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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24348

FusionGeneSummary for NID1_HADHA

check button Fusion gene summary
Fusion gene informationFusion gene name: NID1_HADHA
Fusion gene ID: 24348
HgeneTgene
Gene symbol

NID1

HADHA

Gene ID

4811

3030

Gene namenidogen 1hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
SynonymsNIDECHA|GBP|HADH|LCEH|LCHAD|MTPA|TP-ALPHA
Cytomap

1q42.3

2p23.3

Type of geneprotein-codingprotein-coding
Descriptionnidogen-1NID-1enactinentactintrifunctional enzyme subunit alpha, mitochondrial3-ketoacyl-Coenzyme A (CoA) thiolase, alpha subunit3-oxoacyl-CoA thiolase78 kDa gastrin-binding proteingastrin-binding proteinhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (
Modification date2018052220180523
UniProtAcc

P14543

P40939

Ensembl transtripts involved in fusion geneENST00000366595, ENST00000264187, 
ENST00000380649, ENST00000457468, 
ENST00000461025, 
Fusion gene scores* DoF score4 X 4 X 1=168 X 7 X 7=392
# samples 510
** MAII scorelog2(5/16*10)=1.64385618977472
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(10/392*10)=-1.97085365434048
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NID1 [Title/Abstract] AND HADHA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI110722NID1chr1

236206197

+HADHAchr2

26437998

-
ChiTaRS3.1AF074629NID1chr1

236206197

+HADHAchr2

26437998

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000366595ENST00000380649NID1chr1

236206197

+HADHAchr2

26437998

-
intron-3CDSENST00000366595ENST00000457468NID1chr1

236206197

+HADHAchr2

26437998

-
intron-intronENST00000366595ENST00000461025NID1chr1

236206197

+HADHAchr2

26437998

-
intron-3CDSENST00000264187ENST00000380649NID1chr1

236206197

+HADHAchr2

26437998

-
intron-3CDSENST00000264187ENST00000457468NID1chr1

236206197

+HADHAchr2

26437998

-
intron-intronENST00000264187ENST00000461025NID1chr1

236206197

+HADHAchr2

26437998

-

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FusionProtFeatures for NID1_HADHA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NID1

P14543

HADHA

P40939

Sulfated glycoprotein widely distributed in basementmembranes and tightly associated with laminin. Also binds tocollagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions. Bifunctional subunit.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NID1_HADHA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NID1_HADHA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NID1_HADHA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneNID1P14543DB00013UrokinaseNidogen-1biotechapproved|investigational|withdrawn

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RelatedDiseases for NID1_HADHA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNID1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneNID1C0043094Weight Gain1CTD_human
TgeneHADHAC1969443Trifunctional Protein Deficiency With Myopathy And Neuropathy5CTD_human;HPO;ORPHANET;UNIPROT
TgeneHADHAC0029408Degenerative polyarthritis1CTD_human
TgeneHADHAC0151744Myocardial Ischemia1CTD_human
TgeneHADHAC4277682Chemical and Drug Induced Liver Injury1CTD_human