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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 24380

FusionGeneSummary for NIPAL3_PPP4R1

check button Fusion gene summary
Fusion gene informationFusion gene name: NIPAL3_PPP4R1
Fusion gene ID: 24380
HgeneTgene
Gene symbol

NIPAL3

PPP4R1

Gene ID

57185

9989

Gene nameNIPA like domain containing 3protein phosphatase 4 regulatory subunit 1
SynonymsDJ462O23.2|NPAL3MEG1|PP4(Rmeg)|PP4R1
Cytomap

1p36.11

18p11.22

Type of geneprotein-codingprotein-coding
DescriptionNIPA-like protein 3serine/threonine-protein phosphatase 4 regulatory subunit 1serine/threonine phosphatase 4
Modification date2018052320180523
UniProtAcc

Q6P499

Q8TF05

Ensembl transtripts involved in fusion geneENST00000374399, ENST00000003912, 
ENST00000358028, ENST00000339255, 
ENST00000428131, ENST00000488155, 
ENST00000400556, ENST00000400555, 
ENST00000580583, 
Fusion gene scores* DoF score3 X 4 X 4=488 X 7 X 5=280
# samples 48
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NIPAL3 [Title/Abstract] AND PPP4R1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-XF-AAMY-01ANIPAL3chr1

24790610

+PPP4R1chr18

9547950

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000374399ENST00000400556NIPAL3chr1

24790610

+PPP4R1chr18

9547950

-
Frame-shiftENST00000374399ENST00000400555NIPAL3chr1

24790610

+PPP4R1chr18

9547950

-
5CDS-intronENST00000374399ENST00000580583NIPAL3chr1

24790610

+PPP4R1chr18

9547950

-
In-frameENST00000003912ENST00000400556NIPAL3chr1

24790610

+PPP4R1chr18

9547950

-
Frame-shiftENST00000003912ENST00000400555NIPAL3chr1

24790610

+PPP4R1chr18

9547950

-
5CDS-intronENST00000003912ENST00000580583NIPAL3chr1

24790610

+PPP4R1chr18

9547950

-
intron-3CDSENST00000358028ENST00000400556NIPAL3chr1

24790610

+PPP4R1chr18

9547950

-
intron-3CDSENST00000358028ENST00000400555NIPAL3chr1

24790610

+PPP4R1chr18

9547950

-
intron-intronENST00000358028ENST00000580583NIPAL3chr1

24790610

+PPP4R1chr18

9547950

-
In-frameENST00000339255ENST00000400556NIPAL3chr1

24790610

+PPP4R1chr18

9547950

-
Frame-shiftENST00000339255ENST00000400555NIPAL3chr1

24790610

+PPP4R1chr18

9547950

-
5CDS-intronENST00000339255ENST00000580583NIPAL3chr1

24790610

+PPP4R1chr18

9547950

-
intron-3CDSENST00000428131ENST00000400556NIPAL3chr1

24790610

+PPP4R1chr18

9547950

-
intron-3CDSENST00000428131ENST00000400555NIPAL3chr1

24790610

+PPP4R1chr18

9547950

-
intron-intronENST00000428131ENST00000580583NIPAL3chr1

24790610

+PPP4R1chr18

9547950

-
intron-3CDSENST00000488155ENST00000400556NIPAL3chr1

24790610

+PPP4R1chr18

9547950

-
intron-3CDSENST00000488155ENST00000400555NIPAL3chr1

24790610

+PPP4R1chr18

9547950

-
intron-intronENST00000488155ENST00000580583NIPAL3chr1

24790610

+PPP4R1chr18

9547950

-

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FusionProtFeatures for NIPAL3_PPP4R1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NIPAL3

Q6P499

PPP4R1

Q8TF05

Regulatory subunit of serine/threonine-proteinphosphatase 4. May play a role in regulation of cell division inrenal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role indephosphorylation and regulation of HDAC3.{ECO:0000269|PubMed:15805470}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000003912+121318_21258325Compositional biasNote=Poly-Ser
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000374399+111218_21340407Compositional biasNote=Poly-Ser
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000003912+1213101_121258325TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000003912+1213135_155258325TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000003912+1213171_191258325TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000003912+1213202_222258325TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000003912+1213240_260258325TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000003912+121333_53258325TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000003912+121376_96258325TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000374399+1112101_121340407TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000374399+1112135_155340407TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000374399+1112171_191340407TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000374399+1112202_222340407TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000374399+1112240_260340407TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000374399+1112271_291340407TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000374399+1112300_320340407TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000374399+111233_53340407TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000374399+111276_96340407TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000358028+1818_21-117227Compositional biasNote=Poly-Ser
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000428131+1718_210227Compositional biasNote=Poly-Ser
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000003912+1213271_291258325TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000003912+1213300_320258325TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000358028+18101_121-117227TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000358028+18135_155-117227TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000358028+18171_191-117227TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000358028+18202_222-117227TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000358028+18240_260-117227TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000358028+18271_291-117227TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000358028+18300_320-117227TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000358028+1833_53-117227TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000358028+1876_96-117227TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000428131+17101_1210227TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000428131+17135_1550227TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000428131+17171_1910227TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000428131+17202_2220227TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000428131+17240_2600227TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000428131+17271_2910227TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000428131+17300_3200227TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000428131+1733_530227TransmembraneHelical
HgeneNIPAL3chr1:24790610chr18:9547950ENST00000428131+1776_960227TransmembraneHelical
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400555-1820127_164879934RepeatNote=HEAT 5
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400555-1820168_206879934RepeatNote=HEAT 6
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400555-18201_25879934RepeatNote=HEAT 1
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400555-1820208_246879934RepeatNote=HEAT 7
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400555-1820248_285879934RepeatNote=HEAT 8
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400555-182026_63879934RepeatNote=HEAT 2
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400555-1820287_324879934RepeatNote=HEAT 9
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400555-1820505_542879934RepeatNote=HEAT 10
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400555-1820568_606879934RepeatNote=HEAT 11
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400555-182065_81879934RepeatNote=HEAT 3
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400555-1820698_734879934RepeatNote=HEAT 12
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400555-1820799_837879934RepeatNote=HEAT 13
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400555-182082_119879934RepeatNote=HEAT 4
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400555-1820861_898879934RepeatNote=HEAT 14
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400556-1820127_164896951RepeatNote=HEAT 5
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400556-1820168_206896951RepeatNote=HEAT 6
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400556-18201_25896951RepeatNote=HEAT 1
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400556-1820208_246896951RepeatNote=HEAT 7
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400556-1820248_285896951RepeatNote=HEAT 8
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400556-182026_63896951RepeatNote=HEAT 2
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400556-1820287_324896951RepeatNote=HEAT 9
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400556-1820505_542896951RepeatNote=HEAT 10
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400556-1820568_606896951RepeatNote=HEAT 11
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400556-182065_81896951RepeatNote=HEAT 3
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400556-1820698_734896951RepeatNote=HEAT 12
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400556-1820799_837896951RepeatNote=HEAT 13
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400556-182082_119896951RepeatNote=HEAT 4
TgenePPP4R1chr1:24790610chr18:9547950ENST00000400556-1820861_898896951RepeatNote=HEAT 14


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FusionGeneSequence for NIPAL3_PPP4R1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NIPAL3_ENST00000374399_chr1_24790610_+_PPP4R1_ENST00000400556_chr18_9547950_-_395aa
MDGSHSAALKLQQLPPTSSSSAVSEASFSYKENLIGALLAIFGHLVVSIALNLQKYCHIRLAGSKDPRAYFKTKTWWLGLFLMLLGELGV
FASYAFAPLSLIVPLSAVSVIASAIIGIIFIKEKWKPKDFLRRYVLSFVGCGLAVVGTYLLVTFAPNSHEKMTGENVTRHLVSWPFLLYM
LVEIILFCLLLYFYKEKNANNIVVILLLVALLGSMTVVTVKAVAGMLVLSIQGNLQLDYPIFYVMFVCMVATAVYQAAFLSQASQMYDSS
LIASVGYILSTTIAITAGAIFYLDFIGEDVLHICMFALGCLIAFLGVFLITRNRKKPIPFEPYISMDAMPDYFLASASCHQEAVEQTIMA

>In-frame_NIPAL3_ENST00000003912_chr1_24790610_+_PPP4R1_ENST00000400556_chr18_9547950_-_313aa
MLLGELGVFASYAFAPLSLIVPLSAVSVIASAIIGIIFIKEKWKPKDFLRRYVLSFVGCGLAVVGTYLLVTFAPNSHEKMTGENVTRHLV
SWPFLLYMLVEIILFCLLLYFYKEKNANNIVVILLLVALLGSMTVVTVKAVAGMLVLSIQGNLQLDYPIFYVMFVCMVATAVYQAAFLSQ
ASQMYDSSLIASVGYILSTTIAITAGAIFYLDFIGEDVLHICMFALGCLIAFLGVFLITRNRKKPIPFEPYISMDAMPDYFLASASCHQE

>In-frame_NIPAL3_ENST00000339255_chr1_24790610_+_PPP4R1_ENST00000400556_chr18_9547950_-_395aa
MDGSHSAALKLQQLPPTSSSSAVSEASFSYKENLIGALLAIFGHLVVSIALNLQKYCHIRLAGSKDPRAYFKTKTWWLGLFLMLLGELGV
FASYAFAPLSLIVPLSAVSVIASAIIGIIFIKEKWKPKDFLRRYVLSFVGCGLAVVGTYLLVTFAPNSHEKMTGENVTRHLVSWPFLLYM
LVEIILFCLLLYFYKEKNANNIVVILLLVALLGSMTVVTVKAVAGMLVLSIQGNLQLDYPIFYVMFVCMVATAVYQAAFLSQASQMYDSS
LIASVGYILSTTIAITAGAIFYLDFIGEDVLHICMFALGCLIAFLGVFLITRNRKKPIPFEPYISMDAMPDYFLASASCHQEAVEQTIMA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NIPAL3_ENST00000374399_chr1_24790610_+_PPP4R1_ENST00000400556_chr18_9547950_-_1185nt
ATGGACGGATCCCACAGCGCAGCCCTGAAGCTGCAGCAGCTGCCTCCCACAAGTAGCTCCAGCGCCGTAAGCGAGGCCTCCTTCTCCTAC
AAGGAAAACCTGATTGGCGCCCTCTTGGCGATCTTCGGGCACCTCGTGGTCAGCATTGCACTTAACCTCCAGAAGTACTGCCACATCCGC
CTGGCAGGCTCCAAGGATCCCCGGGCCTATTTCAAGACCAAGACATGGTGGCTGGGCCTGTTCCTGATGCTTCTGGGCGAGCTGGGTGTG
TTCGCCTCCTACGCCTTCGCGCCGCTGTCACTCATCGTGCCCCTCAGCGCAGTTTCTGTGATAGCTAGTGCCATCATAGGAATCATATTC
ATCAAGGAAAAGTGGAAACCGAAAGACTTTCTGAGGCGCTACGTCTTGTCCTTTGTTGGCTGCGGTTTGGCTGTCGTGGGTACCTACCTG
CTGGTGACATTCGCACCCAACAGTCACGAGAAGATGACAGGCGAGAATGTCACCAGGCACCTCGTGAGCTGGCCTTTCCTTTTGTACATG
CTGGTGGAGATCATTCTGTTCTGCTTGCTGCTCTACTTCTACAAGGAGAAGAACGCCAACAACATTGTCGTGATTCTTCTCTTGGTGGCG
TTACTTGGCTCCATGACAGTGGTGACAGTCAAGGCCGTGGCTGGGATGCTTGTCTTGTCCATTCAAGGGAACCTGCAGCTTGACTACCCC
ATCTTCTACGTGATGTTCGTGTGCATGGTGGCAACCGCCGTCTATCAGGCTGCGTTTTTGAGTCAAGCCTCACAGATGTACGACTCCTCT
TTGATTGCCAGTGTGGGCTACATTCTGTCCACAACCATTGCTATCACAGCAGGTGCAATATTTTACCTGGACTTCATCGGGGAGGACGTG
CTGCACATCTGCATGTTTGCACTGGGGTGCCTCATTGCATTCTTGGGCGTCTTCTTAATCACGCGTAACAGGAAGAAGCCCATTCCATTT
GAGCCCTATATTTCCATGGATGCCATGCCAGACTATTTCTTGGCCTCTGCCAGCTGCCACCAGGAGGCTGTGGAGCAGACCATCATGGCT
CTTCAGATGGACCGTGACAGCGATGTCAAGTATTTTGCAAGCATCCACCCTGCCAGTACCAAAATCTCCGAAGATGCCATGAGCACAGCG

>In-frame_NIPAL3_ENST00000003912_chr1_24790610_+_PPP4R1_ENST00000400556_chr18_9547950_-_939nt
ATGCTTCTGGGCGAGCTGGGTGTGTTCGCCTCCTACGCCTTCGCGCCGCTGTCACTCATCGTGCCCCTCAGCGCAGTTTCTGTGATAGCT
AGTGCCATCATAGGAATCATATTCATCAAGGAAAAGTGGAAACCGAAAGACTTTCTGAGGCGCTACGTCTTGTCCTTTGTTGGCTGCGGT
TTGGCTGTCGTGGGTACCTACCTGCTGGTGACATTCGCACCCAACAGTCACGAGAAGATGACAGGCGAGAATGTCACCAGGCACCTCGTG
AGCTGGCCTTTCCTTTTGTACATGCTGGTGGAGATCATTCTGTTCTGCTTGCTGCTCTACTTCTACAAGGAGAAGAACGCCAACAACATT
GTCGTGATTCTTCTCTTGGTGGCGTTACTTGGCTCCATGACAGTGGTGACAGTCAAGGCCGTGGCTGGGATGCTTGTCTTGTCCATTCAA
GGGAACCTGCAGCTTGACTACCCCATCTTCTACGTGATGTTCGTGTGCATGGTGGCAACCGCCGTCTATCAGGCTGCGTTTTTGAGTCAA
GCCTCACAGATGTACGACTCCTCTTTGATTGCCAGTGTGGGCTACATTCTGTCCACAACCATTGCTATCACAGCAGGTGCAATATTTTAC
CTGGACTTCATCGGGGAGGACGTGCTGCACATCTGCATGTTTGCACTGGGGTGCCTCATTGCATTCTTGGGCGTCTTCTTAATCACGCGT
AACAGGAAGAAGCCCATTCCATTTGAGCCCTATATTTCCATGGATGCCATGCCAGACTATTTCTTGGCCTCTGCCAGCTGCCACCAGGAG
GCTGTGGAGCAGACCATCATGGCTCTTCAGATGGACCGTGACAGCGATGTCAAGTATTTTGCAAGCATCCACCCTGCCAGTACCAAAATC

>In-frame_NIPAL3_ENST00000339255_chr1_24790610_+_PPP4R1_ENST00000400556_chr18_9547950_-_1185nt
ATGGACGGATCCCACAGCGCAGCCCTGAAGCTGCAGCAGCTGCCTCCCACAAGTAGCTCCAGCGCCGTAAGCGAGGCCTCCTTCTCCTAC
AAGGAAAACCTGATTGGCGCCCTCTTGGCGATCTTCGGGCACCTCGTGGTCAGCATTGCACTTAACCTCCAGAAGTACTGCCACATCCGC
CTGGCAGGCTCCAAGGATCCCCGGGCCTATTTCAAGACCAAGACATGGTGGCTGGGCCTGTTCCTGATGCTTCTGGGCGAGCTGGGTGTG
TTCGCCTCCTACGCCTTCGCGCCGCTGTCACTCATCGTGCCCCTCAGCGCAGTTTCTGTGATAGCTAGTGCCATCATAGGAATCATATTC
ATCAAGGAAAAGTGGAAACCGAAAGACTTTCTGAGGCGCTACGTCTTGTCCTTTGTTGGCTGCGGTTTGGCTGTCGTGGGTACCTACCTG
CTGGTGACATTCGCACCCAACAGTCACGAGAAGATGACAGGCGAGAATGTCACCAGGCACCTCGTGAGCTGGCCTTTCCTTTTGTACATG
CTGGTGGAGATCATTCTGTTCTGCTTGCTGCTCTACTTCTACAAGGAGAAGAACGCCAACAACATTGTCGTGATTCTTCTCTTGGTGGCG
TTACTTGGCTCCATGACAGTGGTGACAGTCAAGGCCGTGGCTGGGATGCTTGTCTTGTCCATTCAAGGGAACCTGCAGCTTGACTACCCC
ATCTTCTACGTGATGTTCGTGTGCATGGTGGCAACCGCCGTCTATCAGGCTGCGTTTTTGAGTCAAGCCTCACAGATGTACGACTCCTCT
TTGATTGCCAGTGTGGGCTACATTCTGTCCACAACCATTGCTATCACAGCAGGTGCAATATTTTACCTGGACTTCATCGGGGAGGACGTG
CTGCACATCTGCATGTTTGCACTGGGGTGCCTCATTGCATTCTTGGGCGTCTTCTTAATCACGCGTAACAGGAAGAAGCCCATTCCATTT
GAGCCCTATATTTCCATGGATGCCATGCCAGACTATTTCTTGGCCTCTGCCAGCTGCCACCAGGAGGCTGTGGAGCAGACCATCATGGCT
CTTCAGATGGACCGTGACAGCGATGTCAAGTATTTTGCAAGCATCCACCCTGCCAGTACCAAAATCTCCGAAGATGCCATGAGCACAGCG


* Fusion transcript sequences (Full-length transcript).
>In-frame_NIPAL3_ENST00000374399_chr1_24790610_+_PPP4R1_ENST00000400556_chr18_9547950_-_2551nt
GCAGCTCTGAATTGGGAAGGGATGAAGGAGGCTGTGCCTCCGGGTTGCACGAAGAGTCCGAGTCATTTCTCAGAAGGTTTTGATAGGTGG
GCCTTAGAGGAGACGCCGCCGAGCACCGCAAGAACTGGAAAACACACCCCTCTCTGTCTGCCTGGGAGAGCCACGGAAATTGGCACTTCT
CTGAGTGAAGCTGAGGAGAAGGCTGTAAATCTGCCAAAACAGCCTTGAAGTATTCTTTTGTCATGAGGAAGTGACGGCTGCTGGAGGGAG
GTGAACACCACAAGGAGAGATGGCATCTGGCCTGGGCCCCGCCTAGCAGCAGCTCCACCTCCTAGGCCAGGCCCTGTGGGATGCGCCACT
AGACCACCATGGACGGATCCCACAGCGCAGCCCTGAAGCTGCAGCAGCTGCCTCCCACAAGTAGCTCCAGCGCCGTAAGCGAGGCCTCCT
TCTCCTACAAGGAAAACCTGATTGGCGCCCTCTTGGCGATCTTCGGGCACCTCGTGGTCAGCATTGCACTTAACCTCCAGAAGTACTGCC
ACATCCGCCTGGCAGGCTCCAAGGATCCCCGGGCCTATTTCAAGACCAAGACATGGTGGCTGGGCCTGTTCCTGATGCTTCTGGGCGAGC
TGGGTGTGTTCGCCTCCTACGCCTTCGCGCCGCTGTCACTCATCGTGCCCCTCAGCGCAGTTTCTGTGATAGCTAGTGCCATCATAGGAA
TCATATTCATCAAGGAAAAGTGGAAACCGAAAGACTTTCTGAGGCGCTACGTCTTGTCCTTTGTTGGCTGCGGTTTGGCTGTCGTGGGTA
CCTACCTGCTGGTGACATTCGCACCCAACAGTCACGAGAAGATGACAGGCGAGAATGTCACCAGGCACCTCGTGAGCTGGCCTTTCCTTT
TGTACATGCTGGTGGAGATCATTCTGTTCTGCTTGCTGCTCTACTTCTACAAGGAGAAGAACGCCAACAACATTGTCGTGATTCTTCTCT
TGGTGGCGTTACTTGGCTCCATGACAGTGGTGACAGTCAAGGCCGTGGCTGGGATGCTTGTCTTGTCCATTCAAGGGAACCTGCAGCTTG
ACTACCCCATCTTCTACGTGATGTTCGTGTGCATGGTGGCAACCGCCGTCTATCAGGCTGCGTTTTTGAGTCAAGCCTCACAGATGTACG
ACTCCTCTTTGATTGCCAGTGTGGGCTACATTCTGTCCACAACCATTGCTATCACAGCAGGTGCAATATTTTACCTGGACTTCATCGGGG
AGGACGTGCTGCACATCTGCATGTTTGCACTGGGGTGCCTCATTGCATTCTTGGGCGTCTTCTTAATCACGCGTAACAGGAAGAAGCCCA
TTCCATTTGAGCCCTATATTTCCATGGATGCCATGCCAGACTATTTCTTGGCCTCTGCCAGCTGCCACCAGGAGGCTGTGGAGCAGACCA
TCATGGCTCTTCAGATGGACCGTGACAGCGATGTCAAGTATTTTGCAAGCATCCACCCTGCCAGTACCAAAATCTCCGAAGATGCCATGA
GCACAGCGTCCTCAACCTACTAGAAGGCTTGAATCTCGGTGTCTTTCCTGCTTCCATGAGAGCCGAGGTTCAGTGGGCATTCGCCACGCA
TGTGACCTGGGATAGCTTTCGGGGGAGGAGAGACCTTCCTCTCCTGCGGACTTCATTGCAGGTGCAAGTTGCCTACACCCAATACCAGGG
ATTTCAAGAGTCAAGAGAAAGTACAGTAAACACTATTATCTTATCTTGACTTTAAGGGGAAATAATTTCTCAGAGGATTATAATTGTCAC
CGAAGCCTTAAATCCTTCTGTCTTCCTGACTGAATGAAACTTGAATTGGCAGAGCATTTTCCTTATGGAAGGGATGAGATTCCCAGAGAC
CTGCATTGCTTTCTCCTGGTTTTATTTAACAATCGACAAATGAAATTCTTACAGCCTGAAGGCAGACGTGTGCCCAGATGTGAAAGAGAC
CTTCAGTATCAGCCCTAACTCTTCTCTCCCAGGAAGGACTTGCTGGGCTCTGTGGCCAGCTGTCCAGCCCAGCCCTGTGTGTGAATCGTT
TGTGACGTGTGCAAATGGGAAAGGAGGGGTTTTTACATCTCCTAAAGGACCTGATGCCAACACAAGTAGGATTGACTTAAACTCTTAAGC
GCAGCATATTGCTGTACACATTTACAGAATGGTTGCTGAGTGTCTGTGTCTGATTTTTTCATGCTGGTCATGACCTGAAGGAAATTTATT
AGACGTATAATGTATGTCTGGTGTTTTTAACTTGATCATGATCAGCTCTGAGGTGCAACTTCTTCACATACTGTACATACCTGTGACCAC
TCTTGGGAGTGCTGCAGTCTTTAATCATGCTGTTTAAACTGTTGTGGCACAAGTTCTCTTGTCCAAATAAAATTTATTAATAAGATCTAT
AGAGAGAGATATATACACTTTTGATTGTTTTCTAGATGTCTACCAATAAATGCAATTTGTGACCTGTATTAATGATTTAAAGTGGGGAAA

>In-frame_NIPAL3_ENST00000003912_chr1_24790610_+_PPP4R1_ENST00000400556_chr18_9547950_-_2652nt
AATTGGGAAGGGATGAAGGAGGCTGTGCCTCCGGGTTGCACGAAGAGTCCGAGTCATTTCTCAGAAGGTTTTGATAGGTGGGCCTTAGAG
GAGACGCCGCCGAGCACCGCAAGAACTGGAAAACACACCCCTCTCTGTCTGCCTGGGAGAGCCACGGAAATTGGCACTTCTCTGAGTGAA
GCTGAGGAGAAGGCTGTAAATCTGCCAAAACAGCCTTGAAGTATTCTTTTGTCATGAGGAAGTGACGGCTGCTGGAGGGAGGTGAACACC
ACAAGGAGAGATGGCATCTGGCCTGGGCCCCGCCTAGCAGCAGCTCCACCTCCTAGGCCAGGCCCTGTGGGATGCGCCACTAGACCACCA
TGGACGGATCCCACAGCGCAGCCCTGAAGCTGCAGCAGCTGCCTCCCACAAGTAGCTCCAGCGCCGTAAGCGAGGCCTCCTTCTCCTACA
AGCTGCCCTGAGGAGTAAGTACCGTTAATAACTCCATTTTACAGTTGAGGAAACAAATGCCCAAAGATATGTCCGAGTCACAGTGTCATG
AAGGACAGAGGCTGGATTCAAGGAAAACCTGATTGGCGCCCTCTTGGCGATCTTCGGGCACCTCGTGGTCAGCATTGCACTTAACCTCCA
GAAGTACTGCCACATCCGCCTGGCAGGCTCCAAGGATCCCCGGGCCTATTTCAAGACCAAGACATGGTGGCTGGGCCTGTTCCTGATGCT
TCTGGGCGAGCTGGGTGTGTTCGCCTCCTACGCCTTCGCGCCGCTGTCACTCATCGTGCCCCTCAGCGCAGTTTCTGTGATAGCTAGTGC
CATCATAGGAATCATATTCATCAAGGAAAAGTGGAAACCGAAAGACTTTCTGAGGCGCTACGTCTTGTCCTTTGTTGGCTGCGGTTTGGC
TGTCGTGGGTACCTACCTGCTGGTGACATTCGCACCCAACAGTCACGAGAAGATGACAGGCGAGAATGTCACCAGGCACCTCGTGAGCTG
GCCTTTCCTTTTGTACATGCTGGTGGAGATCATTCTGTTCTGCTTGCTGCTCTACTTCTACAAGGAGAAGAACGCCAACAACATTGTCGT
GATTCTTCTCTTGGTGGCGTTACTTGGCTCCATGACAGTGGTGACAGTCAAGGCCGTGGCTGGGATGCTTGTCTTGTCCATTCAAGGGAA
CCTGCAGCTTGACTACCCCATCTTCTACGTGATGTTCGTGTGCATGGTGGCAACCGCCGTCTATCAGGCTGCGTTTTTGAGTCAAGCCTC
ACAGATGTACGACTCCTCTTTGATTGCCAGTGTGGGCTACATTCTGTCCACAACCATTGCTATCACAGCAGGTGCAATATTTTACCTGGA
CTTCATCGGGGAGGACGTGCTGCACATCTGCATGTTTGCACTGGGGTGCCTCATTGCATTCTTGGGCGTCTTCTTAATCACGCGTAACAG
GAAGAAGCCCATTCCATTTGAGCCCTATATTTCCATGGATGCCATGCCAGACTATTTCTTGGCCTCTGCCAGCTGCCACCAGGAGGCTGT
GGAGCAGACCATCATGGCTCTTCAGATGGACCGTGACAGCGATGTCAAGTATTTTGCAAGCATCCACCCTGCCAGTACCAAAATCTCCGA
AGATGCCATGAGCACAGCGTCCTCAACCTACTAGAAGGCTTGAATCTCGGTGTCTTTCCTGCTTCCATGAGAGCCGAGGTTCAGTGGGCA
TTCGCCACGCATGTGACCTGGGATAGCTTTCGGGGGAGGAGAGACCTTCCTCTCCTGCGGACTTCATTGCAGGTGCAAGTTGCCTACACC
CAATACCAGGGATTTCAAGAGTCAAGAGAAAGTACAGTAAACACTATTATCTTATCTTGACTTTAAGGGGAAATAATTTCTCAGAGGATT
ATAATTGTCACCGAAGCCTTAAATCCTTCTGTCTTCCTGACTGAATGAAACTTGAATTGGCAGAGCATTTTCCTTATGGAAGGGATGAGA
TTCCCAGAGACCTGCATTGCTTTCTCCTGGTTTTATTTAACAATCGACAAATGAAATTCTTACAGCCTGAAGGCAGACGTGTGCCCAGAT
GTGAAAGAGACCTTCAGTATCAGCCCTAACTCTTCTCTCCCAGGAAGGACTTGCTGGGCTCTGTGGCCAGCTGTCCAGCCCAGCCCTGTG
TGTGAATCGTTTGTGACGTGTGCAAATGGGAAAGGAGGGGTTTTTACATCTCCTAAAGGACCTGATGCCAACACAAGTAGGATTGACTTA
AACTCTTAAGCGCAGCATATTGCTGTACACATTTACAGAATGGTTGCTGAGTGTCTGTGTCTGATTTTTTCATGCTGGTCATGACCTGAA
GGAAATTTATTAGACGTATAATGTATGTCTGGTGTTTTTAACTTGATCATGATCAGCTCTGAGGTGCAACTTCTTCACATACTGTACATA
CCTGTGACCACTCTTGGGAGTGCTGCAGTCTTTAATCATGCTGTTTAAACTGTTGTGGCACAAGTTCTCTTGTCCAAATAAAATTTATTA
ATAAGATCTATAGAGAGAGATATATACACTTTTGATTGTTTTCTAGATGTCTACCAATAAATGCAATTTGTGACCTGTATTAATGATTTA

>In-frame_NIPAL3_ENST00000339255_chr1_24790610_+_PPP4R1_ENST00000400556_chr18_9547950_-_2531nt
GATGAAGGAGGCTGTGCCTCCGGGTTGCACGAAGAGTCCGAGTCATTTCTCAGAAGGTTTTGATAGGTGGGCCTTAGAGGAGACGCCGCC
GAGCACCGCAAGAACTGGAAAACACACCCCTCTCTGTCTGCCTGGGAGAGCCACGGAAATTGGCACTTCTCTGAGTGAAGCTGAGGAGAA
GGCTGTAAATCTGCCAAAACAGCCTTGAAGTATTCTTTTGTCATGAGGAAGTGACGGCTGCTGGAGGGAGGTGAACACCACAAGGAGAGA
TGGCATCTGGCCTGGGCCCCGCCTAGCAGCAGCTCCACCTCCTAGGCCAGGCCCTGTGGGATGCGCCACTAGACCACCATGGACGGATCC
CACAGCGCAGCCCTGAAGCTGCAGCAGCTGCCTCCCACAAGTAGCTCCAGCGCCGTAAGCGAGGCCTCCTTCTCCTACAAGGAAAACCTG
ATTGGCGCCCTCTTGGCGATCTTCGGGCACCTCGTGGTCAGCATTGCACTTAACCTCCAGAAGTACTGCCACATCCGCCTGGCAGGCTCC
AAGGATCCCCGGGCCTATTTCAAGACCAAGACATGGTGGCTGGGCCTGTTCCTGATGCTTCTGGGCGAGCTGGGTGTGTTCGCCTCCTAC
GCCTTCGCGCCGCTGTCACTCATCGTGCCCCTCAGCGCAGTTTCTGTGATAGCTAGTGCCATCATAGGAATCATATTCATCAAGGAAAAG
TGGAAACCGAAAGACTTTCTGAGGCGCTACGTCTTGTCCTTTGTTGGCTGCGGTTTGGCTGTCGTGGGTACCTACCTGCTGGTGACATTC
GCACCCAACAGTCACGAGAAGATGACAGGCGAGAATGTCACCAGGCACCTCGTGAGCTGGCCTTTCCTTTTGTACATGCTGGTGGAGATC
ATTCTGTTCTGCTTGCTGCTCTACTTCTACAAGGAGAAGAACGCCAACAACATTGTCGTGATTCTTCTCTTGGTGGCGTTACTTGGCTCC
ATGACAGTGGTGACAGTCAAGGCCGTGGCTGGGATGCTTGTCTTGTCCATTCAAGGGAACCTGCAGCTTGACTACCCCATCTTCTACGTG
ATGTTCGTGTGCATGGTGGCAACCGCCGTCTATCAGGCTGCGTTTTTGAGTCAAGCCTCACAGATGTACGACTCCTCTTTGATTGCCAGT
GTGGGCTACATTCTGTCCACAACCATTGCTATCACAGCAGGTGCAATATTTTACCTGGACTTCATCGGGGAGGACGTGCTGCACATCTGC
ATGTTTGCACTGGGGTGCCTCATTGCATTCTTGGGCGTCTTCTTAATCACGCGTAACAGGAAGAAGCCCATTCCATTTGAGCCCTATATT
TCCATGGATGCCATGCCAGACTATTTCTTGGCCTCTGCCAGCTGCCACCAGGAGGCTGTGGAGCAGACCATCATGGCTCTTCAGATGGAC
CGTGACAGCGATGTCAAGTATTTTGCAAGCATCCACCCTGCCAGTACCAAAATCTCCGAAGATGCCATGAGCACAGCGTCCTCAACCTAC
TAGAAGGCTTGAATCTCGGTGTCTTTCCTGCTTCCATGAGAGCCGAGGTTCAGTGGGCATTCGCCACGCATGTGACCTGGGATAGCTTTC
GGGGGAGGAGAGACCTTCCTCTCCTGCGGACTTCATTGCAGGTGCAAGTTGCCTACACCCAATACCAGGGATTTCAAGAGTCAAGAGAAA
GTACAGTAAACACTATTATCTTATCTTGACTTTAAGGGGAAATAATTTCTCAGAGGATTATAATTGTCACCGAAGCCTTAAATCCTTCTG
TCTTCCTGACTGAATGAAACTTGAATTGGCAGAGCATTTTCCTTATGGAAGGGATGAGATTCCCAGAGACCTGCATTGCTTTCTCCTGGT
TTTATTTAACAATCGACAAATGAAATTCTTACAGCCTGAAGGCAGACGTGTGCCCAGATGTGAAAGAGACCTTCAGTATCAGCCCTAACT
CTTCTCTCCCAGGAAGGACTTGCTGGGCTCTGTGGCCAGCTGTCCAGCCCAGCCCTGTGTGTGAATCGTTTGTGACGTGTGCAAATGGGA
AAGGAGGGGTTTTTACATCTCCTAAAGGACCTGATGCCAACACAAGTAGGATTGACTTAAACTCTTAAGCGCAGCATATTGCTGTACACA
TTTACAGAATGGTTGCTGAGTGTCTGTGTCTGATTTTTTCATGCTGGTCATGACCTGAAGGAAATTTATTAGACGTATAATGTATGTCTG
GTGTTTTTAACTTGATCATGATCAGCTCTGAGGTGCAACTTCTTCACATACTGTACATACCTGTGACCACTCTTGGGAGTGCTGCAGTCT
TTAATCATGCTGTTTAAACTGTTGTGGCACAAGTTCTCTTGTCCAAATAAAATTTATTAATAAGATCTATAGAGAGAGATATATACACTT
TTGATTGTTTTCTAGATGTCTACCAATAAATGCAATTTGTGACCTGTATTAATGATTTAAAGTGGGGAAACTAGATTAAAATATTTGTCT


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FusionGenePPI for NIPAL3_PPP4R1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NIPAL3ELAVL1, EDA, VPS45, LMNAPPP4R1PPP4C, DISC1, CEP63, MAP4, EHBP1L1, GPHN, HNRNPR, MTA2, POLR2A, POLR2C, SPTAN1, TRAF2, TRAF6, PPP2CB, PMPCB, AQR, NTRK1, XPO1, CTNND1, LDHB, NDUFB4, PPP2CA, PPP2R1A, PPP2R1B, CCDC6, MAP7, MED24, SEC61A1, FASTKD5, RALBP1, C1S, KIF1B, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NIPAL3_PPP4R1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NIPAL3_PPP4R1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNIPAL3C0033578Prostatic Neoplasms1CTD_human