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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24343

FusionGeneSummary for NHSL1_SPATA13

check button Fusion gene summary
Fusion gene informationFusion gene name: NHSL1_SPATA13
Fusion gene ID: 24343
HgeneTgene
Gene symbol

NHSL1

SPATA13

Gene ID

57224

221178

Gene nameNHS like 1spermatogenesis associated 13
SynonymsC6orf63ARHGEF29|ASEF2
Cytomap

6q24.1

13q12.12

Type of geneprotein-codingprotein-coding
DescriptionNHS-like protein 1spermatogenesis-associated protein 13APC-stimulated guanine nucleotide exchange factor 2adenomatous polyposis coli stimulated exchange factor 2
Modification date2018052320180519
UniProtAcc

Q5SYE7

Q96N96

Ensembl transtripts involved in fusion geneENST00000427025, ENST00000343505, 
ENST00000479393, 		ENST00000424834, 
ENST00000382108, ENST00000382095, 
ENST00000474317, ENST00000399949, 
ENST00000409126, ENST00000343003, 
Fusion gene scores* DoF score10 X 7 X 6=4206 X 4 X 4=96
# samples 116
** MAII scorelog2(11/420*10)=-1.93288580414146
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NHSL1 [Title/Abstract] AND SPATA13 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A2-A25C-01ANHSL1chr6

138817356

-SPATA13chr13

24796957

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000427025ENST00000424834NHSL1chr6

138817356

-SPATA13chr13

24796957

+
5CDS-5UTRENST00000427025ENST00000382108NHSL1chr6

138817356

-SPATA13chr13

24796957

+
5CDS-intronENST00000427025ENST00000382095NHSL1chr6

138817356

-SPATA13chr13

24796957

+
5CDS-intronENST00000427025ENST00000474317NHSL1chr6

138817356

-SPATA13chr13

24796957

+
5CDS-intronENST00000427025ENST00000399949NHSL1chr6

138817356

-SPATA13chr13

24796957

+
5CDS-intronENST00000427025ENST00000409126NHSL1chr6

138817356

-SPATA13chr13

24796957

+
5CDS-intronENST00000427025ENST00000343003NHSL1chr6

138817356

-SPATA13chr13

24796957

+
5CDS-5UTRENST00000343505ENST00000424834NHSL1chr6

138817356

-SPATA13chr13

24796957

+
5CDS-5UTRENST00000343505ENST00000382108NHSL1chr6

138817356

-SPATA13chr13

24796957

+
5CDS-intronENST00000343505ENST00000382095NHSL1chr6

138817356

-SPATA13chr13

24796957

+
5CDS-intronENST00000343505ENST00000474317NHSL1chr6

138817356

-SPATA13chr13

24796957

+
5CDS-intronENST00000343505ENST00000399949NHSL1chr6

138817356

-SPATA13chr13

24796957

+
5CDS-intronENST00000343505ENST00000409126NHSL1chr6

138817356

-SPATA13chr13

24796957

+
5CDS-intronENST00000343505ENST00000343003NHSL1chr6

138817356

-SPATA13chr13

24796957

+
5UTR-5UTRENST00000479393ENST00000424834NHSL1chr6

138817356

-SPATA13chr13

24796957

+
5UTR-5UTRENST00000479393ENST00000382108NHSL1chr6

138817356

-SPATA13chr13

24796957

+
5UTR-intronENST00000479393ENST00000382095NHSL1chr6

138817356

-SPATA13chr13

24796957

+
5UTR-intronENST00000479393ENST00000474317NHSL1chr6

138817356

-SPATA13chr13

24796957

+
5UTR-intronENST00000479393ENST00000399949NHSL1chr6

138817356

-SPATA13chr13

24796957

+
5UTR-intronENST00000479393ENST00000409126NHSL1chr6

138817356

-SPATA13chr13

24796957

+
5UTR-intronENST00000479393ENST00000343003NHSL1chr6

138817356

-SPATA13chr13

24796957

+

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FusionProtFeatures for NHSL1_SPATA13


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NHSL1

Q5SYE7

SPATA13

Q96N96


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NHSL1_SPATA13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NHSL1_SPATA13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NHSL1NCK2, ABI1, CDH1, PTPRM, PTPRU, ABI2, AMZ1, TRIM25SPATA13KHDRBS1, YWHAZ, YWHAG, YWHAE, YWHAB, GLDC, YWHAH, YWHAQ


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NHSL1_SPATA13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NHSL1_SPATA13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource