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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24473

FusionGeneSummary for NLRC3_NLRC3

check button Fusion gene summary
Fusion gene informationFusion gene name: NLRC3_NLRC3
Fusion gene ID: 24473
HgeneTgene
Gene symbol

NLRC3

NLRC3

Gene ID

197358

197358

Gene nameNLR family CARD domain containing 3NLR family CARD domain containing 3
SynonymsCLR16.2|NOD3CLR16.2|NOD3
Cytomap

16p13.3

16p13.3

Type of geneprotein-codingprotein-coding
DescriptionNLR family CARD domain-containing protein 3CARD15-like proteinNACHT, LRR and CARD domains-containing protein 3NOD-like receptor C3caterpiller protein 16.2nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3NLR family CARD domain-containing protein 3CARD15-like proteinNACHT, LRR and CARD domains-containing protein 3NOD-like receptor C3caterpiller protein 16.2nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3
Modification date2018052320180523
UniProtAcc

Q7RTR2

Q7RTR2

Ensembl transtripts involved in fusion geneENST00000301749, ENST00000359128, 
ENST00000419350, ENST00000448023, 
ENST00000603507, ENST00000324659, 
ENST00000301749, ENST00000359128, 
ENST00000419350, ENST00000448023, 
ENST00000603507, ENST00000324659, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 4 X 4=48
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NLRC3 [Title/Abstract] AND NLRC3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNLRC3

GO:0007249

I-kappaB kinase/NF-kappaB signaling

15705585

HgeneNLRC3

GO:0032088

negative regulation of NF-kappaB transcription factor activity

15705585

HgeneNLRC3

GO:0032715

negative regulation of interleukin-6 production

22863753

HgeneNLRC3

GO:0032720

negative regulation of tumor necrosis factor production

22863753

HgeneNLRC3

GO:0050728

negative regulation of inflammatory response

25277106

HgeneNLRC3

GO:1900226

negative regulation of NLRP3 inflammasome complex assembly

25277106

HgeneNLRC3

GO:1901223

negative regulation of NIK/NF-kappaB signaling

25277106

TgeneNLRC3

GO:0007249

I-kappaB kinase/NF-kappaB signaling

15705585

TgeneNLRC3

GO:0032088

negative regulation of NF-kappaB transcription factor activity

15705585

TgeneNLRC3

GO:0032715

negative regulation of interleukin-6 production

22863753

TgeneNLRC3

GO:0032720

negative regulation of tumor necrosis factor production

22863753

TgeneNLRC3

GO:0050728

negative regulation of inflammatory response

25277106

TgeneNLRC3

GO:1900226

negative regulation of NLRP3 inflammasome complex assembly

25277106

TgeneNLRC3

GO:1901223

negative regulation of NIK/NF-kappaB signaling

25277106


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW504437NLRC3chr16

3589108

+NLRC3chr16

3589732

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000301749ENST00000301749NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-3UTRENST00000301749ENST00000359128NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-5UTRENST00000301749ENST00000419350NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-3UTRENST00000301749ENST00000448023NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-intronENST00000301749ENST00000603507NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-intronENST00000301749ENST00000324659NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-3UTRENST00000359128ENST00000301749NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-3UTRENST00000359128ENST00000359128NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-5UTRENST00000359128ENST00000419350NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-3UTRENST00000359128ENST00000448023NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-intronENST00000359128ENST00000603507NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-intronENST00000359128ENST00000324659NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-3UTRENST00000419350ENST00000301749NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-3UTRENST00000419350ENST00000359128NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-5UTRENST00000419350ENST00000419350NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-3UTRENST00000419350ENST00000448023NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-intronENST00000419350ENST00000603507NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-intronENST00000419350ENST00000324659NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-3UTRENST00000448023ENST00000301749NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-3UTRENST00000448023ENST00000359128NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-5UTRENST00000448023ENST00000419350NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-3UTRENST00000448023ENST00000448023NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-intronENST00000448023ENST00000603507NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-intronENST00000448023ENST00000324659NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-3UTRENST00000603507ENST00000301749NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-3UTRENST00000603507ENST00000359128NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-5UTRENST00000603507ENST00000419350NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-3UTRENST00000603507ENST00000448023NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-intronENST00000603507ENST00000603507NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-intronENST00000603507ENST00000324659NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-3UTRENST00000324659ENST00000301749NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-3UTRENST00000324659ENST00000359128NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-5UTRENST00000324659ENST00000419350NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-3UTRENST00000324659ENST00000448023NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-intronENST00000324659ENST00000603507NLRC3chr16

3589108

+NLRC3chr16

3589732

-
intron-intronENST00000324659ENST00000324659NLRC3chr16

3589108

+NLRC3chr16

3589732

-

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FusionProtFeatures for NLRC3_NLRC3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NLRC3

Q7RTR2

NLRC3

Q7RTR2

Negative regulator of the innate immune response(PubMed:15705585, PubMed:22863753, PubMed:25277106). Attenuatessignaling pathways activated by Toll-like receptors (TLRs) and theDNA sensor STING/TMEM173 in response to pathogen-associatedmolecular patterns, such as intracellular poly(dA:dT), but notpoly(I:C), or in response to DNA virus infection, including thatof Herpes simplex virus 1 (HSV1) (By similarity)(PubMed:22863753). May affect TLR4 signaling by acting at thelevel of TRAF6 ubiquitination, decreasing the activating 'Lys-63'-linked ubiquitination and leaving unchanged the degradative 'Lys-48'-linked ubiquitination (PubMed:22863753). Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with theposphatidylinositol 3-kinase regulatory subunit p85(PIK3R1/PIK3R2) and disrupting the association betweenPIK3R1/PIK3R2 and the catalytic subunit p110(PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Viaits regulation of the PI3K-AKT-mTOR pathway, controls cellproliferation, predominantly in intestinal epithelial cells (Bysimilarity). May also affect NOD1- or NOD2-mediated NF-kappa-Bactivation (PubMed:25277106). Might also affect the inflammatoryresponse by preventing NLRP3 inflammasome formation, CASP1cleavage and IL1B maturation (PubMed:25277106).{ECO:0000250|UniProtKB:Q5DU56, ECO:0000269|PubMed:15705585,ECO:0000269|PubMed:22863753, ECO:0000269|PubMed:25277106}. Negative regulator of the innate immune response(PubMed:15705585, PubMed:22863753, PubMed:25277106). Attenuatessignaling pathways activated by Toll-like receptors (TLRs) and theDNA sensor STING/TMEM173 in response to pathogen-associatedmolecular patterns, such as intracellular poly(dA:dT), but notpoly(I:C), or in response to DNA virus infection, including thatof Herpes simplex virus 1 (HSV1) (By similarity)(PubMed:22863753). May affect TLR4 signaling by acting at thelevel of TRAF6 ubiquitination, decreasing the activating 'Lys-63'-linked ubiquitination and leaving unchanged the degradative 'Lys-48'-linked ubiquitination (PubMed:22863753). Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with theposphatidylinositol 3-kinase regulatory subunit p85(PIK3R1/PIK3R2) and disrupting the association betweenPIK3R1/PIK3R2 and the catalytic subunit p110(PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Viaits regulation of the PI3K-AKT-mTOR pathway, controls cellproliferation, predominantly in intestinal epithelial cells (Bysimilarity). May also affect NOD1- or NOD2-mediated NF-kappa-Bactivation (PubMed:25277106). Might also affect the inflammatoryresponse by preventing NLRP3 inflammasome formation, CASP1cleavage and IL1B maturation (PubMed:25277106).{ECO:0000250|UniProtKB:Q5DU56, ECO:0000269|PubMed:15705585,ECO:0000269|PubMed:22863753, ECO:0000269|PubMed:25277106}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NLRC3_NLRC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NLRC3_NLRC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NLRC3_NLRC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NLRC3_NLRC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource