FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 24304

FusionGeneSummary for NFXL1_ERAP2

check button Fusion gene summary
Fusion gene informationFusion gene name: NFXL1_ERAP2
Fusion gene ID: 24304
HgeneTgene
Gene symbol

NFXL1

ERAP2

Gene ID

152518

64167

Gene namenuclear transcription factor, X-box binding like 1endoplasmic reticulum aminopeptidase 2
SynonymsCDZFP|HOZFP|OZFP|URCC5L-RAP|LRAP
Cytomap

4p12

5q15

Type of geneprotein-codingprotein-coding
DescriptionNF-X1-type zinc finger protein NFXL1cytoplasm-distribution zinc finger proteinovarian zinc finger proteinup-regulated in colon cancer 5endoplasmic reticulum aminopeptidase 2leukocyte-derived arginine aminopeptidase
Modification date2018052320180523
UniProtAcc

Q6ZNB6

Q6P179

Ensembl transtripts involved in fusion geneENST00000381538, ENST00000507489, 
ENST00000329043, 
ENST00000437043, 
ENST00000379904, ENST00000510309, 
ENST00000515095, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 2=8
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: NFXL1 [Title/Abstract] AND ERAP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-EJ-5519-01ANFXL1chr4

47877144

-ERAP2chr5

96215268

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000381538ENST00000437043NFXL1chr4

47877144

-ERAP2chr5

96215268

+
5CDS-5UTRENST00000381538ENST00000379904NFXL1chr4

47877144

-ERAP2chr5

96215268

+
5CDS-5UTRENST00000381538ENST00000510309NFXL1chr4

47877144

-ERAP2chr5

96215268

+
5CDS-intronENST00000381538ENST00000515095NFXL1chr4

47877144

-ERAP2chr5

96215268

+
5CDS-5UTRENST00000507489ENST00000437043NFXL1chr4

47877144

-ERAP2chr5

96215268

+
5CDS-5UTRENST00000507489ENST00000379904NFXL1chr4

47877144

-ERAP2chr5

96215268

+
5CDS-5UTRENST00000507489ENST00000510309NFXL1chr4

47877144

-ERAP2chr5

96215268

+
5CDS-intronENST00000507489ENST00000515095NFXL1chr4

47877144

-ERAP2chr5

96215268

+
intron-5UTRENST00000329043ENST00000437043NFXL1chr4

47877144

-ERAP2chr5

96215268

+
intron-5UTRENST00000329043ENST00000379904NFXL1chr4

47877144

-ERAP2chr5

96215268

+
intron-5UTRENST00000329043ENST00000510309NFXL1chr4

47877144

-ERAP2chr5

96215268

+
intron-intronENST00000329043ENST00000515095NFXL1chr4

47877144

-ERAP2chr5

96215268

+

Top

FusionProtFeatures for NFXL1_ERAP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFXL1

Q6ZNB6

ERAP2

Q6P179

Aminopeptidase that plays a central role in peptidetrimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customizelonger precursor peptides to fit them to the correct lengthrequired for presentation on MHC class I molecules. Preferentiallyhydrolyzes the basic residues Arg and Lys.{ECO:0000269|PubMed:12799365, ECO:0000269|PubMed:15908954,ECO:0000269|PubMed:16286653}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for NFXL1_ERAP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for NFXL1_ERAP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NFXL1SARM1, ILF3, CLINT1, RNF2, WDFY2, FOXL1, AURKAERAP2TCTN1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NFXL1_ERAP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NFXL1_ERAP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNFXL1C0008370Cholestasis1CTD_human
HgeneNFXL1C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneERAP2C0010346Crohn Disease1CTD_human