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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24486

FusionGeneSummary for NME1_THRA

check button Fusion gene summary
Fusion gene informationFusion gene name: NME1_THRA
Fusion gene ID: 24486
HgeneTgene
Gene symbol

NME1

THRA

Gene ID

6023

7067

Gene nameRNA component of mitochondrial RNA processing endoribonucleasethyroid hormone receptor alpha
SynonymsCHH|NME1|RMRPR|RRP2AR7|CHNG6|EAR7|ERB-T-1|ERBA|ERBA1|NR1A1|THRA1|THRA2|c-ERBA-1
Cytomap

9p13.3

17q21.1

Type of genencRNAprotein-coding
Description-thyroid hormone receptor alphaEAR-7ERBA-related 7V-erbA-related protein 7c-erbA-alphanuclear receptor subfamily 1 group A member 1thyroid hormone receptor alpha 1thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homo
Modification date2018051920180523
UniProtAcc

P15531

P10827

Ensembl transtripts involved in fusion geneENST00000393196, ENST00000336097, 
ENST00000480143, ENST00000511355, 
ENST00000013034, 
ENST00000394121, 
ENST00000264637, ENST00000584985, 
ENST00000450525, ENST00000546243, 
Fusion gene scores* DoF score2 X 2 X 1=46 X 5 X 5=150
# samples 28
** MAII scorelog2(2/4*10)=2.32192809488736log2(8/150*10)=-0.906890595608519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NME1 [Title/Abstract] AND THRA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNME1

GO:0001172

transcription, RNA-templated

19701182

HgeneNME1

GO:0030422

production of siRNA involved in RNA interference

19701182

HgeneNME1

GO:0032774

RNA biosynthetic process

19701182

TgeneTHRA

GO:0006357

regulation of transcription by RNA polymerase II

18052923

TgeneTHRA

GO:0006366

transcription by RNA polymerase II

8710870|9653119

TgeneTHRA

GO:0009755

hormone-mediated signaling pathway

18052923

TgeneTHRA

GO:0017055

negative regulation of RNA polymerase II transcriptional preinitiation complex assembly

8524305

TgeneTHRA

GO:0045892

negative regulation of transcription, DNA-templated

8710870

TgeneTHRA

GO:2000143

negative regulation of DNA-templated transcription, initiation

8524305


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE765003NME1chr17

49233086

+THRAchr17

38246322

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000393196ENST00000394121NME1chr17

49233086

+THRAchr17

38246322

+
5CDS-intronENST00000393196ENST00000264637NME1chr17

49233086

+THRAchr17

38246322

+
5CDS-intronENST00000393196ENST00000584985NME1chr17

49233086

+THRAchr17

38246322

+
5CDS-3UTRENST00000393196ENST00000450525NME1chr17

49233086

+THRAchr17

38246322

+
5CDS-intronENST00000393196ENST00000546243NME1chr17

49233086

+THRAchr17

38246322

+
5CDS-intronENST00000336097ENST00000394121NME1chr17

49233086

+THRAchr17

38246322

+
5CDS-intronENST00000336097ENST00000264637NME1chr17

49233086

+THRAchr17

38246322

+
5CDS-intronENST00000336097ENST00000584985NME1chr17

49233086

+THRAchr17

38246322

+
5CDS-3UTRENST00000336097ENST00000450525NME1chr17

49233086

+THRAchr17

38246322

+
5CDS-intronENST00000336097ENST00000546243NME1chr17

49233086

+THRAchr17

38246322

+
5CDS-intronENST00000480143ENST00000394121NME1chr17

49233086

+THRAchr17

38246322

+
5CDS-intronENST00000480143ENST00000264637NME1chr17

49233086

+THRAchr17

38246322

+
5CDS-intronENST00000480143ENST00000584985NME1chr17

49233086

+THRAchr17

38246322

+
5CDS-3UTRENST00000480143ENST00000450525NME1chr17

49233086

+THRAchr17

38246322

+
5CDS-intronENST00000480143ENST00000546243NME1chr17

49233086

+THRAchr17

38246322

+
5CDS-intronENST00000511355ENST00000394121NME1chr17

49233086

+THRAchr17

38246322

+
5CDS-intronENST00000511355ENST00000264637NME1chr17

49233086

+THRAchr17

38246322

+
5CDS-intronENST00000511355ENST00000584985NME1chr17

49233086

+THRAchr17

38246322

+
5CDS-3UTRENST00000511355ENST00000450525NME1chr17

49233086

+THRAchr17

38246322

+
5CDS-intronENST00000511355ENST00000546243NME1chr17

49233086

+THRAchr17

38246322

+
5CDS-intronENST00000013034ENST00000394121NME1chr17

49233086

+THRAchr17

38246322

+
5CDS-intronENST00000013034ENST00000264637NME1chr17

49233086

+THRAchr17

38246322

+
5CDS-intronENST00000013034ENST00000584985NME1chr17

49233086

+THRAchr17

38246322

+
5CDS-3UTRENST00000013034ENST00000450525NME1chr17

49233086

+THRAchr17

38246322

+
5CDS-intronENST00000013034ENST00000546243NME1chr17

49233086

+THRAchr17

38246322

+

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FusionProtFeatures for NME1_THRA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NME1

P15531

THRA

P10827

Major role in the synthesis of nucleoside triphosphatesother than ATP. The ATP gamma phosphate is transferred to the NDPbeta phosphate via a ping-pong mechanism, using a phosphorylatedactive-site intermediate. Possesses nucleoside-diphosphate kinase,serine/threonine-specific protein kinase, geranyl and farnesylpyrophosphate kinase, histidine protein kinase and 3'-5'exonuclease activities. Involved in cell proliferation,differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required forneural development including neural patterning and cell fatedetermination. During GZMA-mediated cell death, works in concertwith TREX1. NME1 nicks one strand of DNA and TREX1 removes basesfrom the free 3' end to enhance DNA damage and prevent DNA endreannealing and rapid repair. {ECO:0000269|PubMed:12628186,ECO:0000269|PubMed:16818237, ECO:0000269|PubMed:8810265}. Isoform Alpha-1: Nuclear hormone receptor that can actas a repressor or activator of transcription. High affinityreceptor for thyroid hormones, including triiodothyronine andthyroxine. {ECO:0000269|PubMed:12699376,ECO:0000269|PubMed:14673100, ECO:0000269|PubMed:18237438,ECO:0000269|PubMed:19926848}. Isoform Alpha-2: Does not bind thyroid hormone andfunctions as a weak dominant negative inhibitor of thyroid hormoneaction. {ECO:0000269|PubMed:8910441}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NME1_THRA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NME1_THRA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NME1_THRA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneNME1P15531DB01593ZincNucleoside diphosphate kinase Asmall moleculeapproved|investigational
TgeneTHRAP10827DB00451LevothyroxineThyroid hormone receptor alphasmall moleculeapproved
TgeneTHRAP10827DB00509DextrothyroxineThyroid hormone receptor alphasmall moleculeapproved|investigational
TgeneTHRAP10827DB01118AmiodaroneThyroid hormone receptor alphasmall moleculeapproved|investigational
TgeneTHRAP10827DB00279LiothyronineThyroid hormone receptor alphasmall moleculeapproved|vet_approved

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RelatedDiseases for NME1_THRA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNME1C0007194Hypertrophic Cardiomyopathy1CTD_human
HgeneNME1C0009404Colorectal Neoplasms1CTD_human
HgeneNME1C0027626Neoplasm Invasiveness1CTD_human
HgeneNME1C0027627Neoplasm Metastasis1CTD_human
HgeneNME1C0242184Hypoxia1CTD_human
HgeneNME1C2239176Liver carcinoma1CTD_human
TgeneTHRAC3280817HYPOTHYROIDISM, CONGENITAL, NONGOITROUS, 62UNIPROT
TgeneTHRAC0014175Endometriosis1CTD_human
TgeneTHRAC0019284Diaphragmatic Hernia1CTD_human