FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 24190

FusionGeneSummary for NFE2L2_GPR37L1

check button Fusion gene summary
Fusion gene informationFusion gene name: NFE2L2_GPR37L1
Fusion gene ID: 24190
HgeneTgene
Gene symbol

NFE2L2

GPR37L1

Gene ID

4780

9283

Gene namenuclear factor, erythroid 2 like 2G protein-coupled receptor 37 like 1
SynonymsHEBP1|IMDDHH|NRF2ET(B)R-LP-2|ETBR-LP-2|ETBRLP2
Cytomap

2q31.2

1q32.1

Type of geneprotein-codingprotein-coding
Descriptionnuclear factor erythroid 2-related factor 2nuclear factor erythroid-derived 2-like 2prosaposin receptor GPR37L1endothelin B receptor-like protein 2endothelin type b receptor-like protein 2
Modification date2018052720180520
UniProtAcc

Q16236

O60883

Ensembl transtripts involved in fusion geneENST00000397063, ENST00000397062, 
ENST00000446151, ENST00000464747, 
ENST00000423513, 
ENST00000367282, 
Fusion gene scores* DoF score15 X 14 X 7=14708 X 2 X 6=96
# samples 219
** MAII scorelog2(21/1470*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/96*10)=-0.0931094043914815
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NFE2L2 [Title/Abstract] AND GPR37L1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFE2L2

GO:0010499

proteasomal ubiquitin-independent protein catabolic process

19424503

HgeneNFE2L2

GO:0016567

protein ubiquitination

15983046

HgeneNFE2L2

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

15983046

HgeneNFE2L2

GO:0045944

positive regulation of transcription by RNA polymerase II

17015834

HgeneNFE2L2

GO:0071498

cellular response to fluid shear stress

25190803

TgeneGPR37L1

GO:0007193

adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway

23690594

TgeneGPR37L1

GO:0043410

positive regulation of MAPK cascade

23690594


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-98-A53A-01ANFE2L2chr2

178129260

-GPR37L1chr1

202096869

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000397063ENST00000367282NFE2L2chr2

178129260

-GPR37L1chr1

202096869

+
Frame-shiftENST00000397062ENST00000367282NFE2L2chr2

178129260

-GPR37L1chr1

202096869

+
intron-3CDSENST00000446151ENST00000367282NFE2L2chr2

178129260

-GPR37L1chr1

202096869

+
intron-3CDSENST00000464747ENST00000367282NFE2L2chr2

178129260

-GPR37L1chr1

202096869

+
intron-3CDSENST00000423513ENST00000367282NFE2L2chr2

178129260

-GPR37L1chr1

202096869

+

Top

FusionProtFeatures for NFE2L2_GPR37L1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFE2L2

Q16236

GPR37L1

O60883

Transcription activator that binds to antioxidantresponse (ARE) elements in the promoter regions of target genes.Important for the coordinated up-regulation of genes in responseto oxidative stress and the regulation of cellular redoxconditions. May be involved in the transcriptional activation ofgenes of the beta-globin cluster by mediating enhancer activity ofhypersensitive site 2 of the beta-globin locus control region.{ECO:0000269|PubMed:11035812, ECO:0000269|PubMed:29018201}. Receptor for the neuroprotective and glioprotectivefactor prosaposin. Ligand binding induces endocytosis, followed byan ERK phosphorylation cascade. {ECO:0000269|PubMed:23690594}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for NFE2L2_GPR37L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for NFE2L2_GPR37L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NFE2L2CREBBP, PMF1, EIF2AK3, KEAP1, MAFK, MAFF, JUN, TRIM24, SMARCA4, CUL3, NCOR2, NCOR1, YY1, MYC, BACH1, PRKCD, PRKCA, PRKCQ, PRKCH, PRKCG, SQSTM1, GADD45GIP1, CDKN1A, GSK3B, PGAM5, UBE2E3, UBE2E2, COPS7A, ENC1, MAFG, BPTF, SUMO1, SUMO2, RNF4, SIAH2, NFE2L3, NFE2, ATF4, CREB3, AHR, KPNA3, RBMX, NQO1, BRCA1, AKT1, MAPK8, MAPK9, MAP2K1, MAP2K2, MAPK7, HDAC1, HDAC2, HDAC3, FBXW11, TNNT1, WAC, TCF20, UBC, BTRC, TRIM28, RBM45, MAF, CDH1, PAQR3, PPP1R13L, DCAF11GPR37L1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NFE2L2_GPR37L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NFE2L2_GPR37L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNFE2L2C4277682Chemical and Drug Induced Liver Injury4CTD_human
HgeneNFE2L2C0007131Non-Small Cell Lung Carcinoma2CTD_human
HgeneNFE2L2C0033578Prostatic Neoplasms2CTD_human
HgeneNFE2L2C0007137Squamous cell carcinoma1CTD_human
HgeneNFE2L2C0008370Cholestasis1CTD_human
HgeneNFE2L2C0011881Diabetic Nephropathy1CTD_human
HgeneNFE2L2C0013990Pathological accumulation of air in tissues1CTD_human
HgeneNFE2L2C0014072Experimental Autoimmune Encephalomyelitis1CTD_human
HgeneNFE2L2C0014170Endometrial Neoplasms1CTD_human
HgeneNFE2L2C0017178Gastrointestinal Diseases1CTD_human
HgeneNFE2L2C0020456Hyperglycemia1CTD_human
HgeneNFE2L2C0020507Hyperplasia1CTD_human
HgeneNFE2L2C0022593Keratosis1CTD_human
HgeneNFE2L2C0022658Kidney Diseases1CTD_human
HgeneNFE2L2C0023890Liver Cirrhosis1CTD_human
HgeneNFE2L2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneNFE2L2C0023903Liver neoplasms1CTD_human
HgeneNFE2L2C0027540Necrosis1CTD_human
HgeneNFE2L2C0034069Pulmonary Fibrosis1CTD_human
HgeneNFE2L2C0037286Skin Neoplasms1CTD_human
HgeneNFE2L2C0041755Adverse reaction to drug1CTD_human
HgeneNFE2L2C0085215Ovarian Failure, Premature1CTD_human
HgeneNFE2L2C0162820Dermatitis, Allergic Contact1CTD_human
HgeneNFE2L2C0235032Neurotoxicity Syndromes1CTD_human
HgeneNFE2L2C0242488Acute Lung Injury1CTD_human
HgeneNFE2L2C0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneNFE2L2C0400966Non-alcoholic Fatty Liver Disease1CTD_human
HgeneNFE2L2C0887833Carcinoma, Pancreatic Ductal1CTD_human
HgeneNFE2L2C2239176Liver carcinoma1CTD_human
HgeneNFE2L2C2609414Acute kidney injury1CTD_human