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Fusion gene ID: 24149 |
FusionGeneSummary for NFAT5_IST1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NFAT5_IST1 | Fusion gene ID: 24149 | Hgene | Tgene | Gene symbol | NFAT5 | IST1 | Gene ID | 10725 | 9798 |
| Gene name | nuclear factor of activated T cells 5 | IST1, ESCRT-III associated factor | |
| Synonyms | NF-AT5|NFATL1|NFATZ|OREBP|TONEBP | OLC1 | |
| Cytomap | 16q22.1 | 16q22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear factor of activated T-cells 5NFAT-like protein 1T-cell transcription factor NFAT5TonE-binding proteinglutamine rich protein H65nuclear factor of activated T-cells 5, tonicity-responsiveosmotic response element-binding proteintonicity-respon | IST1 homologIST1, endosomal sorting complex required for transport-III componentincreased sodium tolerance 1 homologoverexpressed in lung cancer 1putative MAPK-activating protein PM28 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | O94916 | P53990 | |
| Ensembl transtripts involved in fusion gene | ENST00000349945, ENST00000432919, ENST00000354436, ENST00000567239, ENST00000393742, ENST00000566899, | ENST00000544564, ENST00000541571, ENST00000535424, ENST00000378799, ENST00000538565, ENST00000606369, ENST00000329908, ENST00000538850, ENST00000378798, | |
| Fusion gene scores | * DoF score | 20 X 6 X 14=1680 | 4 X 3 X 3=36 |
| # samples | 21 | 5 | |
| ** MAII score | log2(21/1680*10)=-3 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/36*10)=0.473931188332412 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: NFAT5 [Title/Abstract] AND IST1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NFAT5 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11485737 |
| Tgene | IST1 | GO:0009838 | abscission | 19129479|19129480 |
| Tgene | IST1 | GO:0019076 | viral release from host cell | 19129479 |
| Tgene | IST1 | GO:0045862 | positive regulation of proteolysis | 20849418 |
| Tgene | IST1 | GO:0046745 | viral capsid secondary envelopment | 19129479 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-E9-A1NA-01A | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000349945 | ENST00000544564 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5UTR-3CDS | ENST00000349945 | ENST00000541571 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5UTR-3CDS | ENST00000349945 | ENST00000535424 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5UTR-3CDS | ENST00000349945 | ENST00000378799 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5UTR-3UTR | ENST00000349945 | ENST00000538565 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5UTR-3UTR | ENST00000349945 | ENST00000606369 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5UTR-3UTR | ENST00000349945 | ENST00000329908 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5UTR-3UTR | ENST00000349945 | ENST00000538850 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5UTR-3UTR | ENST00000349945 | ENST00000378798 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| In-frame | ENST00000432919 | ENST00000544564 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| Frame-shift | ENST00000432919 | ENST00000541571 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| Frame-shift | ENST00000432919 | ENST00000535424 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| Frame-shift | ENST00000432919 | ENST00000378799 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5CDS-3UTR | ENST00000432919 | ENST00000538565 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5CDS-3UTR | ENST00000432919 | ENST00000606369 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5CDS-3UTR | ENST00000432919 | ENST00000329908 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5CDS-3UTR | ENST00000432919 | ENST00000538850 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5CDS-3UTR | ENST00000432919 | ENST00000378798 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| In-frame | ENST00000354436 | ENST00000544564 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| Frame-shift | ENST00000354436 | ENST00000541571 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| Frame-shift | ENST00000354436 | ENST00000535424 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| Frame-shift | ENST00000354436 | ENST00000378799 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5CDS-3UTR | ENST00000354436 | ENST00000538565 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5CDS-3UTR | ENST00000354436 | ENST00000606369 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5CDS-3UTR | ENST00000354436 | ENST00000329908 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5CDS-3UTR | ENST00000354436 | ENST00000538850 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5CDS-3UTR | ENST00000354436 | ENST00000378798 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| In-frame | ENST00000567239 | ENST00000544564 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| Frame-shift | ENST00000567239 | ENST00000541571 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| Frame-shift | ENST00000567239 | ENST00000535424 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| Frame-shift | ENST00000567239 | ENST00000378799 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5CDS-3UTR | ENST00000567239 | ENST00000538565 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5CDS-3UTR | ENST00000567239 | ENST00000606369 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5CDS-3UTR | ENST00000567239 | ENST00000329908 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5CDS-3UTR | ENST00000567239 | ENST00000538850 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5CDS-3UTR | ENST00000567239 | ENST00000378798 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5UTR-3CDS | ENST00000393742 | ENST00000544564 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5UTR-3CDS | ENST00000393742 | ENST00000541571 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5UTR-3CDS | ENST00000393742 | ENST00000535424 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5UTR-3CDS | ENST00000393742 | ENST00000378799 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5UTR-3UTR | ENST00000393742 | ENST00000538565 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5UTR-3UTR | ENST00000393742 | ENST00000606369 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5UTR-3UTR | ENST00000393742 | ENST00000329908 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5UTR-3UTR | ENST00000393742 | ENST00000538850 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5UTR-3UTR | ENST00000393742 | ENST00000378798 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5UTR-3CDS | ENST00000566899 | ENST00000544564 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5UTR-3CDS | ENST00000566899 | ENST00000541571 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5UTR-3CDS | ENST00000566899 | ENST00000535424 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5UTR-3CDS | ENST00000566899 | ENST00000378799 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5UTR-3UTR | ENST00000566899 | ENST00000538565 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5UTR-3UTR | ENST00000566899 | ENST00000606369 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5UTR-3UTR | ENST00000566899 | ENST00000329908 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5UTR-3UTR | ENST00000566899 | ENST00000538850 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
| 5UTR-3UTR | ENST00000566899 | ENST00000378798 | NFAT5 | chr16 | 69600277 | + | IST1 | chr16 | 71961517 | + |
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FusionProtFeatures for NFAT5_IST1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NFAT5 | IST1 |
| ESCRT-III-like protein involved in specific functions ofthe ESCRT machinery. Is required for efficient abscission duringcytokinesis, but not for HIV-1 budding. The involvement in the MVBpathway is not established. Involved in recruiting VPS4A and/orVPS4B to the midbody of dividing cells (PubMed:19129479,PubMed:19129480). During late anaphase, involved in nuclearenvelope reassembly and mitotic spindle disassembly together withthe ESCRT-III complex: IST1 acts by mediating the recruitment ofSPAST to the nuclear membrane, leading to microtubule severing(PubMed:26040712). Regulates early endosomal tubulation togetherwith the ESCRT-III complex by mediating the recruitment of SPAST(PubMed:23897888). {ECO:0000269|PubMed:19129479,ECO:0000269|PubMed:19129480, ECO:0000269|PubMed:23897888,ECO:0000269|PubMed:26040712}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NFAT5_IST1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NFAT5_ENST00000432919_chr16_69600277_+_IST1_ENST00000544564_chr16_71961517_+_91aa MPSDFISLLSADLDLESPKSLYSRGPGPKPEASAKLPSRPADNYDNFVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRRFEELKKKT >In-frame_NFAT5_ENST00000354436_chr16_69600277_+_IST1_ENST00000544564_chr16_71961517_+_91aa MPSDFISLLSADLDLESPKSLYSRGPGPKPEASAKLPSRPADNYDNFVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRRFEELKKKT >In-frame_NFAT5_ENST00000567239_chr16_69600277_+_IST1_ENST00000544564_chr16_71961517_+_91aa MPSDFISLLSADLDLESPKSLYSRGPGPKPEASAKLPSRPADNYDNFVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRRFEELKKKT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NFAT5_ENST00000432919_chr16_69600277_+_IST1_ENST00000544564_chr16_71961517_+_273nt ATGCCCTCGGACTTCATCTCATTGCTCAGCGCGGACCTAGACCTGGAATCGCCCAAGTCCCTCTACTCGCGAGGTCCTGGACCCAAGCCA GAAGCCTCTGCAAAGCTTCCTTCCAGACCTGCAGATAACTATGACAACTTTGTCCTACCAGAGTTGCCATCTGTGCCAGACACACTACCA ACTGCATCTGCTGGTGCCAGCACCTCAGCATCTGAAGACATTGACTTTGATGATCTTTCCCGGAGGTTTGAAGAGCTGAAAAAGAAAACA >In-frame_NFAT5_ENST00000354436_chr16_69600277_+_IST1_ENST00000544564_chr16_71961517_+_273nt ATGCCCTCGGACTTCATCTCATTGCTCAGCGCGGACCTAGACCTGGAATCGCCCAAGTCCCTCTACTCGCGAGGTCCTGGACCCAAGCCA GAAGCCTCTGCAAAGCTTCCTTCCAGACCTGCAGATAACTATGACAACTTTGTCCTACCAGAGTTGCCATCTGTGCCAGACACACTACCA ACTGCATCTGCTGGTGCCAGCACCTCAGCATCTGAAGACATTGACTTTGATGATCTTTCCCGGAGGTTTGAAGAGCTGAAAAAGAAAACA >In-frame_NFAT5_ENST00000567239_chr16_69600277_+_IST1_ENST00000544564_chr16_71961517_+_273nt ATGCCCTCGGACTTCATCTCATTGCTCAGCGCGGACCTAGACCTGGAATCGCCCAAGTCCCTCTACTCGCGAGGTCCTGGACCCAAGCCA GAAGCCTCTGCAAAGCTTCCTTCCAGACCTGCAGATAACTATGACAACTTTGTCCTACCAGAGTTGCCATCTGTGCCAGACACACTACCA ACTGCATCTGCTGGTGCCAGCACCTCAGCATCTGAAGACATTGACTTTGATGATCTTTCCCGGAGGTTTGAAGAGCTGAAAAAGAAAACA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NFAT5_ENST00000432919_chr16_69600277_+_IST1_ENST00000544564_chr16_71961517_+_1558nt TGCAACGGAAACTTTTGGCTCCACGAACAGAAAAGCAAGAGCAAAAACTCAGTTAAATGCGTTCTTCCTCCATCTTTGCCTAGTCCAAAA GGAAAAAAAAAGAAACAGAAAAAAGAAAAACTGTTTGGAAGAGTAGCGTTGAGGTTTGCTTTTTACCTGTTTTTCCTCTAGAACAGCCAG GTGGATTCACATGATCCAATTTTTTAATTGTCTTCTATGTCCCACTCCGAATAACCCGGATGCCCCAGCACAATCAGAGAGATCGTTTTT TTTAAAAAAAATTTCAGCCTCCAAAGGTAGGAGGGGAGTGTTAGGGGAGAAAGTACTTTAATTAAAAATCAATAACTCGAGGTTTTTGGG ATACGGTTTGCCATTTCCTAATTAAGAAATGGGTTTGACAGTCCCTTTGTACACACTGCTATGCAAACCCCAAAGGGTTGGCGGCTGTCC GGGCGATGACACTCCGGTCCCCTGCGAGACCCCGGGCCAGCCAGGCCCGTCCGCCGCCGGCCTCTGGGGTCCGTCCCCGGCTCGCGCAGA CCTCTCGCTTCTCTCGGCTCTGTCTCCTGCGCTCAGCTCTGCTCGGGGCCGGCCGCCTCAGGCTCGCCGCCACCAGGTCGTTGCAAATAC CTTTTCCCTCCCCGGGGCCCCAGCGCGCGGCCACCTCCCAGCCTCCCCCCCTCCCACCCTGGCAGCGGGGCCCTTTCCCGGCTCAGGAAC AGCAGCAGCCCGGGCCGCGCCGGCAGGAAGCGAGGCCCATGTTGCTGCTGTTCCCTGGCGCGCCTCCCCGCCCTCCGGGGGCCGCCACGG CTCTTCCGCGCTCCCGGGCACCCCCCTCCGCGCCTGCGCTGTGCCCCACGGGGGCGGGGCTCAGATTCCTGTCAGCGGCGGCGGCGGTGG CGGCGACCGTCAGTTTTCGCTGAGGAGAAACACGAAACGGACCCTTTGGCTCTCCCCCTTCCCCTTCCCCGTCCTGAACCCCTCTCCTGG TCACCGAGAATCAGTCCCCGTGGAGTTCCCCCTCCACCTCGCCATCGTTTCCTCGGTCCTCGGCCCAGTGGAAGTCACTACCCTCGAGGA GGAGGCAGCGGCAGCCGCCCTCGCGTCGCCGCCCCCGGTTCGGTGCCCGCGGTCCCGGAGAGGAGGTGCCGCCGCCACCGCCGCTCCCCC CCTCCCGCTGCCCTCGGGCCGGGCTGGGTCGAGCTGCGATGCCCTCGGACTTCATCTCATTGCTCAGCGCGGACCTAGACCTGGAATCGC CCAAGTCCCTCTACTCGCGAGGTCCTGGACCCAAGCCAGAAGCCTCTGCAAAGCTTCCTTCCAGACCTGCAGATAACTATGACAACTTTG TCCTACCAGAGTTGCCATCTGTGCCAGACACACTACCAACTGCATCTGCTGGTGCCAGCACCTCAGCATCTGAAGACATTGACTTTGATG ATCTTTCCCGGAGGTTTGAAGAGCTGAAAAAGAAAACATAGGTCTCTTAAACCAGGCAACTTTCACGTTTTGGGAGTTGAGACTGAGCAA >In-frame_NFAT5_ENST00000354436_chr16_69600277_+_IST1_ENST00000544564_chr16_71961517_+_668nt GCGGCGGTGGCGGCGACCGTCAGTTTTCGCTGAGGAGAAACACGAAACGGACCCTTTGGCTCTCCCCCTTCCCCTTCCCCGTCCTGAACC CCTCTCCTGGTCACCGAGAATCAGTCCCCGTGGAGTTCCCCCTCCACCTCGCCATCGTTTCCTCGGTCCTCGGCCCAGTGGAAGTCACTA CCCTCGAGGAGGAGGCAGCGGCAGCCGCCCTCGCGTCGCCGCCCCCGGTTCGGTGCCCGCGGTCCCGGAGAGGAGGTGCCGCCGCCACCG CCGCTCCCCCCCTCCCGCTGCCCTCGGGCCGGGCTGGGTCGAGCTGCGATGCCCTCGGACTTCATCTCATTGCTCAGCGCGGACCTAGAC CTGGAATCGCCCAAGTCCCTCTACTCGCGAGGTCCTGGACCCAAGCCAGAAGCCTCTGCAAAGCTTCCTTCCAGACCTGCAGATAACTAT GACAACTTTGTCCTACCAGAGTTGCCATCTGTGCCAGACACACTACCAACTGCATCTGCTGGTGCCAGCACCTCAGCATCTGAAGACATT GACTTTGATGATCTTTCCCGGAGGTTTGAAGAGCTGAAAAAGAAAACATAGGTCTCTTAAACCAGGCAACTTTCACGTTTTGGGAGTTGA >In-frame_NFAT5_ENST00000567239_chr16_69600277_+_IST1_ENST00000544564_chr16_71961517_+_590nt CCGTCCTGAACCCCTCTCCTGGTCACCGAGAATCAGTCCCCGTGGAGTTCCCCCTCCACCTCGCCATCGTTTCCTCGGTCCTCGGCCCAG TGGAAGTCACTACCCTCGAGGAGGAGGCAGCGGCAGCCGCCCTCGCGTCGCCGCCCCCGGTTCGGTGCCCGCGGTCCCGGAGAGGAGGTG CCGCCGCCACCGCCGCTCCCCCCCTCCCGCTGCCCTCGGGCCGGGCTGGGTCGAGCTGCGATGCCCTCGGACTTCATCTCATTGCTCAGC GCGGACCTAGACCTGGAATCGCCCAAGTCCCTCTACTCGCGAGGTCCTGGACCCAAGCCAGAAGCCTCTGCAAAGCTTCCTTCCAGACCT GCAGATAACTATGACAACTTTGTCCTACCAGAGTTGCCATCTGTGCCAGACACACTACCAACTGCATCTGCTGGTGCCAGCACCTCAGCA TCTGAAGACATTGACTTTGATGATCTTTCCCGGAGGTTTGAAGAGCTGAAAAAGAAAACATAGGTCTCTTAAACCAGGCAACTTTCACGT |
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FusionGenePPI for NFAT5_IST1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NFAT5 | NFAT5, FOS, JUN, PRKACA, TRIM25 | IST1 | APEH, CHMP1B, ANAPC2, CDC20, FZR1, SPAST, ATXN1, ATP6V1B1, HSPA5, MAT1A, ERGIC1, FN1, VCAM1, ITGA4, BTF3L4, TIMM13, CAPN7, UBQLN1, HEY2, CHMP1A, AP1G2, IQGAP3, MIB2, VPS4A, VPS4B, CLTC, RAB5C, RAB7A, ATP6AP2, TFG, GOLT1B, CHMP4B, NF2, PTAR1, CDH1, USP47, DLD |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NFAT5_IST1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NFAT5_IST1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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