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Fusion gene ID: 24498 |
FusionGeneSummary for NME7_KMO |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NME7_KMO | Fusion gene ID: 24498 | Hgene | Tgene | Gene symbol | NME7 | KMO | Gene ID | 29922 | 8564 |
| Gene name | NME/NM23 family member 7 | kynurenine 3-monooxygenase | |
| Synonyms | CFAP67|MN23H7|NDK 7|NDK7|nm23-H7 | dJ317G22.1 | |
| Cytomap | 1q24.2 | 1q43 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nucleoside diphosphate kinase 7NDP kinase 7cilia and flagella associated protein 67non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase) | kynurenine 3-monooxygenasekynurenine 3-hydroxylase | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9Y5B8 | O15229 | |
| Ensembl transtripts involved in fusion gene | ENST00000472647, ENST00000367811, ENST00000469474, | ENST00000366558, ENST00000366559, ENST00000484628, ENST00000366557, | |
| Fusion gene scores | * DoF score | 5 X 3 X 3=45 | 3 X 2 X 3=18 |
| # samples | 5 | 4 | |
| ** MAII score | log2(5/45*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: NME7 [Title/Abstract] AND KMO [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | KMO | GO:0009651 | response to salt stress | 10672018 |
| Tgene | KMO | GO:0019674 | NAD metabolic process | 23575632|29429898 |
| Tgene | KMO | GO:0070189 | kynurenine metabolic process | 10672018|26752518|29208702|29429898 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-VP-A87D-01A | NME7 | chr1 | 169199956 | - | KMO | chr1 | 241749981 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000472647 | ENST00000366558 | NME7 | chr1 | 169199956 | - | KMO | chr1 | 241749981 | + |
| Frame-shift | ENST00000472647 | ENST00000366559 | NME7 | chr1 | 169199956 | - | KMO | chr1 | 241749981 | + |
| 5CDS-intron | ENST00000472647 | ENST00000484628 | NME7 | chr1 | 169199956 | - | KMO | chr1 | 241749981 | + |
| 5CDS-intron | ENST00000472647 | ENST00000366557 | NME7 | chr1 | 169199956 | - | KMO | chr1 | 241749981 | + |
| In-frame | ENST00000367811 | ENST00000366558 | NME7 | chr1 | 169199956 | - | KMO | chr1 | 241749981 | + |
| In-frame | ENST00000367811 | ENST00000366559 | NME7 | chr1 | 169199956 | - | KMO | chr1 | 241749981 | + |
| 5CDS-intron | ENST00000367811 | ENST00000484628 | NME7 | chr1 | 169199956 | - | KMO | chr1 | 241749981 | + |
| 5CDS-intron | ENST00000367811 | ENST00000366557 | NME7 | chr1 | 169199956 | - | KMO | chr1 | 241749981 | + |
| intron-3CDS | ENST00000469474 | ENST00000366558 | NME7 | chr1 | 169199956 | - | KMO | chr1 | 241749981 | + |
| intron-3CDS | ENST00000469474 | ENST00000366559 | NME7 | chr1 | 169199956 | - | KMO | chr1 | 241749981 | + |
| intron-intron | ENST00000469474 | ENST00000484628 | NME7 | chr1 | 169199956 | - | KMO | chr1 | 241749981 | + |
| intron-intron | ENST00000469474 | ENST00000366557 | NME7 | chr1 | 169199956 | - | KMO | chr1 | 241749981 | + |
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FusionProtFeatures for NME7_KMO |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NME7 | KMO |
| Major role in the synthesis of nucleoside triphosphatesother than ATP. The ATP gamma phosphate is transferred to the NDPbeta phosphate via a ping-pong mechanism, using a phosphorylatedactive-site intermediate. | Catalyzes the hydroxylation of L-kynurenine (L-Kyn) toform 3-hydroxy-L-kynurenine (L-3OHKyn) (PubMed:29429898,PubMed:23575632, PubMed:26752518, PubMed:28604669,PubMed:29208702). Required for synthesis of quinolinic acid, aneurotoxic NMDA receptor antagonist and potential endogenousinhibitor of NMDA receptor signaling in axonal targeting,synaptogenesis and apoptosis during brain development. Quinolinicacid may also affect NMDA receptor signaling in pancreatic betacells, osteoblasts, myocardial cells, and the gastrointestinaltract (Probable). {ECO:0000269|PubMed:23575632,ECO:0000269|PubMed:26752518, ECO:0000269|PubMed:28604669,ECO:0000269|PubMed:29208702, ECO:0000269|PubMed:29429898,ECO:0000305|PubMed:12402501}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NME7_KMO |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NME7_ENST00000367811_chr1_169199956_-_KMO_ENST00000366558_chr1_241749981_+_485aa MNHSERFVFIAEWYDPNASLLRRYELLFYPGDGSVEMHDVKNHRTFLKRTKYDNLHLEDLFIGNKVNVFSRQLVLIDYGDQYTARQLGSR KEKTLALIKPDAISKAGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAICEWKRLLGPAN SGVARTDASESIRALFGTDGIRNAAHGPDSFASAAREMELFFPSSGGCGPANTAKFTNCTCCIVKPHAVSEGLLGKILMAIRDAGFEISA MQMFNMDRVNVEEFYEVYKGVVTEYHDMVTEMYSGPCVAMEIQQNNATKTFREFCGPADPGFEDCLVFDELMDKFSNDLSLCLPVFSRLR IPDDHAISDLSMYNYIEKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLR >In-frame_NME7_ENST00000367811_chr1_169199956_-_KMO_ENST00000366559_chr1_241749981_+_498aa MNHSERFVFIAEWYDPNASLLRRYELLFYPGDGSVEMHDVKNHRTFLKRTKYDNLHLEDLFIGNKVNVFSRQLVLIDYGDQYTARQLGSR KEKTLALIKPDAISKAGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAICEWKRLLGPAN SGVARTDASESIRALFGTDGIRNAAHGPDSFASAAREMELFFPSSGGCGPANTAKFTNCTCCIVKPHAVSEGLLGKILMAIRDAGFEISA MQMFNMDRVNVEEFYEVYKGVVTEYHDMVTEMYSGPCVAMEIQQNNATKTFREFCGPADPGFEDCLVFDELMDKFSNDLSLCLPVFSRLR IPDDHAISDLSMYNYIEMRAHVNSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTY |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NME7_ENST00000367811_chr1_169199956_-_KMO_ENST00000366558_chr1_241749981_+_1455nt ATGAATCATAGTGAAAGATTCGTTTTCATTGCAGAGTGGTATGATCCAAATGCTTCACTTCTTCGACGTTATGAGCTTTTATTTTACCCA GGGGATGGATCTGTTGAAATGCATGATGTAAAGAATCATCGCACCTTTTTAAAGCGGACCAAATATGATAACCTGCACTTGGAAGATTTA TTTATAGGCAACAAAGTGAATGTCTTTTCTCGACAACTGGTATTAATTGACTATGGGGATCAATATACAGCTCGCCAGCTGGGCAGTAGG AAAGAAAAAACGCTAGCCCTAATTAAACCAGATGCAATATCAAAGGCTGGAGAAATAATTGAAATAATAAACAAAGCTGGATTTACTATA ACCAAACTCAAAATGATGATGCTTTCAAGGAAAGAAGCATTGGATTTTCATGTAGATCACCAGTCAAGACCCTTTTTCAATGAGCTGATC CAGTTTATTACAACTGGTCCTATTATTGCCATGGAGATTTTAAGAGATGATGCTATATGTGAATGGAAAAGACTGCTGGGACCTGCAAAC TCTGGAGTGGCACGCACAGATGCTTCTGAAAGCATTAGAGCCCTCTTTGGAACAGATGGCATAAGAAATGCAGCGCATGGCCCTGATTCT TTTGCTTCTGCGGCCAGAGAAATGGAGTTGTTTTTTCCTTCAAGTGGAGGTTGTGGGCCGGCAAACACTGCTAAATTTACTAATTGTACC TGTTGCATTGTTAAACCCCATGCTGTCAGTGAAGGACTGTTGGGAAAGATCCTGATGGCTATCCGAGATGCAGGTTTTGAAATCTCAGCT ATGCAGATGTTCAATATGGATCGGGTTAATGTTGAGGAATTCTATGAAGTTTATAAAGGAGTAGTGACCGAATATCATGACATGGTGACA GAAATGTATTCTGGCCCTTGTGTAGCAATGGAGATTCAACAGAATAATGCTACAAAGACATTTCGAGAATTTTGTGGACCTGCTGATCCT GGCTTTGAAGACTGCTTGGTATTTGATGAGTTAATGGATAAATTCAGTAACGACCTTAGTTTGTGTCTTCCTGTGTTCTCAAGATTGAGA ATCCCAGATGATCACGCGATTTCAGACCTATCCATGTACAATTACATAGAGAAGAACATGGAGAGATTTCTTCATGCGATTATGCCATCG ACCTTTATCCCTCTCTATACAATGGTCACTTTTTCCAGAATAAGATACCATGAGGCTGTGCAGCGTTGGCATTGGCAAAAAAAGGTGATA AACAAAGGACTCTTTTTCTTGGGATCACTGATAGCCATCAGCAGTACCTACCTACTTATACACTACATGTCACCACGATCTTTCCTCCGC TTGAGAAGACCATGGAACTGGATAGCTCACTTCCGGAATACAACATGTTTCCCCGCAAAGGCCGTGGACTCCCTAGAACAAATTTCCAAT >In-frame_NME7_ENST00000367811_chr1_169199956_-_KMO_ENST00000366559_chr1_241749981_+_1494nt ATGAATCATAGTGAAAGATTCGTTTTCATTGCAGAGTGGTATGATCCAAATGCTTCACTTCTTCGACGTTATGAGCTTTTATTTTACCCA GGGGATGGATCTGTTGAAATGCATGATGTAAAGAATCATCGCACCTTTTTAAAGCGGACCAAATATGATAACCTGCACTTGGAAGATTTA TTTATAGGCAACAAAGTGAATGTCTTTTCTCGACAACTGGTATTAATTGACTATGGGGATCAATATACAGCTCGCCAGCTGGGCAGTAGG AAAGAAAAAACGCTAGCCCTAATTAAACCAGATGCAATATCAAAGGCTGGAGAAATAATTGAAATAATAAACAAAGCTGGATTTACTATA ACCAAACTCAAAATGATGATGCTTTCAAGGAAAGAAGCATTGGATTTTCATGTAGATCACCAGTCAAGACCCTTTTTCAATGAGCTGATC CAGTTTATTACAACTGGTCCTATTATTGCCATGGAGATTTTAAGAGATGATGCTATATGTGAATGGAAAAGACTGCTGGGACCTGCAAAC TCTGGAGTGGCACGCACAGATGCTTCTGAAAGCATTAGAGCCCTCTTTGGAACAGATGGCATAAGAAATGCAGCGCATGGCCCTGATTCT TTTGCTTCTGCGGCCAGAGAAATGGAGTTGTTTTTTCCTTCAAGTGGAGGTTGTGGGCCGGCAAACACTGCTAAATTTACTAATTGTACC TGTTGCATTGTTAAACCCCATGCTGTCAGTGAAGGACTGTTGGGAAAGATCCTGATGGCTATCCGAGATGCAGGTTTTGAAATCTCAGCT ATGCAGATGTTCAATATGGATCGGGTTAATGTTGAGGAATTCTATGAAGTTTATAAAGGAGTAGTGACCGAATATCATGACATGGTGACA GAAATGTATTCTGGCCCTTGTGTAGCAATGGAGATTCAACAGAATAATGCTACAAAGACATTTCGAGAATTTTGTGGACCTGCTGATCCT GGCTTTGAAGACTGCTTGGTATTTGATGAGTTAATGGATAAATTCAGTAACGACCTTAGTTTGTGTCTTCCTGTGTTCTCAAGATTGAGA ATCCCAGATGATCACGCGATTTCAGACCTATCCATGTACAATTACATAGAGATGCGAGCACATGTCAACTCAAGCTGGTTCATTTTTCAG AAGAACATGGAGAGATTTCTTCATGCGATTATGCCATCGACCTTTATCCCTCTCTATACAATGGTCACTTTTTCCAGAATAAGATACCAT GAGGCTGTGCAGCGTTGGCATTGGCAAAAAAAGGTGATAAACAAAGGACTCTTTTTCTTGGGATCACTGATAGCCATCAGCAGTACCTAC CTACTTATACACTACATGTCACCACGATCTTTCCTCCGCTTGAGAAGACCATGGAACTGGATAGCTCACTTCCGGAATACAACATGTTTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NME7_ENST00000367811_chr1_169199956_-_KMO_ENST00000366558_chr1_241749981_+_1847nt GGAAGTAAAACTGCCGGAAACAGAATAATGGCGTCTCGTAGCCCCAGGCGACAGCGTGGAGGGGCGGGTCTGTCGATTGGATGAACGCAG CTGAGATTACTCCCAGCCACTAAGGACGAAGAGGTGGGGCGGTGGCGTCCCACGCCTCGTGCGACAGTGGGCGGGGCTTTGTTGCCTGAG TAACCGTATGATGGTGGTGGTGGTGGTGTCTTCCTGTCTCAACGATACCTATTTTCTAGTGCTGAGATCCTGAGACAATGAATCATAGTG AAAGATTCGTTTTCATTGCAGAGTGGTATGATCCAAATGCTTCACTTCTTCGACGTTATGAGCTTTTATTTTACCCAGGGGATGGATCTG TTGAAATGCATGATGTAAAGAATCATCGCACCTTTTTAAAGCGGACCAAATATGATAACCTGCACTTGGAAGATTTATTTATAGGCAACA AAGTGAATGTCTTTTCTCGACAACTGGTATTAATTGACTATGGGGATCAATATACAGCTCGCCAGCTGGGCAGTAGGAAAGAAAAAACGC TAGCCCTAATTAAACCAGATGCAATATCAAAGGCTGGAGAAATAATTGAAATAATAAACAAAGCTGGATTTACTATAACCAAACTCAAAA TGATGATGCTTTCAAGGAAAGAAGCATTGGATTTTCATGTAGATCACCAGTCAAGACCCTTTTTCAATGAGCTGATCCAGTTTATTACAA CTGGTCCTATTATTGCCATGGAGATTTTAAGAGATGATGCTATATGTGAATGGAAAAGACTGCTGGGACCTGCAAACTCTGGAGTGGCAC GCACAGATGCTTCTGAAAGCATTAGAGCCCTCTTTGGAACAGATGGCATAAGAAATGCAGCGCATGGCCCTGATTCTTTTGCTTCTGCGG CCAGAGAAATGGAGTTGTTTTTTCCTTCAAGTGGAGGTTGTGGGCCGGCAAACACTGCTAAATTTACTAATTGTACCTGTTGCATTGTTA AACCCCATGCTGTCAGTGAAGGACTGTTGGGAAAGATCCTGATGGCTATCCGAGATGCAGGTTTTGAAATCTCAGCTATGCAGATGTTCA ATATGGATCGGGTTAATGTTGAGGAATTCTATGAAGTTTATAAAGGAGTAGTGACCGAATATCATGACATGGTGACAGAAATGTATTCTG GCCCTTGTGTAGCAATGGAGATTCAACAGAATAATGCTACAAAGACATTTCGAGAATTTTGTGGACCTGCTGATCCTGGCTTTGAAGACT GCTTGGTATTTGATGAGTTAATGGATAAATTCAGTAACGACCTTAGTTTGTGTCTTCCTGTGTTCTCAAGATTGAGAATCCCAGATGATC ACGCGATTTCAGACCTATCCATGTACAATTACATAGAGAAGAACATGGAGAGATTTCTTCATGCGATTATGCCATCGACCTTTATCCCTC TCTATACAATGGTCACTTTTTCCAGAATAAGATACCATGAGGCTGTGCAGCGTTGGCATTGGCAAAAAAAGGTGATAAACAAAGGACTCT TTTTCTTGGGATCACTGATAGCCATCAGCAGTACCTACCTACTTATACACTACATGTCACCACGATCTTTCCTCCGCTTGAGAAGACCAT GGAACTGGATAGCTCACTTCCGGAATACAACATGTTTCCCCGCAAAGGCCGTGGACTCCCTAGAACAAATTTCCAATCTCATTAGCAGGT GATAGAAAGGTTTTGTGGTAGCAAATGCATGATTTCTCTGTGACCAAAATTAAGCATGAAAAAAATGTTTCCATTGCCATATTTGATTCA >In-frame_NME7_ENST00000367811_chr1_169199956_-_KMO_ENST00000366559_chr1_241749981_+_5240nt GGAAGTAAAACTGCCGGAAACAGAATAATGGCGTCTCGTAGCCCCAGGCGACAGCGTGGAGGGGCGGGTCTGTCGATTGGATGAACGCAG CTGAGATTACTCCCAGCCACTAAGGACGAAGAGGTGGGGCGGTGGCGTCCCACGCCTCGTGCGACAGTGGGCGGGGCTTTGTTGCCTGAG TAACCGTATGATGGTGGTGGTGGTGGTGTCTTCCTGTCTCAACGATACCTATTTTCTAGTGCTGAGATCCTGAGACAATGAATCATAGTG AAAGATTCGTTTTCATTGCAGAGTGGTATGATCCAAATGCTTCACTTCTTCGACGTTATGAGCTTTTATTTTACCCAGGGGATGGATCTG TTGAAATGCATGATGTAAAGAATCATCGCACCTTTTTAAAGCGGACCAAATATGATAACCTGCACTTGGAAGATTTATTTATAGGCAACA AAGTGAATGTCTTTTCTCGACAACTGGTATTAATTGACTATGGGGATCAATATACAGCTCGCCAGCTGGGCAGTAGGAAAGAAAAAACGC TAGCCCTAATTAAACCAGATGCAATATCAAAGGCTGGAGAAATAATTGAAATAATAAACAAAGCTGGATTTACTATAACCAAACTCAAAA TGATGATGCTTTCAAGGAAAGAAGCATTGGATTTTCATGTAGATCACCAGTCAAGACCCTTTTTCAATGAGCTGATCCAGTTTATTACAA CTGGTCCTATTATTGCCATGGAGATTTTAAGAGATGATGCTATATGTGAATGGAAAAGACTGCTGGGACCTGCAAACTCTGGAGTGGCAC GCACAGATGCTTCTGAAAGCATTAGAGCCCTCTTTGGAACAGATGGCATAAGAAATGCAGCGCATGGCCCTGATTCTTTTGCTTCTGCGG CCAGAGAAATGGAGTTGTTTTTTCCTTCAAGTGGAGGTTGTGGGCCGGCAAACACTGCTAAATTTACTAATTGTACCTGTTGCATTGTTA AACCCCATGCTGTCAGTGAAGGACTGTTGGGAAAGATCCTGATGGCTATCCGAGATGCAGGTTTTGAAATCTCAGCTATGCAGATGTTCA ATATGGATCGGGTTAATGTTGAGGAATTCTATGAAGTTTATAAAGGAGTAGTGACCGAATATCATGACATGGTGACAGAAATGTATTCTG GCCCTTGTGTAGCAATGGAGATTCAACAGAATAATGCTACAAAGACATTTCGAGAATTTTGTGGACCTGCTGATCCTGGCTTTGAAGACT GCTTGGTATTTGATGAGTTAATGGATAAATTCAGTAACGACCTTAGTTTGTGTCTTCCTGTGTTCTCAAGATTGAGAATCCCAGATGATC ACGCGATTTCAGACCTATCCATGTACAATTACATAGAGATGCGAGCACATGTCAACTCAAGCTGGTTCATTTTTCAGAAGAACATGGAGA GATTTCTTCATGCGATTATGCCATCGACCTTTATCCCTCTCTATACAATGGTCACTTTTTCCAGAATAAGATACCATGAGGCTGTGCAGC GTTGGCATTGGCAAAAAAAGGTGATAAACAAAGGACTCTTTTTCTTGGGATCACTGATAGCCATCAGCAGTACCTACCTACTTATACACT ACATGTCACCACGATCTTTCCTCCGCTTGAGAAGACCATGGAACTGGATAGCTCACTTCCGGAATACAACATGTTTCCCCGCAAAGGCCG TGGACTCCCTAGAACAAATTTCCAATCTCATTAGCAGGTGATAGAAAGGTTTTGTGGTAGCAAATGCATGATTTCTCTGTGACCAAAATT AAGCATGAAAAAAATGTTTCCATTGCCATATTTGATTCACTAGTGGAAGATAGTGTTCTGCTTATAATTAAACTGAATGTAGAGTATCTC TGTATGTTAATTGCAATTACTGGTTGGGGGGTGCATTTTAAAAGATGAAACATGCAGCTTCCCTACATTACACACACTCAGGTTGAGTCA TTCTAACTATAAAAGTGCAATGACTAAGATCCTTCACTTCTCTGAAAGTAAGGCCCTAGATGCCTCAGGGAAGACAGTAATCATGCCTTT TCTTTAAAAGACACAATAGGACTCGCAACAGCATTGACTCAACACCTAGGACTAAAAATCACAACTTAACTAGCATGTTAACTGCACTTT TCATTACGTGAATGGAACTTACCTAACCACAGGGCTCAGACTTACTAGATAAAACCAGAAATGGAAATAAGGAATTCAGGGGAGTTCCAG AGACTTACAAAATGAACTCATTTTATTTTCCCACCTTCAAATATAAGTATTATCATCTATCTGTTTATCGTCTATCTATCTATCATCTAT CTATCTATCTATCATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTCTATTTATTTATGTATTTAGAGATCAGGTCTCA CTCTGTTGACCAGGCTGGAGTGCAGTGGTGAGATCTGGGTTCACTGCAACCTCTGCCTCCTGGGCTCAAGCAATCCTCCCACTTCAGCCT CCCAAATAGCTGGGGCTACCATGGTATTTTTCAGTAGAGACCGGGTCTTGCCATGCTGCCCAGGCCAGTCTCAAACTCCTGGCCTCATGT GATCTGCCCACCTCAGCCTCCCAAAGTACAGGGATTAGAGTTGTGAGCCACCGCTGCCAGCCCAGAGTTACCCTCTAAAGATAAGAAAAA GGCTATTAATATCATACTAAGTGAAGGACAGGAAAGGGTTTTATTCATAAATTAAATGTCTACATGTGCCAGAATGGAAAGGAAACAAGG GGAGACAACTTTTATAGAAATACAAAGCCATTACTTTATTCAATTTCAGACCCTCAGAAGCAATTTACTAATTTATTCTTCGACTACATA CTGCAGCAGAACCAGCAATACACTTGATTTTTAAAAGCACATTTAGTGAAATGTTTTCTTTGGTTCATCCTTCTTTAACAGGCTGCTGAG TCACTCAGAAATCCTTCAAACATGATTAATTATGAAGATGAAACACTAGAGTCATATAAGAAATAAAAATTGGGCAATAAAATAAAATGA TTCAGTGTTTCTTTTCTATATTGTCAATGAAAACCTTGAGTTCTAATAATCCATGTTCAGTTTGTAGGGAAAGAAAAAATAATTTTTCCT TCTACCCACTTTAGGTTCCTTGGCTGGGGCCCCTATAACAAAAGACAGATTGACAAGAGAAAAACAAACATAAATTTATTAGCGGGTATA TGTAATATATATGTGGGAAATACAGGGGAATGAGCAAATCTCAAAGAGCTGGCGTCTTAGAACTCCCTGGCTTATATAGCATCGACAAAG AACAGTAAATTTTTAGAGAAACAACAAAACAAAGAAAAAGAGCTTTGAGTCTGTAGGGGCAGCAATTTGGGGGAAGCAAATATATGGGAG TTTGCCTTGTAGATTCCTCTGGTGCTGGTCTCCAGGCTGACAAGGATTCAAAGTTGTCTCTGAAACTCCTCTTTGTCATACTGCACATAT AAAACGTCTTTTGTTTCCAACAAGAGGATTTTCTTTTTCATTCTAGAATTATCTCCTTGATAACTTGATCAGATATAGGACATGACACTG AATAGAGTCCAACAGTACAAAAAAAATTCAGTATGTTCTAGCTACTTCACACATGTGTACGCGACAGTTATTTTTACAGTAAGGTATTTT CGAGAAAAATGCATTACGTGTTTTGGAAAATAGAGTAATTTAAAAAATATATTTGAAATGAAAATCTCCAACACATTAGAAGATGATGAT GTTAGATGCCCATCGTGTGCCACAAGTGGTTTTTTCATTATGTAAAGCACCCGTTGAATTAAAAGAATTTGTTTTTGTTCAACCTCTTCC TGAGGCCCAAGAGCATATGGGCAATTCGGATTTCCTGCTGGACCACAAGGTTCTGTTGATATTACATAGAACGGGTATTCCAGACACTTC TTATGATGAAAGTCCAAAAGTGGCATCCAATTTAAGGCCCCATCTTTCGTTGCCATTCTTCATTCCTACAAAGGACGAACTTGGATTACA TCAACTTTGGACCCATTGGTTTTGTCGCTGTCGTCAACTGACAGTGATTCATCACTGGTGATGATAAAAATGATGGAAGAAGAGTTGAAA GTCACTTTTTTCTTTGGCCTGTCCCCATCTTTCTGTGACATCACAATGGGTCTGATCTGCATTTCACTTCCAGCTGCTGGTAGGTCTTTA GCAGGCCTCTGGCACCTCAGCAGTCGGAGGCACAGAAGCTGCAAAAGGGATCTTCGAAACTGGGCAGAGAAAAAATAAAGTGGAATATTA AGTAAAAGTTGGGCACTAATCTGGATTAACATTCGAGGAAATCAGTTGAGCTGAATTTAAGTTGTTTTTTGTTTGTTAGCAGGTGTGGAT GTGGGGTTATGTGGTCATGCTCAGATCTACCTAAATCACCCCAGAGCTTTATGTCTTTTATTCATTCTAATTCTTATTAACCGGAATATG TAGGACCATTTCAATACCTTGTAATCCTCCAAGCTTCAATCTGCACACACTTTCTATGAGGGCAGGTACAACTATTAAGAGATTTTGAAC ATTAAGTTAGTCCACAAATATTCAGTGGGCATCTACTAGGTGACAGCCACTGTGCTATAATTAGAGACTTTTTACTATAAGCATCAAAAA CAGATAAGGCTCTTCCTGGCAGAGTTTACAGCCTGGTGTACTTGCTAATGTCTCTTTAATTAGGTGAAGAATTTTTTTTTTCTATCGAAA TTACTAATCAGTTGGGGAAAAAAATACTATAGCAGACAGCACTAATGTCATCAACAAACATTGTTCTTCTCCGTGTCCTGGGTACAACAT CGAATAATATTTCTTGGCCTCCTTTCCGCTTCTCCTCTCTGCTGTTCCTCTCTACAAGAACCTGGGAGGCCAACGCCTAAAGATCATAAT ATCACACAATGGAAGGAACCTAGATTCCTAAATGACTGCATAGGACAGATCCCATCTCCTCCACCCAATACATTATTAGACTGAACTGTG ACCTGAAATGAGCAATAAACTCTGTATTAATTCACTGAAATGTTGGGGTTGCTTGTTATAGTAGTCGGTCCATCATGACCAGTAAAACAT AAATCAAAAGTTAATGTAATTGTTATCCCATTATTTAGAGCGAAATAAATGTTGAATATATGGACTTTCTCAGATTAGGAAATACCAATT |
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FusionGenePPI for NME7_KMO |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NME7 | FKBP6, NT5C2, TCHP, KRT18, ZNF263, CDK5RAP2, TUFT1, DDX1, OFD1, MAP4K4, TNIP1, YWHAQ, LATS2, TUBG1, TUBGCP2, TUBGCP3, GOLGA2, ZBTB48, NAB2, NEFL, REL, TRIM27, TCF4, FOSL1, MYOT, CDC42EP2, CCHCR1, CEP72, KIAA1598, LNX1, SYCE1, C1orf189, CSPP1, MZT2B, WNT2, GLUL, LPPR2, PCED1B, BTRC, SSX2IP, PCM1, CEP170, KIAA0753, CEP104, CEP162, CEP290, CNTROB, CEP128, CEP135, CEP63, CEP89, CNTRL, NINL, NIN, ODF2, RPGRIP1L, STIL, LGALS3BP, SCAF11, TUBGCP4, TUBGCP5, NEDD1, MZT1, TXNDC12, TUBG2, PRICKLE3, KIAA1683, AMPD2 | KMO | HSPA7, GPHN |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NME7_KMO |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NME7_KMO |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NME7 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| Tgene | KMO | C0036341 | Schizophrenia | 5 | PSYGENET |
| Tgene | KMO | C0041696 | Unipolar Depression | 2 | PSYGENET |
| Tgene | KMO | C1269683 | Major Depressive Disorder | 2 | PSYGENET |
| Tgene | KMO | C0005587 | Depression, Bipolar | 1 | PSYGENET |
| Tgene | KMO | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | KMO | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |
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