIBCH | chr2 | 191077801 | - |
| 5CDS-5UTR | ENST00000298815 | ENST00000486981 | ARHGAP42 | chr11 | 100665897 | + | HIBCH | chr2 | 191077801 | - |
| 3UTR-3CDS | ENST00000534060 | ENST00000392332 | ARHGAP42 | chr11 | 100665897 | + | HIBCH | chr2 | 191077801 | - |
| 3UTR-3CDS | ENST00000534060 | ENST00000359678 | ARHGAP42 | chr11 | 100665897 | + | HIBCH | chr2 | 191077801 | - |
| 3UTR-3CDS | ENST00000534060 | ENST00000410045 | ARHGAP42 | chr11 | 100665897 | + | HIBCH | chr2 | 191077801 | - |
| 3UTR-5UTR | ENST00000534060 | ENST00000486981 | ARHGAP42 | chr11 | 100665897 | + | HIBCH | chr2 | 191077801 | - |
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FusionProtFeatures for ARHGAP42_HIBCH |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARHGAP42 | HIBCH |
| May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle.{ECO:0000269|PubMed:24335996}. | Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a salinecatabolite. Has high activity toward isobutyryl-CoA. Could be anisobutyryl-CoA dehydrogenase that functions in valine catabolism.Also hydrolyzes 3-hydroxypropanoyl-CoA.{ECO:0000269|PubMed:8824301}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ARHGAP42 | chr11:100665897 | chr2:191077801 | ENST00000298815 | + | 3 | 24 | 225_261 | 104 | 875 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >ARHGAP42 | chr11:100665897 | chr2:191077801 | ENST00000298815 | + | 3 | 24 | 619_762 | 104 | 875 | Compositional bias | Note=Ser-rich |
| Hgene | >ARHGAP42 | chr11:100665897 | chr2:191077801 | ENST00000298815 | + | 3 | 24 | 265_374 | 104 | 875 | Domain | PH |
| Hgene | >ARHGAP42 | chr11:100665897 | chr2:191077801 | ENST00000298815 | + | 3 | 24 | 376_572 | 104 | 875 | Domain | Rho-GAP |
| Hgene | >ARHGAP42 | chr11:100665897 | chr2:191077801 | ENST00000298815 | + | 3 | 24 | 7_262 | 104 | 875 | Domain | Note=BAR |
| Hgene | >ARHGAP42 | chr11:100665897 | chr2:191077801 | ENST00000298815 | + | 3 | 24 | 816_874 | 104 | 875 | Domain | SH3 |
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FusionGeneSequence for ARHGAP42_HIBCH |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ARHGAP42_ENST00000524892_chr11_100665897_+_HIBCH_ENST00000392332_chr2_191077801_-_146aa MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF >In-frame_ARHGAP42_ENST00000524892_chr11_100665897_+_HIBCH_ENST00000359678_chr2_191077801_-_194aa MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF ARLLIAVEEERRRLVINKMSPTSLKITLRQLMEGSSKTLQEVLTMEYRLSQACMRGHDFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLN >In-frame_ARHGAP42_ENST00000524892_chr11_100665897_+_HIBCH_ENST00000410045_chr2_191077801_-_194aa MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF ARLLIAVEEERRRLVINKMSPTSLKITLRQLMEGSSKTLQEVLTMEYRLSQACMRGHDFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLN >In-frame_ARHGAP42_ENST00000298815_chr11_100665897_+_HIBCH_ENST00000392332_chr2_191077801_-_146aa MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF >In-frame_ARHGAP42_ENST00000298815_chr11_100665897_+_HIBCH_ENST00000359678_chr2_191077801_-_194aa MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF ARLLIAVEEERRRLVINKMSPTSLKITLRQLMEGSSKTLQEVLTMEYRLSQACMRGHDFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLN >In-frame_ARHGAP42_ENST00000298815_chr11_100665897_+_HIBCH_ENST00000410045_chr2_191077801_-_194aa MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF ARLLIAVEEERRRLVINKMSPTSLKITLRQLMEGSSKTLQEVLTMEYRLSQACMRGHDFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ARHGAP42_ENST00000524892_chr11_100665897_+_HIBCH_ENST00000392332_chr2_191077801_-_438nt ATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTGGAG CGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAATCTGTCTATGGCAGTGCAGAAATTT TCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTAGTATTGCTCAGTCACTAAAAGAATTT GCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGGTAATTAATAAAATGTCTCCAACATCTCTAAAGATCACACTAAGGCAA >In-frame_ARHGAP42_ENST00000524892_chr11_100665897_+_HIBCH_ENST00000359678_chr2_191077801_-_582nt ATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTGGAG CGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAATCTGTCTATGGCAGTGCAGAAATTT TCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTAGTATTGCTCAGTCACTAAAAGAATTT GCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGGTAATTAATAAAATGTCTCCAACATCTCTAAAGATCACACTAAGGCAA CTCATGGAGGGGTCTTCAAAGACCTTGCAAGAAGTACTAACTATGGAGTATCGGCTAAGTCAAGCTTGTATGAGAGGTCATGACTTTCAT GAAGGCGTTAGAGCTGTTTTAATTGATAAAGACCAGAGTCCAAAATGGAAACCAGCTGATCTAAAAGAAGTTACTGAGGAAGATTTGAAT >In-frame_ARHGAP42_ENST00000524892_chr11_100665897_+_HIBCH_ENST00000410045_chr2_191077801_-_582nt ATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTGGAG CGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAATCTGTCTATGGCAGTGCAGAAATTT TCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTAGTATTGCTCAGTCACTAAAAGAATTT GCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGGTAATTAATAAAATGTCTCCAACATCTCTAAAGATCACACTAAGGCAA CTCATGGAGGGGTCTTCAAAGACCTTGCAAGAAGTACTAACTATGGAGTATCGGCTAAGTCAAGCTTGTATGAGAGGTCATGACTTTCAT GAAGGCGTTAGAGCTGTTTTAATTGATAAAGACCAGAGTCCAAAATGGAAACCAGCTGATCTAAAAGAAGTTACTGAGGAAGATTTGAAT >In-frame_ARHGAP42_ENST00000298815_chr11_100665897_+_HIBCH_ENST00000392332_chr2_191077801_-_438nt ATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTGGAG CGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAATCTGTCTATGGCAGTGCAGAAATTT TCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTAGTATTGCTCAGTCACTAAAAGAATTT GCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGGTAATTAATAAAATGTCTCCAACATCTCTAAAGATCACACTAAGGCAA >In-frame_ARHGAP42_ENST00000298815_chr11_100665897_+_HIBCH_ENST00000359678_chr2_191077801_-_582nt ATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTGGAG CGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAATCTGTCTATGGCAGTGCAGAAATTT TCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTAGTATTGCTCAGTCACTAAAAGAATTT GCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGGTAATTAATAAAATGTCTCCAACATCTCTAAAGATCACACTAAGGCAA CTCATGGAGGGGTCTTCAAAGACCTTGCAAGAAGTACTAACTATGGAGTATCGGCTAAGTCAAGCTTGTATGAGAGGTCATGACTTTCAT GAAGGCGTTAGAGCTGTTTTAATTGATAAAGACCAGAGTCCAAAATGGAAACCAGCTGATCTAAAAGAAGTTACTGAGGAAGATTTGAAT >In-frame_ARHGAP42_ENST00000298815_chr11_100665897_+_HIBCH_ENST00000410045_chr2_191077801_-_582nt ATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTGGAG CGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAATCTGTCTATGGCAGTGCAGAAATTT TCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTAGTATTGCTCAGTCACTAAAAGAATTT GCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGGTAATTAATAAAATGTCTCCAACATCTCTAAAGATCACACTAAGGCAA CTCATGGAGGGGTCTTCAAAGACCTTGCAAGAAGTACTAACTATGGAGTATCGGCTAAGTCAAGCTTGTATGAGAGGTCATGACTTTCAT GAAGGCGTTAGAGCTGTTTTAATTGATAAAGACCAGAGTCCAAAATGGAAACCAGCTGATCTAAAAGAAGTTACTGAGGAAGATTTGAAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ARHGAP42_ENST00000524892_chr11_100665897_+_HIBCH_ENST00000392332_chr2_191077801_-_1770nt CGGCCGCCGCTGGCAGCGCCTGTGCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCT TGCAGTGTCACGAGATTGAGCTGGAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGA ATCTGTCTATGGCAGTGCAGAAATTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTA GTATTGCTCAGTCACTAAAAGAATTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGGTAATTAATAAAATGTCTCCAA CATCTCTAAAGATCACACTAAGGCAACTCATGGAGGGGTCTTCAAAGACCTTGCAAGAAGTACTAACTATGGAGTATCGGCTAAGTCAAG CTTGTATGTTTTAATTGATAAAGACCAGAGTCCAAAATGGAAACCAGCTGATCTAAAAGAAGTTACTGAGGAAGATTTGAATAATCACTT TAAGTCTTTGGGAAGCAGTGATTTGAAATTTTGAGGTGACAGGCTTTTAAGGTATATTTTGTAGCATGGGTTGGCAATCTACAGCATGTG GGCCAAATCCAGCCTGCTGCCTGTTTTTATATACCCTGTAAGCTAAGAATGGTTTCCGCATTTTTAAATGGTTGGGAAAAGAAATCAAAG ACTAATAATTCATGACGTGAAAATTATCAGAATTCACAAATAAAGCTTTATTGGAACTAGCTATACTCATCTGTTTATATATTATCTGTG GCTGCTTTGAAATGAGTAGTTGCAATAGAGATGGTAAAGCCTACAAAGCCTAATTATTTACTGTCTGGTTTTTGTCAGAAAAAAGTTTGT CAATCCTTGTTTTAGAAGATGGAAAAATGTGAAGATCTTTGGAGATTCTCTTGAGTGGTATATCTAATTGAAATGGGATCTTCGTTTGGC TTGTATGTTGATGAAATCAACTTAGGTATACAATATAAAAAATAAAGACCCTGAAAATTGTTTTGGATACTGTGTTAATGCCTCATAGAA TTTTTGTTTTGGATACTGTGTTAATGCCTCATAGAATTTTCTCCATATATGAGTGTGTTTTAAAGTAACTGAGTTACTGTAGCAGAAGAG CTCCTTTTATAAACATTAGAAACCTTGGGCAGAGAGAAAAGATTTTTATTAACGTCCCTCTTCAGTATTAACTCAGACTTGGTCTTCCCT AAAATAATCAGAATACCATCCCATGGTGAAACTGAAAGGATTATTTTCTTGTTATTTGTGATATTTGTTAATCTGGTAGAATGAGAAATT AGGAAACTCCAATCTCTTAGATAGAGACACTCTGTTTTTTTATAATTTACGTAAGACTTTTGTGTGATAATTATCCTTACAAACAAGGTT CAAGTCAGGAGAAAAAAATTAATTGAAAGCAAGAAGACTTTTGTTCAAAAGATATATTCAATAATTGATATTGTTAATGAAGTAAGTACT TTTTAAGGTATGAAAGAACTAAAAGGTATTCCAGACTCAGAACCTTAAAGTTCTAGGCAAGAATAATTTTTAAACTAAAGGTAAGTTTAT AAATTAACAAAGTAAACAAAATTTATGATTTTGTTTTTTGTTTGTAATTTTTGTTTAATTTTAAAGGTAAGTTTATAAATTAACAAACAA >In-frame_ARHGAP42_ENST00000524892_chr11_100665897_+_HIBCH_ENST00000359678_chr2_191077801_-_1091nt CGGCCGCCGCTGGCAGCGCCTGTGCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCT TGCAGTGTCACGAGATTGAGCTGGAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGA ATCTGTCTATGGCAGTGCAGAAATTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTA GTATTGCTCAGTCACTAAAAGAATTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGGTAATTAATAAAATGTCTCCAA CATCTCTAAAGATCACACTAAGGCAACTCATGGAGGGGTCTTCAAAGACCTTGCAAGAAGTACTAACTATGGAGTATCGGCTAAGTCAAG CTTGTATGAGAGGTCATGACTTTCATGAAGGCGTTAGAGCTGTTTTAATTGATAAAGACCAGAGTCCAAAATGGAAACCAGCTGATCTAA AAGAAGTTACTGAGGAAGATTTGAATAATCACTTTAAGTCTTTGGGAAGCAGTGATTTGAAATTTTGAGGTGACAGGCTTTTAAGGTATA TTTTGTAGCATGGGTTGGCAATCTACAGCATGTGGGCCAAATCCAGCCTGCTGCCTGTTTTTATATACCCTGTAAGCTAAGAATGGTTTC CGCATTTTTAAATGGTTGGGAAAAGAAATCAAAGACTAATAATTCATGACGTGAAAATTATCAGAATTCACAAATAAAGCTTTATTGGAA CTAGCTATACTCATCTGTTTATATATTATCTGTGGCTGCTTTGAAATGAGTAGTTGCAATAGAGATGGTAAAGCCTACAAAGCCTAATTA TTTACTGTCTGGTTTTTGTCAGAAAAAAGTTTGTCAATCCTTGTTTTAGAAGATGGAAAAATGTGAAGATCTTTGGAGATTCTCTTGAGT GGTATATCTAATTGAAATGGGATCTTCGTTTGGCTTGTATGTTGATGAAATCAACTTAGGTATACAATATAAAAAATAAAGACCCTGAAA >In-frame_ARHGAP42_ENST00000524892_chr11_100665897_+_HIBCH_ENST00000410045_chr2_191077801_-_710nt CGGCCGCCGCTGGCAGCGCCTGTGCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCT TGCAGTGTCACGAGATTGAGCTGGAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGA ATCTGTCTATGGCAGTGCAGAAATTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTA GTATTGCTCAGTCACTAAAAGAATTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGGTAATTAATAAAATGTCTCCAA CATCTCTAAAGATCACACTAAGGCAACTCATGGAGGGGTCTTCAAAGACCTTGCAAGAAGTACTAACTATGGAGTATCGGCTAAGTCAAG CTTGTATGAGAGGTCATGACTTTCATGAAGGCGTTAGAGCTGTTTTAATTGATAAAGACCAGAGTCCAAAATGGAAACCAGCTGATCTAA AAGAAGTTACTGAGGAAGATTTGAATAATCACTTTAAGTCTTTGGGAAGCAGTGATTTGAAATTTTGAGGTGACAGGCTTTTAAGGTATA >In-frame_ARHGAP42_ENST00000298815_chr11_100665897_+_HIBCH_ENST00000392332_chr2_191077801_-_1747nt GCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTG GAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAATCTGTCTATGGCAGTGCAGAAA TTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTAGTATTGCTCAGTCACTAAAAGAA TTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGGTAATTAATAAAATGTCTCCAACATCTCTAAAGATCACACTAAGG CAACTCATGGAGGGGTCTTCAAAGACCTTGCAAGAAGTACTAACTATGGAGTATCGGCTAAGTCAAGCTTGTATGTTTTAATTGATAAAG ACCAGAGTCCAAAATGGAAACCAGCTGATCTAAAAGAAGTTACTGAGGAAGATTTGAATAATCACTTTAAGTCTTTGGGAAGCAGTGATT TGAAATTTTGAGGTGACAGGCTTTTAAGGTATATTTTGTAGCATGGGTTGGCAATCTACAGCATGTGGGCCAAATCCAGCCTGCTGCCTG TTTTTATATACCCTGTAAGCTAAGAATGGTTTCCGCATTTTTAAATGGTTGGGAAAAGAAATCAAAGACTAATAATTCATGACGTGAAAA TTATCAGAATTCACAAATAAAGCTTTATTGGAACTAGCTATACTCATCTGTTTATATATTATCTGTGGCTGCTTTGAAATGAGTAGTTGC AATAGAGATGGTAAAGCCTACAAAGCCTAATTATTTACTGTCTGGTTTTTGTCAGAAAAAAGTTTGTCAATCCTTGTTTTAGAAGATGGA AAAATGTGAAGATCTTTGGAGATTCTCTTGAGTGGTATATCTAATTGAAATGGGATCTTCGTTTGGCTTGTATGTTGATGAAATCAACTT AGGTATACAATATAAAAAATAAAGACCCTGAAAATTGTTTTGGATACTGTGTTAATGCCTCATAGAATTTTTGTTTTGGATACTGTGTTA ATGCCTCATAGAATTTTCTCCATATATGAGTGTGTTTTAAAGTAACTGAGTTACTGTAGCAGAAGAGCTCCTTTTATAAACATTAGAAAC CTTGGGCAGAGAGAAAAGATTTTTATTAACGTCCCTCTTCAGTATTAACTCAGACTTGGTCTTCCCTAAAATAATCAGAATACCATCCCA TGGTGAAACTGAAAGGATTATTTTCTTGTTATTTGTGATATTTGTTAATCTGGTAGAATGAGAAATTAGGAAACTCCAATCTCTTAGATA GAGACACTCTGTTTTTTTATAATTTACGTAAGACTTTTGTGTGATAATTATCCTTACAAACAAGGTTCAAGTCAGGAGAAAAAAATTAAT TGAAAGCAAGAAGACTTTTGTTCAAAAGATATATTCAATAATTGATATTGTTAATGAAGTAAGTACTTTTTAAGGTATGAAAGAACTAAA AGGTATTCCAGACTCAGAACCTTAAAGTTCTAGGCAAGAATAATTTTTAAACTAAAGGTAAGTTTATAAATTAACAAAGTAAACAAAATT TATGATTTTGTTTTTTGTTTGTAATTTTTGTTTAATTTTAAAGGTAAGTTTATAAATTAACAAACAAAATTTATAATTTTTTGTTTGTAA >In-frame_ARHGAP42_ENST00000298815_chr11_100665897_+_HIBCH_ENST00000359678_chr2_191077801_-_1068nt GCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTG GAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAATCTGTCTATGGCAGTGCAGAAA TTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTAGTATTGCTCAGTCACTAAAAGAA TTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGGTAATTAATAAAATGTCTCCAACATCTCTAAAGATCACACTAAGG CAACTCATGGAGGGGTCTTCAAAGACCTTGCAAGAAGTACTAACTATGGAGTATCGGCTAAGTCAAGCTTGTATGAGAGGTCATGACTTT CATGAAGGCGTTAGAGCTGTTTTAATTGATAAAGACCAGAGTCCAAAATGGAAACCAGCTGATCTAAAAGAAGTTACTGAGGAAGATTTG AATAATCACTTTAAGTCTTTGGGAAGCAGTGATTTGAAATTTTGAGGTGACAGGCTTTTAAGGTATATTTTGTAGCATGGGTTGGCAATC TACAGCATGTGGGCCAAATCCAGCCTGCTGCCTGTTTTTATATACCCTGTAAGCTAAGAATGGTTTCCGCATTTTTAAATGGTTGGGAAA AGAAATCAAAGACTAATAATTCATGACGTGAAAATTATCAGAATTCACAAATAAAGCTTTATTGGAACTAGCTATACTCATCTGTTTATA TATTATCTGTGGCTGCTTTGAAATGAGTAGTTGCAATAGAGATGGTAAAGCCTACAAAGCCTAATTATTTACTGTCTGGTTTTTGTCAGA AAAAAGTTTGTCAATCCTTGTTTTAGAAGATGGAAAAATGTGAAGATCTTTGGAGATTCTCTTGAGTGGTATATCTAATTGAAATGGGAT >In-frame_ARHGAP42_ENST00000298815_chr11_100665897_+_HIBCH_ENST00000410045_chr2_191077801_-_687nt GCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTG GAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAATCTGTCTATGGCAGTGCAGAAA TTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTAGTATTGCTCAGTCACTAAAAGAA TTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGGTAATTAATAAAATGTCTCCAACATCTCTAAAGATCACACTAAGG CAACTCATGGAGGGGTCTTCAAAGACCTTGCAAGAAGTACTAACTATGGAGTATCGGCTAAGTCAAGCTTGTATGAGAGGTCATGACTTT CATGAAGGCGTTAGAGCTGTTTTAATTGATAAAGACCAGAGTCCAAAATGGAAACCAGCTGATCTAAAAGAAGTTACTGAGGAAGATTTG AATAATCACTTTAAGTCTTTGGGAAGCAGTGATTTGAAATTTTGAGGTGACAGGCTTTTAAGGTATATTTTGTAGCATGGGTTGGCAATC |
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FusionGenePPI for ARHGAP42_HIBCH |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ARHGAP42 | DEF6, CAPZA2, MYO19, ARHGAP26, DENND2C | HIBCH | H2AFX, ACOT1, IRF2BPL, ACADVL, KIAA0391, MKRN2, OXLD1, ACOT9, ALDH6A1, CAB39, CLIC1, CLIC4, CLIC5, ACADM, ALDH7A1, C12orf10, DSTN, ECI1, FH, NEDD8, PPA2, PSME3, SOD1, HNRNPH1, HNRNPH2, LSM12, NME2, NME1-NME2, PRCP, UFM1, UMPS, TMEM184A, GATC, GTF2E2, SOX2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ARHGAP42_HIBCH |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ARHGAP42_HIBCH |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | HIBCH | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
| Tgene | HIBCH | C0342738 | Beta-Hydroxyisobutyryl CoA Deacylase Deficiency | 1 | CTD_human;ORPHANET;UNIPROT |
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