FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 24294

FusionGeneSummary for NFX1_DAAM1

check button Fusion gene summary
Fusion gene informationFusion gene name: NFX1_DAAM1
Fusion gene ID: 24294
HgeneTgene
Gene symbol

NFX1

DAAM1

Gene ID

4799

23002

Gene namenuclear transcription factor, X-box binding 1dishevelled associated activator of morphogenesis 1
SynonymsNFX2|TEG-42|Tex42-
Cytomap

9p13.3

14q23.1

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional repressor NF-X1nuclear transcription factor, X box-binding protein 1disheveled-associated activator of morphogenesis 1
Modification date2018052320180519
UniProtAcc

Q12986

Q9Y4D1

Ensembl transtripts involved in fusion geneENST00000379540, ENST00000379521, 
ENST00000318524, ENST00000463421, 
ENST00000360909, ENST00000351081, 
ENST00000395125, ENST00000556135, 
ENST00000553966, 
Fusion gene scores* DoF score13 X 11 X 8=11444 X 6 X 3=72
# samples 156
** MAII scorelog2(15/1144*10)=-2.93105264628251
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NFX1 [Title/Abstract] AND DAAM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFX1

GO:0000122

negative regulation of transcription by RNA polymerase II

7964459


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG003552NFX1chr9

33294715

+DAAM1chr14

59662872

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000379540ENST00000360909NFX1chr9

33294715

+DAAM1chr14

59662872

+
5CDS-intronENST00000379540ENST00000351081NFX1chr9

33294715

+DAAM1chr14

59662872

+
5CDS-intronENST00000379540ENST00000395125NFX1chr9

33294715

+DAAM1chr14

59662872

+
5CDS-intronENST00000379540ENST00000556135NFX1chr9

33294715

+DAAM1chr14

59662872

+
5CDS-intronENST00000379540ENST00000553966NFX1chr9

33294715

+DAAM1chr14

59662872

+
5CDS-intronENST00000379521ENST00000360909NFX1chr9

33294715

+DAAM1chr14

59662872

+
5CDS-intronENST00000379521ENST00000351081NFX1chr9

33294715

+DAAM1chr14

59662872

+
5CDS-intronENST00000379521ENST00000395125NFX1chr9

33294715

+DAAM1chr14

59662872

+
5CDS-intronENST00000379521ENST00000556135NFX1chr9

33294715

+DAAM1chr14

59662872

+
5CDS-intronENST00000379521ENST00000553966NFX1chr9

33294715

+DAAM1chr14

59662872

+
5CDS-intronENST00000318524ENST00000360909NFX1chr9

33294715

+DAAM1chr14

59662872

+
5CDS-intronENST00000318524ENST00000351081NFX1chr9

33294715

+DAAM1chr14

59662872

+
5CDS-intronENST00000318524ENST00000395125NFX1chr9

33294715

+DAAM1chr14

59662872

+
5CDS-intronENST00000318524ENST00000556135NFX1chr9

33294715

+DAAM1chr14

59662872

+
5CDS-intronENST00000318524ENST00000553966NFX1chr9

33294715

+DAAM1chr14

59662872

+
intron-intronENST00000463421ENST00000360909NFX1chr9

33294715

+DAAM1chr14

59662872

+
intron-intronENST00000463421ENST00000351081NFX1chr9

33294715

+DAAM1chr14

59662872

+
intron-intronENST00000463421ENST00000395125NFX1chr9

33294715

+DAAM1chr14

59662872

+
intron-intronENST00000463421ENST00000556135NFX1chr9

33294715

+DAAM1chr14

59662872

+
intron-intronENST00000463421ENST00000553966NFX1chr9

33294715

+DAAM1chr14

59662872

+

Top

FusionProtFeatures for NFX1_DAAM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFX1

Q12986

DAAM1

Q9Y4D1

Binds to the X-box motif of MHC class II genes andrepresses their expression. May play an important role inregulating the duration of an inflammatory response by limitingthe period in which MHC class II molecules are induced byinterferon-gamma. Isoform 3 binds to the X-box motif of TERTpromoter and represses its expression. Together with PABPC1 orPABPC4, isoform 1 acts as a coactivator for TERT expression.Mediates E2-dependent ubiquitination.{ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:15371341,ECO:0000269|PubMed:17267499}. Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as ascaffolding protein to recruit Rho-GDP and Rho-GEF, therebyenhancing Rho-GTP formation. Can direct nucleation and elongationof new actin filaments. Involved in building functional cilia(PubMed:16630611, PubMed:17482208). Involved in the organizationof the subapical actin network in multiciliated epithelial cells(By similarity). Together with DAAM2, required for myocardialmaturation and sarcomere assembly (By similarity).{ECO:0000250|UniProtKB:B0DOB5, ECO:0000250|UniProtKB:Q8BPM0,ECO:0000269|PubMed:16630611, ECO:0000269|PubMed:17482208}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for NFX1_DAAM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for NFX1_DAAM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NFX1_DAAM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NFX1_DAAM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource