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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24370

FusionGeneSummary for NIN_TAGLN

check button Fusion gene summary
Fusion gene informationFusion gene name: NIN_TAGLN
Fusion gene ID: 24370
HgeneTgene
Gene symbol

NIN

TAGLN

Gene ID

51199

6876

Gene namenineintransgelin
SynonymsSCKL7SM22|SM22-alpha|SMCC|TAGLN1|WS3-10
Cytomap

14q22.1

11q23.3

Type of geneprotein-codingprotein-coding
Descriptionnineinglycogen synthase kinase 3 beta-interacting proteinhNineinninein (GSK3B interacting protein)ninein centrosomal proteintransgelin22 kDa actin-binding proteinsmooth muscle protein 22-alphatransgelin variant 2
Modification date2018052320180519
UniProtAcc

Q8N4C6

Q01995

Ensembl transtripts involved in fusion geneENST00000245441, ENST00000389868, 
ENST00000530997, ENST00000382043, 
ENST00000382041, ENST00000324330, 
ENST00000453196, ENST00000486200, 
ENST00000392951, ENST00000530649, 
ENST00000532870, 
Fusion gene scores* DoF score9 X 9 X 5=4058 X 13 X 4=416
# samples 1016
** MAII scorelog2(10/405*10)=-2.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(16/416*10)=-1.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NIN [Title/Abstract] AND TAGLN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTAGLN

GO:0030855

epithelial cell differentiation

21492153


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1W48800NINchr14

51237151

-TAGLNchr11

117075401

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000245441ENST00000392951NINchr14

51237151

-TAGLNchr11

117075401

+
intron-3UTRENST00000245441ENST00000530649NINchr14

51237151

-TAGLNchr11

117075401

+
intron-3UTRENST00000245441ENST00000532870NINchr14

51237151

-TAGLNchr11

117075401

+
intron-intronENST00000389868ENST00000392951NINchr14

51237151

-TAGLNchr11

117075401

+
intron-3UTRENST00000389868ENST00000530649NINchr14

51237151

-TAGLNchr11

117075401

+
intron-3UTRENST00000389868ENST00000532870NINchr14

51237151

-TAGLNchr11

117075401

+
intron-intronENST00000530997ENST00000392951NINchr14

51237151

-TAGLNchr11

117075401

+
intron-3UTRENST00000530997ENST00000530649NINchr14

51237151

-TAGLNchr11

117075401

+
intron-3UTRENST00000530997ENST00000532870NINchr14

51237151

-TAGLNchr11

117075401

+
intron-intronENST00000382043ENST00000392951NINchr14

51237151

-TAGLNchr11

117075401

+
intron-3UTRENST00000382043ENST00000530649NINchr14

51237151

-TAGLNchr11

117075401

+
intron-3UTRENST00000382043ENST00000532870NINchr14

51237151

-TAGLNchr11

117075401

+
intron-intronENST00000382041ENST00000392951NINchr14

51237151

-TAGLNchr11

117075401

+
intron-3UTRENST00000382041ENST00000530649NINchr14

51237151

-TAGLNchr11

117075401

+
intron-3UTRENST00000382041ENST00000532870NINchr14

51237151

-TAGLNchr11

117075401

+
intron-intronENST00000324330ENST00000392951NINchr14

51237151

-TAGLNchr11

117075401

+
intron-3UTRENST00000324330ENST00000530649NINchr14

51237151

-TAGLNchr11

117075401

+
intron-3UTRENST00000324330ENST00000532870NINchr14

51237151

-TAGLNchr11

117075401

+
intron-intronENST00000453196ENST00000392951NINchr14

51237151

-TAGLNchr11

117075401

+
intron-3UTRENST00000453196ENST00000530649NINchr14

51237151

-TAGLNchr11

117075401

+
intron-3UTRENST00000453196ENST00000532870NINchr14

51237151

-TAGLNchr11

117075401

+
intron-intronENST00000486200ENST00000392951NINchr14

51237151

-TAGLNchr11

117075401

+
intron-3UTRENST00000486200ENST00000530649NINchr14

51237151

-TAGLNchr11

117075401

+
intron-3UTRENST00000486200ENST00000532870NINchr14

51237151

-TAGLNchr11

117075401

+

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FusionProtFeatures for NIN_TAGLN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NIN

Q8N4C6

TAGLN

Q01995

Actin cross-linking/gelling protein (By similarity).Involved in calcium interactions and contractile properties of thecell that may contribute to replicative senescence. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NIN_TAGLN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NIN_TAGLN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NIN_TAGLN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NIN_TAGLN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTAGLNC0023794Lipoidosis3CTD_human
TgeneTAGLNC0009375Colonic Neoplasms1CTD_human
TgeneTAGLNC0014175Endometriosis1CTD_human
TgeneTAGLNC0022548Keloid1CTD_human
TgeneTAGLNC0279626Squamous cell carcinoma of esophagus1CTD_human