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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24276

FusionGeneSummary for NFKBID_NXF1

check button Fusion gene summary
Fusion gene informationFusion gene name: NFKBID_NXF1
Fusion gene ID: 24276
HgeneTgene
Gene symbol

NFKBID

NXF1

Gene ID

84807

10482

Gene nameNFKB inhibitor deltanuclear RNA export factor 1
SynonymsIkappaBNS|TA-NFKBHMEX67|TAP
Cytomap

19q13.12

11q12.3

Type of geneprotein-codingprotein-coding
DescriptionNF-kappa-B inhibitor deltaI-kappa-B-deltaT-cell activation NFKB-like proteinikB-deltaikappaBdeltanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, deltanuclear RNA export factor 1mRNA export factor TAPtip associating proteintip-associated protein
Modification date2018052320180523
UniProtAcc

Q8NI38

Q9UBU9

Ensembl transtripts involved in fusion geneENST00000340950, ENST00000396901, 
ENST00000352614, ENST00000606253, 
ENST00000585544, 
ENST00000531709, 
ENST00000294172, ENST00000532297, 
ENST00000533048, ENST00000531131, 
ENST00000439713, 
Fusion gene scores* DoF score3 X 3 X 3=275 X 5 X 4=100
# samples 35
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NFKBID [Title/Abstract] AND NXF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNXF1

GO:0006406

mRNA export from nucleus

19165146


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB136765NFKBIDchr19

36388677

-NXF1chr11

62567601

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000340950ENST00000531709NFKBIDchr19

36388677

-NXF1chr11

62567601

-
intron-intronENST00000340950ENST00000294172NFKBIDchr19

36388677

-NXF1chr11

62567601

-
intron-intronENST00000340950ENST00000532297NFKBIDchr19

36388677

-NXF1chr11

62567601

-
intron-intronENST00000340950ENST00000533048NFKBIDchr19

36388677

-NXF1chr11

62567601

-
intron-3UTRENST00000340950ENST00000531131NFKBIDchr19

36388677

-NXF1chr11

62567601

-
intron-intronENST00000340950ENST00000439713NFKBIDchr19

36388677

-NXF1chr11

62567601

-
intron-3UTRENST00000396901ENST00000531709NFKBIDchr19

36388677

-NXF1chr11

62567601

-
intron-intronENST00000396901ENST00000294172NFKBIDchr19

36388677

-NXF1chr11

62567601

-
intron-intronENST00000396901ENST00000532297NFKBIDchr19

36388677

-NXF1chr11

62567601

-
intron-intronENST00000396901ENST00000533048NFKBIDchr19

36388677

-NXF1chr11

62567601

-
intron-3UTRENST00000396901ENST00000531131NFKBIDchr19

36388677

-NXF1chr11

62567601

-
intron-intronENST00000396901ENST00000439713NFKBIDchr19

36388677

-NXF1chr11

62567601

-
intron-3UTRENST00000352614ENST00000531709NFKBIDchr19

36388677

-NXF1chr11

62567601

-
intron-intronENST00000352614ENST00000294172NFKBIDchr19

36388677

-NXF1chr11

62567601

-
intron-intronENST00000352614ENST00000532297NFKBIDchr19

36388677

-NXF1chr11

62567601

-
intron-intronENST00000352614ENST00000533048NFKBIDchr19

36388677

-NXF1chr11

62567601

-
intron-3UTRENST00000352614ENST00000531131NFKBIDchr19

36388677

-NXF1chr11

62567601

-
intron-intronENST00000352614ENST00000439713NFKBIDchr19

36388677

-NXF1chr11

62567601

-
intron-3UTRENST00000606253ENST00000531709NFKBIDchr19

36388677

-NXF1chr11

62567601

-
intron-intronENST00000606253ENST00000294172NFKBIDchr19

36388677

-NXF1chr11

62567601

-
intron-intronENST00000606253ENST00000532297NFKBIDchr19

36388677

-NXF1chr11

62567601

-
intron-intronENST00000606253ENST00000533048NFKBIDchr19

36388677

-NXF1chr11

62567601

-
intron-3UTRENST00000606253ENST00000531131NFKBIDchr19

36388677

-NXF1chr11

62567601

-
intron-intronENST00000606253ENST00000439713NFKBIDchr19

36388677

-NXF1chr11

62567601

-
5CDS-3UTRENST00000585544ENST00000531709NFKBIDchr19

36388677

-NXF1chr11

62567601

-
5CDS-intronENST00000585544ENST00000294172NFKBIDchr19

36388677

-NXF1chr11

62567601

-
5CDS-intronENST00000585544ENST00000532297NFKBIDchr19

36388677

-NXF1chr11

62567601

-
5CDS-intronENST00000585544ENST00000533048NFKBIDchr19

36388677

-NXF1chr11

62567601

-
5CDS-3UTRENST00000585544ENST00000531131NFKBIDchr19

36388677

-NXF1chr11

62567601

-
5CDS-intronENST00000585544ENST00000439713NFKBIDchr19

36388677

-NXF1chr11

62567601

-

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FusionProtFeatures for NFKBID_NXF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFKBID

Q8NI38

NXF1

Q9UBU9

Regulates the expression of IL-2, IL-6, and othercytokines through regulation on NF-kappa-B activity. Functions inthe regulation of inflammatory responses. Involved in theinduction of T helper 17 cells (Th17) differentiation uponrecognition of antigen by T cell antigen receptor (TCR). May alsoregulate TCR-induced negative selection of thymocytes.{ECO:0000250|UniProtKB:Q2TB02}. Involved in the nuclear export of mRNA species bearingretroviral constitutive transport elements (CTE) and in the exportof mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway)(PubMed:10924507). The NXF1-NXT1 heterodimer is involved in theexport of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5components of the TREX complex (PubMed:18364396, PubMed:19165146,PubMed:9660949). ALYREF/THOC4-bound mRNA is thought to betransferred to the NXF1-NXT1 heterodimer for export(PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involvedin nuclear export of m6A-containing mRNAs: interaction betweenSRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to bothSRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244).{ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:18364396,ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:28984244,ECO:0000269|PubMed:9660949}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NFKBID_NXF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NFKBID_NXF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NFKBID_NXF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NFKBID_NXF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource