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Fusion gene ID: 2437 |
FusionGeneSummary for ARHGAP32_DONSON |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARHGAP32_DONSON | Fusion gene ID: 2437 | Hgene | Tgene | Gene symbol | ARHGAP32 | DONSON | Gene ID | 9743 | 29980 |
| Gene name | Rho GTPase activating protein 32 | downstream neighbor of SON | |
| Synonyms | GC-GAP|GRIT|PX-RICS|RICS|p200RhoGAP|p250GAP | B17|C21orf60|MIMIS|MISSLA | |
| Cytomap | 11q24.3 | 21q22.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho GTPase-activating protein 32GAB-associated CDC42GAB-associated Cdc42/Rac GTPase-activating proteinGTPase regulator interacting with TrkAGTPase-activating protein for Cdc42 and Rac1RhoGAP involved in the -catenin-N-cadherin and NMDA receptor signa | protein downstream neighbor of Son | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | A7KAX9 | Q9NYP3 | |
| Ensembl transtripts involved in fusion gene | ENST00000310343, ENST00000524655, ENST00000392657, ENST00000527272, | ENST00000303113, ENST00000453626, ENST00000303071, ENST00000432378, | |
| Fusion gene scores | * DoF score | 9 X 7 X 4=252 | 7 X 7 X 1=49 |
| # samples | 9 | 8 | |
| ** MAII score | log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/49*10)=0.707218250772154 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ARHGAP32 [Title/Abstract] AND DONSON [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE817796 | ARHGAP32 | chr11 | 128838183 | - | DONSON | chr21 | 35153717 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000310343 | ENST00000303113 | ARHGAP32 | chr11 | 128838183 | - | DONSON | chr21 | 35153717 | + |
| intron-intron | ENST00000310343 | ENST00000453626 | ARHGAP32 | chr11 | 128838183 | - | DONSON | chr21 | 35153717 | + |
| intron-intron | ENST00000310343 | ENST00000303071 | ARHGAP32 | chr11 | 128838183 | - | DONSON | chr21 | 35153717 | + |
| intron-intron | ENST00000310343 | ENST00000432378 | ARHGAP32 | chr11 | 128838183 | - | DONSON | chr21 | 35153717 | + |
| intron-intron | ENST00000524655 | ENST00000303113 | ARHGAP32 | chr11 | 128838183 | - | DONSON | chr21 | 35153717 | + |
| intron-intron | ENST00000524655 | ENST00000453626 | ARHGAP32 | chr11 | 128838183 | - | DONSON | chr21 | 35153717 | + |
| intron-intron | ENST00000524655 | ENST00000303071 | ARHGAP32 | chr11 | 128838183 | - | DONSON | chr21 | 35153717 | + |
| intron-intron | ENST00000524655 | ENST00000432378 | ARHGAP32 | chr11 | 128838183 | - | DONSON | chr21 | 35153717 | + |
| intron-intron | ENST00000392657 | ENST00000303113 | ARHGAP32 | chr11 | 128838183 | - | DONSON | chr21 | 35153717 | + |
| intron-intron | ENST00000392657 | ENST00000453626 | ARHGAP32 | chr11 | 128838183 | - | DONSON | chr21 | 35153717 | + |
| intron-intron | ENST00000392657 | ENST00000303071 | ARHGAP32 | chr11 | 128838183 | - | DONSON | chr21 | 35153717 | + |
| intron-intron | ENST00000392657 | ENST00000432378 | ARHGAP32 | chr11 | 128838183 | - | DONSON | chr21 | 35153717 | + |
| intron-intron | ENST00000527272 | ENST00000303113 | ARHGAP32 | chr11 | 128838183 | - | DONSON | chr21 | 35153717 | + |
| intron-intron | ENST00000527272 | ENST00000453626 | ARHGAP32 | chr11 | 128838183 | - | DONSON | chr21 | 35153717 | + |
| intron-intron | ENST00000527272 | ENST00000303071 | ARHGAP32 | chr11 | 128838183 | - | DONSON | chr21 | 35153717 | + |
| intron-intron | ENST00000527272 | ENST00000432378 | ARHGAP32 | chr11 | 128838183 | - | DONSON | chr21 | 35153717 | + |
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FusionProtFeatures for ARHGAP32_DONSON |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARHGAP32 | DONSON |
| GTPase-activating protein (GAP) promoting GTP hydrolysison RHOA, CDC42 and RAC1 small GTPases. May be involved in thedifferentiation of neuronal cells during the formation of neuriteextensions. Involved in NMDA receptor activity-dependent actinreorganization in dendritic spines. May mediate cross-talksbetween Ras- and Rho-regulated signaling pathways in cell growthregulation. Isoform 2 has higher GAP activity (By similarity).{ECO:0000250, ECO:0000269|PubMed:12446789,ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901,ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203,ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. | Replisome component that maintains genome stability byprotecting stalled or damaged replication forks. After theinduction of replication stress, required for the stabilization ofstalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance ofgenome stability. {ECO:0000269|PubMed:28191891}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ARHGAP32_DONSON |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ARHGAP32_DONSON |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ARHGAP32_DONSON |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ARHGAP32_DONSON |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ARHGAP32 | C0036341 | Schizophrenia | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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