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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24570

FusionGeneSummary for NOLC1_HTR7

check button Fusion gene summary
Fusion gene informationFusion gene name: NOLC1_HTR7
Fusion gene ID: 24570
HgeneTgene
Gene symbol

NOLC1

HTR7

Gene ID

9221

3363

Gene namenucleolar and coiled-body phosphoprotein 15-hydroxytryptamine receptor 7
SynonymsNOPP130|NOPP140|NS5ATP13|P1305-HT7
Cytomap

10q24.32

10q23.31

Type of geneprotein-codingprotein-coding
Descriptionnucleolar and coiled-body phosphoprotein 1140 kDa nucleolar phosphoproteinHCV NS5A trans-regulated protein 13HCV NS5A-transactivated protein 13hepatitis C virus NS5A-transactivated protein 13nucleolar 130 kDa proteinnucleolar and coiled-body phosphp5-hydroxytryptamine receptor 75-HT-75-HT-X5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
Modification date2018052320180523
UniProtAcc

Q14978

P34969

Ensembl transtripts involved in fusion geneENST00000605788, ENST00000405356, 
ENST00000603742, ENST00000488254, 
ENST00000477977, 		ENST00000371721, 
ENST00000277874, ENST00000336152, 
ENST00000371719, 
Fusion gene scores* DoF score7 X 7 X 2=981 X 1 X 1=1
# samples 81
** MAII scorelog2(8/98*10)=-0.292781749227846
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: NOLC1 [Title/Abstract] AND HTR7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCSTCGA-NG-A4VU-01ANOLC1chr10

103912287

+HTR7chr10

92509351

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000605788ENST00000371721NOLC1chr10

103912287

+HTR7chr10

92509351

-
Frame-shiftENST00000605788ENST00000277874NOLC1chr10

103912287

+HTR7chr10

92509351

-
Frame-shiftENST00000605788ENST00000336152NOLC1chr10

103912287

+HTR7chr10

92509351

-
Frame-shiftENST00000605788ENST00000371719NOLC1chr10

103912287

+HTR7chr10

92509351

-
Frame-shiftENST00000405356ENST00000371721NOLC1chr10

103912287

+HTR7chr10

92509351

-
Frame-shiftENST00000405356ENST00000277874NOLC1chr10

103912287

+HTR7chr10

92509351

-
Frame-shiftENST00000405356ENST00000336152NOLC1chr10

103912287

+HTR7chr10

92509351

-
Frame-shiftENST00000405356ENST00000371719NOLC1chr10

103912287

+HTR7chr10

92509351

-
5UTR-3CDSENST00000603742ENST00000371721NOLC1chr10

103912287

+HTR7chr10

92509351

-
5UTR-3CDSENST00000603742ENST00000277874NOLC1chr10

103912287

+HTR7chr10

92509351

-
5UTR-3CDSENST00000603742ENST00000336152NOLC1chr10

103912287

+HTR7chr10

92509351

-
5UTR-3CDSENST00000603742ENST00000371719NOLC1chr10

103912287

+HTR7chr10

92509351

-
Frame-shiftENST00000488254ENST00000371721NOLC1chr10

103912287

+HTR7chr10

92509351

-
Frame-shiftENST00000488254ENST00000277874NOLC1chr10

103912287

+HTR7chr10

92509351

-
Frame-shiftENST00000488254ENST00000336152NOLC1chr10

103912287

+HTR7chr10

92509351

-
Frame-shiftENST00000488254ENST00000371719NOLC1chr10

103912287

+HTR7chr10

92509351

-
intron-3CDSENST00000477977ENST00000371721NOLC1chr10

103912287

+HTR7chr10

92509351

-
intron-3CDSENST00000477977ENST00000277874NOLC1chr10

103912287

+HTR7chr10

92509351

-
intron-3CDSENST00000477977ENST00000336152NOLC1chr10

103912287

+HTR7chr10

92509351

-
intron-3CDSENST00000477977ENST00000371719NOLC1chr10

103912287

+HTR7chr10

92509351

-

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FusionProtFeatures for NOLC1_HTR7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NOLC1

Q14978

HTR7

P34969

Nucleolar protein that acts as a regulator of RNApolymerase I by connecting RNA polymerase I with enzymesresponsible for ribosomal processing and modification(PubMed:10567578, PubMed:26399832). Required for neural crestspecification: following monoubiquitination by the BCR(KBTBD8)complex, associates with TCOF1 and acts as a platform to connectRNA polymerase I with enzymes responsible for ribosomal processingand modification, leading to remodel the translational program ofdifferentiating cells in favor of neural crest specification(PubMed:26399832). Involved in nucleologenesis, possibly byplaying a role in the maintenance of the fundamental structure ofthe fibrillar center and dense fibrillar component in thenucleolus (PubMed:9016786). It has intrinsic GTPase and ATPaseactivities (PubMed:9016786). {ECO:0000269|PubMed:10567578,ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}. This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functionsas a neurotransmitter, a hormone, and a mitogen. The activity ofthis receptor is mediated by G proteins that stimulate adenylatecyclase.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NOLC1_HTR7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NOLC1_HTR7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NOLC1ARRB2, ARRB1, YWHAZ, COIL, POLR1A, CEBPB, CSNK2B, MME, NOP56, YWHAG, CHD4, SIRT7, CHMP4B, GRK5, APP, FBL, RPS14, RSL1D1, NHP2L1, RPL15, RPL23A, RPL18A, RPL19, RPL6, RPL11, NOP58, RPS6, RPS23, RPL5, RPL4, RPS4X, RRP7A, UTP14A, PTRF, IK, NOP16, GPRC5A, RRS1, G3BP1, SAP18, GTF3C1, PNKP, PAN2, YWHAE, YWHAQ, CD2AP, SPAG9, RABEP2, WWOX, ERG, CSNK2A2, MOV10, NXF1, CUL7, OBSL1, SUZ12, EED, RNF2, CSNK2A1, FAM9A, DENND2D, BRIX1, CDK11A, CEBPZ, DDX56, DHX15, NOP2, PELP1, SRP14, SRRM1, SUB1, SSRP1, WDR36, SCARNA22, SRPK2, CC2D2A, XPO1, ATM, MKNK2, HDAC1, KLC1, KIF11, LLGL2, SUPT5H, TMPO, EZR, MYH13, VPS26A, ING4, POLK, KIF21A, KLC3, CEP170P1, MCM2, CDC5L, OTUB1, DAXX, KBTBD8, TCOF1, POLR1B, DKC1, NHP2, MDM2, CAMKV, PIP4K2A, GRK6, GTF2IRD1, RAB11FIP1, TWISTNB, HOXB9, AP3B1, EAF1, POLD1, CCDC154, MFAP1, COX15, DLD, HEY1, BRCA1, TESHTR7RHOBTB3, CUL3, GPRASP1, GPRASP2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NOLC1_HTR7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneNOLC1Q14978DB00997DoxorubicinNucleolar and coiled-body phosphoprotein 1 {ECO:0000305}small moleculeapproved|investigational
TgeneHTR7P34969DB00246Ziprasidone5-hydroxytryptamine receptor 7small moleculeapproved
TgeneHTR7P34969DB00247Methysergide5-hydroxytryptamine receptor 7small moleculeapproved
TgeneHTR7P34969DB00248Cabergoline5-hydroxytryptamine receptor 7small moleculeapproved
TgeneHTR7P34969DB00321Amitriptyline5-hydroxytryptamine receptor 7small moleculeapproved
TgeneHTR7P34969DB00363Clozapine5-hydroxytryptamine receptor 7small moleculeapproved
TgeneHTR7P34969DB00370Mirtazapine5-hydroxytryptamine receptor 7small moleculeapproved
TgeneHTR7P34969DB00408Loxapine5-hydroxytryptamine receptor 7small moleculeapproved
TgeneHTR7P34969DB00434Cyproheptadine5-hydroxytryptamine receptor 7small moleculeapproved
TgeneHTR7P34969DB00458Imipramine5-hydroxytryptamine receptor 7small moleculeapproved
TgeneHTR7P34969DB00543Amoxapine5-hydroxytryptamine receptor 7small moleculeapproved
TgeneHTR7P34969DB00988Dopamine5-hydroxytryptamine receptor 7small moleculeapproved
TgeneHTR7P34969DB01224Quetiapine5-hydroxytryptamine receptor 7small moleculeapproved
TgeneHTR7P34969DB01267Paliperidone5-hydroxytryptamine receptor 7small moleculeapproved
TgeneHTR7P34969DB04946Iloperidone5-hydroxytryptamine receptor 7small moleculeapproved
TgeneHTR7P34969DB06216Asenapine5-hydroxytryptamine receptor 7small moleculeapproved
TgeneHTR7P34969DB00216Eletriptan5-hydroxytryptamine receptor 7small moleculeapproved|investigational
TgeneHTR7P34969DB00334Olanzapine5-hydroxytryptamine receptor 7small moleculeapproved|investigational
TgeneHTR7P34969DB00589Lisuride5-hydroxytryptamine receptor 7small moleculeapproved|investigational
TgeneHTR7P34969DB00734Risperidone5-hydroxytryptamine receptor 7small moleculeapproved|investigational
TgeneHTR7P34969DB00751Epinastine5-hydroxytryptamine receptor 7small moleculeapproved|investigational
TgeneHTR7P34969DB00934Maprotiline5-hydroxytryptamine receptor 7small moleculeapproved|investigational
TgeneHTR7P34969DB01200Bromocriptine5-hydroxytryptamine receptor 7small moleculeapproved|investigational
TgeneHTR7P34969DB01238Aripiprazole5-hydroxytryptamine receptor 7small moleculeapproved|investigational
TgeneHTR7P34969DB06148Mianserin5-hydroxytryptamine receptor 7small moleculeapproved|investigational
TgeneHTR7P34969DB06288Amisulpride5-hydroxytryptamine receptor 7small moleculeapproved|investigational
TgeneHTR7P34969DB08815Lurasidone5-hydroxytryptamine receptor 7small moleculeapproved|investigational
TgeneHTR7P34969DB09068Vortioxetine5-hydroxytryptamine receptor 7small moleculeapproved|investigational
TgeneHTR7P34969DB00477Chlorpromazine5-hydroxytryptamine receptor 7small moleculeapproved|investigational|vet_approved
TgeneHTR7P34969DB09225Zotepine5-hydroxytryptamine receptor 7small moleculeapproved|investigational|withdrawn

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RelatedDiseases for NOLC1_HTR7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHTR7C0011581Depressive disorder6CTD_human;PSYGENET
TgeneHTR7C0011570Mental Depression5PSYGENET
TgeneHTR7C0001973Alcoholic Intoxication, Chronic2PSYGENET
TgeneHTR7C0003469Anxiety Disorders1CTD_human
TgeneHTR7C0023186Learning Disorders1CTD_human
TgeneHTR7C0025261Memory Disorders1CTD_human
TgeneHTR7C0026848Myopathy1CTD_human
TgeneHTR7C0030193Pain1CTD_human
TgeneHTR7C0036341Schizophrenia1CTD_human
TgeneHTR7C0525045Mood Disorders1PSYGENET
TgeneHTR7C4042891Sleep Wake Disorders1CTD_human