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Fusion gene ID: 24487 |
FusionGeneSummary for NME2_ACBD4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NME2_ACBD4 | Fusion gene ID: 24487 | Hgene | Tgene | Gene symbol | NME2 | ACBD4 | Gene ID | 4831 | 79777 |
| Gene name | NME/NM23 nucleoside diphosphate kinase 2 | acyl-CoA binding domain containing 4 | |
| Synonyms | NDKB|NDPK-B|NDPKB|NM23-H2|NM23B|PUF | HMFT0700 | |
| Cytomap | 17q21.33 | 17q21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nucleoside diphosphate kinase BHEL-S-155anNDP kinase Bc-myc purine-binding transcription factor PUFc-myc transcription factorepididymis secretory sperm binding protein Li 155anhistidine protein kinase NDKBnon-metastatic cells 2, protein (NM23) expr | acyl-CoA-binding domain-containing protein 4acyl-Coenzyme A binding domain containing 4 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P22392 | Q8NC06 | |
| Ensembl transtripts involved in fusion gene | ENST00000393193, ENST00000376392, ENST00000555572, | ENST00000431281, ENST00000591859, ENST00000586346, ENST00000398322, ENST00000592162, ENST00000376955, ENST00000321854, ENST00000591136, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 2 X 2 X 2=8 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: NME2 [Title/Abstract] AND ACBD4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NME2 | GO:0007229 | integrin-mediated signaling pathway | 11919189 |
| Hgene | NME2 | GO:0009142 | nucleoside triphosphate biosynthetic process | 1851158 |
| Hgene | NME2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 15703214 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-44-3396-01A | NME2 | chr17 | 49244317 | + | ACBD4 | chr17 | 43216388 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000393193 | ENST00000431281 | NME2 | chr17 | 49244317 | + | ACBD4 | chr17 | 43216388 | + |
| In-frame | ENST00000393193 | ENST00000591859 | NME2 | chr17 | 49244317 | + | ACBD4 | chr17 | 43216388 | + |
| In-frame | ENST00000393193 | ENST00000586346 | NME2 | chr17 | 49244317 | + | ACBD4 | chr17 | 43216388 | + |
| Frame-shift | ENST00000393193 | ENST00000398322 | NME2 | chr17 | 49244317 | + | ACBD4 | chr17 | 43216388 | + |
| 5CDS-intron | ENST00000393193 | ENST00000592162 | NME2 | chr17 | 49244317 | + | ACBD4 | chr17 | 43216388 | + |
| 5CDS-intron | ENST00000393193 | ENST00000376955 | NME2 | chr17 | 49244317 | + | ACBD4 | chr17 | 43216388 | + |
| 5CDS-intron | ENST00000393193 | ENST00000321854 | NME2 | chr17 | 49244317 | + | ACBD4 | chr17 | 43216388 | + |
| 5CDS-intron | ENST00000393193 | ENST00000591136 | NME2 | chr17 | 49244317 | + | ACBD4 | chr17 | 43216388 | + |
| In-frame | ENST00000376392 | ENST00000431281 | NME2 | chr17 | 49244317 | + | ACBD4 | chr17 | 43216388 | + |
| In-frame | ENST00000376392 | ENST00000591859 | NME2 | chr17 | 49244317 | + | ACBD4 | chr17 | 43216388 | + |
| In-frame | ENST00000376392 | ENST00000586346 | NME2 | chr17 | 49244317 | + | ACBD4 | chr17 | 43216388 | + |
| Frame-shift | ENST00000376392 | ENST00000398322 | NME2 | chr17 | 49244317 | + | ACBD4 | chr17 | 43216388 | + |
| 5CDS-intron | ENST00000376392 | ENST00000592162 | NME2 | chr17 | 49244317 | + | ACBD4 | chr17 | 43216388 | + |
| 5CDS-intron | ENST00000376392 | ENST00000376955 | NME2 | chr17 | 49244317 | + | ACBD4 | chr17 | 43216388 | + |
| 5CDS-intron | ENST00000376392 | ENST00000321854 | NME2 | chr17 | 49244317 | + | ACBD4 | chr17 | 43216388 | + |
| 5CDS-intron | ENST00000376392 | ENST00000591136 | NME2 | chr17 | 49244317 | + | ACBD4 | chr17 | 43216388 | + |
| In-frame | ENST00000555572 | ENST00000431281 | NME2 | chr17 | 49244317 | + | ACBD4 | chr17 | 43216388 | + |
| In-frame | ENST00000555572 | ENST00000591859 | NME2 | chr17 | 49244317 | + | ACBD4 | chr17 | 43216388 | + |
| In-frame | ENST00000555572 | ENST00000586346 | NME2 | chr17 | 49244317 | + | ACBD4 | chr17 | 43216388 | + |
| Frame-shift | ENST00000555572 | ENST00000398322 | NME2 | chr17 | 49244317 | + | ACBD4 | chr17 | 43216388 | + |
| 5CDS-intron | ENST00000555572 | ENST00000592162 | NME2 | chr17 | 49244317 | + | ACBD4 | chr17 | 43216388 | + |
| 5CDS-intron | ENST00000555572 | ENST00000376955 | NME2 | chr17 | 49244317 | + | ACBD4 | chr17 | 43216388 | + |
| 5CDS-intron | ENST00000555572 | ENST00000321854 | NME2 | chr17 | 49244317 | + | ACBD4 | chr17 | 43216388 | + |
| 5CDS-intron | ENST00000555572 | ENST00000591136 | NME2 | chr17 | 49244317 | + | ACBD4 | chr17 | 43216388 | + |
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FusionProtFeatures for NME2_ACBD4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NME2 | ACBD4 |
| Major role in the synthesis of nucleoside triphosphatesother than ATP. Negatively regulates Rho activity by interactingwith AKAP13/LBC. Acts as a transcriptional activator of the MYCgene; binds DNA non-specifically (PubMed:8392752). Exhibitshistidine protein kinase activity. {ECO:0000269|PubMed:15249197,ECO:0000269|PubMed:20946858, ECO:0000269|PubMed:8392752}. | Binds medium- and long-chain acyl-CoA esters and mayfunction as an intracellular carrier of acyl-CoA esters. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ACBD4 | chr17:49244317 | chr17:43216388 | ENST00000321854 | + | 7 | 10 | 12_101 | 216 | 306 | Domain | ACB |
| Tgene | ACBD4 | chr17:49244317 | chr17:43216388 | ENST00000376955 | + | 7 | 10 | 12_101 | 213 | 269 | Domain | ACB |
| Tgene | ACBD4 | chr17:49244317 | chr17:43216388 | ENST00000398322 | + | 6 | 9 | 12_101 | 216 | 306 | Domain | ACB |
| Tgene | ACBD4 | chr17:49244317 | chr17:43216388 | ENST00000431281 | + | 9 | 12 | 12_101 | 229 | 342 | Domain | ACB |
| Tgene | ACBD4 | chr17:49244317 | chr17:43216388 | ENST00000586346 | + | 7 | 10 | 12_101 | 229 | 342 | Domain | ACB |
| Tgene | ACBD4 | chr17:49244317 | chr17:43216388 | ENST00000591859 | + | 9 | 12 | 12_101 | 229 | 342 | Domain | ACB |
| Tgene | ACBD4 | chr17:49244317 | chr17:43216388 | ENST00000321854 | + | 7 | 10 | 23_32 | 216 | 306 | Region | Note=Acyl-CoA binding |
| Tgene | ACBD4 | chr17:49244317 | chr17:43216388 | ENST00000321854 | + | 7 | 10 | 43_47 | 216 | 306 | Region | Note=Acyl-CoA binding |
| Tgene | ACBD4 | chr17:49244317 | chr17:43216388 | ENST00000376955 | + | 7 | 10 | 23_32 | 213 | 269 | Region | Note=Acyl-CoA binding |
| Tgene | ACBD4 | chr17:49244317 | chr17:43216388 | ENST00000376955 | + | 7 | 10 | 43_47 | 213 | 269 | Region | Note=Acyl-CoA binding |
| Tgene | ACBD4 | chr17:49244317 | chr17:43216388 | ENST00000398322 | + | 6 | 9 | 23_32 | 216 | 306 | Region | Note=Acyl-CoA binding |
| Tgene | ACBD4 | chr17:49244317 | chr17:43216388 | ENST00000398322 | + | 6 | 9 | 43_47 | 216 | 306 | Region | Note=Acyl-CoA binding |
| Tgene | ACBD4 | chr17:49244317 | chr17:43216388 | ENST00000431281 | + | 9 | 12 | 23_32 | 229 | 342 | Region | Note=Acyl-CoA binding |
| Tgene | ACBD4 | chr17:49244317 | chr17:43216388 | ENST00000431281 | + | 9 | 12 | 43_47 | 229 | 342 | Region | Note=Acyl-CoA binding |
| Tgene | ACBD4 | chr17:49244317 | chr17:43216388 | ENST00000586346 | + | 7 | 10 | 23_32 | 229 | 342 | Region | Note=Acyl-CoA binding |
| Tgene | ACBD4 | chr17:49244317 | chr17:43216388 | ENST00000586346 | + | 7 | 10 | 43_47 | 229 | 342 | Region | Note=Acyl-CoA binding |
| Tgene | ACBD4 | chr17:49244317 | chr17:43216388 | ENST00000591859 | + | 9 | 12 | 23_32 | 229 | 342 | Region | Note=Acyl-CoA binding |
| Tgene | ACBD4 | chr17:49244317 | chr17:43216388 | ENST00000591859 | + | 9 | 12 | 43_47 | 229 | 342 | Region | Note=Acyl-CoA binding |
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FusionGeneSequence for NME2_ACBD4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NME2_ENST00000393193_chr17_49244317_+_ACBD4_ENST00000431281_chr17_43216388_+_270aa MANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVVKTGRVM LGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRRGCGAARRGPRSWTCGCWGQFEH YRRACRRCRRGCRAWRACPGPLSRGRSPGPVLGHGPLGSRGPRCSSSSCGPSSSSGSSECFGPKRGDCQWRGLCSQLRLSCCALSLPRVX >In-frame_NME2_ENST00000393193_chr17_49244317_+_ACBD4_ENST00000591859_chr17_43216388_+_270aa MANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVVKTGRVM LGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRRGCGAARRGPRSWTCGCWGQFEH YRRACRRCRRGCRAWRACPGPLSRGRSPGPVLGHGPLGSRGPRCSSSSCGPSSSSGSSECFGPKRGDCQWRGLCSQLRLSCCALSLPRVX >In-frame_NME2_ENST00000393193_chr17_49244317_+_ACBD4_ENST00000586346_chr17_43216388_+_270aa MANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVVKTGRVM LGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRRGCGAARRGPRSWTCGCWGQFEH YRRACRRCRRGCRAWRACPGPLSRGRSPGPVLGHGPLGSRGPRCSSSSCGPSSSSGSSECFGPKRGDCQWRGLCSQLRLSCCALSLPRVX >In-frame_NME2_ENST00000376392_chr17_49244317_+_ACBD4_ENST00000431281_chr17_43216388_+_270aa MANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVVKTGRVM LGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRRGCGAARRGPRSWTCGCWGQFEH YRRACRRCRRGCRAWRACPGPLSRGRSPGPVLGHGPLGSRGPRCSSSSCGPSSSSGSSECFGPKRGDCQWRGLCSQLRLSCCALSLPRVX >In-frame_NME2_ENST00000376392_chr17_49244317_+_ACBD4_ENST00000591859_chr17_43216388_+_270aa MANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVVKTGRVM LGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRRGCGAARRGPRSWTCGCWGQFEH YRRACRRCRRGCRAWRACPGPLSRGRSPGPVLGHGPLGSRGPRCSSSSCGPSSSSGSSECFGPKRGDCQWRGLCSQLRLSCCALSLPRVX >In-frame_NME2_ENST00000376392_chr17_49244317_+_ACBD4_ENST00000586346_chr17_43216388_+_270aa MANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVVKTGRVM LGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRRGCGAARRGPRSWTCGCWGQFEH YRRACRRCRRGCRAWRACPGPLSRGRSPGPVLGHGPLGSRGPRCSSSSCGPSSSSGSSECFGPKRGDCQWRGLCSQLRLSCCALSLPRVX >In-frame_NME2_ENST00000555572_chr17_49244317_+_ACBD4_ENST00000431281_chr17_43216388_+_295aa MVLLSTLGIVFQGEGPPISSCDTGTMANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLV KYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKF LRRGCGAARRGPRSWTCGCWGQFEHYRRACRRCRRGCRAWRACPGPLSRGRSPGPVLGHGPLGSRGPRCSSSSCGPSSSSGSSECFGPKR >In-frame_NME2_ENST00000555572_chr17_49244317_+_ACBD4_ENST00000591859_chr17_43216388_+_295aa MVLLSTLGIVFQGEGPPISSCDTGTMANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLV KYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKF LRRGCGAARRGPRSWTCGCWGQFEHYRRACRRCRRGCRAWRACPGPLSRGRSPGPVLGHGPLGSRGPRCSSSSCGPSSSSGSSECFGPKR >In-frame_NME2_ENST00000555572_chr17_49244317_+_ACBD4_ENST00000586346_chr17_43216388_+_295aa MVLLSTLGIVFQGEGPPISSCDTGTMANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLV KYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKF LRRGCGAARRGPRSWTCGCWGQFEHYRRACRRCRRGCRAWRACPGPLSRGRSPGPVLGHGPLGSRGPRCSSSSCGPSSSSGSSECFGPKR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NME2_ENST00000393193_chr17_49244317_+_ACBD4_ENST00000431281_chr17_43216388_+_810nt ATGGCCAACTGTGAGCGTACCTTCATTGCGATCAAACCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAG AAAGGATTCCGCCTTGTTGGTCTGAAATTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTC TTTGCCGGCCTGGTGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATG CTCGGGGAGACCAACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAG CGCACCTTCATCGCCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTC GTGGCCATGAAGTTCCTCCGGAGGGGTTGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTCGAGCAC TACAGGAGAGCATGCAGGAGGTGCAGGCGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGAGGCCGCAGCCCAGGCCCA GTGCTCGGCCATGGCCCCTTGGGCTCCCGGGGCCCGCGCTGCTCTTCTTCCTCCTGTGGCCCTTCGTCGTCCAGTGGCTCTTCCGAATGT TTCGGACCCAAAAGAGGTGACTGTCAGTGGAGGGGTCTCTGCAGCCAACTGAGACTATCTTGCTGTGCCCTGAGCCTTCCTAGGGTTTAG >In-frame_NME2_ENST00000393193_chr17_49244317_+_ACBD4_ENST00000591859_chr17_43216388_+_810nt ATGGCCAACTGTGAGCGTACCTTCATTGCGATCAAACCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAG AAAGGATTCCGCCTTGTTGGTCTGAAATTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTC TTTGCCGGCCTGGTGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATG CTCGGGGAGACCAACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAG CGCACCTTCATCGCCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTC GTGGCCATGAAGTTCCTCCGGAGGGGTTGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTCGAGCAC TACAGGAGAGCATGCAGGAGGTGCAGGCGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGAGGCCGCAGCCCAGGCCCA GTGCTCGGCCATGGCCCCTTGGGCTCCCGGGGCCCGCGCTGCTCTTCTTCCTCCTGTGGCCCTTCGTCGTCCAGTGGCTCTTCCGAATGT TTCGGACCCAAAAGAGGTGACTGTCAGTGGAGGGGTCTCTGCAGCCAACTGAGACTATCTTGCTGTGCCCTGAGCCTTCCTAGGGTTTAG >In-frame_NME2_ENST00000393193_chr17_49244317_+_ACBD4_ENST00000586346_chr17_43216388_+_810nt ATGGCCAACTGTGAGCGTACCTTCATTGCGATCAAACCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAG AAAGGATTCCGCCTTGTTGGTCTGAAATTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTC TTTGCCGGCCTGGTGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATG CTCGGGGAGACCAACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAG CGCACCTTCATCGCCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTC GTGGCCATGAAGTTCCTCCGGAGGGGTTGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTCGAGCAC TACAGGAGAGCATGCAGGAGGTGCAGGCGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGAGGCCGCAGCCCAGGCCCA GTGCTCGGCCATGGCCCCTTGGGCTCCCGGGGCCCGCGCTGCTCTTCTTCCTCCTGTGGCCCTTCGTCGTCCAGTGGCTCTTCCGAATGT TTCGGACCCAAAAGAGGTGACTGTCAGTGGAGGGGTCTCTGCAGCCAACTGAGACTATCTTGCTGTGCCCTGAGCCTTCCTAGGGTTTAG >In-frame_NME2_ENST00000376392_chr17_49244317_+_ACBD4_ENST00000431281_chr17_43216388_+_810nt ATGGCCAACTGTGAGCGTACCTTCATTGCGATCAAACCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAG AAAGGATTCCGCCTTGTTGGTCTGAAATTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTC TTTGCCGGCCTGGTGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATG CTCGGGGAGACCAACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAG CGCACCTTCATCGCCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTC GTGGCCATGAAGTTCCTCCGGAGGGGTTGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTCGAGCAC TACAGGAGAGCATGCAGGAGGTGCAGGCGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGAGGCCGCAGCCCAGGCCCA GTGCTCGGCCATGGCCCCTTGGGCTCCCGGGGCCCGCGCTGCTCTTCTTCCTCCTGTGGCCCTTCGTCGTCCAGTGGCTCTTCCGAATGT TTCGGACCCAAAAGAGGTGACTGTCAGTGGAGGGGTCTCTGCAGCCAACTGAGACTATCTTGCTGTGCCCTGAGCCTTCCTAGGGTTTAG >In-frame_NME2_ENST00000376392_chr17_49244317_+_ACBD4_ENST00000591859_chr17_43216388_+_810nt ATGGCCAACTGTGAGCGTACCTTCATTGCGATCAAACCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAG AAAGGATTCCGCCTTGTTGGTCTGAAATTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTC TTTGCCGGCCTGGTGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATG CTCGGGGAGACCAACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAG CGCACCTTCATCGCCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTC GTGGCCATGAAGTTCCTCCGGAGGGGTTGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTCGAGCAC TACAGGAGAGCATGCAGGAGGTGCAGGCGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGAGGCCGCAGCCCAGGCCCA GTGCTCGGCCATGGCCCCTTGGGCTCCCGGGGCCCGCGCTGCTCTTCTTCCTCCTGTGGCCCTTCGTCGTCCAGTGGCTCTTCCGAATGT TTCGGACCCAAAAGAGGTGACTGTCAGTGGAGGGGTCTCTGCAGCCAACTGAGACTATCTTGCTGTGCCCTGAGCCTTCCTAGGGTTTAG >In-frame_NME2_ENST00000376392_chr17_49244317_+_ACBD4_ENST00000586346_chr17_43216388_+_810nt ATGGCCAACTGTGAGCGTACCTTCATTGCGATCAAACCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAG AAAGGATTCCGCCTTGTTGGTCTGAAATTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTC TTTGCCGGCCTGGTGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATG CTCGGGGAGACCAACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAG CGCACCTTCATCGCCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTC GTGGCCATGAAGTTCCTCCGGAGGGGTTGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTCGAGCAC TACAGGAGAGCATGCAGGAGGTGCAGGCGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGAGGCCGCAGCCCAGGCCCA GTGCTCGGCCATGGCCCCTTGGGCTCCCGGGGCCCGCGCTGCTCTTCTTCCTCCTGTGGCCCTTCGTCGTCCAGTGGCTCTTCCGAATGT TTCGGACCCAAAAGAGGTGACTGTCAGTGGAGGGGTCTCTGCAGCCAACTGAGACTATCTTGCTGTGCCCTGAGCCTTCCTAGGGTTTAG >In-frame_NME2_ENST00000555572_chr17_49244317_+_ACBD4_ENST00000431281_chr17_43216388_+_885nt ATGGTGCTACTGTCTACTTTAGGGATCGTCTTTCAAGGCGAGGGGCCTCCTATCTCAAGCTGTGATACAGGAACCATGGCCAACTGTGAG CGTACCTTCATTGCGATCAAACCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAGAAAGGATTCCGCCTT GTTGGTCTGAAATTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGCCTGGTG AAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCAAC CCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTCATCGCC ATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGTTC CTCCGGAGGGGTTGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTCGAGCACTACAGGAGAGCATGC AGGAGGTGCAGGCGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGAGGCCGCAGCCCAGGCCCAGTGCTCGGCCATGGC CCCTTGGGCTCCCGGGGCCCGCGCTGCTCTTCTTCCTCCTGTGGCCCTTCGTCGTCCAGTGGCTCTTCCGAATGTTTCGGACCCAAAAGA >In-frame_NME2_ENST00000555572_chr17_49244317_+_ACBD4_ENST00000591859_chr17_43216388_+_885nt ATGGTGCTACTGTCTACTTTAGGGATCGTCTTTCAAGGCGAGGGGCCTCCTATCTCAAGCTGTGATACAGGAACCATGGCCAACTGTGAG CGTACCTTCATTGCGATCAAACCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAGAAAGGATTCCGCCTT GTTGGTCTGAAATTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGCCTGGTG AAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCAAC CCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTCATCGCC ATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGTTC CTCCGGAGGGGTTGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTCGAGCACTACAGGAGAGCATGC AGGAGGTGCAGGCGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGAGGCCGCAGCCCAGGCCCAGTGCTCGGCCATGGC CCCTTGGGCTCCCGGGGCCCGCGCTGCTCTTCTTCCTCCTGTGGCCCTTCGTCGTCCAGTGGCTCTTCCGAATGTTTCGGACCCAAAAGA >In-frame_NME2_ENST00000555572_chr17_49244317_+_ACBD4_ENST00000586346_chr17_43216388_+_885nt ATGGTGCTACTGTCTACTTTAGGGATCGTCTTTCAAGGCGAGGGGCCTCCTATCTCAAGCTGTGATACAGGAACCATGGCCAACTGTGAG CGTACCTTCATTGCGATCAAACCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAGAAAGGATTCCGCCTT GTTGGTCTGAAATTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGCCTGGTG AAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCAAC CCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTCATCGCC ATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGTTC CTCCGGAGGGGTTGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTCGAGCACTACAGGAGAGCATGC AGGAGGTGCAGGCGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGAGGCCGCAGCCCAGGCCCAGTGCTCGGCCATGGC CCCTTGGGCTCCCGGGGCCCGCGCTGCTCTTCTTCCTCCTGTGGCCCTTCGTCGTCCAGTGGCTCTTCCGAATGTTTCGGACCCAAAAGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NME2_ENST00000393193_chr17_49244317_+_ACBD4_ENST00000431281_chr17_43216388_+_1418nt AACCACGTGGGTCCCGGGCGCGTTTCGGGTGCTGGCGGCTGCAGCCGGAGTTCAAACCTAAGCAGCTGGAAGGAACCATGGCCAACTGTG AGCGTACCTTCATTGCGATCAAACCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAGAAAGGATTCCGCC TTGTTGGTCTGAAATTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGCCTGG TGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCA ACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTCATCG CCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGT TCCTCCGGAGGGGTTGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTCGAGCACTACAGGAGAGCAT GCAGGAGGTGCAGGCGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGAGGCCGCAGCCCAGGCCCAGTGCTCGGCCATG GCCCCTTGGGCTCCCGGGGCCCGCGCTGCTCTTCTTCCTCCTGTGGCCCTTCGTCGTCCAGTGGCTCTTCCGAATGTTTCGGACCCAAAA GAGGTGACTGTCAGTGGAGGGGTCTCTGCAGCCAACTGAGACTATCTTGCTGTGCCCTGAGCCTTCCTAGGGTTTAGAAGAACAGCATTC AAAATTCCCCGTCCTGTCAGTGTTTGCCTTCGCACCTCCTCCCCTAAAGCAGCGCGGGGGGCAAATAAGACCCCACCCCTCCCTGCAGCT TCACAGGGACGCTTCCTTCCCTCCCCGCAACCACCCCAGGCTCCCCTGGGAGGCTGCAGTTGTGGTACACGTCCCCGGTGCTGGGTTGGC CGTGACTCGGGGGCGGGGCGATCGGGTCTCAGCCCCTGCCTTCCCCAGTCTCTGGGTCACCCGAATTTTCCCACCCCTGCTTCTCCCCGA GGAGGTTGAGCTCTTGAGCAAGTTGGGACTTGGGCCGGGGCCTGGAAGAATGATTGGCTGGGAGGCCGCGGGAGGGAGGCCAGGAGGCCC GGACCAGTTGGGAGGAGTGAGCAGGCCCCGGGGGAGGGGGATGAGCGCAGTTTGCTCGCTTTCCTCCCCTGCCGGCCCCCTCCGCCCCCA >In-frame_NME2_ENST00000393193_chr17_49244317_+_ACBD4_ENST00000591859_chr17_43216388_+_1422nt AACCACGTGGGTCCCGGGCGCGTTTCGGGTGCTGGCGGCTGCAGCCGGAGTTCAAACCTAAGCAGCTGGAAGGAACCATGGCCAACTGTG AGCGTACCTTCATTGCGATCAAACCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAGAAAGGATTCCGCC TTGTTGGTCTGAAATTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGCCTGG TGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCA ACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTCATCG CCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGT TCCTCCGGAGGGGTTGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTCGAGCACTACAGGAGAGCAT GCAGGAGGTGCAGGCGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGAGGCCGCAGCCCAGGCCCAGTGCTCGGCCATG GCCCCTTGGGCTCCCGGGGCCCGCGCTGCTCTTCTTCCTCCTGTGGCCCTTCGTCGTCCAGTGGCTCTTCCGAATGTTTCGGACCCAAAA GAGGTGACTGTCAGTGGAGGGGTCTCTGCAGCCAACTGAGACTATCTTGCTGTGCCCTGAGCCTTCCTAGGGTTTAGAAGAACAGCATTC AAAATTCCCCGTCCTGTCAGTGTTTGCCTTCGCACCTCCTCCCCTAAAGCAGCGCGGGGGGCAAATAAGACCCCACCCCTCCCTGCAGCT TCACAGGGACGCTTCCTTCCCTCCCCGCAACCACCCCAGGCTCCCCTGGGAGGCTGCAGTTGTGGTACACGTCCCCGGTGCTGGGTTGGC CGTGACTCGGGGGCGGGGCGATCGGGTCTCAGCCCCTGCCTTCCCCAGTCTCTGGGTCACCCGAATTTTCCCACCCCTGCTTCTCCCCGA GGAGGTTGAGCTCTTGAGCAAGTTGGGACTTGGGCCGGGGCCTGGAAGAATGATTGGCTGGGAGGCCGCGGGAGGGAGGCCAGGAGGCCC GGACCAGTTGGGAGGAGTGAGCAGGCCCCGGGGGAGGGGGATGAGCGCAGTTTGCTCGCTTTCCTCCCCTGCCGGCCCCCTCCGCCCCCA >In-frame_NME2_ENST00000393193_chr17_49244317_+_ACBD4_ENST00000586346_chr17_43216388_+_1096nt AACCACGTGGGTCCCGGGCGCGTTTCGGGTGCTGGCGGCTGCAGCCGGAGTTCAAACCTAAGCAGCTGGAAGGAACCATGGCCAACTGTG AGCGTACCTTCATTGCGATCAAACCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAGAAAGGATTCCGCC TTGTTGGTCTGAAATTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGCCTGG TGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCA ACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTCATCG CCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGT TCCTCCGGAGGGGTTGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTCGAGCACTACAGGAGAGCAT GCAGGAGGTGCAGGCGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGAGGCCGCAGCCCAGGCCCAGTGCTCGGCCATG GCCCCTTGGGCTCCCGGGGCCCGCGCTGCTCTTCTTCCTCCTGTGGCCCTTCGTCGTCCAGTGGCTCTTCCGAATGTTTCGGACCCAAAA GAGGTGACTGTCAGTGGAGGGGTCTCTGCAGCCAACTGAGACTATCTTGCTGTGCCCTGAGCCTTCCTAGGGTTTAGAAGAACAGCATTC AAAATTCCCCGTCCTGTCAGTGTTTGCCTTCGCACCTCCTCCCCTAAAGCAGCGCGGGGGGCAAATAAGACCCCACCCCTCCCTGCAGCT TCACAGGGACGCTTCCTTCCCTCCCCGCAACCACCCCAGGCTCCCCTGGGAGGCTGCAGTTGTGGTACACGTCCCCGGTGCTGGGTTGGC >In-frame_NME2_ENST00000376392_chr17_49244317_+_ACBD4_ENST00000431281_chr17_43216388_+_1404nt CGGGCGCGTTTCGGGTGCTGGCGGCTGCAGCCGGAGTTCAAACCTAAGCAGCTGGAAGGAACCATGGCCAACTGTGAGCGTACCTTCATT GCGATCAAACCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAGAAAGGATTCCGCCTTGTTGGTCTGAAA TTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGCCTGGTGAAATACATGCAC TCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCAACCCTGCAGACTCC AAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTCATCGCCATCAAGCCGGAC GGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGTTCCTCCGGAGGGGT TGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTCGAGCACTACAGGAGAGCATGCAGGAGGTGCAGG CGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGAGGCCGCAGCCCAGGCCCAGTGCTCGGCCATGGCCCCTTGGGCTCC CGGGGCCCGCGCTGCTCTTCTTCCTCCTGTGGCCCTTCGTCGTCCAGTGGCTCTTCCGAATGTTTCGGACCCAAAAGAGGTGACTGTCAG TGGAGGGGTCTCTGCAGCCAACTGAGACTATCTTGCTGTGCCCTGAGCCTTCCTAGGGTTTAGAAGAACAGCATTCAAAATTCCCCGTCC TGTCAGTGTTTGCCTTCGCACCTCCTCCCCTAAAGCAGCGCGGGGGGCAAATAAGACCCCACCCCTCCCTGCAGCTTCACAGGGACGCTT CCTTCCCTCCCCGCAACCACCCCAGGCTCCCCTGGGAGGCTGCAGTTGTGGTACACGTCCCCGGTGCTGGGTTGGCCGTGACTCGGGGGC GGGGCGATCGGGTCTCAGCCCCTGCCTTCCCCAGTCTCTGGGTCACCCGAATTTTCCCACCCCTGCTTCTCCCCGAGGAGGTTGAGCTCT TGAGCAAGTTGGGACTTGGGCCGGGGCCTGGAAGAATGATTGGCTGGGAGGCCGCGGGAGGGAGGCCAGGAGGCCCGGACCAGTTGGGAG GAGTGAGCAGGCCCCGGGGGAGGGGGATGAGCGCAGTTTGCTCGCTTTCCTCCCCTGCCGGCCCCCTCCGCCCCCACACACACTCGGGAC >In-frame_NME2_ENST00000376392_chr17_49244317_+_ACBD4_ENST00000591859_chr17_43216388_+_1408nt CGGGCGCGTTTCGGGTGCTGGCGGCTGCAGCCGGAGTTCAAACCTAAGCAGCTGGAAGGAACCATGGCCAACTGTGAGCGTACCTTCATT GCGATCAAACCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAGAAAGGATTCCGCCTTGTTGGTCTGAAA TTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGCCTGGTGAAATACATGCAC TCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCAACCCTGCAGACTCC AAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTCATCGCCATCAAGCCGGAC GGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGTTCCTCCGGAGGGGT TGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTCGAGCACTACAGGAGAGCATGCAGGAGGTGCAGG CGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGAGGCCGCAGCCCAGGCCCAGTGCTCGGCCATGGCCCCTTGGGCTCC CGGGGCCCGCGCTGCTCTTCTTCCTCCTGTGGCCCTTCGTCGTCCAGTGGCTCTTCCGAATGTTTCGGACCCAAAAGAGGTGACTGTCAG TGGAGGGGTCTCTGCAGCCAACTGAGACTATCTTGCTGTGCCCTGAGCCTTCCTAGGGTTTAGAAGAACAGCATTCAAAATTCCCCGTCC TGTCAGTGTTTGCCTTCGCACCTCCTCCCCTAAAGCAGCGCGGGGGGCAAATAAGACCCCACCCCTCCCTGCAGCTTCACAGGGACGCTT CCTTCCCTCCCCGCAACCACCCCAGGCTCCCCTGGGAGGCTGCAGTTGTGGTACACGTCCCCGGTGCTGGGTTGGCCGTGACTCGGGGGC GGGGCGATCGGGTCTCAGCCCCTGCCTTCCCCAGTCTCTGGGTCACCCGAATTTTCCCACCCCTGCTTCTCCCCGAGGAGGTTGAGCTCT TGAGCAAGTTGGGACTTGGGCCGGGGCCTGGAAGAATGATTGGCTGGGAGGCCGCGGGAGGGAGGCCAGGAGGCCCGGACCAGTTGGGAG GAGTGAGCAGGCCCCGGGGGAGGGGGATGAGCGCAGTTTGCTCGCTTTCCTCCCCTGCCGGCCCCCTCCGCCCCCACACACACTCGGGAC >In-frame_NME2_ENST00000376392_chr17_49244317_+_ACBD4_ENST00000586346_chr17_43216388_+_1082nt CGGGCGCGTTTCGGGTGCTGGCGGCTGCAGCCGGAGTTCAAACCTAAGCAGCTGGAAGGAACCATGGCCAACTGTGAGCGTACCTTCATT GCGATCAAACCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAGAAAGGATTCCGCCTTGTTGGTCTGAAA TTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGCCTGGTGAAATACATGCAC TCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCAACCCTGCAGACTCC AAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTCATCGCCATCAAGCCGGAC GGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGTTCCTCCGGAGGGGT TGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTCGAGCACTACAGGAGAGCATGCAGGAGGTGCAGG CGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGAGGCCGCAGCCCAGGCCCAGTGCTCGGCCATGGCCCCTTGGGCTCC CGGGGCCCGCGCTGCTCTTCTTCCTCCTGTGGCCCTTCGTCGTCCAGTGGCTCTTCCGAATGTTTCGGACCCAAAAGAGGTGACTGTCAG TGGAGGGGTCTCTGCAGCCAACTGAGACTATCTTGCTGTGCCCTGAGCCTTCCTAGGGTTTAGAAGAACAGCATTCAAAATTCCCCGTCC TGTCAGTGTTTGCCTTCGCACCTCCTCCCCTAAAGCAGCGCGGGGGGCAAATAAGACCCCACCCCTCCCTGCAGCTTCACAGGGACGCTT CCTTCCCTCCCCGCAACCACCCCAGGCTCCCCTGGGAGGCTGCAGTTGTGGTACACGTCCCCGGTGCTGGGTTGGCCGTGACTCGGGGGC >In-frame_NME2_ENST00000555572_chr17_49244317_+_ACBD4_ENST00000431281_chr17_43216388_+_1592nt GGAGTTCAAACCTAAGCAGCTGGAAGGGCCCTGTGGCTAGGTACCATAGAGTCTCTACACAGGACTAAGTCAGCCTGGTGTGCAGGGGAG GCAGACACACAAACAGAAAATTGGACTACAGTGCTAAGATGCTGTAAGAAGAGGTTAACTAAAGGACAGGAAGATGGGGCCAAGAGATGG TGCTACTGTCTACTTTAGGGATCGTCTTTCAAGGCGAGGGGCCTCCTATCTCAAGCTGTGATACAGGAACCATGGCCAACTGTGAGCGTA CCTTCATTGCGATCAAACCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAGAAAGGATTCCGCCTTGTTG GTCTGAAATTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGCCTGGTGAAAT ACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCAACCCTG CAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTCATCGCCATCA AGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGTTCCTCC GGAGGGGTTGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTCGAGCACTACAGGAGAGCATGCAGGA GGTGCAGGCGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGAGGCCGCAGCCCAGGCCCAGTGCTCGGCCATGGCCCCT TGGGCTCCCGGGGCCCGCGCTGCTCTTCTTCCTCCTGTGGCCCTTCGTCGTCCAGTGGCTCTTCCGAATGTTTCGGACCCAAAAGAGGTG ACTGTCAGTGGAGGGGTCTCTGCAGCCAACTGAGACTATCTTGCTGTGCCCTGAGCCTTCCTAGGGTTTAGAAGAACAGCATTCAAAATT CCCCGTCCTGTCAGTGTTTGCCTTCGCACCTCCTCCCCTAAAGCAGCGCGGGGGGCAAATAAGACCCCACCCCTCCCTGCAGCTTCACAG GGACGCTTCCTTCCCTCCCCGCAACCACCCCAGGCTCCCCTGGGAGGCTGCAGTTGTGGTACACGTCCCCGGTGCTGGGTTGGCCGTGAC TCGGGGGCGGGGCGATCGGGTCTCAGCCCCTGCCTTCCCCAGTCTCTGGGTCACCCGAATTTTCCCACCCCTGCTTCTCCCCGAGGAGGT TGAGCTCTTGAGCAAGTTGGGACTTGGGCCGGGGCCTGGAAGAATGATTGGCTGGGAGGCCGCGGGAGGGAGGCCAGGAGGCCCGGACCA GTTGGGAGGAGTGAGCAGGCCCCGGGGGAGGGGGATGAGCGCAGTTTGCTCGCTTTCCTCCCCTGCCGGCCCCCTCCGCCCCCACACACA >In-frame_NME2_ENST00000555572_chr17_49244317_+_ACBD4_ENST00000591859_chr17_43216388_+_1596nt GGAGTTCAAACCTAAGCAGCTGGAAGGGCCCTGTGGCTAGGTACCATAGAGTCTCTACACAGGACTAAGTCAGCCTGGTGTGCAGGGGAG GCAGACACACAAACAGAAAATTGGACTACAGTGCTAAGATGCTGTAAGAAGAGGTTAACTAAAGGACAGGAAGATGGGGCCAAGAGATGG TGCTACTGTCTACTTTAGGGATCGTCTTTCAAGGCGAGGGGCCTCCTATCTCAAGCTGTGATACAGGAACCATGGCCAACTGTGAGCGTA CCTTCATTGCGATCAAACCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAGAAAGGATTCCGCCTTGTTG GTCTGAAATTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGCCTGGTGAAAT ACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCAACCCTG CAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTCATCGCCATCA AGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGTTCCTCC GGAGGGGTTGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTCGAGCACTACAGGAGAGCATGCAGGA GGTGCAGGCGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGAGGCCGCAGCCCAGGCCCAGTGCTCGGCCATGGCCCCT TGGGCTCCCGGGGCCCGCGCTGCTCTTCTTCCTCCTGTGGCCCTTCGTCGTCCAGTGGCTCTTCCGAATGTTTCGGACCCAAAAGAGGTG ACTGTCAGTGGAGGGGTCTCTGCAGCCAACTGAGACTATCTTGCTGTGCCCTGAGCCTTCCTAGGGTTTAGAAGAACAGCATTCAAAATT CCCCGTCCTGTCAGTGTTTGCCTTCGCACCTCCTCCCCTAAAGCAGCGCGGGGGGCAAATAAGACCCCACCCCTCCCTGCAGCTTCACAG GGACGCTTCCTTCCCTCCCCGCAACCACCCCAGGCTCCCCTGGGAGGCTGCAGTTGTGGTACACGTCCCCGGTGCTGGGTTGGCCGTGAC TCGGGGGCGGGGCGATCGGGTCTCAGCCCCTGCCTTCCCCAGTCTCTGGGTCACCCGAATTTTCCCACCCCTGCTTCTCCCCGAGGAGGT TGAGCTCTTGAGCAAGTTGGGACTTGGGCCGGGGCCTGGAAGAATGATTGGCTGGGAGGCCGCGGGAGGGAGGCCAGGAGGCCCGGACCA GTTGGGAGGAGTGAGCAGGCCCCGGGGGAGGGGGATGAGCGCAGTTTGCTCGCTTTCCTCCCCTGCCGGCCCCCTCCGCCCCCACACACA >In-frame_NME2_ENST00000555572_chr17_49244317_+_ACBD4_ENST00000586346_chr17_43216388_+_1270nt GGAGTTCAAACCTAAGCAGCTGGAAGGGCCCTGTGGCTAGGTACCATAGAGTCTCTACACAGGACTAAGTCAGCCTGGTGTGCAGGGGAG GCAGACACACAAACAGAAAATTGGACTACAGTGCTAAGATGCTGTAAGAAGAGGTTAACTAAAGGACAGGAAGATGGGGCCAAGAGATGG TGCTACTGTCTACTTTAGGGATCGTCTTTCAAGGCGAGGGGCCTCCTATCTCAAGCTGTGATACAGGAACCATGGCCAACTGTGAGCGTA CCTTCATTGCGATCAAACCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAGAAAGGATTCCGCCTTGTTG GTCTGAAATTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGCCTGGTGAAAT ACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCAACCCTG CAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTCATCGCCATCA AGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGTTCCTCC GGAGGGGTTGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTCGAGCACTACAGGAGAGCATGCAGGA GGTGCAGGCGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGAGGCCGCAGCCCAGGCCCAGTGCTCGGCCATGGCCCCT TGGGCTCCCGGGGCCCGCGCTGCTCTTCTTCCTCCTGTGGCCCTTCGTCGTCCAGTGGCTCTTCCGAATGTTTCGGACCCAAAAGAGGTG ACTGTCAGTGGAGGGGTCTCTGCAGCCAACTGAGACTATCTTGCTGTGCCCTGAGCCTTCCTAGGGTTTAGAAGAACAGCATTCAAAATT CCCCGTCCTGTCAGTGTTTGCCTTCGCACCTCCTCCCCTAAAGCAGCGCGGGGGGCAAATAAGACCCCACCCCTCCCTGCAGCTTCACAG GGACGCTTCCTTCCCTCCCCGCAACCACCCCAGGCTCCCCTGGGAGGCTGCAGTTGTGGTACACGTCCCCGGTGCTGGGTTGGCCGTGAC |
Top |
FusionGenePPI for NME2_ACBD4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NME2 | DYNC1H1, PPP1R7, EPPK1, ACLY, HIST1H2BC, LYZ, POLR2H, HTR1B, PPP1R8, RUVBL2, PDIA6, ATIC, PSMA2, PSMA7, STIP1, KIF5B, RPL38, NME3, NME2, VIM, HERC3, HERC5, HERC6, NME1, SVIL, MDM2, PARK2, RPS3, SOD1, VCP, NOS2, BNIPL, NME1-NME2, NME4, CTBP1, RAB5A, GIT2, TBXA2R, ESR1, HSF1, TRABD, AHCY, AKR1A1, AKR1B1, ENO1, ENO2, ENO3, FKBP1A, FKBP1B, FKBP2, GOT1, ADSS, AK2, CFL1, CFL2, DSTN, HIBCH, HINT1, LDHA, LDHB, LDHC, OAT, TKT, WDR1, PRDX5, TAGLN, TAGLN2, UBE2V1, TMEM189-UBE2V1, MCM2, PPM1K, HYPK, WWOX, SMOC1, NPC2, FGB, SLC48A1, CCNG2, APP, MAPT, CFB, DAO, LRG1 | ACBD4 | APP, VAPB, VAPA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | NME2 | chr17:49244317 | chr17:43216388 | ENST00000393193 | + | 5 | 8 | 1_66 | 157 | 268 | AKAP13 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NME2_ACBD4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NME2_ACBD4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NME2 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Hgene | NME2 | C0025500 | Mesothelioma | 1 | CTD_human |
| Hgene | NME2 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
| Hgene | NME2 | C0919267 | ovarian neoplasm | 1 | CTD_human |
| Tgene | ACBD4 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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