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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24249

FusionGeneSummary for NFIX_DAND5

check button Fusion gene summary
Fusion gene informationFusion gene name: NFIX_DAND5
Fusion gene ID: 24249
HgeneTgene
Gene symbol

NFIX

DAND5

Gene ID

4784

199699

Gene namenuclear factor I XDAN domain BMP antagonist family member 5
SynonymsCTF|MRSHSS|NF-I/X|NF1-X|NF1A|SOTOS2CER2|CERL2|CKTSF1B3|COCO|CRL2|DANTE|GREM3|SP1
Cytomap

19p13.13

19p13.13

Type of geneprotein-codingprotein-coding
Descriptionnuclear factor 1 X-typeCCAAT-binding transcription factorCCAAT-box-binding transcription factorTGGCA-binding proteinnuclear factor 1/XDAN domain family member 5DAN domain family member 5, BMP antagonistDAN domain family, member 5cerberus 2cerberus-like 2cerberus-like protein 2cerl-2cysteine knot superfamily 1, BMP antagonist 3gremlin-3
Modification date2018052320180523
UniProtAcc

Q14938

Q8N907

Ensembl transtripts involved in fusion geneENST00000397661, ENST00000592199, 
ENST00000587760, ENST00000585575, 
ENST00000360105, ENST00000588228, 
ENST00000587260, ENST00000358552, 
ENST00000588680, 
ENST00000585548, 
ENST00000317060, 
Fusion gene scores* DoF score21 X 12 X 14=35287 X 2 X 5=70
# samples 299
** MAII scorelog2(29/3528*10)=-3.60472575554259
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/70*10)=0.362570079384708
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NFIX [Title/Abstract] AND DAND5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFIX

GO:0000122

negative regulation of transcription by RNA polymerase II

19706729

HgeneNFIX

GO:0045944

positive regulation of transcription by RNA polymerase II

19706729


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-C8-A26X-01ANFIXchr19

13201204

+DAND5chr19

13084203

+
TCGALDBRCATCGA-D8-A27H-01ANFIXchr19

13136366

+DAND5chr19

13084203

+
TCGARVLUADTCGA-38-4630-01ANFIXchr19

13201204

+DAND5chr19

13084203

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000397661ENST00000585548NFIXchr19

13201204

+DAND5chr19

13084203

+
3UTR-3UTRENST00000397661ENST00000317060NFIXchr19

13201204

+DAND5chr19

13084203

+
5CDS-3UTRENST00000592199ENST00000585548NFIXchr19

13201204

+DAND5chr19

13084203

+
5CDS-3UTRENST00000592199ENST00000317060NFIXchr19

13201204

+DAND5chr19

13084203

+
3UTR-3UTRENST00000587760ENST00000585548NFIXchr19

13201204

+DAND5chr19

13084203

+
3UTR-3UTRENST00000587760ENST00000317060NFIXchr19

13201204

+DAND5chr19

13084203

+
5CDS-3UTRENST00000585575ENST00000585548NFIXchr19

13201204

+DAND5chr19

13084203

+
5CDS-3UTRENST00000585575ENST00000317060NFIXchr19

13201204

+DAND5chr19

13084203

+
3UTR-3UTRENST00000360105ENST00000585548NFIXchr19

13201204

+DAND5chr19

13084203

+
3UTR-3UTRENST00000360105ENST00000317060NFIXchr19

13201204

+DAND5chr19

13084203

+
5CDS-3UTRENST00000588228ENST00000585548NFIXchr19

13201204

+DAND5chr19

13084203

+
5CDS-3UTRENST00000588228ENST00000317060NFIXchr19

13201204

+DAND5chr19

13084203

+
3UTR-3UTRENST00000587260ENST00000585548NFIXchr19

13201204

+DAND5chr19

13084203

+
3UTR-3UTRENST00000587260ENST00000317060NFIXchr19

13201204

+DAND5chr19

13084203

+
5CDS-3UTRENST00000358552ENST00000585548NFIXchr19

13201204

+DAND5chr19

13084203

+
5CDS-3UTRENST00000358552ENST00000317060NFIXchr19

13201204

+DAND5chr19

13084203

+
intron-3UTRENST00000588680ENST00000585548NFIXchr19

13201204

+DAND5chr19

13084203

+
intron-3UTRENST00000588680ENST00000317060NFIXchr19

13201204

+DAND5chr19

13084203

+
5CDS-3UTRENST00000397661ENST00000585548NFIXchr19

13136366

+DAND5chr19

13084203

+
5CDS-3UTRENST00000397661ENST00000317060NFIXchr19

13136366

+DAND5chr19

13084203

+
5CDS-3UTRENST00000592199ENST00000585548NFIXchr19

13136366

+DAND5chr19

13084203

+
5CDS-3UTRENST00000592199ENST00000317060NFIXchr19

13136366

+DAND5chr19

13084203

+
5CDS-3UTRENST00000587760ENST00000585548NFIXchr19

13136366

+DAND5chr19

13084203

+
5CDS-3UTRENST00000587760ENST00000317060NFIXchr19

13136366

+DAND5chr19

13084203

+
5CDS-3UTRENST00000585575ENST00000585548NFIXchr19

13136366

+DAND5chr19

13084203

+
5CDS-3UTRENST00000585575ENST00000317060NFIXchr19

13136366

+DAND5chr19

13084203

+
5CDS-3UTRENST00000360105ENST00000585548NFIXchr19

13136366

+DAND5chr19

13084203

+
5CDS-3UTRENST00000360105ENST00000317060NFIXchr19

13136366

+DAND5chr19

13084203

+
5CDS-3UTRENST00000588228ENST00000585548NFIXchr19

13136366

+DAND5chr19

13084203

+
5CDS-3UTRENST00000588228ENST00000317060NFIXchr19

13136366

+DAND5chr19

13084203

+
5CDS-3UTRENST00000587260ENST00000585548NFIXchr19

13136366

+DAND5chr19

13084203

+
5CDS-3UTRENST00000587260ENST00000317060NFIXchr19

13136366

+DAND5chr19

13084203

+
5CDS-3UTRENST00000358552ENST00000585548NFIXchr19

13136366

+DAND5chr19

13084203

+
5CDS-3UTRENST00000358552ENST00000317060NFIXchr19

13136366

+DAND5chr19

13084203

+
intron-3UTRENST00000588680ENST00000585548NFIXchr19

13136366

+DAND5chr19

13084203

+
intron-3UTRENST00000588680ENST00000317060NFIXchr19

13136366

+DAND5chr19

13084203

+

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FusionProtFeatures for NFIX_DAND5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFIX

Q14938

DAND5

Q8N907

Seems to play a role in the correct specification of theleft-right axis. May antagonize NODAL and BMP4 signaling. Cystineknot-containing proteins play important roles during development,organogenesis, tissue growth and differentiation (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NFIX_DAND5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NFIX_DAND5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NFIXRFX1, HDAC1, RB1, SKI, NFIB, PIR, ISG15, JMJD6, NFIX, QRICH1, ZNF614, CREB1, FOS, JUN, RBPJ, SMAD4, FOXA1, FOXC1, FOXN1, TRIM25DAND5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NFIX_DAND5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneDAND5Q8N907DB01593ZincDAN domain family member 5small moleculeapproved|investigational

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RelatedDiseases for NFIX_DAND5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNFIXC3553660SOTOS SYNDROME 23ORPHANET;UNIPROT
HgeneNFIXC0005586Bipolar Disorder1PSYGENET