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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24541

FusionGeneSummary for NOL10_ROCK2

check button Fusion gene summary
Fusion gene informationFusion gene name: NOL10_ROCK2
Fusion gene ID: 24541
HgeneTgene
Gene symbol

NOL10

ROCK2

Gene ID

79954

9475

Gene namenucleolar protein 10Rho associated coiled-coil containing protein kinase 2
SynonymsPQBP5ROCK-II
Cytomap

2p25.1

2p25.1

Type of geneprotein-codingprotein-coding
Descriptionnucleolar protein 10H_NH0074G24.1polyglutamine binding protein 5rho-associated protein kinase 2p164 ROCK-2rho-associated, coiled-coil-containing protein kinase II
Modification date2018052320180527
UniProtAcc

Q9BSC4

O75116

Ensembl transtripts involved in fusion geneENST00000345985, ENST00000381685, 
ENST00000542668, ENST00000538384, 
ENST00000315872, ENST00000462366, 
ENST00000401753, 
Fusion gene scores* DoF score5 X 4 X 4=803 X 3 X 2=18
# samples 53
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NOL10 [Title/Abstract] AND ROCK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneROCK2

GO:0006468

protein phosphorylation

18559669


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-BR-8590-01ANOL10chr2

10824693

-ROCK2chr2

11323566

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000345985ENST00000315872NOL10chr2

10824693

-ROCK2chr2

11323566

-
5CDS-intronENST00000345985ENST00000462366NOL10chr2

10824693

-ROCK2chr2

11323566

-
5CDS-intronENST00000345985ENST00000401753NOL10chr2

10824693

-ROCK2chr2

11323566

-
Frame-shiftENST00000381685ENST00000315872NOL10chr2

10824693

-ROCK2chr2

11323566

-
5CDS-intronENST00000381685ENST00000462366NOL10chr2

10824693

-ROCK2chr2

11323566

-
5CDS-intronENST00000381685ENST00000401753NOL10chr2

10824693

-ROCK2chr2

11323566

-
intron-3CDSENST00000542668ENST00000315872NOL10chr2

10824693

-ROCK2chr2

11323566

-
intron-intronENST00000542668ENST00000462366NOL10chr2

10824693

-ROCK2chr2

11323566

-
intron-intronENST00000542668ENST00000401753NOL10chr2

10824693

-ROCK2chr2

11323566

-
Frame-shiftENST00000538384ENST00000315872NOL10chr2

10824693

-ROCK2chr2

11323566

-
5CDS-intronENST00000538384ENST00000462366NOL10chr2

10824693

-ROCK2chr2

11323566

-
5CDS-intronENST00000538384ENST00000401753NOL10chr2

10824693

-ROCK2chr2

11323566

-

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FusionProtFeatures for NOL10_ROCK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NOL10

Q9BSC4

ROCK2

O75116

Protein kinase which is a key regulator of actincytoskeleton and cell polarity. Involved in regulation of smoothmuscle contraction, actin cytoskeleton organization, stress fiberand focal adhesion formation, neurite retraction, cell adhesionand motility via phosphorylation of ADD1, BRCA2, CNN1, EZR,DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM.Phosphorylates SORL1 and IRF4. Acts as a negative regulator ofVEGF-induced angiogenic endothelial cell activation. Positivelyregulates the activation of p42/MAPK1-p44/MAPK3 and ofp90RSK/RPS6KA1 during myogenic differentiation. Plays an importantrole in the timely initiation of centrosome duplication. Inhibitskeratinocyte terminal differentiation. May regulate closure of theeyelids and ventral body wall through organization of actomyosinbundles. Plays a critical role in the regulation of spine andsynaptic properties in the hippocampus. Plays an important role ingenerating the circadian rhythm of the aortic myofilament Ca(2+)sensitivity and vascular contractility by modulating the myosinlight chain phosphorylation. {ECO:0000269|PubMed:10579722,ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662,ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646,ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279,ECO:0000269|PubMed:21147781}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NOL10_ROCK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NOL10_ROCK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NOL10SIRT7, EED, RPS2, RPS8, AATF, GRWD1, DDX18, DDX52, IMP3, IMP4, MPHOSPH10, MRTO4, NOL6, PPP5C, RBM19, WDR36, SCARNA22, IFI16, BTRC, SPICE1, CDC14B, NGDN, DDX47, NAT10, CCT7, CCT3, DGCR8, FGF3, PPAN, WDR46, FOXA1, TRIM25ROCK2IKBKE, STK16, RHOA, ELAVL1, MAGEC1, KIAA0196, RABGEF1, FAM21A, GPHN, LMNA, MTA2, NHP2L1, ZW10, DNAJB11, RACGAP1, NTRK1, SNW1, CDC5L, CDKN3, POLR1C, ROCK1, FBXO42, LRPAP1, ADD2, MYL2, LZTFL1, CYLD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NOL10_ROCK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NOL10_ROCK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource