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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24517

FusionGeneSummary for NMT2_FKBP4

check button Fusion gene summary
Fusion gene informationFusion gene name: NMT2_FKBP4
Fusion gene ID: 24517
HgeneTgene
Gene symbol

NMT2

FKBP4

Gene ID

9397

63943

Gene nameN-myristoyltransferase 2FK506 binding protein like
Synonyms-DIR1|FKBP4|NG7|WISP39
Cytomap

10p13

6p21.32

Type of geneprotein-codingprotein-coding
Descriptionglycylpeptide N-tetradecanoyltransferase 2NMT 2glycylpeptide N-tetradecanoyltransferase 2 variant 3glycylpeptide N-tetradecanoyltransferase 2 variant 4myristoyl-CoA:protein N-myristoyltransferase 2peptide N-myristoyltransferase 2type II N-myristoyltFK506-binding protein-likeWAF-1/CIP1 stabilizing protein 39peptidyl-prolyl cis-trans isomerase
Modification date2018052320180519
UniProtAcc

O60551

Q02790

Ensembl transtripts involved in fusion geneENST00000378165, ENST00000378150, 
ENST00000535341, ENST00000466201, 
ENST00000540259, 
ENST00000001008, 
ENST00000540260, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 1=4
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: NMT2 [Title/Abstract] AND FKBP4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNMT2

GO:0018008

N-terminal peptidyl-glycine N-myristoylation

25255805


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI004482NMT2chr10

15175093

-FKBP4chr12

2907895

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000378165ENST00000001008NMT2chr10

15175093

-FKBP4chr12

2907895

+
intron-intronENST00000378165ENST00000540260NMT2chr10

15175093

-FKBP4chr12

2907895

+
intron-3CDSENST00000378150ENST00000001008NMT2chr10

15175093

-FKBP4chr12

2907895

+
intron-intronENST00000378150ENST00000540260NMT2chr10

15175093

-FKBP4chr12

2907895

+
intron-3CDSENST00000535341ENST00000001008NMT2chr10

15175093

-FKBP4chr12

2907895

+
intron-intronENST00000535341ENST00000540260NMT2chr10

15175093

-FKBP4chr12

2907895

+
intron-3CDSENST00000466201ENST00000001008NMT2chr10

15175093

-FKBP4chr12

2907895

+
intron-intronENST00000466201ENST00000540260NMT2chr10

15175093

-FKBP4chr12

2907895

+
intron-3CDSENST00000540259ENST00000001008NMT2chr10

15175093

-FKBP4chr12

2907895

+
intron-intronENST00000540259ENST00000540260NMT2chr10

15175093

-FKBP4chr12

2907895

+

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FusionProtFeatures for NMT2_FKBP4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NMT2

O60551

FKBP4

Q02790

Adds a myristoyl group to the N-terminal glycine residueof certain cellular and viral proteins.{ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:9506952}. Immunophilin protein with PPIase and co-chaperoneactivities. Component of steroid receptors heterocomplexes throughinteraction with heat-shock protein 90 (HSP90). May play a role inthe intracellular trafficking of heterooligomeric forms of steroidhormone receptors between cytoplasm and nuclear compartments. Theisomerase activity controls neuronal growth cones via regulationof TRPC1 channel opening. Acts also as a regulator of microtubuledynamics by inhibiting MAPT/TAU ability to promote microtubuleassembly. May have a protective role against oxidative stress inmitochondria. {ECO:0000269|PubMed:1279700,ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390,ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NMT2_FKBP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NMT2_FKBP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NMT2_FKBP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NMT2_FKBP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNMT2C0029927Ovarian Cysts1CTD_human
TgeneFKBP4C0041696Unipolar Depression3PSYGENET
TgeneFKBP4C1269683Major Depressive Disorder3PSYGENET