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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24404

FusionGeneSummary for NISCH_CYHR1

check button Fusion gene summary
Fusion gene informationFusion gene name: NISCH_CYHR1
Fusion gene ID: 24404
HgeneTgene
Gene symbol

NISCH

CYHR1

Gene ID

11188

50626

Gene namenischarincysteine and histidine rich 1
SynonymsI-1|IR1|IRAS|hIRASCHRP
Cytomap

3p21.1

8q24.3

Type of geneprotein-codingprotein-coding
DescriptionnischarinI-1 receptor candidate proteinI1R candidate proteinimidazoline receptor 1imidazoline receptor antisera selectedcysteine and histidine-rich protein 1cysteine and histidine rich proteincysteine/histidine-rich 1
Modification date2018052320180519
UniProtAcc

Q9Y2I1

Q6ZMK1

Ensembl transtripts involved in fusion geneENST00000479054, ENST00000345716, 
ENST00000488380, ENST00000420808, 
ENST00000464280, 		ENST00000438911, 
ENST00000530374, ENST00000403000, 
ENST00000424149, ENST00000306145, 
Fusion gene scores* DoF score6 X 6 X 4=1445 X 4 X 4=80
# samples 65
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NISCH [Title/Abstract] AND CYHR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDGBMTCGA-14-0787-01ANISCHchr3

52504923

+CYHR1chr8

145690479

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000479054ENST00000438911NISCHchr3

52504923

+CYHR1chr8

145690479

-
5CDS-intronENST00000479054ENST00000530374NISCHchr3

52504923

+CYHR1chr8

145690479

-
5CDS-5UTRENST00000479054ENST00000403000NISCHchr3

52504923

+CYHR1chr8

145690479

-
5CDS-5UTRENST00000479054ENST00000424149NISCHchr3

52504923

+CYHR1chr8

145690479

-
5CDS-5UTRENST00000479054ENST00000306145NISCHchr3

52504923

+CYHR1chr8

145690479

-
5CDS-intronENST00000345716ENST00000438911NISCHchr3

52504923

+CYHR1chr8

145690479

-
5CDS-intronENST00000345716ENST00000530374NISCHchr3

52504923

+CYHR1chr8

145690479

-
5CDS-5UTRENST00000345716ENST00000403000NISCHchr3

52504923

+CYHR1chr8

145690479

-
5CDS-5UTRENST00000345716ENST00000424149NISCHchr3

52504923

+CYHR1chr8

145690479

-
5CDS-5UTRENST00000345716ENST00000306145NISCHchr3

52504923

+CYHR1chr8

145690479

-
5CDS-intronENST00000488380ENST00000438911NISCHchr3

52504923

+CYHR1chr8

145690479

-
5CDS-intronENST00000488380ENST00000530374NISCHchr3

52504923

+CYHR1chr8

145690479

-
5CDS-5UTRENST00000488380ENST00000403000NISCHchr3

52504923

+CYHR1chr8

145690479

-
5CDS-5UTRENST00000488380ENST00000424149NISCHchr3

52504923

+CYHR1chr8

145690479

-
5CDS-5UTRENST00000488380ENST00000306145NISCHchr3

52504923

+CYHR1chr8

145690479

-
5CDS-intronENST00000420808ENST00000438911NISCHchr3

52504923

+CYHR1chr8

145690479

-
5CDS-intronENST00000420808ENST00000530374NISCHchr3

52504923

+CYHR1chr8

145690479

-
5CDS-5UTRENST00000420808ENST00000403000NISCHchr3

52504923

+CYHR1chr8

145690479

-
5CDS-5UTRENST00000420808ENST00000424149NISCHchr3

52504923

+CYHR1chr8

145690479

-
5CDS-5UTRENST00000420808ENST00000306145NISCHchr3

52504923

+CYHR1chr8

145690479

-
intron-intronENST00000464280ENST00000438911NISCHchr3

52504923

+CYHR1chr8

145690479

-
intron-intronENST00000464280ENST00000530374NISCHchr3

52504923

+CYHR1chr8

145690479

-
intron-5UTRENST00000464280ENST00000403000NISCHchr3

52504923

+CYHR1chr8

145690479

-
intron-5UTRENST00000464280ENST00000424149NISCHchr3

52504923

+CYHR1chr8

145690479

-
intron-5UTRENST00000464280ENST00000306145NISCHchr3

52504923

+CYHR1chr8

145690479

-

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FusionProtFeatures for NISCH_CYHR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NISCH

Q9Y2I1

CYHR1

Q6ZMK1


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NISCH_CYHR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NISCH_CYHR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NISCHIRS4, IRS1, IRS2, CUL3, GRB2, LGR4, FOXH1, HAVCR2, PIK3R3, CNKSR3, UBE2M, CSNK1G2, ODAM, UNC119, MANSC1, KIAA0430, HELZ, PCGF5, SOWAHA, CTBP1, PAN2, EIF4ENIF1, KIAA1671, PIK3R1, CREBBP, ARID3A, PCGF3, ERF, POM121C, NUP50, UBE2ACYHR1ALDH3A1, MAPK9, APEH, CLINT1, DNM1L, H1FX, HIST1H1B, JMJD6, NMI, SEC24A, SHMT2, TOLLIP, VPS26A, VPS35, KPNA4, FAM189B, DEGS1, DNAJB2, EPN3, UBE2K, LITAF, SDC1, HAO2, RABGEF1, SLC45A2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NISCH_CYHR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneNISCHQ9Y2I1DB00697TizanidineNischarinsmall moleculeapproved|investigational
HgeneNISCHQ9Y2I1DB09242MoxonidineNischarinsmall moleculeapproved|investigational

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RelatedDiseases for NISCH_CYHR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNISCHC0020649Hypotension2CTD_human
HgeneNISCHC0428977Bradycardia1CTD_human