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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24360

FusionGeneSummary for NINL_NAA20

check button Fusion gene summary
Fusion gene informationFusion gene name: NINL_NAA20
Fusion gene ID: 24360
HgeneTgene
Gene symbol

NINL

NAA20

Gene ID

22981

51126

Gene nameninein likeN(alpha)-acetyltransferase 20, NatB catalytic subunit
SynonymsNLPNAT3|NAT3P|NAT5|NAT5P|dJ1002M8.1
Cytomap

20p11.21

20p11.23

Type of geneprotein-codingprotein-coding
Descriptionninein-like proteinN-alpha-acetyltransferase 20N-acetyltransferase 3 homologN-acetyltransferase 5 (ARD1 homolog, S. cerevisiae)N-acetyltransferase 5 (GCN5-related, putative)N-acetyltransferase 5, ARD1 subunit (arrest-defective 1, S. cerevisiae, homolog)N-terminal acety
Modification date2018052320180523
UniProtAcc

Q9Y2I6

P61599

Ensembl transtripts involved in fusion geneENST00000278886, ENST00000422516, 
ENST00000464285, 		ENST00000334982, 
ENST00000484480, ENST00000310450, 
ENST00000398602, 
Fusion gene scores* DoF score5 X 4 X 5=1002 X 2 X 2=8
# samples 52
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: NINL [Title/Abstract] AND NAA20 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-G9-6351-01ANINLchr20

25507044

-NAA20chr20

20007428

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000278886ENST00000334982NINLchr20

25507044

-NAA20chr20

20007428

+
5CDS-3UTRENST00000278886ENST00000484480NINLchr20

25507044

-NAA20chr20

20007428

+
5CDS-3UTRENST00000278886ENST00000310450NINLchr20

25507044

-NAA20chr20

20007428

+
5CDS-3UTRENST00000278886ENST00000398602NINLchr20

25507044

-NAA20chr20

20007428

+
In-frameENST00000422516ENST00000334982NINLchr20

25507044

-NAA20chr20

20007428

+
5CDS-3UTRENST00000422516ENST00000484480NINLchr20

25507044

-NAA20chr20

20007428

+
5CDS-3UTRENST00000422516ENST00000310450NINLchr20

25507044

-NAA20chr20

20007428

+
5CDS-3UTRENST00000422516ENST00000398602NINLchr20

25507044

-NAA20chr20

20007428

+
intron-3CDSENST00000464285ENST00000334982NINLchr20

25507044

-NAA20chr20

20007428

+
intron-3UTRENST00000464285ENST00000484480NINLchr20

25507044

-NAA20chr20

20007428

+
intron-3UTRENST00000464285ENST00000310450NINLchr20

25507044

-NAA20chr20

20007428

+
intron-3UTRENST00000464285ENST00000398602NINLchr20

25507044

-NAA20chr20

20007428

+

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FusionProtFeatures for NINL_NAA20


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NINL

Q9Y2I6

NAA20

P61599

Involved in the microtubule organization in interphasecells. Overexpression induces the fragmentation of the Golgi, andcauses lysosomes to disperse toward the cell periphery; it alsointerferes with mitotic spindle assembly. May play a role inovarian carcinogenesis. {ECO:0000269|PubMed:12852856,ECO:0000269|PubMed:16254247, ECO:0000269|PubMed:18538832}. Catalytic subunit of the NatB complex which catalyzesacetylation of the N-terminal methionine residues of peptidesbeginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteinswith cell cycle functions are overrepresented in the pool of NatBsubstrates. Required for maintaining the structure and function ofactomyosin fibers and for proper cellular migration.{ECO:0000269|PubMed:18570629}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNINLchr20:25507044chr20:20007428ENST00000278886-2247_42601383DomainEF-hand 1
HgeneNINLchr20:25507044chr20:20007428ENST00000422516-2237_42601034DomainEF-hand 1

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNINLchr20:25507044chr20:20007428ENST00000278886-224246_257601383Calcium bindingOntology_term=ECO:0000255
HgeneNINLchr20:25507044chr20:20007428ENST00000422516-223246_257601034Calcium bindingOntology_term=ECO:0000255
HgeneNINLchr20:25507044chr20:20007428ENST00000278886-2241046_1375601383Coiled coilOntology_term=ECO:0000255
HgeneNINLchr20:25507044chr20:20007428ENST00000278886-224384_424601383Coiled coilOntology_term=ECO:0000255
HgeneNINLchr20:25507044chr20:20007428ENST00000278886-224484_579601383Coiled coilOntology_term=ECO:0000255
HgeneNINLchr20:25507044chr20:20007428ENST00000278886-224616_699601383Coiled coilOntology_term=ECO:0000255
HgeneNINLchr20:25507044chr20:20007428ENST00000422516-2231046_1375601034Coiled coilOntology_term=ECO:0000255
HgeneNINLchr20:25507044chr20:20007428ENST00000422516-223384_424601034Coiled coilOntology_term=ECO:0000255
HgeneNINLchr20:25507044chr20:20007428ENST00000422516-223484_579601034Coiled coilOntology_term=ECO:0000255
HgeneNINLchr20:25507044chr20:20007428ENST00000422516-223616_699601034Coiled coilOntology_term=ECO:0000255
HgeneNINLchr20:25507044chr20:20007428ENST00000278886-224296_299601383Compositional biasNote=Poly-Thr
HgeneNINLchr20:25507044chr20:20007428ENST00000278886-224805_810601383Compositional biasNote=Poly-Glu
HgeneNINLchr20:25507044chr20:20007428ENST00000422516-223296_299601034Compositional biasNote=Poly-Thr
HgeneNINLchr20:25507044chr20:20007428ENST00000422516-223805_810601034Compositional biasNote=Poly-Glu
HgeneNINLchr20:25507044chr20:20007428ENST00000278886-224196_231601383DomainEF-hand 3
HgeneNINLchr20:25507044chr20:20007428ENST00000278886-224233_268601383DomainEF-hand 4
HgeneNINLchr20:25507044chr20:20007428ENST00000278886-22441_76601383DomainEF-hand 2
HgeneNINLchr20:25507044chr20:20007428ENST00000422516-223196_231601034DomainEF-hand 3
HgeneNINLchr20:25507044chr20:20007428ENST00000422516-223233_268601034DomainEF-hand 4
HgeneNINLchr20:25507044chr20:20007428ENST00000422516-22341_76601034DomainEF-hand 2
HgeneNINLchr20:25507044chr20:20007428ENST00000278886-224633_641601383MotifNote=D-box
HgeneNINLchr20:25507044chr20:20007428ENST00000422516-223633_641601034MotifNote=D-box
TgeneNAA20chr20:25507044chr20:20007428ENST00000310450+252_15756112DomainN-acetyltransferase
TgeneNAA20chr20:25507044chr20:20007428ENST00000334982+262_15756179DomainN-acetyltransferase


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FusionGeneSequence for NINL_NAA20


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NINL_ENST00000278886_chr20_25507044_-_NAA20_ENST00000334982_chr20_20007428_+_182aa
MDEEENHYVSQLREVYSSCDTTGTGFLDRQELTQLCLKLHLEQQLPVLLQTLLGNDHFARLWVKQKAQXLGKNGTGTSQLCLLPQNFDAL
VWLLNLWSYXRRFQKERVDFLWISLXEYLTKLQLTCTSSWATVYIGRSXSTIRPATGSLMRTLMIXGKHFPGILRRNPSYHYLILXGLKT

>In-frame_NINL_ENST00000422516_chr20_25507044_-_NAA20_ENST00000334982_chr20_20007428_+_182aa
MDEEENHYVSQLREVYSSCDTTGTGFLDRQELTQLCLKLHLEQQLPVLLQTLLGNDHFARLWVKQKAQXLGKNGTGTSQLCLLPQNFDAL
VWLLNLWSYXRRFQKERVDFLWISLXEYLTKLQLTCTSSWATVYIGRSXSTIRPATGSLMRTLMIXGKHFPGILRRNPSYHYLILXGLKT


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NINL_ENST00000278886_chr20_25507044_-_NAA20_ENST00000334982_chr20_20007428_+_548nt
ATGGATGAAGAAGAGAACCACTATGTCTCGCAGCTCAGGGAAGTCTACAGCAGCTGCGACACCACGGGGACTGGCTTTCTGGACCGCCAG
GAGCTGACCCAGCTCTGCCTTAAGCTTCACCTGGAGCAGCAGCTGCCCGTCCTCCTGCAGACGCTTCTCGGAAACGACCATTTCGCCAGG
TTATGGGTAAAGCAGAAGGCTCAGTAGCTAGGGAAGAATGGCACGGGCACGTCACAGCTCTGTCTGTTGCCCCAGAATTTCGACGCCTTG
GTTTGGCTGCTAAACTTATGGAGTTACTAGAGGAGATTTCAGAAAGAAAGGGTGGATTTTTTGTGGATCTCTTTGTAAGAGTATCTAACC
AAGTTGCAGTTAACATGTACAAGCAGTTGGGCTACAGTGTATATAGGACGGTCATAGAGTACTATTCGGCCAGCAACGGGGAGCCTGATG
AGGACGCTTATGATATGAGGAAAGCACTTTCCAGGGATACTGAGAAGAAATCCATCATACCATTACCTCATCCTGTGAGGCCTGAAGACA

>In-frame_NINL_ENST00000422516_chr20_25507044_-_NAA20_ENST00000334982_chr20_20007428_+_548nt
ATGGATGAAGAAGAGAACCACTATGTCTCGCAGCTCAGGGAAGTCTACAGCAGCTGCGACACCACGGGGACTGGCTTTCTGGACCGCCAG
GAGCTGACCCAGCTCTGCCTTAAGCTTCACCTGGAGCAGCAGCTGCCCGTCCTCCTGCAGACGCTTCTCGGAAACGACCATTTCGCCAGG
TTATGGGTAAAGCAGAAGGCTCAGTAGCTAGGGAAGAATGGCACGGGCACGTCACAGCTCTGTCTGTTGCCCCAGAATTTCGACGCCTTG
GTTTGGCTGCTAAACTTATGGAGTTACTAGAGGAGATTTCAGAAAGAAAGGGTGGATTTTTTGTGGATCTCTTTGTAAGAGTATCTAACC
AAGTTGCAGTTAACATGTACAAGCAGTTGGGCTACAGTGTATATAGGACGGTCATAGAGTACTATTCGGCCAGCAACGGGGAGCCTGATG
AGGACGCTTATGATATGAGGAAAGCACTTTCCAGGGATACTGAGAAGAAATCCATCATACCATTACCTCATCCTGTGAGGCCTGAAGACA


* Fusion transcript sequences (Full-length transcript).
>In-frame_NINL_ENST00000278886_chr20_25507044_-_NAA20_ENST00000334982_chr20_20007428_+_1064nt
GCGGTACGGGGGTGGTGCCGCGCTCCTGGCCCCGCGCGGGCGGACGGCGGAGGCGCCTCCCAGCCTGCTATGGGATGGATGAAGAAGAGA
ACCACTATGTCTCGCAGCTCAGGGAAGTCTACAGCAGCTGCGACACCACGGGGACTGGCTTTCTGGACCGCCAGGAGCTGACCCAGCTCT
GCCTTAAGCTTCACCTGGAGCAGCAGCTGCCCGTCCTCCTGCAGACGCTTCTCGGAAACGACCATTTCGCCAGGTTATGGGTAAAGCAGA
AGGCTCAGTAGCTAGGGAAGAATGGCACGGGCACGTCACAGCTCTGTCTGTTGCCCCAGAATTTCGACGCCTTGGTTTGGCTGCTAAACT
TATGGAGTTACTAGAGGAGATTTCAGAAAGAAAGGGTGGATTTTTTGTGGATCTCTTTGTAAGAGTATCTAACCAAGTTGCAGTTAACAT
GTACAAGCAGTTGGGCTACAGTGTATATAGGACGGTCATAGAGTACTATTCGGCCAGCAACGGGGAGCCTGATGAGGACGCTTATGATAT
GAGGAAAGCACTTTCCAGGGATACTGAGAAGAAATCCATCATACCATTACCTCATCCTGTGAGGCCTGAAGACATTGAATAACCCTGGGC
AGTGGTTCTTAGGCAGATACTCTAGATGCTTTATGGACAATATTATTTTCATTGGATGATTCTGGAGCTCTATTAGGAGAAAAGTAATCA
TTTTAGGTCTTAAAGACTTCAAGAAAATACAGGTTATCAATTTATTTTAAATCTCATTGTTTCCAGTTAGCAATATCATACCTATTAAAG
CTGTTCATTGTAACAAAATTCAATCAAAAAGGCAGCTAGGTCAGAAGGAAACATACCACTCTCATGGTTCATAGTATTCACTGTATGTAT
GCTAGGGAAAAGACTTGCTCCAGTCTCCTCCTCAGTTCTGTGCCTGAGAACCACTGCTGCATATATTTGTTTTTAAATTTTGTATTGAAC

>In-frame_NINL_ENST00000422516_chr20_25507044_-_NAA20_ENST00000334982_chr20_20007428_+_1064nt
GCGGTACGGGGGTGGTGCCGCGCTCCTGGCCCCGCGCGGGCGGACGGCGGAGGCGCCTCCCAGCCTGCTATGGGATGGATGAAGAAGAGA
ACCACTATGTCTCGCAGCTCAGGGAAGTCTACAGCAGCTGCGACACCACGGGGACTGGCTTTCTGGACCGCCAGGAGCTGACCCAGCTCT
GCCTTAAGCTTCACCTGGAGCAGCAGCTGCCCGTCCTCCTGCAGACGCTTCTCGGAAACGACCATTTCGCCAGGTTATGGGTAAAGCAGA
AGGCTCAGTAGCTAGGGAAGAATGGCACGGGCACGTCACAGCTCTGTCTGTTGCCCCAGAATTTCGACGCCTTGGTTTGGCTGCTAAACT
TATGGAGTTACTAGAGGAGATTTCAGAAAGAAAGGGTGGATTTTTTGTGGATCTCTTTGTAAGAGTATCTAACCAAGTTGCAGTTAACAT
GTACAAGCAGTTGGGCTACAGTGTATATAGGACGGTCATAGAGTACTATTCGGCCAGCAACGGGGAGCCTGATGAGGACGCTTATGATAT
GAGGAAAGCACTTTCCAGGGATACTGAGAAGAAATCCATCATACCATTACCTCATCCTGTGAGGCCTGAAGACATTGAATAACCCTGGGC
AGTGGTTCTTAGGCAGATACTCTAGATGCTTTATGGACAATATTATTTTCATTGGATGATTCTGGAGCTCTATTAGGAGAAAAGTAATCA
TTTTAGGTCTTAAAGACTTCAAGAAAATACAGGTTATCAATTTATTTTAAATCTCATTGTTTCCAGTTAGCAATATCATACCTATTAAAG
CTGTTCATTGTAACAAAATTCAATCAAAAAGGCAGCTAGGTCAGAAGGAAACATACCACTCTCATGGTTCATAGTATTCACTGTATGTAT
GCTAGGGAAAAGACTTGCTCCAGTCTCCTCCTCAGTTCTGTGCCTGAGAACCACTGCTGCATATATTTGTTTTTAAATTTTGTATTGAAC


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FusionGenePPI for NINL_NAA20


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NINLSPERT, TCEB3, CCDC33, MAD1L1, AKAP17A, UTP14A, ZNF646, GPKOW, LZTS2, ZFC3H1, KANSL1, DCTN5, SH3BP5L, TSPYL4, JUNB, ZNF426, ZFHX3, CLEC1B, SYT17, RIBC2, KAT7, GCC1, RGS2, CCDC130, APEX2, EWSR1, MCM10, ZNF250, TCEANC, RCOR3, TNNT1, MBIP, FAM107A, EZH2, LRSAM1, ANAPC2, CDC27, CDC20, FZR1, BRCA1, TUBG1, TUBGCP4, PLK1, LATS2, CEP250, KAT5, CCHCR1, RBM41, CCDC146, SH2D4A, FAM161A, L3MBTL4, HAUS1, ZNF417, LRRC39, CEP128, ABLIM1, ALDH3A2, ARHGAP21, ARRB2, CEP131, C1orf198, CC2D1A, CCDC138, CCDC14, CCDC66, CCDC85C, CCP110, CEP162, CEP350, CEP55, CEP85, CEP97, CKAP2, CNOT1, CSPP1, DYNC1H1, DYNC1LI2, FGFR1OP, GPATCH1, GPS2, IFT74, IFT81, KANK2, GSE1, KIAA1671, KIF14, KIF1B, ERVK3-1, LPP, LUZP1, MAP7D3, MPHOSPH9, MZT2A, NCKAP5L, NCOR1, NEDD1, NME7, OFD1, PALLD, PDLIM7, PPP1R13B, PRRC2B, SCYL2, SDCCAG3, SIPA1L3, SVIL, TCHP, TNRC6A, TNRC6B, TP53, TP53BP2, TROAP, TTK, TXLNA, TXLNG, WDR83, ZNF598, ANKHD1-EIF4EBP3, BCR, PROSER3, CAMK2B, CAMSAP1, CAMSAP2, CAMSAP3, CCDC112, CCDC22, CCDC77, CEP170, CEP192, CEP89, CEP95, CKAP5, CNOT10, CNOT3, COMMD2, CRKL, CYLD, DAPK3, DCAF7, DCP1B, DHX35, DIAPH3, DLG5, DNMBP, DSP, DYNC1LI1, EIF4ENIF1, ERC1, FAM83H, GIGYF1, GIGYF2, GTSE1, HAUS2, HAUS5, HAUS6, HAUS7, HDAC3, HSPA1B, HSPA1L, ITSN2, CEP170B, KIAA0753, KIAA1217, CEP295, KIF7, LATS1, LMO7, MICAL3, MIS18A, MIS18BP1, MPP5, MTUS1, NDEL1, PCM1, PDZD11, PIK3C2A, PLEKHA7, PLEKHG1, PPP1CA, PTPN13, RASSF8, RAVER1, RCOR1, RPGRIP1L, RQCD1, SASS6, SH3RF1, SHKBP1, SIPA1L1, SIPA1L2, SMG7, TANC1, TBK1, TBL1XR1, TDRD3, TNIP1, TTC28, TTF2, TUBGCP2, USP54, VPS45, XRN1, RBSN, CENPJ, LZTS3, GAN, ZNF408, CCDC172, MRPS34, NKAP, TPM2, CAMK2A, DCTN2, AHI1, DCTN1NAA20IKBKB, NAA25, NHEJ1, SMAD5, ADIPOR1, CACYBP, CIRBP, MARS, NAA15, PAK4, SWAP70, TNFRSF8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NINL_NAA20


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NINL_NAA20


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource