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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24530

FusionGeneSummary for NOC3L_PLCE1

check button Fusion gene summary
Fusion gene informationFusion gene name: NOC3L_PLCE1
Fusion gene ID: 24530
HgeneTgene
Gene symbol

NOC3L

PLCE1

Gene ID

64318

51196

Gene nameNOC3 like DNA replication regulatorphospholipase C epsilon 1
SynonymsAD24|C10orf117|FAD24NPHS3|PLCE|PPLC
Cytomap

10q23.33

10q23.33

Type of geneprotein-codingprotein-coding
Descriptionnucleolar complex protein 3 homologNOC3 protein homologNOC3L DNA replication regulatorfactor for adipocyte differentiation 24nucleolar complex associated 3 homolognucleolar complex-associated protein 3-like protein1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1PLC-epsilon-1pancreas-enriched phospholipase Cphosphoinositide phospholipase Cphosphoinositide phospholipase C-epsilon-1phosphoinositide-specific phospholipase C epsilon-1
Modification date2018052320180522
UniProtAcc

Q8WTT2

Q9P212

Ensembl transtripts involved in fusion geneENST00000543788, ENST00000371361, 
ENST00000371350, ENST00000463649, 
ENST00000260766, ENST00000371380, 
ENST00000371385, ENST00000371375, 
ENST00000464214, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 4 X 4=64
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NOC3L [Title/Abstract] AND PLCE1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePLCE1

GO:0000187

activation of MAPK activity

11022047

TgenePLCE1

GO:0007200

phospholipase C-activating G-protein coupled receptor signaling pathway

11022047|11022048

TgenePLCE1

GO:0007265

Ras protein signal transduction

11022048

TgenePLCE1

GO:0008277

regulation of G-protein coupled receptor protein signaling pathway

11022047

TgenePLCE1

GO:0045859

regulation of protein kinase activity

11022047

TgenePLCE1

GO:0046578

regulation of Ras protein signal transduction

11022047


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-CD-8527-01ANOC3Lchr10

96122587

-PLCE1chr10

96087725

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000543788ENST00000260766NOC3Lchr10

96122587

-PLCE1chr10

96087725

+
intron-3UTRENST00000543788ENST00000371380NOC3Lchr10

96122587

-PLCE1chr10

96087725

+
intron-3UTRENST00000543788ENST00000371385NOC3Lchr10

96122587

-PLCE1chr10

96087725

+
intron-intronENST00000543788ENST00000371375NOC3Lchr10

96122587

-PLCE1chr10

96087725

+
intron-intronENST00000543788ENST00000464214NOC3Lchr10

96122587

-PLCE1chr10

96087725

+
5CDS-3UTRENST00000371361ENST00000260766NOC3Lchr10

96122587

-PLCE1chr10

96087725

+
5CDS-3UTRENST00000371361ENST00000371380NOC3Lchr10

96122587

-PLCE1chr10

96087725

+
5CDS-3UTRENST00000371361ENST00000371385NOC3Lchr10

96122587

-PLCE1chr10

96087725

+
5CDS-intronENST00000371361ENST00000371375NOC3Lchr10

96122587

-PLCE1chr10

96087725

+
5CDS-intronENST00000371361ENST00000464214NOC3Lchr10

96122587

-PLCE1chr10

96087725

+
intron-3UTRENST00000371350ENST00000260766NOC3Lchr10

96122587

-PLCE1chr10

96087725

+
intron-3UTRENST00000371350ENST00000371380NOC3Lchr10

96122587

-PLCE1chr10

96087725

+
intron-3UTRENST00000371350ENST00000371385NOC3Lchr10

96122587

-PLCE1chr10

96087725

+
intron-intronENST00000371350ENST00000371375NOC3Lchr10

96122587

-PLCE1chr10

96087725

+
intron-intronENST00000371350ENST00000464214NOC3Lchr10

96122587

-PLCE1chr10

96087725

+
5UTR-3UTRENST00000463649ENST00000260766NOC3Lchr10

96122587

-PLCE1chr10

96087725

+
5UTR-3UTRENST00000463649ENST00000371380NOC3Lchr10

96122587

-PLCE1chr10

96087725

+
5UTR-3UTRENST00000463649ENST00000371385NOC3Lchr10

96122587

-PLCE1chr10

96087725

+
5UTR-intronENST00000463649ENST00000371375NOC3Lchr10

96122587

-PLCE1chr10

96087725

+
5UTR-intronENST00000463649ENST00000464214NOC3Lchr10

96122587

-PLCE1chr10

96087725

+

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FusionProtFeatures for NOC3L_PLCE1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NOC3L

Q8WTT2

PLCE1

Q9P212

May be required for adipogenesis. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NOC3L_PLCE1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NOC3L_PLCE1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NOC3LUSP39, EIF2AK2, SIRT7, SRPK3, DICER1, LIN28A, PRKRA, TARBP2, ZNF622, RNF2, RPL14, NPM1, PRR11, DDX24, BRIX1, EBNA1BP2, FBL, NOP2, NOP58, PNO1, PUS7, WDR12, PES1, RPL4, RPLP0, RRP12, SRP72, TBL3, NTRK1, IFI16, HNRNPU, ZNF746, CDC14B, MAK16, RPL37A, RPL18A, FGF8, RBM34, PDGFB, ZNF2, WDR46, HIST1H1E, MAGEB10, H2AFY2, GPATCH4, RPL18, PLEKHO1, WDR55, DGCR8, DLSTPLCE1NRAS, SIAH1, SIAH2, HSP90AA1, FUS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NOC3L_PLCE1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NOC3L_PLCE1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePLCE1C0279626Squamous cell carcinoma of esophagus2CTD_human
TgenePLCE1C0001418Adenocarcinoma1CTD_human
TgenePLCE1C0019100Severe Dengue1CTD_human
TgenePLCE1C0038356Stomach Neoplasms1CTD_human
TgenePLCE1C1853124NEPHROTIC SYNDROME, TYPE 31CTD_human;UNIPROT