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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2445

FusionGeneSummary for ARHGAP35_C2orf61

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP35_C2orf61
Fusion gene ID: 2445
HgeneTgene
Gene symbol

ARHGAP35

C2orf61

Gene ID

2909

Gene nameRho GTPase activating protein 35
SynonymsGRF-1|GRLF1|P190-A|P190A|p190ARhoGAP|p190RhoGAP
Cytomap

19q13.32

Type of geneprotein-coding
Descriptionrho GTPase-activating protein 35glucocorticoid receptor DNA-binding factor 1glucocorticoid receptor repression factor 1rho GAP p190A
Modification date20180522
UniProtAcc

Q9NRY4

Ensembl transtripts involved in fusion geneENST00000404338, ENST00000598548, 
ENST00000464527, ENST00000445927, 
ENST00000294947, 
Fusion gene scores* DoF score11 X 5 X 8=4405 X 3 X 4=60
# samples 116
** MAII scorelog2(11/440*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/60*10)=0
Context

PubMed: ARHGAP35 [Title/Abstract] AND C2orf61 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARHGAP35

GO:0000122

negative regulation of transcription by RNA polymerase II

1894621

HgeneARHGAP35

GO:0045892

negative regulation of transcription, DNA-templated

1894621


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-K1-A3PO-01AARHGAP35chr19

47440665

+C2orf61chr2

47397903

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000404338ENST00000464527ARHGAP35chr19

47440665

+C2orf61chr2

47397903

-
5CDS-intronENST00000404338ENST00000445927ARHGAP35chr19

47440665

+C2orf61chr2

47397903

-
5CDS-intronENST00000404338ENST00000294947ARHGAP35chr19

47440665

+C2orf61chr2

47397903

-
intron-intronENST00000598548ENST00000464527ARHGAP35chr19

47440665

+C2orf61chr2

47397903

-
intron-intronENST00000598548ENST00000445927ARHGAP35chr19

47440665

+C2orf61chr2

47397903

-
intron-intronENST00000598548ENST00000294947ARHGAP35chr19

47440665

+C2orf61chr2

47397903

-

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FusionProtFeatures for ARHGAP35_C2orf61


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP35

Q9NRY4

C2orf61

Rho GTPase-activating protein (GAP) (PubMed:19673492,PubMed:28894085). Binds several acidic phospholipids whichinhibits the Rho GAP activity to promote the Rac GAP activity(PubMed:19673492). This binding is inhibited by phosphorylation byPRKCA (PubMed:19673492). Involved in cell differentiation as wellas cell adhesion and migration, plays an important role in retinaltissue morphogenesis, neural tube fusion, midline fusion of thecerebral hemispheres and mammary gland branching morphogenesis (Bysimilarity). Transduces signals from p21-ras to the nucleus,acting via the ras GTPase-activating protein (GAP) (Bysimilarity). Transduces SRC-dependent signals from cell-surfaceadhesion molecules, such as laminin, to promote neurite outgrowth.Regulates axon outgrowth, guidance and fasciculation (Bysimilarity). Modulates Rho GTPase-dependent F-actinpolymerization, organization and assembly, is involved inpolarized cell migration and in the positive regulation ofciliogenesis and cilia elongation (By similarity). During mammarygland development, is required in both the epithelial and stromalcompartments for ductal outgrowth (By similarity). Repressestranscription of the glucocorticoid receptor by binding to thecis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; thisfunction is however unclear and would need additional experimentalevidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128,ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621,ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARHGAP35_C2orf61


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARHGAP35_C2orf61


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARHGAP35RASA1, RHOA, GRB2, BCL6, RND1, RND2, RND3, KRT31, TCERG1, NTRK1, CDC42, RAC1, SERPINB2C2orf61EGFR, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARHGAP35_C2orf61


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARHGAP35_C2orf61


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARHGAP35C0152013Adenocarcinoma of lung (disorder)1CTD_human