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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 24461

FusionGeneSummary for NLK_ELMO1

check button Fusion gene summary
Fusion gene informationFusion gene name: NLK_ELMO1
Fusion gene ID: 24461
HgeneTgene
Gene symbol

NLK

ELMO1

Gene ID

51701

9844

Gene namenemo like kinaseengulfment and cell motility 1
Synonyms-CED-12|CED12|ELMO-1
Cytomap

17q11.2

7p14.2-p14.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase NLKengulfment and cell motility protein 1ced-12 homolog 1
Modification date2018052320180519
UniProtAcc

Q9UBE8

Q92556

Ensembl transtripts involved in fusion geneENST00000407008, ENST00000583517, 
ENST00000582037, 		ENST00000341056, 
ENST00000396045, ENST00000310758, 
ENST00000396040, ENST00000442504, 
ENST00000448602, ENST00000479447, 
Fusion gene scores* DoF score13 X 7 X 8=72810 X 7 X 7=490
# samples 1512
** MAII scorelog2(15/728*10)=-2.27897594970282
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/490*10)=-2.02974734339405
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NLK [Title/Abstract] AND ELMO1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNLK

GO:0050821

protein stabilization

25512613


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-FG-A70Z-01ANLKchr17

26449758

+ELMO1chr7

37172839

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000407008ENST00000341056NLKchr17

26449758

+ELMO1chr7

37172839

-
5CDS-intronENST00000407008ENST00000396045NLKchr17

26449758

+ELMO1chr7

37172839

-
5CDS-intronENST00000407008ENST00000310758NLKchr17

26449758

+ELMO1chr7

37172839

-
5CDS-intronENST00000407008ENST00000396040NLKchr17

26449758

+ELMO1chr7

37172839

-
5CDS-intronENST00000407008ENST00000442504NLKchr17

26449758

+ELMO1chr7

37172839

-
5CDS-intronENST00000407008ENST00000448602NLKchr17

26449758

+ELMO1chr7

37172839

-
5CDS-intronENST00000407008ENST00000479447NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-3CDSENST00000583517ENST00000341056NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-intronENST00000583517ENST00000396045NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-intronENST00000583517ENST00000310758NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-intronENST00000583517ENST00000396040NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-intronENST00000583517ENST00000442504NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-intronENST00000583517ENST00000448602NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-intronENST00000583517ENST00000479447NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-3CDSENST00000582037ENST00000341056NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-intronENST00000582037ENST00000396045NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-intronENST00000582037ENST00000310758NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-intronENST00000582037ENST00000396040NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-intronENST00000582037ENST00000442504NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-intronENST00000582037ENST00000448602NLKchr17

26449758

+ELMO1chr7

37172839

-
intron-intronENST00000582037ENST00000479447NLKchr17

26449758

+ELMO1chr7

37172839

-

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FusionProtFeatures for NLK_ELMO1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NLK

Q9UBE8

ELMO1

Q92556

Serine/threonine-protein kinase that regulates a numberof transcription factors with key roles in cell fatedetermination. Positive effector of the non-canonical Wntsignaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 andHIPK2. Activation of this pathway causes binding to andphosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading tomethylation of PPARG target promoters at histone H3K9 andtranscriptional silencing. The resulting loss of PPARG target genetranscription inhibits adipogenesis and promotesosteoblastogenesis in mesenchymal stem cells (MSCs). Negativeregulator of the canonical Wnt/beta-catenin signaling pathway.Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting thedissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, aswell as the ubiquitination and subsequent proteolysis of LEF1.Together these effects inhibit the transcriptional activation ofcanonical Wnt/beta-catenin target genes. Negative regulator of theNotch signaling pathway. Binds to and phosphorylates NOTCH1,thereby preventing the formation of a transcriptionally activeternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negativeregulator of the MYB family of transcription factors.Phosphorylation of MYB leads to its subsequent proteolysis whilephosphorylation of MYBL1 and MYBL2 inhibits their interaction withthe coactivator CREBBP. Other transcription factors may also beinhibited by direct phosphorylation of CREBBP itself. Actsdownstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which isin turn required for activation of NLK by MAP3K7/TAK1. Upon IL1Bstimulus, cooperates with ATF5 to activate the transactivationactivity of C/EBP subfamily members. Phosphorylates ATF5 but alsostabilizes ATF5 protein levels in a kinase-independent manner(PubMed:25512613). {ECO:0000250|UniProtKB:O54949,ECO:0000269|PubMed:12482967, ECO:0000269|PubMed:14960582,ECO:0000269|PubMed:15004007, ECO:0000269|PubMed:15764709,ECO:0000269|PubMed:17952062, ECO:0000269|PubMed:20061393,ECO:0000269|PubMed:20118921, ECO:0000269|PubMed:20874444,ECO:0000269|PubMed:21454679, ECO:0000269|PubMed:25512613}. Involved in cytoskeletal rearrangements required forphagocytosis of apoptotic cells and cell motility. Acts inassociation with DOCK1 and CRK. Was initially proposed to berequired in complex with DOCK1 to activate Rac Rho small GTPases.May enhance the guanine nucleotide exchange factor (GEF) activityof DOCK1. {ECO:0000269|PubMed:11595183,ECO:0000269|PubMed:12134158}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNLKchr17:26449758chr7:37172839ENST00000407008+211106_111196528Compositional biasNote=Poly-Ala
HgeneNLKchr17:26449758chr7:37172839ENST00000407008+211115_119196528Compositional biasNote=Poly-Ala
HgeneNLKchr17:26449758chr7:37172839ENST00000407008+21122_25196528Compositional biasNote=Poly-Ala
HgeneNLKchr17:26449758chr7:37172839ENST00000407008+21127_34196528Compositional biasNote=Poly-His
HgeneNLKchr17:26449758chr7:37172839ENST00000407008+21142_48196528Compositional biasNote=Poly-His
HgeneNLKchr17:26449758chr7:37172839ENST00000407008+21171_83196528Compositional biasNote=Poly-Ala
HgeneNLKchr17:26449758chr7:37172839ENST00000407008+211144_152196528Nucleotide bindingATP
TgeneELMO1chr17:26449758chr7:37172839ENST00000310758-1222555_676362728DomainNote=PH
TgeneELMO1chr17:26449758chr7:37172839ENST00000341056-010319_49264430DomainELMO
TgeneELMO1chr17:26449758chr7:37172839ENST00000341056-010555_67664430DomainNote=PH
TgeneELMO1chr17:26449758chr7:37172839ENST00000396040-07319_492-50248DomainELMO
TgeneELMO1chr17:26449758chr7:37172839ENST00000396040-07555_676-50248DomainNote=PH
TgeneELMO1chr17:26449758chr7:37172839ENST00000396045-07319_492-197248DomainELMO
TgeneELMO1chr17:26449758chr7:37172839ENST00000396045-07555_676-197248DomainNote=PH
TgeneELMO1chr17:26449758chr7:37172839ENST00000442504-1222555_676362728DomainNote=PH
TgeneELMO1chr17:26449758chr7:37172839ENST00000448602-1222555_676362728DomainNote=PH
TgeneELMO1chr17:26449758chr7:37172839ENST00000310758-1222707_714362728MotifNote=SH3-binding
TgeneELMO1chr17:26449758chr7:37172839ENST00000341056-010707_71464430MotifNote=SH3-binding
TgeneELMO1chr17:26449758chr7:37172839ENST00000396040-07707_714-50248MotifNote=SH3-binding
TgeneELMO1chr17:26449758chr7:37172839ENST00000396045-07707_714-197248MotifNote=SH3-binding
TgeneELMO1chr17:26449758chr7:37172839ENST00000442504-1222707_714362728MotifNote=SH3-binding
TgeneELMO1chr17:26449758chr7:37172839ENST00000448602-1222707_714362728MotifNote=SH3-binding

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNLKchr17:26449758chr7:37172839ENST00000407008+211138_427196528DomainProtein kinase
HgeneNLKchr17:26449758chr7:37172839ENST00000407008+211298_300196528MotifNote=TQE
HgeneNLKchr17:26449758chr7:37172839ENST00000407008+211428_527196528RegionRequired for homodimerization and kinase activation and localization to the nucleus
TgeneELMO1chr17:26449758chr7:37172839ENST00000310758-1222319_492362728DomainELMO
TgeneELMO1chr17:26449758chr7:37172839ENST00000442504-1222319_492362728DomainELMO
TgeneELMO1chr17:26449758chr7:37172839ENST00000448602-1222319_492362728DomainELMO


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FusionGeneSequence for NLK_ELMO1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NLK_ENST00000407008_chr17_26449758_+_ELMO1_ENST00000341056_chr7_37172839_-_562aa
MSLCGARANAKMMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAAVHPVQQHTSSAAAAAAAAAAAAAMLNPGQQ
QPYFPSPAPGQAPGPAAAAPAQVQAAAAATVKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCK
RVFRELKMLCFFKHDNNHVNPAMDFTQTPPGMLALDNMLYFAKHHQDAYIRIVLENSSREDKHECPFGRSSIELTKMLCEILKVGELPSE
TCNDFHPMFFTHDRSFEEFFCICIQLLNKTWKEMRATSEDFNKVMQVVKEQVMRALTTKPSSLDQFKSKLQNLSYTEILKIRQSERMNQE
DFQSRPILELKEKIQPEILELIKQQRLNRLVEGTCFRKLNARRRQDKFWYCRLSPNHKVLHYGDLEESPQGEVPHDSLQDKLPVADIKAV
VTGKDCPHMKEKGALKQNKEVLELAFSILYDSNCQLNFIAPDKHEYCIWTDGLNALLGKDMMSDLTRNDLDTLLSMEIKLRLLDLENIQI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NLK_ENST00000407008_chr17_26449758_+_ELMO1_ENST00000341056_chr7_37172839_-_1686nt
ATGTCTCTTTGTGGCGCAAGAGCCAACGCAAAAATGATGGCGGCTTACAATGGCGGTACATCTGCAGCAGCAGCAGGTCACCACCACCAC
CATCACCACCACCTTCCACACCTCCCTCCTCCTCACCTGCACCACCACCACCACCCTCAACACCATCTTCATCCGGGGTCGGCTGCCGCT
GTACACCCTGTACAGCAGCACACCTCTTCGGCAGCTGCGGCAGCCGCAGCAGCGGCTGCAGCTGCAGCCATGTTAAACCCTGGGCAACAA
CAGCCATATTTCCCATCACCGGCACCGGGGCAGGCTCCTGGACCAGCTGCAGCAGCCCCAGCTCAGGTACAGGCTGCCGCAGCTGCTACA
GTTAAGGCGCACCATCATCAGCACTCGCATCATCCACAGCAGCAGCTGGATATTGAGCCGGATAGACCTATTGGATATGGAGCCTTTGGT
GTTGTCTGGTCAGTAACAGATCCAAGAGATGGAAAGAGAGTAGCGCTCAAAAAGATGCCCAACGTCTTCCAGAATCTGGTCTCTTGCAAA
AGGGTCTTCCGGGAATTGAAGATGTTGTGTTTTTTTAAGCATGATAATAATCATGTCAACCCTGCCATGGACTTCACGCAGACTCCACCT
GGGATGTTGGCTCTGGACAACATGCTGTACTTTGCCAAGCACCACCAAGATGCCTACATCCGGATTGTGCTTGAGAACAGTAGTCGAGAA
GACAAGCATGAATGTCCCTTTGGCCGCAGTAGTATAGAGCTGACCAAGATGCTATGTGAGATCTTGAAAGTGGGCGAGTTGCCTAGTGAG
ACCTGCAACGACTTCCACCCGATGTTCTTCACCCACGACAGATCCTTTGAGGAGTTTTTCTGCATCTGTATCCAGCTCCTGAACAAGACA
TGGAAGGAAATGAGGGCAACTTCTGAAGACTTCAACAAGGTAATGCAGGTGGTGAAGGAGCAGGTTATGAGAGCACTTACAACCAAGCCT
AGCTCCCTGGACCAGTTCAAGAGCAAACTGCAGAACCTGAGCTACACTGAGATCCTGAAAATCCGCCAGTCCGAGAGGATGAACCAGGAA
GATTTCCAGTCCCGCCCGATTTTGGAACTAAAGGAGAAGATTCAGCCAGAAATCTTAGAGCTGATCAAACAGCAACGCCTGAACCGCCTT
GTGGAAGGGACCTGCTTTAGGAAACTCAATGCCCGGCGGAGGCAAGACAAGTTTTGGTATTGTCGGCTTTCGCCAAATCACAAAGTCCTG
CATTACGGAGACTTAGAAGAGAGTCCTCAGGGAGAAGTGCCCCACGATTCCTTGCAGGACAAACTGCCGGTGGCAGATATCAAAGCCGTG
GTGACGGGAAAGGACTGCCCTCATATGAAAGAGAAAGGTGCCCTTAAACAAAACAAGGAGGTGCTTGAACTCGCTTTCTCCATCTTGTAT
GACTCAAACTGCCAACTGAACTTCATCGCTCCTGACAAGCATGAGTACTGTATCTGGACGGATGGACTGAATGCGCTACTCGGGAAGGAC
ATGATGAGCGACCTGACGCGGAATGACCTGGACACCCTGCTCAGCATGGAAATCAAGCTCCGCCTCCTGGACCTGGAAAACATCCAGATC


* Fusion transcript sequences (Full-length transcript).
>In-frame_NLK_ENST00000407008_chr17_26449758_+_ELMO1_ENST00000341056_chr7_37172839_-_3599nt
CCCCGGCTCTCTTTCTCCTCTCTGTCCTGCTGTCGCCTCCTCTCCTCACTCCAGCCTCCTTCCCTGGCTTATTCTGCCCAGGAAAGTTTG
GAACCCCCGCCCCCCCTCCCCAATCAGGTCAACCTGACTAGGAGTAGGGGGAGATGTAGGAAGGCCTGAGAGTTCGGGGGGGGGGAAGCT
GGAAGCTGGTTTCCCAGAAAATTTCCCCCCATCTTCTCCATTTAGGGTGGTGGGAATTTTTTTTAATCCTGTTTTTGAGGAGGTGGTAGG
TGTTTAGAAAAGGATGTGGGAATGGAAGGGGTAGATGAGTCAACCCTCTTTCAAGATTCCAAGGGTGGTGTGTTACCTGATCCTTTTCGT
GTGTGGAGTTCAGGGGGTCGGGAGGTTTGGCCTTTATTCCCACATTCAAAGTTGGAACCTCCCCCAAATTAAGAATGGAGTTTTAGTACC
CACTTGTGGCAGGAATCCTGGGGGGAAGGGGTCCTTTTTTCCTTTTTCTTTTCTTTTTTCCCTTTTTTTTCCTTTTGGCAACCCACACCC
TTCCACACACGCTCACCCCAAAATTAAACACCAAGATCCTCTAACTTGTTTGGATTGACTGATGAAGACATAAAGCTCTATGTTTTTTGA
GGTGGAGTGAGTGGTTTTTCTTCATTTTTAAATGGCCAAATGACAGCTTGACCCAGTTTGCTTTCCAATCAAAGGGCATTTATTTTGAAT
GTCTCTTTGTGGCGCAAGAGCCAACGCAAAAATGATGGCGGCTTACAATGGCGGTACATCTGCAGCAGCAGCAGGTCACCACCACCACCA
TCACCACCACCTTCCACACCTCCCTCCTCCTCACCTGCACCACCACCACCACCCTCAACACCATCTTCATCCGGGGTCGGCTGCCGCTGT
ACACCCTGTACAGCAGCACACCTCTTCGGCAGCTGCGGCAGCCGCAGCAGCGGCTGCAGCTGCAGCCATGTTAAACCCTGGGCAACAACA
GCCATATTTCCCATCACCGGCACCGGGGCAGGCTCCTGGACCAGCTGCAGCAGCCCCAGCTCAGGTACAGGCTGCCGCAGCTGCTACAGT
TAAGGCGCACCATCATCAGCACTCGCATCATCCACAGCAGCAGCTGGATATTGAGCCGGATAGACCTATTGGATATGGAGCCTTTGGTGT
TGTCTGGTCAGTAACAGATCCAAGAGATGGAAAGAGAGTAGCGCTCAAAAAGATGCCCAACGTCTTCCAGAATCTGGTCTCTTGCAAAAG
GGTCTTCCGGGAATTGAAGATGTTGTGTTTTTTTAAGCATGATAATAATCATGTCAACCCTGCCATGGACTTCACGCAGACTCCACCTGG
GATGTTGGCTCTGGACAACATGCTGTACTTTGCCAAGCACCACCAAGATGCCTACATCCGGATTGTGCTTGAGAACAGTAGTCGAGAAGA
CAAGCATGAATGTCCCTTTGGCCGCAGTAGTATAGAGCTGACCAAGATGCTATGTGAGATCTTGAAAGTGGGCGAGTTGCCTAGTGAGAC
CTGCAACGACTTCCACCCGATGTTCTTCACCCACGACAGATCCTTTGAGGAGTTTTTCTGCATCTGTATCCAGCTCCTGAACAAGACATG
GAAGGAAATGAGGGCAACTTCTGAAGACTTCAACAAGGTAATGCAGGTGGTGAAGGAGCAGGTTATGAGAGCACTTACAACCAAGCCTAG
CTCCCTGGACCAGTTCAAGAGCAAACTGCAGAACCTGAGCTACACTGAGATCCTGAAAATCCGCCAGTCCGAGAGGATGAACCAGGAAGA
TTTCCAGTCCCGCCCGATTTTGGAACTAAAGGAGAAGATTCAGCCAGAAATCTTAGAGCTGATCAAACAGCAACGCCTGAACCGCCTTGT
GGAAGGGACCTGCTTTAGGAAACTCAATGCCCGGCGGAGGCAAGACAAGTTTTGGTATTGTCGGCTTTCGCCAAATCACAAAGTCCTGCA
TTACGGAGACTTAGAAGAGAGTCCTCAGGGAGAAGTGCCCCACGATTCCTTGCAGGACAAACTGCCGGTGGCAGATATCAAAGCCGTGGT
GACGGGAAAGGACTGCCCTCATATGAAAGAGAAAGGTGCCCTTAAACAAAACAAGGAGGTGCTTGAACTCGCTTTCTCCATCTTGTATGA
CTCAAACTGCCAACTGAACTTCATCGCTCCTGACAAGCATGAGTACTGTATCTGGACGGATGGACTGAATGCGCTACTCGGGAAGGACAT
GATGAGCGACCTGACGCGGAATGACCTGGACACCCTGCTCAGCATGGAAATCAAGCTCCGCCTCCTGGACCTGGAAAACATCCAGATCCC
TGACGCACCTCCGCCGATTCCCAAGGAGCCCAGCAACTATGACTTCGTCTATGACTGTAACTGAAGTGGCCGGGCCCAGACATGCCCCTT
CCAAAACTGGAACACCTAGCTAACAGGAGAGAGGAATGAAAACACACCCACGCCTTGGAACCGTCCTTTGGTAAAGGGAAGCTGTGGGTC
CACATTCCCTTCAGCATCACCTCTAGCCCTGGCAACTTTCAGCCCCTAGCTGGCATCTTGCTCACCGCCCTGATTCTGTTCCTCGGCTCC
ACTGCTTCAGGTCACTTCCCATGGCTGCAGTCCACTGGTGGGACAAGAGCAAAGCCCACTGCCAGTAAGAAGGCCAAAGGGCCCTTCCAT
CCTAGCCCTCTGCAGGCATGCCCTTCCTTCCCTTGGGCAGGAAAGCCAGCAGCCCCAGACTGCCCAAAAACTTGCCCACCAGACCAAGGG
CAGTGCCCCAAGGCCCCTGTCTGGAGGAAATGGCCTAGCTATTTGATGAGAAGACCAAACCCCACATCCTCCTTTCCCCTCTCTCTAGAA
TCATCTCGCACCACCAGTTACACTTGAATTAAGATCTGCGCTCAAATCTCCTCCCACCTCTCTCCCTGCTTTTGCCTTGCTCTGTTCCTC
TTTGGTCCCAAGAGCAGCAGCCGCAGCCTCCTCGTGATCCTCCCTAGCATAAATTTCCCAAACAGTCCACAGGTCCCATGCCCACTTTGC
GTCTGCACTGTGATCGTGACAAATCTTCCCTCCTCACCAGCTAGTCTGGGGTTTCCTCTCCCTGCCCCAGGCCAGAACTGCCTTCTTCAT
TTCCACCCACGCTCCCAGCCTCTTAGCTGAAAGCACAAATGGTGAAATCAGTAGTCTCGCTCCATCTCTAATAGACTAAACCTAAATGCC
TCTAGGACGGACTGTTGCTATCCAAGCGTTTGGTGTTACCTTCTCCTGGGAGGTCCTGCTGCAACTCAAGTTCCACAGGATGGTCAAGCT
GTCAGACATCCAAGTTTACATCATTGTAATTATTACTGGTATTTACAATTTGCAAGAGTTTTGGGTTAGTTTTTTTTTTTTTTTTTGCTT
TGTTTTTGTACAAAAGAGTCTAACATTTTTTGCCAAACAGATATATATTTAATGAAAAGAAGAGATACATAAATGTGTGAATTTCCAGTT


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FusionGenePPI for NLK_ELMO1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NLKLEF1, CTNNB1, TCF7L2, FBXW4, FBXW5, SKP2, CUL1, MYB, HIPK2, MYBL1, MYBL2, CREBBP, FOXO4, FOXO1, FOXO3, ASGR1, ELAVL1, USP4, ATXN1, TAB2, MAP3K7, NLK, SMAD4, RCHY1, SDR16C5, KPNB1, RANBP2, C2orf44, FAM222B, FAM222A, RNF219, TNKS1BP1, SKI, RANGAP1, TLE3, CEP97, PASK, CNOT2, CCP110, UBAP2L, TRPS1, CNOT11, BACH1, CNOT3, SHANK2, PKM, TP53, MDM2, GRN, KRTAP5-9, ZHX3, QRICH1, KRTAP4-2, KRTAP10-3, KRTAP5-6, STAT5AELMO1HCK, DOCK1, BAG3, PTGS2, TRIM54, ZNF398, DOCK4, DOCK3, USP4, MED31, DOCK5, TTC19, ELMO2, CALML3, NTRK1, RHOG, DOCK2, BAI1, BAI3, ARL4A, CDC27, ARHGEF16, ELMO3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NLK_ELMO1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NLK_ELMO1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneELMO1C0011881Diabetic Nephropathy1CTD_human
TgeneELMO1C0038325Stevens-Johnson Syndrome1CTD_human
TgeneELMO1C0279628Adenocarcinoma Of Esophagus1CTD_human