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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24260

FusionGeneSummary for NFIX_RBM5

check button Fusion gene summary
Fusion gene informationFusion gene name: NFIX_RBM5
Fusion gene ID: 24260
HgeneTgene
Gene symbol

NFIX

RBM5

Gene ID

4784

10181

Gene namenuclear factor I XRNA binding motif protein 5
SynonymsCTF|MRSHSS|NF-I/X|NF1-X|NF1A|SOTOS2G15|H37|LUCA15|RMB5
Cytomap

19p13.13

3p21.31

Type of geneprotein-codingprotein-coding
Descriptionnuclear factor 1 X-typeCCAAT-binding transcription factorCCAAT-box-binding transcription factorTGGCA-binding proteinnuclear factor 1/XRNA-binding protein 5putative tumor suppressor LUCA15renal carcinoma antigen NY-REN-9
Modification date2018052320180519
UniProtAcc

Q14938

P52756

Ensembl transtripts involved in fusion geneENST00000397661, ENST00000592199, 
ENST00000587760, ENST00000585575, 
ENST00000360105, ENST00000588228, 
ENST00000587260, ENST00000358552, 
ENST00000588680, 
ENST00000347869, 
ENST00000469838, ENST00000441812, 
Fusion gene scores* DoF score21 X 12 X 14=35283 X 3 X 1=9
# samples 293
** MAII scorelog2(29/3528*10)=-3.60472575554259
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NFIX [Title/Abstract] AND RBM5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFIX

GO:0000122

negative regulation of transcription by RNA polymerase II

19706729

HgeneNFIX

GO:0045944

positive regulation of transcription by RNA polymerase II

19706729

TgeneRBM5

GO:0000245

spliceosomal complex assembly

18951082

TgeneRBM5

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

18840686|18951082

TgeneRBM5

GO:0043065

positive regulation of apoptotic process

18840686


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB028954NFIXchr19

13206543

+RBM5chr3

50141679

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000397661ENST00000347869NFIXchr19

13206543

+RBM5chr3

50141679

+
3UTR-intronENST00000397661ENST00000469838NFIXchr19

13206543

+RBM5chr3

50141679

+
3UTR-intronENST00000397661ENST00000441812NFIXchr19

13206543

+RBM5chr3

50141679

+
intron-3CDSENST00000592199ENST00000347869NFIXchr19

13206543

+RBM5chr3

50141679

+
intron-intronENST00000592199ENST00000469838NFIXchr19

13206543

+RBM5chr3

50141679

+
intron-intronENST00000592199ENST00000441812NFIXchr19

13206543

+RBM5chr3

50141679

+
intron-3CDSENST00000587760ENST00000347869NFIXchr19

13206543

+RBM5chr3

50141679

+
intron-intronENST00000587760ENST00000469838NFIXchr19

13206543

+RBM5chr3

50141679

+
intron-intronENST00000587760ENST00000441812NFIXchr19

13206543

+RBM5chr3

50141679

+
intron-3CDSENST00000585575ENST00000347869NFIXchr19

13206543

+RBM5chr3

50141679

+
intron-intronENST00000585575ENST00000469838NFIXchr19

13206543

+RBM5chr3

50141679

+
intron-intronENST00000585575ENST00000441812NFIXchr19

13206543

+RBM5chr3

50141679

+
3UTR-3CDSENST00000360105ENST00000347869NFIXchr19

13206543

+RBM5chr3

50141679

+
3UTR-intronENST00000360105ENST00000469838NFIXchr19

13206543

+RBM5chr3

50141679

+
3UTR-intronENST00000360105ENST00000441812NFIXchr19

13206543

+RBM5chr3

50141679

+
intron-3CDSENST00000588228ENST00000347869NFIXchr19

13206543

+RBM5chr3

50141679

+
intron-intronENST00000588228ENST00000469838NFIXchr19

13206543

+RBM5chr3

50141679

+
intron-intronENST00000588228ENST00000441812NFIXchr19

13206543

+RBM5chr3

50141679

+
intron-3CDSENST00000587260ENST00000347869NFIXchr19

13206543

+RBM5chr3

50141679

+
intron-intronENST00000587260ENST00000469838NFIXchr19

13206543

+RBM5chr3

50141679

+
intron-intronENST00000587260ENST00000441812NFIXchr19

13206543

+RBM5chr3

50141679

+
3UTR-3CDSENST00000358552ENST00000347869NFIXchr19

13206543

+RBM5chr3

50141679

+
3UTR-intronENST00000358552ENST00000469838NFIXchr19

13206543

+RBM5chr3

50141679

+
3UTR-intronENST00000358552ENST00000441812NFIXchr19

13206543

+RBM5chr3

50141679

+
intron-3CDSENST00000588680ENST00000347869NFIXchr19

13206543

+RBM5chr3

50141679

+
intron-intronENST00000588680ENST00000469838NFIXchr19

13206543

+RBM5chr3

50141679

+
intron-intronENST00000588680ENST00000441812NFIXchr19

13206543

+RBM5chr3

50141679

+

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FusionProtFeatures for NFIX_RBM5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFIX

Q14938

RBM5

P52756


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NFIX_RBM5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NFIX_RBM5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NFIX_RBM5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NFIX_RBM5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNFIXC3553660SOTOS SYNDROME 23ORPHANET;UNIPROT
HgeneNFIXC0005586Bipolar Disorder1PSYGENET