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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24429

FusionGeneSummary for NKIRAS1_NHSL1

check button Fusion gene summary
Fusion gene informationFusion gene name: NKIRAS1_NHSL1
Fusion gene ID: 24429
HgeneTgene
Gene symbol

NKIRAS1

NHSL1

Gene ID

28512

57224

Gene nameNFKB inhibitor interacting Ras like 1NHS like 1
SynonymsKBRAS1|kappaB-Ras1C6orf63
Cytomap

3p24.2

6q24.1

Type of geneprotein-codingprotein-coding
DescriptionNF-kappa-B inhibitor-interacting Ras-like protein 1I-kappa-B-interacting Ras-like protein 1NFKB inhibitor interacting Ras-like protein 1kappa B-Ras protein 1kappa B-ras 1NHS-like protein 1
Modification date2018051920180523
UniProtAcc

Q9NYS0

Q5SYE7

Ensembl transtripts involved in fusion geneENST00000421515, ENST00000388759, 
ENST00000443659, ENST00000425478, 
ENST00000437230, ENST00000412028, 
ENST00000415901, ENST00000416026, 
ENST00000427025, ENST00000343505, 
ENST00000479393, 
Fusion gene scores* DoF score4 X 5 X 1=203 X 3 X 3=27
# samples 53
** MAII scorelog2(5/20*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NKIRAS1 [Title/Abstract] AND NHSL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI278837NKIRAS1chr3

23960903

-NHSL1chr6

138743836

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000421515ENST00000427025NKIRAS1chr3

23960903

-NHSL1chr6

138743836

+
intron-3UTRENST00000421515ENST00000343505NKIRAS1chr3

23960903

-NHSL1chr6

138743836

+
intron-intronENST00000421515ENST00000479393NKIRAS1chr3

23960903

-NHSL1chr6

138743836

+
intron-3UTRENST00000388759ENST00000427025NKIRAS1chr3

23960903

-NHSL1chr6

138743836

+
intron-3UTRENST00000388759ENST00000343505NKIRAS1chr3

23960903

-NHSL1chr6

138743836

+
intron-intronENST00000388759ENST00000479393NKIRAS1chr3

23960903

-NHSL1chr6

138743836

+
intron-3UTRENST00000443659ENST00000427025NKIRAS1chr3

23960903

-NHSL1chr6

138743836

+
intron-3UTRENST00000443659ENST00000343505NKIRAS1chr3

23960903

-NHSL1chr6

138743836

+
intron-intronENST00000443659ENST00000479393NKIRAS1chr3

23960903

-NHSL1chr6

138743836

+
intron-3UTRENST00000425478ENST00000427025NKIRAS1chr3

23960903

-NHSL1chr6

138743836

+
intron-3UTRENST00000425478ENST00000343505NKIRAS1chr3

23960903

-NHSL1chr6

138743836

+
intron-intronENST00000425478ENST00000479393NKIRAS1chr3

23960903

-NHSL1chr6

138743836

+
intron-3UTRENST00000437230ENST00000427025NKIRAS1chr3

23960903

-NHSL1chr6

138743836

+
intron-3UTRENST00000437230ENST00000343505NKIRAS1chr3

23960903

-NHSL1chr6

138743836

+
intron-intronENST00000437230ENST00000479393NKIRAS1chr3

23960903

-NHSL1chr6

138743836

+
intron-3UTRENST00000412028ENST00000427025NKIRAS1chr3

23960903

-NHSL1chr6

138743836

+
intron-3UTRENST00000412028ENST00000343505NKIRAS1chr3

23960903

-NHSL1chr6

138743836

+
intron-intronENST00000412028ENST00000479393NKIRAS1chr3

23960903

-NHSL1chr6

138743836

+
intron-3UTRENST00000415901ENST00000427025NKIRAS1chr3

23960903

-NHSL1chr6

138743836

+
intron-3UTRENST00000415901ENST00000343505NKIRAS1chr3

23960903

-NHSL1chr6

138743836

+
intron-intronENST00000415901ENST00000479393NKIRAS1chr3

23960903

-NHSL1chr6

138743836

+
intron-3UTRENST00000416026ENST00000427025NKIRAS1chr3

23960903

-NHSL1chr6

138743836

+
intron-3UTRENST00000416026ENST00000343505NKIRAS1chr3

23960903

-NHSL1chr6

138743836

+
intron-intronENST00000416026ENST00000479393NKIRAS1chr3

23960903

-NHSL1chr6

138743836

+

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FusionProtFeatures for NKIRAS1_NHSL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NKIRAS1

Q9NYS0

NHSL1

Q5SYE7

Atypical Ras-like protein that acts as a potentregulator of NF-kappa-B activity by preventing the degradation ofNF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining whyNFKBIB is more resistant to degradation. May act by blockingphosphorylation of NFKBIB and mediating cytoplasmic retention ofp65/RELA NF-kappa-B subunit. It is unclear whether it acts as aGTPase. Both GTP- and GDP-bound forms block phosphorylation ofNFKBIB. {ECO:0000269|PubMed:10657303, ECO:0000269|PubMed:12672800,ECO:0000269|PubMed:15024091}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NKIRAS1_NHSL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NKIRAS1_NHSL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NKIRAS1_NHSL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NKIRAS1_NHSL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource