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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24371

FusionGeneSummary for NIN_TPM1

check button Fusion gene summary
Fusion gene informationFusion gene name: NIN_TPM1
Fusion gene ID: 24371
HgeneTgene
Gene symbol

NIN

TPM1

Gene ID

51199

7168

Gene namenineintropomyosin 1
SynonymsSCKL7C15orf13|CMD1Y|CMH3|HEL-S-265|HTM-alpha|LVNC9|TMSA
Cytomap

14q22.1

15q22.2

Type of geneprotein-codingprotein-coding
Descriptionnineinglycogen synthase kinase 3 beta-interacting proteinhNineinninein (GSK3B interacting protein)ninein centrosomal proteintropomyosin alpha-1 chainalpha-tropomyosincardiomyopathy, hypertrophic 3epididymis secretory protein Li 265sarcomeric tropomyosin kappatropomyosin 1 (alpha)
Modification date2018052320180523
UniProtAcc

Q8N4C6

P09493

Ensembl transtripts involved in fusion geneENST00000245441, ENST00000389868, 
ENST00000530997, ENST00000382043, 
ENST00000382041, ENST00000324330, 
ENST00000453196, ENST00000486200, 
ENST00000288398, ENST00000358278, 
ENST00000560445, ENST00000403994, 
ENST00000357980, ENST00000559556, 
ENST00000559397, ENST00000267996, 
ENST00000334895, ENST00000404484, 
ENST00000560959, ENST00000559281, 
ENST00000317516, 
Fusion gene scores* DoF score9 X 9 X 5=4056 X 6 X 4=144
# samples 107
** MAII scorelog2(10/405*10)=-2.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NIN [Title/Abstract] AND TPM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-CC-5263-01ANINchr14

51297182

-TPM1chr15

63349184

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000245441ENST00000288398NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-3CDSENST00000245441ENST00000358278NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000245441ENST00000560445NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000245441ENST00000403994NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000245441ENST00000357980NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000245441ENST00000559556NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000245441ENST00000559397NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000245441ENST00000267996NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000245441ENST00000334895NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000245441ENST00000404484NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000245441ENST00000560959NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000245441ENST00000559281NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000245441ENST00000317516NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-3CDSENST00000389868ENST00000288398NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-3CDSENST00000389868ENST00000358278NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000389868ENST00000560445NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000389868ENST00000403994NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000389868ENST00000357980NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000389868ENST00000559556NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000389868ENST00000559397NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000389868ENST00000267996NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000389868ENST00000334895NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000389868ENST00000404484NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000389868ENST00000560959NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000389868ENST00000559281NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000389868ENST00000317516NINchr14

51297182

-TPM1chr15

63349184

+
intron-3CDSENST00000530997ENST00000288398NINchr14

51297182

-TPM1chr15

63349184

+
intron-3CDSENST00000530997ENST00000358278NINchr14

51297182

-TPM1chr15

63349184

+
intron-intronENST00000530997ENST00000560445NINchr14

51297182

-TPM1chr15

63349184

+
intron-intronENST00000530997ENST00000403994NINchr14

51297182

-TPM1chr15

63349184

+
intron-intronENST00000530997ENST00000357980NINchr14

51297182

-TPM1chr15

63349184

+
intron-intronENST00000530997ENST00000559556NINchr14

51297182

-TPM1chr15

63349184

+
intron-intronENST00000530997ENST00000559397NINchr14

51297182

-TPM1chr15

63349184

+
intron-intronENST00000530997ENST00000267996NINchr14

51297182

-TPM1chr15

63349184

+
intron-intronENST00000530997ENST00000334895NINchr14

51297182

-TPM1chr15

63349184

+
intron-intronENST00000530997ENST00000404484NINchr14

51297182

-TPM1chr15

63349184

+
intron-intronENST00000530997ENST00000560959NINchr14

51297182

-TPM1chr15

63349184

+
intron-intronENST00000530997ENST00000559281NINchr14

51297182

-TPM1chr15

63349184

+
intron-intronENST00000530997ENST00000317516NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-3CDSENST00000382043ENST00000288398NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-3CDSENST00000382043ENST00000358278NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000382043ENST00000560445NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000382043ENST00000403994NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000382043ENST00000357980NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000382043ENST00000559556NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000382043ENST00000559397NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000382043ENST00000267996NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000382043ENST00000334895NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000382043ENST00000404484NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000382043ENST00000560959NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000382043ENST00000559281NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000382043ENST00000317516NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-3CDSENST00000382041ENST00000288398NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-3CDSENST00000382041ENST00000358278NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000382041ENST00000560445NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000382041ENST00000403994NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000382041ENST00000357980NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000382041ENST00000559556NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000382041ENST00000559397NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000382041ENST00000267996NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000382041ENST00000334895NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000382041ENST00000404484NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000382041ENST00000560959NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000382041ENST00000559281NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000382041ENST00000317516NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-3CDSENST00000324330ENST00000288398NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-3CDSENST00000324330ENST00000358278NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000324330ENST00000560445NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000324330ENST00000403994NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000324330ENST00000357980NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000324330ENST00000559556NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000324330ENST00000559397NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000324330ENST00000267996NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000324330ENST00000334895NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000324330ENST00000404484NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000324330ENST00000560959NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000324330ENST00000559281NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000324330ENST00000317516NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-3CDSENST00000453196ENST00000288398NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-3CDSENST00000453196ENST00000358278NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000453196ENST00000560445NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000453196ENST00000403994NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000453196ENST00000357980NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000453196ENST00000559556NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000453196ENST00000559397NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000453196ENST00000267996NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000453196ENST00000334895NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000453196ENST00000404484NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000453196ENST00000560959NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000453196ENST00000559281NINchr14

51297182

-TPM1chr15

63349184

+
5UTR-intronENST00000453196ENST00000317516NINchr14

51297182

-TPM1chr15

63349184

+
intron-3CDSENST00000486200ENST00000288398NINchr14

51297182

-TPM1chr15

63349184

+
intron-3CDSENST00000486200ENST00000358278NINchr14

51297182

-TPM1chr15

63349184

+
intron-intronENST00000486200ENST00000560445NINchr14

51297182

-TPM1chr15

63349184

+
intron-intronENST00000486200ENST00000403994NINchr14

51297182

-TPM1chr15

63349184

+
intron-intronENST00000486200ENST00000357980NINchr14

51297182

-TPM1chr15

63349184

+
intron-intronENST00000486200ENST00000559556NINchr14

51297182

-TPM1chr15

63349184

+
intron-intronENST00000486200ENST00000559397NINchr14

51297182

-TPM1chr15

63349184

+
intron-intronENST00000486200ENST00000267996NINchr14

51297182

-TPM1chr15

63349184

+
intron-intronENST00000486200ENST00000334895NINchr14

51297182

-TPM1chr15

63349184

+
intron-intronENST00000486200ENST00000404484NINchr14

51297182

-TPM1chr15

63349184

+
intron-intronENST00000486200ENST00000560959NINchr14

51297182

-TPM1chr15

63349184

+
intron-intronENST00000486200ENST00000559281NINchr14

51297182

-TPM1chr15

63349184

+
intron-intronENST00000486200ENST00000317516NINchr14

51297182

-TPM1chr15

63349184

+

Top

FusionProtFeatures for NIN_TPM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NIN

Q8N4C6

TPM1

P09493


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NIN_TPM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NIN_TPM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NINNIN, PRKACA, AURKA, GSK3B, AMOT, ELAVL1, LATS2, CEP170, CCDC68, TMOD1, CASQ2, C17orf59, CEP63, MED4, HERC2, OFD1, CEP128, CNTRL, ACTR1A, ANLN, AP3D1, CEP131, BAIAP2, CAMK2D, CC2D1A, CCDC138, CCNB1, CCNB2, CENPE, CEP164, CEP350, CKAP2, CLASP1, CLASP2, CSPP1, DBT, DCTN1, DCTN2, DHX35, DIAPH3, DYNC1H1, DYNC1I2, DYNC1LI1, DYNC1LI2, ECH1, EIF4ENIF1, ERC1, FAM83B, FGFR1OP, GPATCH1, HAUS1, HAUS3, HAUS4, HAUS5, HAUS6, HAUS7, HAUS8, HECTD1, HMMR, IQCB1, KIAA1671, KIF14, LUZP1, MAP7D3, MGA, NCKAP5L, NEDD1, NME7, PALLD, PCM1, PLK1, RASSF8, RLTPR, SAMD4B, SDCCAG3, SPC24, SVIL, TJP1, TNRC6B, TP53, TP53BP2, TTC28, TTF2, TTK, TXLNA, UNC45A, UPF1, WDR83, ACTR2, AHCY, ARPC3, CEP192, CSNK1A1, HMGN3, ISOC1, PIBF1, PMPCB, RAB2A, SSX2IP, TCHP, YWHAH, POC5, KIAA1244, NHP2L1, BAX, MYH13, DOT1L, CDC14A, SYCE3, TCP10L, ZNF331, COG5TPM1KXD1, TNNT1, CNN1, TPM1, TNNT2, TPM2, EGFR, YWHAQ, ELAVL1, SP1, ERG, MYOC, LRRK2, ACTC1, ACTA2, TPM4, SRXN1, RBM15, ZYX, TPM3, DBN1, NUDCD2, SF3B2, SULT1A1, SF3B1, THOC1, THOC2, SORD, PPP4R2, AHCYL1, SEC23A, CNN2, RPS3, BRCA1, MDC1, ATF2, SPTBN1, TGFBR1, PAN2, LRCH3, PARK2, ABI2, APPL2, CDC37, ETFA, FOXK1, HSP90B1, KIAA1598, MGEA5, PPP6R3, STUB1, DNAJC7, TP53, GOLGA2, MAD1L1, TFPT, SYCE1, C1orf216, CAGE1, TSSC4, GOLGA3, CROCC, EXOC4, IKBKG, KLHL21, CCDC102A, CNTLN, RUFY2, HOMER1, JUND, DLG5, ENDOG, SCLT1, NEB, ACTN1, CKB, COX5A, MYH4, MYH6, ACTN2, ACTN4, ATP5F1, COX4I1, MYH1, MYH2, MYH7B, MYH8, NDUFB10, TNNI1, CAPZA2, CDK2, FLNA, MYH9, PPP1CB, IQGAP1, PDLIM7, SYNPO, ANLN, MYO19, MYO18A, CFAP97, C10orf2, RBPJ, ZNF746, SPAG9, COX15, DLD, DLST, DNM1L, PARK7, SOAT1, VDAC1, G3BP1, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NIN_TPM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneTPM1P09493DB11638ArtenimolTropomyosin alpha-1 chainsmall moleculeapproved|investigational

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RelatedDiseases for NIN_TPM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTPM1C1861863CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 3 (disorder)5CTD_human;UNIPROT
TgeneTPM1C2678476Cardiomyopathy, Dilated, 1y2CTD_human;UNIPROT
TgeneTPM1C0014859Esophageal Neoplasms1CTD_human
TgeneTPM1C0020538Hypertensive disease1CTD_human
TgeneTPM1C0022548Keloid1CTD_human
TgeneTPM1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneTPM1C0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneTPM1C0949658Cardiomyopathy, Hypertrophic, Familial1CTD_human