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Fusion gene ID: 24285 |
FusionGeneSummary for NFRKB_FEN1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NFRKB_FEN1 | Fusion gene ID: 24285 | Hgene | Tgene | Gene symbol | NFRKB | FEN1 | Gene ID | 4798 | 2237 |
| Gene name | nuclear factor related to kappaB binding protein | flap structure-specific endonuclease 1 | |
| Synonyms | INO80G | FEN-1|MF1|RAD2 | |
| Cytomap | 11q24.3 | 11q12.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear factor related to kappa-B-binding proteinDNA-binding protein R kappa BINO80 complex subunit G | flap endonuclease 1DNase IVmaturation factor-1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q6P4R8 | P39748 | |
| Ensembl transtripts involved in fusion gene | ENST00000446488, ENST00000304521, ENST00000524794, ENST00000524746, ENST00000526940, | ENST00000305885, | |
| Fusion gene scores | * DoF score | 4 X 5 X 4=80 | 2 X 2 X 2=8 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: NFRKB [Title/Abstract] AND FEN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | FEN1 | GO:0043137 | DNA replication, removal of RNA primer | 18995831 |
| Tgene | FEN1 | GO:0090305 | nucleic acid phosphodiester bond hydrolysis | 18499658 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | HNSC | TCGA-CR-7382-01A | NFRKB | chr11 | 129762610 | - | FEN1 | chr11 | 61564394 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000446488 | ENST00000305885 | NFRKB | chr11 | 129762610 | - | FEN1 | chr11 | 61564394 | + |
| 5CDS-3UTR | ENST00000304521 | ENST00000305885 | NFRKB | chr11 | 129762610 | - | FEN1 | chr11 | 61564394 | + |
| 5CDS-3UTR | ENST00000524794 | ENST00000305885 | NFRKB | chr11 | 129762610 | - | FEN1 | chr11 | 61564394 | + |
| 5CDS-3UTR | ENST00000524746 | ENST00000305885 | NFRKB | chr11 | 129762610 | - | FEN1 | chr11 | 61564394 | + |
| 5CDS-3UTR | ENST00000526940 | ENST00000305885 | NFRKB | chr11 | 129762610 | - | FEN1 | chr11 | 61564394 | + |
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FusionProtFeatures for NFRKB_FEN1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NFRKB | FEN1 |
| Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'.{ECO:0000269|PubMed:18922472}. Putative regulatory component of the chromatinremodeling INO80 complex which is involved in transcriptionalregulation, DNA replication and probably DNA repair. Modulates thedeubiquitinase activity of UCHL5 in the INO80 complex.{ECO:0000269|PubMed:18922472}. | Structure-specific nuclease with 5'-flap endonucleaseand 5'-3' exonuclease activities involved in DNA replication andrepair. During DNA replication, cleaves the 5'-overhanging flapstructure that is generated by displacement synthesis when DNApolymerase encounters the 5'-end of a downstream Okazaki fragment.It enters the flap from the 5'-end and then tracks to cleave theflap base, leaving a nick for ligation. Also involved in the longpatch base excision repair (LP-BER) pathway, by cleaving withinthe apurinic/apyrimidinic (AP) site-terminated flap. Acts as agenome stabilization factor that prevents flaps from equilibratinginto structurs that lead to duplications and deletions. Alsopossesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved inreplication and repair of rDNA and in repairing mitochondrial DNA.{ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:10744741,ECO:0000269|PubMed:11986308, ECO:0000269|PubMed:18443037,ECO:0000269|PubMed:20729856, ECO:0000269|PubMed:7961795,ECO:0000269|PubMed:8621570}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NFRKB_FEN1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NFRKB_FEN1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NFRKB | UCHL5, RUVBL2, INO80, TERF2, INO80E, YY1, RUVBL1, ACTR5, ACTR8, TFPT, INO80B, INO80C, INO80D, MCRS1, ACTL6A, CUL2, HSP90AA1, TRDMT1, EPHB3, IPO7, XPOT, SPINT2, PRPS1, CARD9, DLK1, CARD8, KPTN, PSMC3, CCNDBP1, EWSR1, DYNLT1, BCL7C, IL20RA, MANSC1, CAV3, CCDC102B, EMILIN1, TMEM52B, KLHL40, TMEM171 | FEN1 | HNRNPA1, BLM, WRN, CDK2, CCNA2, CDK1, PCNA, EP300, ARHGDIA, EEF1G, APEX1, HUS1, RAD9A, RAD1, NCAPG, DDX11, ENDOG, GSK3B, RAD21, TERF1, APP, RAP1A, VRK1, PAXIP1, FN1, AICDA, ELAC2, HARS, PFDN1, TNPO3, LPP, PPP2R5D, SHFM1, SHMT2, MOV10, NXF1, DNA2, WDR76, DUSP19, DRG1, LIG1, MRE11A, MSH2, MSH6, RECQL, WBSCR22, TFG, NTRK1, LRPPRC, LTN1, PPP1R21, TRA2A, CHPF2, FOXA3, FOXL1, FOXO4, FOXP3, SNW1, CDC5L, EGFR, WDR4, SNRNP27, GTF2E2, FGB, USP47, ACTL6A, PTCRA, ATM, UBE2N, HLTF, PARP1, PARP2, DLD, HSD17B10, SOD1, HEY1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NFRKB_FEN1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | FEN1 | P39748 | DB01592 | Iron | Flap endonuclease 1 {ECO:0000255|HAMAP-Rule:MF_03140} | small molecule | approved |
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RelatedDiseases for NFRKB_FEN1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | FEN1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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