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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24352

FusionGeneSummary for NID2_ZFP91

check button Fusion gene summary
Fusion gene informationFusion gene name: NID2_ZFP91
Fusion gene ID: 24352
HgeneTgene
Gene symbol

NID2

ZFP91

Gene ID

22795

80829

Gene namenidogen 2ZFP91 zinc finger protein
SynonymsNID-2DMS-8|DSM-8|FKSG11|PZF|ZFP-91|ZNF757
Cytomap

14q22.1

11q12.1

Type of geneprotein-codingprotein-coding
Descriptionnidogen-2osteonidogenE3 ubiquitin-protein ligase ZFP91RING-type E3 ubiquitin transferase ZFP91drug resistance-associated sequence in melanoma 8penta zinc finger proteinzinc finger protein 757zinc finger protein 91 homologzinc finger protein homologous to Zfp91 in mouse
Modification date2018052220180519
UniProtAcc

Q14112

Q96JP5

Ensembl transtripts involved in fusion geneENST00000541773, ENST00000216286, 
ENST00000316059, 
Fusion gene scores* DoF score2 X 2 X 1=46 X 6 X 2=72
# samples 27
** MAII scorelog2(2/4*10)=2.32192809488736log2(7/72*10)=-0.0406419844973459
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NID2 [Title/Abstract] AND ZFP91 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneZFP91

GO:0007250

activation of NF-kappaB-inducing kinase activity

20682767

TgeneZFP91

GO:0070534

protein K63-linked ubiquitination

20682767


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ301232NID2chr14

52472159

+ZFP91chr11

58387416

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000541773ENST00000316059NID2chr14

52472159

+ZFP91chr11

58387416

+
intron-3UTRENST00000216286ENST00000316059NID2chr14

52472159

+ZFP91chr11

58387416

+

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FusionProtFeatures for NID2_ZFP91


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NID2

Q14112

ZFP91

Q96JP5

Cell adhesion glycoprotein which is widely distributedin basement membranes. Binds to collagens I and IV, to perlecanand to laminin 1. Does not bind fibulins. It probably has a rolein cell-extracellular matrix interactions. Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize andactivate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an importantrole in cell proliferation and/or anti-apoptosis.{ECO:0000269|PubMed:12738986, ECO:0000269|PubMed:20682767}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NID2_ZFP91


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NID2_ZFP91


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NID2_ZFP91


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NID2_ZFP91


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNID2C0023893Liver Cirrhosis, Experimental1CTD_human