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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2440

FusionGeneSummary for ARHGAP32_LARP4

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP32_LARP4
Fusion gene ID: 2440
HgeneTgene
Gene symbol

ARHGAP32

LARP4

Gene ID

9743

113251

Gene nameRho GTPase activating protein 32La ribonucleoprotein domain family member 4
SynonymsGC-GAP|GRIT|PX-RICS|RICS|p200RhoGAP|p250GAPPP13296
Cytomap

11q24.3

12q13.12

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 32GAB-associated CDC42GAB-associated Cdc42/Rac GTPase-activating proteinGTPase regulator interacting with TrkAGTPase-activating protein for Cdc42 and Rac1RhoGAP involved in the -catenin-N-cadherin and NMDA receptor signala-related protein 4c-Mpl binding protein
Modification date2018052320180527
UniProtAcc

A7KAX9

Q71RC2

Ensembl transtripts involved in fusion geneENST00000310343, ENST00000524655, 
ENST00000392657, ENST00000527272, 
ENST00000293618, ENST00000429001, 
ENST00000398473, ENST00000518444, 
ENST00000347328, ENST00000522085, 
ENST00000518561, 
Fusion gene scores* DoF score9 X 7 X 4=2526 X 7 X 5=210
# samples 98
** MAII scorelog2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGAP32 [Title/Abstract] AND LARP4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP417572ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000310343ENST00000293618ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
intron-3CDSENST00000310343ENST00000429001ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
intron-3CDSENST00000310343ENST00000398473ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
intron-3CDSENST00000310343ENST00000518444ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
intron-3CDSENST00000310343ENST00000347328ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
intron-intronENST00000310343ENST00000522085ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
intron-intronENST00000310343ENST00000518561ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
intron-3CDSENST00000524655ENST00000293618ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
intron-3CDSENST00000524655ENST00000429001ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
intron-3CDSENST00000524655ENST00000398473ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
intron-3CDSENST00000524655ENST00000518444ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
intron-3CDSENST00000524655ENST00000347328ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
intron-intronENST00000524655ENST00000522085ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
intron-intronENST00000524655ENST00000518561ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
intron-3CDSENST00000392657ENST00000293618ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
intron-3CDSENST00000392657ENST00000429001ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
intron-3CDSENST00000392657ENST00000398473ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
intron-3CDSENST00000392657ENST00000518444ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
intron-3CDSENST00000392657ENST00000347328ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
intron-intronENST00000392657ENST00000522085ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
intron-intronENST00000392657ENST00000518561ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
intron-3CDSENST00000527272ENST00000293618ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
intron-3CDSENST00000527272ENST00000429001ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
intron-3CDSENST00000527272ENST00000398473ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
intron-3CDSENST00000527272ENST00000518444ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
intron-3CDSENST00000527272ENST00000347328ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
intron-intronENST00000527272ENST00000522085ARHGAP32chr11

129056163

+LARP4chr12

50867893

+
intron-intronENST00000527272ENST00000518561ARHGAP32chr11

129056163

+LARP4chr12

50867893

+

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FusionProtFeatures for ARHGAP32_LARP4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP32

A7KAX9

LARP4

Q71RC2

GTPase-activating protein (GAP) promoting GTP hydrolysison RHOA, CDC42 and RAC1 small GTPases. May be involved in thedifferentiation of neuronal cells during the formation of neuriteextensions. Involved in NMDA receptor activity-dependent actinreorganization in dendritic spines. May mediate cross-talksbetween Ras- and Rho-regulated signaling pathways in cell growthregulation. Isoform 2 has higher GAP activity (By similarity).{ECO:0000250, ECO:0000269|PubMed:12446789,ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901,ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203,ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. RNA binding protein that binds to the poly-A tract ofmRNA molecules (PubMed:21098120). Associates with the 40Sribosomal subunit and with polysomes (PubMed:21098120). Plays arole in the regulation of mRNA translation (PubMed:21098120).Plays a role in the regulation of cell morphology and cytoskeletalorganization (PubMed:21834987, PubMed:27615744).{ECO:0000269|PubMed:21098120, ECO:0000269|PubMed:21834987,ECO:0000269|PubMed:27615744}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARHGAP32_LARP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARHGAP32_LARP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARHGAP32_LARP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARHGAP32_LARP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARHGAP32C0036341Schizophrenia1PSYGENET
TgeneLARP4C0032460Polycystic Ovary Syndrome1CTD_human