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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24440

FusionGeneSummary for NLE1_BAIAP2

check button Fusion gene summary
Fusion gene informationFusion gene name: NLE1_BAIAP2
Fusion gene ID: 24440
HgeneTgene
Gene symbol

NLE1

BAIAP2

Gene ID

54475

10458

Gene namenotchless homolog 1BAI1 associated protein 2
SynonymsNLEBAP2|FLAF3|IRSP53
Cytomap

17q12

17q25.3

Type of geneprotein-codingprotein-coding
Descriptionnotchless protein homolog 1Notchless gene homologbrain-specific angiogenesis inhibitor 1-associated protein 2IRS-58IRSp53/58fas ligand-associated factor 3insulin receptor substrate of 53 kDainsulin receptor substrate p53/p58insulin receptor substrate protein of 53 kDa
Modification date2018052320180523
UniProtAcc

Q9NVX2

Q9UQB8

Ensembl transtripts involved in fusion geneENST00000586869, ENST00000442241, 
ENST00000360831, ENST00000593176, 
ENST00000392411, ENST00000321280, 
ENST00000428708, ENST00000575712, 
ENST00000575245, ENST00000435091, 
ENST00000321300, ENST00000573894, 
ENST00000416299, 
Fusion gene scores* DoF score2 X 2 X 2=810 X 7 X 6=420
# samples 210
** MAII scorelog2(2/8*10)=1.32192809488736log2(10/420*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NLE1 [Title/Abstract] AND BAIAP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-BH-A0BJ-01ANLE1chr17

33468998

-BAIAP2chr17

79027468

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000586869ENST00000392411NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5UTR-intronENST00000586869ENST00000321280NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5UTR-intronENST00000586869ENST00000428708NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5UTR-intronENST00000586869ENST00000575712NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5UTR-intronENST00000586869ENST00000575245NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5UTR-intronENST00000586869ENST00000435091NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5UTR-intronENST00000586869ENST00000321300NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5UTR-3UTRENST00000586869ENST00000573894NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5UTR-intronENST00000586869ENST00000416299NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5CDS-intronENST00000442241ENST00000392411NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5CDS-intronENST00000442241ENST00000321280NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5CDS-intronENST00000442241ENST00000428708NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5CDS-intronENST00000442241ENST00000575712NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5CDS-intronENST00000442241ENST00000575245NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5CDS-intronENST00000442241ENST00000435091NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5CDS-intronENST00000442241ENST00000321300NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5CDS-3UTRENST00000442241ENST00000573894NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5CDS-intronENST00000442241ENST00000416299NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5CDS-intronENST00000360831ENST00000392411NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5CDS-intronENST00000360831ENST00000321280NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5CDS-intronENST00000360831ENST00000428708NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5CDS-intronENST00000360831ENST00000575712NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5CDS-intronENST00000360831ENST00000575245NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5CDS-intronENST00000360831ENST00000435091NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5CDS-intronENST00000360831ENST00000321300NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5CDS-3UTRENST00000360831ENST00000573894NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5CDS-intronENST00000360831ENST00000416299NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5UTR-intronENST00000593176ENST00000392411NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5UTR-intronENST00000593176ENST00000321280NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5UTR-intronENST00000593176ENST00000428708NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5UTR-intronENST00000593176ENST00000575712NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5UTR-intronENST00000593176ENST00000575245NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5UTR-intronENST00000593176ENST00000435091NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5UTR-intronENST00000593176ENST00000321300NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5UTR-3UTRENST00000593176ENST00000573894NLE1chr17

33468998

-BAIAP2chr17

79027468

+
5UTR-intronENST00000593176ENST00000416299NLE1chr17

33468998

-BAIAP2chr17

79027468

+

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FusionProtFeatures for NLE1_BAIAP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NLE1

Q9NVX2

BAIAP2

Q9UQB8

Plays a role in regulating Notch activity. Plays a rolein regulating the expression of CDKN1A and several members of theWnt pathway, probably via its effects on Notch activity. Requiredduring embryogenesis for inner mass cell survival (By similarity).{ECO:0000250}. Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of theactin cytoskeleton by WASF family members and the Arp2/3 complex.Plays a role in neurite growth. Acts syngeristically with ENAH topromote filipodia formation. Plays a role in the reorganization ofthe actin cytoskeleton in response to bacterial infection.Participates in actin bundling when associated with EPS8,promoting filopodial protrusions. {ECO:0000269|PubMed:11130076,ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106,ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NLE1_BAIAP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NLE1_BAIAP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NLE1EWSR1, WDR5, SIRT7, CUL3, OBSL1, NOL12, NSA2, NIFK, THAP7, GBE1, HNRNPH3, MTHFD1, CYCS, SKIV2L2, SPAG7, IFI16, MDN1, CHMP4B, NOP9, NLE1, CCT2, CCT4, CCT6A, CCT5, CCT7, CNBP, RPL18, IGHMBP2, RPL15, GPATCH4, RBM4, H2AFY2, RPL30, MECP2, PLEKHO1, TRIM25BAIAP2NCKIPSD, EPS8, YWHAG, C14orf1, SHANK1, CDC42, ENAH, ATN1, WASF1, WASF2, RAC1, PAK1, NEDD4, BRD4, APP, RHOA, YWHAE, RTN4, WASL, SRPK2, YWHAB, HECW2, KDM1A, WWOX, MARK2, TP53BP2, SF3B4, BAIAP2, PRR13, C19orf25, ZDHHC17, EGFR, NCK2, NCKAP1, CYFIP2, CYFIP1, BAIAP2L1, RAP1GDS1, KIAA1522, ABI1, GRB10, PCM1, NIN, CRY1, CSNK1E, DECR1, MPZL1, RAB11FIP2, PPIL2, TFB1M, RBM26, CHMP6, RAB11FIP1, BAI1, CDH1, PTPRA, PTPRE, KCTD3, KIF13B, ZBTB21, KSR1, CBY1, RAB3IP, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NLE1_BAIAP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NLE1_BAIAP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource