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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24547

FusionGeneSummary for NOL11_ZNF510

check button Fusion gene summary
Fusion gene informationFusion gene name: NOL11_ZNF510
Fusion gene ID: 24547
HgeneTgene
Gene symbol

NOL11

ZNF510

Gene ID

25926

22869

Gene namenucleolar protein 11zinc finger protein 510
Synonyms--
Cytomap

17q24.2

9q22.33

Type of geneprotein-codingprotein-coding
Descriptionnucleolar protein 11zinc finger protein 510
Modification date2018051920180523
UniProtAcc

Q9H8H0

Q9Y2H8

Ensembl transtripts involved in fusion geneENST00000253247, ENST00000581966, 
ENST00000535137, 
ENST00000223428, 
ENST00000375231, ENST00000472201, 
Fusion gene scores* DoF score5 X 5 X 3=751 X 1 X 1=1
# samples 51
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: NOL11 [Title/Abstract] AND ZNF510 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ421599NOL11chr17

65739995

-ZNF510chr9

99519979

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000253247ENST00000223428NOL11chr17

65739995

-ZNF510chr9

99519979

-
3UTR-3UTRENST00000253247ENST00000375231NOL11chr17

65739995

-ZNF510chr9

99519979

-
3UTR-intronENST00000253247ENST00000472201NOL11chr17

65739995

-ZNF510chr9

99519979

-
intron-3UTRENST00000581966ENST00000223428NOL11chr17

65739995

-ZNF510chr9

99519979

-
intron-3UTRENST00000581966ENST00000375231NOL11chr17

65739995

-ZNF510chr9

99519979

-
intron-intronENST00000581966ENST00000472201NOL11chr17

65739995

-ZNF510chr9

99519979

-
3UTR-3UTRENST00000535137ENST00000223428NOL11chr17

65739995

-ZNF510chr9

99519979

-
3UTR-3UTRENST00000535137ENST00000375231NOL11chr17

65739995

-ZNF510chr9

99519979

-
3UTR-intronENST00000535137ENST00000472201NOL11chr17

65739995

-ZNF510chr9

99519979

-

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FusionProtFeatures for NOL11_ZNF510


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NOL11

Q9H8H0

ZNF510

Q9Y2H8

Ribosome biogenesis factor. May be required for bothoptimal rDNA transcription and small subunit (SSU) pre-rRNAprocessing at sites A', A0, 1 and 2b.{ECO:0000269|PubMed:22916032}. May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NOL11_ZNF510


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NOL11_ZNF510


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NOL11_ZNF510


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NOL11_ZNF510


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource