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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24573

FusionGeneSummary for NOLC1_ZDHHC22

check button Fusion gene summary
Fusion gene informationFusion gene name: NOLC1_ZDHHC22
Fusion gene ID: 24573
HgeneTgene
Gene symbol

NOLC1

ZDHHC22

Gene ID

9221

283576

Gene namenucleolar and coiled-body phosphoprotein 1zinc finger DHHC-type containing 22
SynonymsNOPP130|NOPP140|NS5ATP13|P130C14orf59
Cytomap

10q24.32

14q24.3

Type of geneprotein-codingprotein-coding
Descriptionnucleolar and coiled-body phosphoprotein 1140 kDa nucleolar phosphoproteinHCV NS5A trans-regulated protein 13HCV NS5A-transactivated protein 13hepatitis C virus NS5A-transactivated protein 13nucleolar 130 kDa proteinnucleolar and coiled-body phosphppalmitoyltransferase ZDHHC22DHHC-22putative palmitoyltransferase ZDHHC22zinc finger DHHC domain-containing protein 22zinc finger, DHHC domain containing 22
Modification date2018052320180523
UniProtAcc

Q14978

Q8N966

Ensembl transtripts involved in fusion geneENST00000605788, ENST00000405356, 
ENST00000603742, ENST00000488254, 
ENST00000477977, 
ENST00000319374, 
Fusion gene scores* DoF score7 X 7 X 2=981 X 1 X 1=1
# samples 81
** MAII scorelog2(8/98*10)=-0.292781749227846
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: NOLC1 [Title/Abstract] AND ZDHHC22 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA794807NOLC1chr10

103917020

+ZDHHC22chr14

77605647

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000605788ENST00000319374NOLC1chr10

103917020

+ZDHHC22chr14

77605647

-
In-frameENST00000405356ENST00000319374NOLC1chr10

103917020

+ZDHHC22chr14

77605647

-
intron-3CDSENST00000603742ENST00000319374NOLC1chr10

103917020

+ZDHHC22chr14

77605647

-
In-frameENST00000488254ENST00000319374NOLC1chr10

103917020

+ZDHHC22chr14

77605647

-
intron-3CDSENST00000477977ENST00000319374NOLC1chr10

103917020

+ZDHHC22chr14

77605647

-

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FusionProtFeatures for NOLC1_ZDHHC22


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NOLC1

Q14978

ZDHHC22

Q8N966

Nucleolar protein that acts as a regulator of RNApolymerase I by connecting RNA polymerase I with enzymesresponsible for ribosomal processing and modification(PubMed:10567578, PubMed:26399832). Required for neural crestspecification: following monoubiquitination by the BCR(KBTBD8)complex, associates with TCOF1 and acts as a platform to connectRNA polymerase I with enzymes responsible for ribosomal processingand modification, leading to remodel the translational program ofdifferentiating cells in favor of neural crest specification(PubMed:26399832). Involved in nucleologenesis, possibly byplaying a role in the maintenance of the fundamental structure ofthe fibrillar center and dense fibrillar component in thenucleolus (PubMed:9016786). It has intrinsic GTPase and ATPaseactivities (PubMed:9016786). {ECO:0000269|PubMed:10567578,ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}. Palmitoyltransferase that mediates palmitoylation ofKCNMA1, regulating localization of KCNMA1 to the plasma membrane(PubMed:22399288). Might also mediate palmitoylation of NOV/CNN3(By similarity). {ECO:0000250|UniProtKB:A0PK84,ECO:0000269|PubMed:22399288}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NOLC1_ZDHHC22


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NOLC1_ENST00000605788_chr10_103917020_+_ZDHHC22_ENST00000319374_chr14_77605647_-_0aa

>In-frame_NOLC1_ENST00000405356_chr10_103917020_+_ZDHHC22_ENST00000319374_chr14_77605647_-_0aa

>In-frame_NOLC1_ENST00000488254_chr10_103917020_+_ZDHHC22_ENST00000319374_chr14_77605647_-_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NOLC1_ENST00000605788_chr10_103917020_+_ZDHHC22_ENST00000319374_chr14_77605647_-_0nt

>In-frame_NOLC1_ENST00000405356_chr10_103917020_+_ZDHHC22_ENST00000319374_chr14_77605647_-_0nt

>In-frame_NOLC1_ENST00000488254_chr10_103917020_+_ZDHHC22_ENST00000319374_chr14_77605647_-_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_NOLC1_ENST00000605788_chr10_103917020_+_ZDHHC22_ENST00000319374_chr14_77605647_-_0nt

>In-frame_NOLC1_ENST00000405356_chr10_103917020_+_ZDHHC22_ENST00000319374_chr14_77605647_-_0nt

>In-frame_NOLC1_ENST00000488254_chr10_103917020_+_ZDHHC22_ENST00000319374_chr14_77605647_-_0nt


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FusionGenePPI for NOLC1_ZDHHC22


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NOLC1_ZDHHC22


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneNOLC1Q14978DB00997DoxorubicinNucleolar and coiled-body phosphoprotein 1 {ECO:0000305}small moleculeapproved|investigational

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RelatedDiseases for NOLC1_ZDHHC22


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource