FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 24151

FusionGeneSummary for NFAT5_NOB1

check button Fusion gene summary
Fusion gene informationFusion gene name: NFAT5_NOB1
Fusion gene ID: 24151
HgeneTgene
Gene symbol

NFAT5

NOB1

Gene ID

10725

28987

Gene namenuclear factor of activated T cells 5NIN1 (RPN12) binding protein 1 homolog
SynonymsNF-AT5|NFATL1|NFATZ|OREBP|TONEBPART-4|MST158|MSTP158|NOB1P|PSMD8BP1
Cytomap

16q22.1

16q22.1

Type of geneprotein-codingprotein-coding
Descriptionnuclear factor of activated T-cells 5NFAT-like protein 1T-cell transcription factor NFAT5TonE-binding proteinglutamine rich protein H65nuclear factor of activated T-cells 5, tonicity-responsiveosmotic response element-binding proteintonicity-responRNA-binding protein NOB1NIN1/PSMD8 binding protein 1 homologPSMD8 binding protein 1adenocarcinoma antigen recognized by T lymphocytes 4nin one binding proteinphosphorylation regulatory protein HP-10protein ART-4
Modification date2018052320180523
UniProtAcc

O94916

Q9ULX3

Ensembl transtripts involved in fusion geneENST00000349945, ENST00000432919, 
ENST00000354436, ENST00000567239, 
ENST00000393742, ENST00000566899, 
ENST00000268802, 
Fusion gene scores* DoF score20 X 6 X 14=16802 X 1 X 2=4
# samples 212
** MAII scorelog2(21/1680*10)=-3
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: NFAT5 [Title/Abstract] AND NOB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFAT5

GO:0045944

positive regulation of transcription by RNA polymerase II

11485737


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-43-A56V-01ANFAT5chr16

69602451

+NOB1chr16

69788629

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000349945ENST00000268802NFAT5chr16

69602451

+NOB1chr16

69788629

-
Frame-shiftENST00000432919ENST00000268802NFAT5chr16

69602451

+NOB1chr16

69788629

-
intron-3CDSENST00000354436ENST00000268802NFAT5chr16

69602451

+NOB1chr16

69788629

-
Frame-shiftENST00000567239ENST00000268802NFAT5chr16

69602451

+NOB1chr16

69788629

-
intron-3CDSENST00000393742ENST00000268802NFAT5chr16

69602451

+NOB1chr16

69788629

-
intron-3CDSENST00000566899ENST00000268802NFAT5chr16

69602451

+NOB1chr16

69788629

-

Top

FusionProtFeatures for NFAT5_NOB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFAT5

O94916

NOB1

Q9ULX3

May play a role in mRNA degradation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for NFAT5_NOB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for NFAT5_NOB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NFAT5NFAT5, FOS, JUN, PRKACA, TRIM25NOB1PRNP, TXNL4B, APP, VHL, UPF2, FBXO6, FTSJ3, LIN28A, RNF2, PNO1, HLA-DPA1, RPS2, BYSL, GNL2, ARCN1, CSNK1D, CSNK1E, POLR1D, POLR3B, WDR36, TSR1, POC1A, XPO1, NPM1, RPL10, RPS14, ANKHD1-EIF4EBP3, DNA2, KLHL22, LRRC4C, ANKHD1, POMGNT2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NFAT5_NOB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NFAT5_NOB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource