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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24136

FusionGeneSummary for NFASC_PRELP

check button Fusion gene summary
Fusion gene informationFusion gene name: NFASC_PRELP
Fusion gene ID: 24136
HgeneTgene
Gene symbol

NFASC

PRELP

Gene ID

23114

5549

Gene nameneurofascinproline and arginine rich end leucine rich repeat protein
SynonymsNF|NRCAMLMST161|MSTP161|SLRR2A
Cytomap

1q32.1

1q32.1

Type of geneprotein-codingprotein-coding
Descriptionneurofascinneurofascin homologprolargin55 kDa leucine-rich repeat protein of articular cartilageprolargin proteoglycanproline-arginine-rich end leucine-rich repeat protein
Modification date2018052220180523
UniProtAcc

O94856

P51888

Ensembl transtripts involved in fusion geneENST00000338586, ENST00000338515, 
ENST00000367171, ENST00000367169, 
ENST00000539706, ENST00000339876, 
ENST00000367170, ENST00000360049, 
ENST00000367172, ENST00000403080, 
ENST00000404076, ENST00000401399, 
ENST00000404907, ENST00000513543, 
ENST00000495396, 
ENST00000343110, 
Fusion gene scores* DoF score11 X 6 X 4=2646 X 4 X 4=96
# samples 137
** MAII scorelog2(13/264*10)=-1.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/96*10)=-0.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NFASC [Title/Abstract] AND PRELP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVGBMTCGA-06-0210-02ANFASCchr1

204797910

+PRELPchr1

203452297

+
TCGARVGBMTCGA-06-0210-01ANFASCchr1

204797910

+PRELPchr1

203452297

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000338586ENST00000343110NFASCchr1

204797910

+PRELPchr1

203452297

+
5UTR-5UTRENST00000338515ENST00000343110NFASCchr1

204797910

+PRELPchr1

203452297

+
5UTR-5UTRENST00000367171ENST00000343110NFASCchr1

204797910

+PRELPchr1

203452297

+
5UTR-5UTRENST00000367169ENST00000343110NFASCchr1

204797910

+PRELPchr1

203452297

+
5UTR-5UTRENST00000539706ENST00000343110NFASCchr1

204797910

+PRELPchr1

203452297

+
5UTR-5UTRENST00000339876ENST00000343110NFASCchr1

204797910

+PRELPchr1

203452297

+
5UTR-5UTRENST00000367170ENST00000343110NFASCchr1

204797910

+PRELPchr1

203452297

+
5UTR-5UTRENST00000360049ENST00000343110NFASCchr1

204797910

+PRELPchr1

203452297

+
5UTR-5UTRENST00000367172ENST00000343110NFASCchr1

204797910

+PRELPchr1

203452297

+
5UTR-5UTRENST00000403080ENST00000343110NFASCchr1

204797910

+PRELPchr1

203452297

+
intron-5UTRENST00000404076ENST00000343110NFASCchr1

204797910

+PRELPchr1

203452297

+
intron-5UTRENST00000401399ENST00000343110NFASCchr1

204797910

+PRELPchr1

203452297

+
intron-5UTRENST00000404907ENST00000343110NFASCchr1

204797910

+PRELPchr1

203452297

+
intron-5UTRENST00000513543ENST00000343110NFASCchr1

204797910

+PRELPchr1

203452297

+
intron-5UTRENST00000495396ENST00000343110NFASCchr1

204797910

+PRELPchr1

203452297

+

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FusionProtFeatures for NFASC_PRELP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFASC

O94856

PRELP

P51888

May anchor basement membranes to the underlyingconnective tissue. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NFASC_PRELP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NFASC_PRELP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NFASCPRELPHSPG2, FBLN2, COL1A1, COL2A1, TSEN2, AMD1, COL14A1, CKAP4, YTHDF1, TRIM68, PPP2R2D, DHRS4, FSTL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NFASC_PRELP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NFASC_PRELP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNFASCC0036341Schizophrenia1PSYGENET