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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24514

FusionGeneSummary for NMT1_NME1-NME2

check button Fusion gene summary
Fusion gene informationFusion gene name: NMT1_NME1-NME2
Fusion gene ID: 24514
HgeneTgene
Gene symbol

NMT1

NME1-NME2

Gene ID

4836

654364

Gene nameN-myristoyltransferase 1NME1-NME2 readthrough
SynonymsNMTNM23-LV|NMELV
Cytomap

17q21.31

17q21.33

Type of geneprotein-codingprotein-coding
Descriptionglycylpeptide N-tetradecanoyltransferase 1alternative, short form NMT-Slong form, NMT-Lmyristoyl-CoA:protein N-myristoyltransferase 1type I N-myristoyltransferaseNME1-NME2 proteinNME1-NME2 readthrough transcript
Modification date2018052320180519
UniProtAcc

P30419

Ensembl transtripts involved in fusion geneENST00000592782, ENST00000258960, 
ENST00000590114, 
ENST00000393198, 
ENST00000608447, ENST00000514264, 
ENST00000393185, ENST00000513177, 
ENST00000512737, ENST00000503064, 
ENST00000393183, ENST00000393190, 
Fusion gene scores* DoF score6 X 5 X 4=1202 X 2 X 2=8
# samples 62
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: NMT1 [Title/Abstract] AND NME1-NME2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNMT1

GO:0018008

N-terminal peptidyl-glycine N-myristoylation

25255805

HgeneNMT1

GO:0042180

cellular ketone metabolic process

22865860


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-43-2581-01ANMT1chr17

43138828

+NME1-NME2chr17

49233012

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000592782ENST00000393198NMT1chr17

43138828

+NME1-NME2chr17

49233012

+
5CDS-5UTRENST00000592782ENST00000608447NMT1chr17

43138828

+NME1-NME2chr17

49233012

+
5CDS-intronENST00000592782ENST00000514264NMT1chr17

43138828

+NME1-NME2chr17

49233012

+
5CDS-intronENST00000592782ENST00000393185NMT1chr17

43138828

+NME1-NME2chr17

49233012

+
5CDS-intronENST00000592782ENST00000513177NMT1chr17

43138828

+NME1-NME2chr17

49233012

+
5CDS-intronENST00000592782ENST00000512737NMT1chr17

43138828

+NME1-NME2chr17

49233012

+
5CDS-intronENST00000592782ENST00000503064NMT1chr17

43138828

+NME1-NME2chr17

49233012

+
5CDS-intronENST00000592782ENST00000393183NMT1chr17

43138828

+NME1-NME2chr17

49233012

+
5CDS-intronENST00000592782ENST00000393190NMT1chr17

43138828

+NME1-NME2chr17

49233012

+
5CDS-5UTRENST00000258960ENST00000393198NMT1chr17

43138828

+NME1-NME2chr17

49233012

+
5CDS-5UTRENST00000258960ENST00000608447NMT1chr17

43138828

+NME1-NME2chr17

49233012

+
5CDS-intronENST00000258960ENST00000514264NMT1chr17

43138828

+NME1-NME2chr17

49233012

+
5CDS-intronENST00000258960ENST00000393185NMT1chr17

43138828

+NME1-NME2chr17

49233012

+
5CDS-intronENST00000258960ENST00000513177NMT1chr17

43138828

+NME1-NME2chr17

49233012

+
5CDS-intronENST00000258960ENST00000512737NMT1chr17

43138828

+NME1-NME2chr17

49233012

+
5CDS-intronENST00000258960ENST00000503064NMT1chr17

43138828

+NME1-NME2chr17

49233012

+
5CDS-intronENST00000258960ENST00000393183NMT1chr17

43138828

+NME1-NME2chr17

49233012

+
5CDS-intronENST00000258960ENST00000393190NMT1chr17

43138828

+NME1-NME2chr17

49233012

+
3UTR-5UTRENST00000590114ENST00000393198NMT1chr17

43138828

+NME1-NME2chr17

49233012

+
3UTR-5UTRENST00000590114ENST00000608447NMT1chr17

43138828

+NME1-NME2chr17

49233012

+
3UTR-intronENST00000590114ENST00000514264NMT1chr17

43138828

+NME1-NME2chr17

49233012

+
3UTR-intronENST00000590114ENST00000393185NMT1chr17

43138828

+NME1-NME2chr17

49233012

+
3UTR-intronENST00000590114ENST00000513177NMT1chr17

43138828

+NME1-NME2chr17

49233012

+
3UTR-intronENST00000590114ENST00000512737NMT1chr17

43138828

+NME1-NME2chr17

49233012

+
3UTR-intronENST00000590114ENST00000503064NMT1chr17

43138828

+NME1-NME2chr17

49233012

+
3UTR-intronENST00000590114ENST00000393183NMT1chr17

43138828

+NME1-NME2chr17

49233012

+
3UTR-intronENST00000590114ENST00000393190NMT1chr17

43138828

+NME1-NME2chr17

49233012

+

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FusionProtFeatures for NMT1_NME1-NME2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NMT1

P30419

NME1-NME2

Adds a myristoyl group to the N-terminal glycine residueof certain cellular and viral proteins.{ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:9353336,ECO:0000269|PubMed:9506952}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NMT1_NME1-NME2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NMT1_NME1-NME2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NMT1LYN, FYN, CABP2, CABP1, CSNK2A1, HNRNPM, HNRNPU, IARS, IGF2BP3, ILF2, MAP2, MRE11A, ABCF1, C14orf166, RTCB, NELFB, YBX3, DDX1, DHX9, DIMT1, DYNC1LI2, EDC4, EIF2B2, EIF2B3, FKBP3, FLII, PA2G4, POLR1C, QARS, RFC4, RPL19, RPL38, YBX1, PDCD6, RPL23A, NXF1, CAPN1, TP53, CDCA3, FBXO17, ODF3L2, FAM84B, PLCXD1, EID3, RP2, TGFB1, ABLIM1, DTNA, ZNRF1, ACSL4, MARS, NTRK1, AHI1, CEP89, FBF1, SCLT1, DCTN1, CEP19, STIL, VIM, NOP56, FBXW7, MCM2, GPRC5C, NCS1, MARCKSL1, AIFM3, TLDC1, ANGPTL7, MGST3, DEFB1, ANGPTL4, BAG4, RFTN2, TBCE, MLF1, DNAJC13, EDRF1, C1orf168, IRF2BP1NME1-NME2NME4, NME2, FDPS, HPRT1, IDH1, NME1, TALDO1, AHCY, AKR1A1, AKR1B1, AKR1B15, ENO1, ENO2, ENO3, FKBP1A, FKBP1B, FKBP2, GOT1, ADSS, AK2, CFL1, CFL2, DSTN, HINT1, LDHA, LDHB, LDHC, OAT, PIN1, SNX3, SOD1, TKT, WDR1, HIBCH, PPIF, PRDX5, SNX12, STIP1, TAGLN, TAGLN2, TAGLN3, UBE2V1, TMEM189-UBE2V1, MCM2, NME3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NMT1_NME1-NME2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NMT1_NME1-NME2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource