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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 24159

FusionGeneSummary for NFATC1_NFATC1

check button Fusion gene summary
Fusion gene informationFusion gene name: NFATC1_NFATC1
Fusion gene ID: 24159
HgeneTgene
Gene symbol

NFATC1

NFATC1

Gene ID

4772

4772

Gene namenuclear factor of activated T cells 1nuclear factor of activated T cells 1
SynonymsNF-ATC|NF-ATc1.2|NFAT2|NFATcNF-ATC|NF-ATc1.2|NFAT2|NFATc
Cytomap

18q23

18q23

Type of geneprotein-codingprotein-coding
Descriptionnuclear factor of activated T-cells, cytoplasmic 1NFAT transcription complex cytosolic componentnuclear factor of activated T-cells 'c'nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1nuclear factor of activated T-cells, cytoplasmic 1NFAT transcription complex cytosolic componentnuclear factor of activated T-cells 'c'nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Modification date2018052720180527
UniProtAcc

O95644

O95644

Ensembl transtripts involved in fusion geneENST00000253506, ENST00000591814, 
ENST00000397790, ENST00000587635, 
ENST00000427363, ENST00000542384, 
ENST00000318065, ENST00000545796, 
ENST00000592223, ENST00000329101, 
ENST00000586434, ENST00000590172, 
ENST00000253506, ENST00000591814, 
ENST00000397790, ENST00000587635, 
ENST00000427363, ENST00000542384, 
ENST00000318065, ENST00000545796, 
ENST00000592223, ENST00000329101, 
ENST00000586434, ENST00000590172, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 6 X 5=180
# samples 18
** MAII scorelog2(1/1*10)=3.32192809488736log2(8/180*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NFATC1 [Title/Abstract] AND NFATC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFATC1

GO:0033173

calcineurin-NFAT signaling cascade

14979875

HgeneNFATC1

GO:0035556

intracellular signal transduction

14749367

HgeneNFATC1

GO:0045893

positive regulation of transcription, DNA-templated

14749367|14979875

HgeneNFATC1

GO:0045944

positive regulation of transcription by RNA polymerase II

14979875

HgeneNFATC1

GO:1905064

negative regulation of vascular smooth muscle cell differentiation

23853098

TgeneNFATC1

GO:0033173

calcineurin-NFAT signaling cascade

14979875

TgeneNFATC1

GO:0035556

intracellular signal transduction

14749367

TgeneNFATC1

GO:0045893

positive regulation of transcription, DNA-templated

14749367|14979875

TgeneNFATC1

GO:0045944

positive regulation of transcription by RNA polymerase II

14979875

TgeneNFATC1

GO:1905064

negative regulation of vascular smooth muscle cell differentiation

23853098


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ710263NFATC1chr18

77170952

-NFATC1chr18

77171050

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000253506ENST00000253506NFATC1chr18

77170952

-NFATC1chr18

77171050

+
Frame-shitENST00000253506ENST00000591814NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000253506ENST00000397790NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000253506ENST00000587635NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000253506ENST00000427363NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000253506ENST00000542384NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000253506ENST00000318065NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000253506ENST00000545796NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000253506ENST00000592223NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000253506ENST00000329101NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000253506ENST00000586434NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000253506ENST00000590172NFATC1chr18

77170952

-NFATC1chr18

77171050

+
Frame-shitENST00000591814ENST00000253506NFATC1chr18

77170952

-NFATC1chr18

77171050

+
Frame-shitENST00000591814ENST00000591814NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000591814ENST00000397790NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000591814ENST00000587635NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000591814ENST00000427363NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000591814ENST00000542384NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000591814ENST00000318065NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000591814ENST00000545796NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000591814ENST00000592223NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000591814ENST00000329101NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000591814ENST00000586434NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000591814ENST00000590172NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-3CDSENST00000397790ENST00000253506NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-3CDSENST00000397790ENST00000591814NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000397790ENST00000397790NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000397790ENST00000587635NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000397790ENST00000427363NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000397790ENST00000542384NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000397790ENST00000318065NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000397790ENST00000545796NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000397790ENST00000592223NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000397790ENST00000329101NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000397790ENST00000586434NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000397790ENST00000590172NFATC1chr18

77170952

-NFATC1chr18

77171050

+
Frame-shitENST00000587635ENST00000253506NFATC1chr18

77170952

-NFATC1chr18

77171050

+
Frame-shitENST00000587635ENST00000591814NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000587635ENST00000397790NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000587635ENST00000587635NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000587635ENST00000427363NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000587635ENST00000542384NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000587635ENST00000318065NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000587635ENST00000545796NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000587635ENST00000592223NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000587635ENST00000329101NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000587635ENST00000586434NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000587635ENST00000590172NFATC1chr18

77170952

-NFATC1chr18

77171050

+
Frame-shitENST00000427363ENST00000253506NFATC1chr18

77170952

-NFATC1chr18

77171050

+
Frame-shitENST00000427363ENST00000591814NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000427363ENST00000397790NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000427363ENST00000587635NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000427363ENST00000427363NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000427363ENST00000542384NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000427363ENST00000318065NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000427363ENST00000545796NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000427363ENST00000592223NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000427363ENST00000329101NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000427363ENST00000586434NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000427363ENST00000590172NFATC1chr18

77170952

-NFATC1chr18

77171050

+
Frame-shitENST00000542384ENST00000253506NFATC1chr18

77170952

-NFATC1chr18

77171050

+
Frame-shitENST00000542384ENST00000591814NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000542384ENST00000397790NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000542384ENST00000587635NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000542384ENST00000427363NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000542384ENST00000542384NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000542384ENST00000318065NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000542384ENST00000545796NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000542384ENST00000592223NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000542384ENST00000329101NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000542384ENST00000586434NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000542384ENST00000590172NFATC1chr18

77170952

-NFATC1chr18

77171050

+
Frame-shitENST00000318065ENST00000253506NFATC1chr18

77170952

-NFATC1chr18

77171050

+
Frame-shitENST00000318065ENST00000591814NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000318065ENST00000397790NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000318065ENST00000587635NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000318065ENST00000427363NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000318065ENST00000542384NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000318065ENST00000318065NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000318065ENST00000545796NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000318065ENST00000592223NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000318065ENST00000329101NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000318065ENST00000586434NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000318065ENST00000590172NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-3CDSENST00000545796ENST00000253506NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-3CDSENST00000545796ENST00000591814NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000545796ENST00000397790NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000545796ENST00000587635NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000545796ENST00000427363NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000545796ENST00000542384NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000545796ENST00000318065NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000545796ENST00000545796NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000545796ENST00000592223NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000545796ENST00000329101NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000545796ENST00000586434NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000545796ENST00000590172NFATC1chr18

77170952

-NFATC1chr18

77171050

+
Frame-shitENST00000592223ENST00000253506NFATC1chr18

77170952

-NFATC1chr18

77171050

+
Frame-shitENST00000592223ENST00000591814NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000592223ENST00000397790NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000592223ENST00000587635NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000592223ENST00000427363NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000592223ENST00000542384NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000592223ENST00000318065NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000592223ENST00000545796NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000592223ENST00000592223NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000592223ENST00000329101NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000592223ENST00000586434NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000592223ENST00000590172NFATC1chr18

77170952

-NFATC1chr18

77171050

+
Frame-shitENST00000329101ENST00000253506NFATC1chr18

77170952

-NFATC1chr18

77171050

+
Frame-shitENST00000329101ENST00000591814NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000329101ENST00000397790NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000329101ENST00000587635NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000329101ENST00000427363NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000329101ENST00000542384NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000329101ENST00000318065NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000329101ENST00000545796NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000329101ENST00000592223NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000329101ENST00000329101NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000329101ENST00000586434NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000329101ENST00000590172NFATC1chr18

77170952

-NFATC1chr18

77171050

+
Frame-shitENST00000586434ENST00000253506NFATC1chr18

77170952

-NFATC1chr18

77171050

+
Frame-shitENST00000586434ENST00000591814NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000586434ENST00000397790NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000586434ENST00000587635NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000586434ENST00000427363NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000586434ENST00000542384NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000586434ENST00000318065NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000586434ENST00000545796NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000586434ENST00000592223NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000586434ENST00000329101NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000586434ENST00000586434NFATC1chr18

77170952

-NFATC1chr18

77171050

+
5CDS-intronENST00000586434ENST00000590172NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-3CDSENST00000590172ENST00000253506NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-3CDSENST00000590172ENST00000591814NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000590172ENST00000397790NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000590172ENST00000587635NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000590172ENST00000427363NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000590172ENST00000542384NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000590172ENST00000318065NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000590172ENST00000545796NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000590172ENST00000592223NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000590172ENST00000329101NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000590172ENST00000586434NFATC1chr18

77170952

-NFATC1chr18

77171050

+
intron-intronENST00000590172ENST00000590172NFATC1chr18

77170952

-NFATC1chr18

77171050

+

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FusionProtFeatures for NFATC1_NFATC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFATC1

O95644

NFATC1

O95644


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NFATC1_NFATC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NFATC1_NFATC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NFATC1_NFATC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneNFATC1O95644DB00852PseudoephedrineNuclear factor of activated T-cells, cytoplasmic 1small moleculeapproved
TgeneNFATC1O95644DB00852PseudoephedrineNuclear factor of activated T-cells, cytoplasmic 1small moleculeapproved

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RelatedDiseases for NFATC1_NFATC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource