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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24274

FusionGeneSummary for NFKBIB_BGN

check button Fusion gene summary
Fusion gene informationFusion gene name: NFKBIB_BGN
Fusion gene ID: 24274
HgeneTgene
Gene symbol

NFKBIB

BGN

Gene ID

4793

633

Gene nameNFKB inhibitor betabiglycan
SynonymsIKBB|TRIP9DSPG1|MRLS|PG-S1|PGI|SEMDX|SLRR1A
Cytomap

19q13.2

Xq28

Type of geneprotein-codingprotein-coding
DescriptionNF-kappa-B inhibitor betaI-kappa-B-betaNF-kappa-BIBTR-interacting protein 9TRIP-9ikB-BikB-betaikappaBbetanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, betathyroid receptor-interacting protein 9biglycanbone/cartilage proteoglycan-Idermatan sulphate proteoglycan Ismall leucine-rich protein 1A
Modification date2018052220180522
UniProtAcc

Q15653

P21810

Ensembl transtripts involved in fusion geneENST00000572515, ENST00000392079, 
ENST00000313582, 
ENST00000331595, 
ENST00000480756, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 7 X 2=98
# samples 27
** MAII scorelog2(2/8*10)=1.32192809488736log2(7/98*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NFKBIB [Title/Abstract] AND BGN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW613805NFKBIBchr19

39398899

-BGNchrX

152774300

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000572515ENST00000331595NFKBIBchr19

39398899

-BGNchrX

152774300

-
3UTR-3UTRENST00000572515ENST00000480756NFKBIBchr19

39398899

-BGNchrX

152774300

-
3UTR-3UTRENST00000392079ENST00000331595NFKBIBchr19

39398899

-BGNchrX

152774300

-
3UTR-3UTRENST00000392079ENST00000480756NFKBIBchr19

39398899

-BGNchrX

152774300

-
intron-3UTRENST00000313582ENST00000331595NFKBIBchr19

39398899

-BGNchrX

152774300

-
intron-3UTRENST00000313582ENST00000480756NFKBIBchr19

39398899

-BGNchrX

152774300

-

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FusionProtFeatures for NFKBIB_BGN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFKBIB

Q15653

BGN

P21810

Inhibits NF-kappa-B by complexing with and trapping itin the cytoplasm. However, the unphosphorylated form resynthesizedafter cell stimulation is able to bind NF-kappa-B allowing itstransport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylationrendering it more resistant to degradation, explaining its slowerdegradation. May be involved in collagen fiber assembly.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NFKBIB_BGN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NFKBIB_BGN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NFKBIB_BGN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NFKBIB_BGN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneBGNC0003873Rheumatoid Arthritis1CTD_human
TgeneBGNC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneBGNC1848097Spondyloepimetaphyseal Dysplasia, X-Linked1ORPHANET;UNIPROT